Novel murine polynucleotide sequences and mutant cells and mutant animals defined thereby

ABSTRACT

Novel murine polynucleotides are disclosed that individually identify novel genes into which a retroviral gene trap vector has integrated. Additionally, novel mutated murine ES cells are described that stably incorporate retroviral gene trap constructs into the specifically identified genes. The novel genes and cells thus defined are useful in functional genomic analysis, and in the discovery and development of new therapeutic and diagnostics agents and methods.

[0001] The present application claims the benefit of U.S. Provisional Application Ser. No. 60/168,358, filed Dec. 1, 1999, herein incorporated by reference, and further incorporates by reference U.S. applications Ser. Nos. 08/726,867, 08/728,963, 08/907,598, 08/942,806, 60/109,302, 09/276,533 and U.S. Pat. No. 6,080,576 which issued Jun. 27, 2000 and their respective disclosures in their entirety.

1.0. FIELD OF THE INVENTION

[0002] The present invention is in the field of molecular genetics. The application discloses novel nucleic acid sequences that: each define the locus of a corresponding mutated murine embryonic stem cell clone, partially define the scope of exons that can be trapped and identified by the disclosed vectors/methods, and that are also useful, inter alia, for identifying the coding regions of the murine genome.

2.0. BACKGROUND OF THE INVENTION

[0003] Most mammalian genes are divided into exons and introns. Exons are the portions of the gene that are spliced into mRNA and encode the protein product of a gene. In genomic DNA, these coding exons are divided by noncoding intron sequences. Although RNA polymerase transcribes both intron and exon sequences, the intron sequences must be removed from the transcript so that the resulting mRNA can be translated into protein. Accordingly, all mammalian, and most eukaryotic, cells have the machinery to splice exons into mRNA. Gene trap vectors have been designed to integrate into introns or genes in a manner that allows the cellular splicing machinery to splice vector encoded exons to cellular mRNAs. Commonly, gene trap vectors contain selectable marker sequences that are preceded by strong splice acceptor sequences and are not preceded by a promoter. Thus, when such vectors integrate into a gene, the cellular splicing machinery splices exons from the trapped gene onto the 5′ end of the selectable marker sequence. Typically, such selectable marker genes can only be expressed if the vector encoding the gene has integrated into an intron. The resulting gene trap events are subsequently identified by selecting for cells that can survive selective culture.

[0004] Gene trapping has generally proven to be an efficient method of mutating large numbers of genes. The insertion of the gene trap vector creates a mutation in the trapped gene, and also provides a molecular tag for ease of identifying the gene that has been trapped. When ROSA Bgeo was used to trap genes it was demonstrated that at least 50% of the resulting mutations resulted in a phenotype when examined in mice. This indicates that the gene trap insertion vectors are useful mutagens. Although a powerful tool for mutating genes, the potential of the method has historically been limited by the difficulty in identifying the trapped genes. Methods that have been used to identify trap events rely on the fusion transcripts resulting from the splicing of exon sequences from the trapped gene to sequences encoded by the gene trap vector. Common gene identification protocols used to obtain sequences from these fusion transcripts include 5′ RACE, cDNA cloning, and cloning of genomic DNA surrounding the site of vector integration. However, these methods have proven labor intensive, not readily amenable to automation, and generally impractical for high-throughput.

[0005] More recently, vectors have been developed that rely on a new strategy of gene trapping that uses a vector that contains a selectable marker gene preceded by a promoter and followed by a splice donor sequence instead of a polyadenylation sequence. These vectors do not provide selection unless they integrate into a gene and subsequently trap downstream exons which provide a polyadenylation sequence. Integration of such vectors into the chromosome results in the splicing of the selectable marker gene to 3′ exons of the trapped gene. These vectors provide a number of advantages. They can be used to trap genes regardless of whether the genes are normally expressed in the cell type in which the vector has integrated. In addition, cells harboring such vectors can be screened using automated (e.g., 96-well plate format) gene identification assays such as 3′ RACE (see generally, Frohman, 1994, PCR Methods and Applications, 4:S40-S58). Using these vectors it is possible to produce large numbers of mutations and rapidly identify the mutated, or trapped, gene by DNA sequence analysis.

3.0. SUMMARY OF THE INVENTION

[0006] The subject invention provides numerous isolated and purified mammalian, particularly murine, cDNAs produced using gene trap technology. The OMNIBANK gene trapped sequences (GTSs) of the subject invention are disclosed as SEQ ID NOS:1-891 in the appended Sequence Listing.

[0007] The subject invention contemplates the use of one or more of the subject GTSs, or portions thereof, to isolate cDNAs, genomic clones, or full-length genes/polynucleotides, or homologs, heterologs, paralogs, or orthologs thereof, that are capable of hybridizing to one or more of the disclosed GTSs under stringent conditions.

[0008] The subject invention additionally contemplates methods of analyzing biopolymer (e.g., oligonucleotides, polynucleotides, oligopeptides, peptides, polypeptides, proteins, etc.) sequence information comprising the steps of loading a first biopolymer sequence into or onto an electronic data storage medium (e.g., digital or analogue versions of electronic, magnetic, or optical memory, and the like) and comparing said first sequence to at least a portion of one of the polynucleotide sequences, or amino acid sequence encoded thereby, that is first disclosed in, or otherwise unique to, SEQ ID NOS:1-891. Typically, the polynucleotide sequences, or amino acid sequences encoded thereby, will also be present on, or loaded into or onto a form of electronic data storage medium, or transferred therefrom, concurrent with or prior to comparison with the first polynucleotide.

[0009] Another embodiment of the claimed invention is the use of a oligonucleotide or polynucleotide sequence first disclosed in at least a portion of at least one of the GTS sequences of SEQ ID NOS:1-891 as a hybridization probe. Of particular interest is the use of such sequences in conjunction with a solid support matrix/substrate (resins, beads, membranes, plastics, polymers, metal or metallized substrates, crystalline or polycrystalline substrates, etc.). Of particular note are spatially addressable arrays (i.e., gene chips, microtiter plates, etc.) of polynucleotides wherein at least one of the polynucleotides on the spatially addressable array comprises an oligonucleotide or polynucleotide sequence first disclosed in at least one of the GTS sequences of SEQ ID NOS:1-891.

[0010] Moreover, an oligonucleotide or polynucleotide sequence first disclosed in at least one of the GTS sequences of SEQ ID NOS:1-891 can be incorporated into a phage display system that can be used to screen for proteins, or other ligands, that are capable of binding an amino acid sequence encoded by an oligonucleotide or polynucleotide sequence first disclosed in at least one of the GTS sequences of SEQ ID NOS:1-891.

[0011] An additional embodiment of the present invention is a library comprising individually isolated linear DNA molecules corresponding to at least a portion of the described GTSs which are useful for synthesizing physically contiguous sequences of overlapping related GTSs by, for example, the polymerase chain reaction (PCR).

[0012] The subject invention also provides for an oligonucleotide hybridization probe comprising sequence that is identical or complementary to a portion of a sequence that is first disclosed in, or preferably unique to, at least one of the GTS polynucleotides the sequence listing. The oligonucleotide probes will generally comprise between about 8 nucleotides and about 80 nucleotides, preferably between about 15 and about 40 nucleotides, and more preferably between about 20 and about 35 nucleotides.

[0013] The subject invention also provides for an antisense molecule which comprises at least a portion of sequence that is first disclosed in, or preferably unique to, at least one of the GTS polynucleotides.

[0014] The subject invention also contemplates a purified polypeptide in which at least a portion of the polypeptide is encoded by, and thus first disclosed by, at least a portion of a GTS of the present invention.

[0015] The subject invention further contemplates a mutated ES cell, or a mutated cell, tissue, or animal derived therefrom, that stably incorporates a gene trap vector into a specifically identified gene or a gene comprising one or more of the disclosed GTS polynucleotide sequences.

[0016] In summary, the unique sequences described in SEQ ID NOS:1-891 are usefull for the identification of coding sequence and the mapping of a unique gene to a particular chromosome. These novel sequences can also be used in addressable arrays, such as gene chips, to identify and characterize temporal and tissue specific gene expression. When the unique sequences described in SEQ ID NOS:1-891 are expressed in mouse embryonic stem cells (“ES cells”) these novel sequences provide a method of identifying phenotypic expression of the a particular gene as well as a method of assigning function to preveously unknown genes. The unique sequences described in SEQ ID NOS:1-891 can be further used to identify the gene of interest from many sources including, but not limited to, libraries consisting of cDNA or genomic clones and for the in silico screening of nucleic acid and protein databases. Additionally, SEQ ID NOS:1-891 can be incorporated into a phage display system and used to screen for proteins, or other ligands. The unique sequences described in SEQ ID NOS:1-891 have further utility for genetic manipulations such as antisense inhibition and gene targeting.

4.0. DESCRIPTION OF THE SEQUENCE LISTING AND FIGURES

[0017] The Sequence Listing is a compilation of nucleotide sequences obtained by sequencing a gene trap library that at least partially identifies the genes in the target cell genome that can be trapped by the described gene trap vectors (i.e., the repertoire of genes that are active, or have not been inactivated, with the tested ES cell population). The Sequence Listing was prepared using the conventions described in the 1996 edition of the 37 C.F.R. sections 1.801-1.825, and/or WIPO Standard ST.25 as referenced by the 1999 edition of 37 C.F.R. sections 1.801-1.825

[0018] FIGS. 1A-1C present a diagrammatic representation of representative gene trap vectors used to generate the described sequences.

5.0. DETAILED DESCRIPTION OF THE INVENTION

[0019] The current invention relates to novel polynucleotides which are expressed in mouse embryonic stem cells (“ES cells”) and which provide unique tools for gene discovery, diagnostic gene expression analysis, cross species hybridization analysis, and for genetic manipulations using a variety of techniques known to those skilled in the art, like, for example, antisense inhibition, gene targeting, etc. Furthermore, the expression of these novel polynucleotides in ES cells suggests their involvement in developmental and cell differentiation processes, making them good candidates to treat disorders and abnormalities affecting development and cell differentiation.

[0020] Additionally, because they are totipotent, the disclosed mutated ES cells (Lex-1 cells from murine strain A129) can be microinjected into blastocysts, introduced to pseudopregnant host animals, and the offspring bred to produce mutated animals as described, for example, in “Mouse Mutagenesis”, 1998, Zambrowicz et al., eds., Lexicon Press, The Woodlands, Tex., and periodic updates thereof, and U.S. patent application Ser. No. 08/943,687 both of which are herein incorporated by reference. Consequently, an additional aspect of the subject invention are mutated mammalian, and preferably murine, cells that have been mutated by a process involving the use genetically engineered vectors or nucleotides to alter the naturally occurring function, sequence, or expression of a genetic locus encoding a novel portion of sequence (e.g., an exon, oligonucleotide sequence, splice junction, etc.) presented in one of the presently described GTSs.

5.1. Polynucleotides of the Present Invention

[0021] The nucleotide sequences of the various isolated GTSs of the present invention appear in the Sequence Listing as SEQ ID NOS:1-891. Additional embodiments of the present invention are GTS variants, or homologs, paralogs, orthologs, etc., which include isolated polynucleotides, or complements thereof, that hybridize to one or more of the disclosed GTSs of SEQ ID NOS:1-891 under stringent, or preferably highly stringent, conditions.

[0022] By way of example and not limitation, high stringency hybridization conditions can be defined as follows: Prehybridization of filters containing DNA to be screened is carried out for 8 h to overnight at 65° C. in a buffer containing 6×SSC, 50 mM Tris-HCl (pH 7.5), 1 mM EDTA, 0.02% PVP, 0.02% Ficoll, 0.02% BSA, and 500 μg/ml denatured salmon sperm DNA. Filters are hybridized for 48 h at 65° C. in prehybridization mixture containing 100 μg/ml denatured salmon sperm DNA and 5-20×10⁶ cpm of ³²P-labeled probe (alternatively, as in all hybridizations described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used). The filters are then washed in approximately 1× wash mix (10× wash mix contains 3M NaCl, 0.6M Tris base, and 0.02M EDTA, alternatively, as with all washes described herein, 2×, 3×, 4×, 5×, 6× wash mix, or more, can be used) twice for 5 minutes each at room temperature, then in 1× wash mix containing 1% SDS at 60° C. (alternatively, as in all washes described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min, and finally in 0.3× wash mix (alternatively, as in all final washes described herein, approximately, 0.2×, 0.4×, 0.6×, 0.8×, 1×, or any concentration between about 2× and about 6× can be used in conjunction with a suitable wash temperature) containing 0.1% SDS at 60° C. (alternatively, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min. The filters are then air dried and exposed to x-ray film for autoradiography. In an alternative protocol, washing of filters is done for 37° C. for 1 h in a solution containing 2×SSC, 0.01% PVP, 0.01% Ficoll, and 0.01% BSA. This is followed by a wash in 0.1×SSC at 50° C. for 45 min before autoradiography. Another example of hybridization under highly stringent conditions is hybridization to filter-bound DNA in 0.5 M NaHPO₄, 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C., and washing in 0.1×SSC/0.1% SDS at 68° C. (Ausubel F. M. et al., eds., 1989, Current Protocols in Molecular Biology, Vol. I, Green Publishing Associates, Inc., and John Wiley & sons, Inc., New York, at p. 2.10.3).

[0023] Additionally contemplated are GTS polynucleotides that are at least about 99, 95, 90, or about 85 percent similar to corresponding regions of one of SEQ ID NOS:1-891 (as measured by BLAST sequence comparison analysis using, for example, the GCG sequence analysis package using default parameters).

[0024] Preferably, such GTS variants will encode at least a portion or domain of a, preferably naturally occurring, protein or polypeptide that encodes a functional equivalent to a protein or polypeptide, or portion or domain thereof, encoded by the disclosed GTSs. Additional examples of GTS variants include polynucleotides, or complements thereof, that are capable of binding to the disclosed GTSs under less stringent conditions, such as moderately stringent conditions, (e.g., washing in 0.2×SSC/0.1% SDS at 42° C. (Ausubel et al., 1989, supra). Moderately stringent conditions can be additionally defined, for example, as follows: Filters containing DNA are pretreated for 6 h at 55° C. in a solution containing 6×SSC, 5×Denhart's solution, 0.5% SDS and 100 lg/ml denatured salmon sperm DNA. Hybridizations are carried out in the same solution and 5-20×10⁶ cpm ³²P-labeled probe is used. Filters are incubated in hybridization mixture for 18-20 h at 55° C. (alternatively, as in all hybridizations described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used in combination with a suitable concentration of salt). The filters are then washed in approximately 1× wash mix (10× wash mix contains 3M NaCl, 0.6M Tris base, and 0.02M EDTA, alternatively, as with all washes described herein, 2×, 3×, 4×, 5×, 6× wash mix, or more, can be used) twice for 5 minutes each at room temperature, then in 1× wash mix containing 1% SDS at 60° C. (alternatively, as in all washes described herein, approximately, 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min, and finally in 0.3× wash mix (alternatively, as in all final washes described herein approximately 0.2×, 0.4×, 0.6×, 0.8×, 1×, or any concentration between about 2× and about 6× can be used in conjunction with a suitable wash temperature) containing 0.1% SDS at 60° C. (alternatively, approximately 42, 44, 45, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min. The filters are then air dried and exposed to x-ray film for autoradiography.

[0025] In an alternative protocol, washing of filters is done twice for 30 minutes at 60° C. in a solution containing 1×SSC and 0.1% SDS. Filters are blotted dry and exposed for autoradiography.

[0026] Other conditions of moderate stringency which may be used are well-known in the art. For example, washing of filters can be done at 37° C. for 1 h in a solution containing 2×SSC, 0.1% SDS. Another example of hybridization under moderately stringent conditions is washing in 0.2×SSC/0.1% SDS at 42° C. (Ausubel et al., 1989, supra). Such less stringent conditions may also be, for example, low stringency hybridization conditions. By way of example and not limitation, procedures using such conditions of low stringency are as follows (see also Shilo and Weinberg, 1981, Proc. Natl. Acad. Sci. USA 78:6789-6792): Filters containing DNA are pretreated for 6 h at 40° C. in a solution containing 35% formamide, 5×SSC, 50 mM Tris-HCl (pH 7.5), 5 mM EDTA, 0.1% PVP, 0.1% Ficoll, 1% BSA, and 500 μg/ml denatured salmon sperm DNA. Hybridizations are carried out in the same solution with the following modifications: 0.02% PVP, 0.02% Ficoll, 0.2% BSA, 100 μg/ml salmon sperm DNA, 10% (wt/vol) dextran sulfate, and 5-20×10⁶ cpm ³²P-labeled probe is used. Filters are incubated in hybridization mixture for 18-20 h at 40° C. (alternatively, as in all hybridizations described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used). The filters are then washed in approximately 1× wash mix (10× wash mix contains 3M NaCl, 0.6M Tris base, and 0.02M EDTA, alternatively, as with all washes described herein, 2×, 3×, 4×, 5×, 6× wash mix, or more, can be used) twice for five minutes each at room temperature, then in 1× wash mix containing 1% SDS at 60° C. (alternatively, as in all washes described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min, and finally in 0.3× wash mix (alternatively, as in all final washes described herein, approximately, 0.2×, 0.4×, 0.6×, 0.8×, 1×, or any concentration between about 2× and about 6× can be used in conjunction with a suitable wash temperature) containing 0.1% SDS at 60° C. (alternatively, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min. The filters are then air dried and exposed to x-ray film for autoradiography. In yet another alternative protocol, washing of filters is done for 1.5 h at 55° C. in a solution containing 2×SSC, 25 mM Tris-HCl (pH 7.4), 5 mM EDTA, and 0.1% SDS. The wash solution is replaced with fresh solution and incubated an additional 1.5 h at 60° C. Filters are then blotted dry and exposed for autoradiography. If necessary, filters are washed for a third time at 65-68° C. and reexposed to film. Other conditions of low stringency which may be used are well known in the art (e.g., as employed for cross-species hybridizations). Preferably, GTS variants identified or isolated using the above methods will also encode a functionally equivalent gene product (i.e., protein, polypeptide, or domain thereof, encoding or otherwise associated with a function or structure at least partially encoded by the complementary GTS).

[0027] Additional embodiments contemplated by the present invention include any polynucleotide sequence comprising a continuous stretch of nucleotide sequence originally disclosed in, or otherwise unique to, any of the GTSs of SEQ ID NOS:1-891 that are at least 8, or at least 10, or at least 14, or at least 20, or at least 30, or at least about 40, and preferably at least about 60 consecutive nucleotides up to about several hundred bases of nucleotide sequence or an entire GTS sequence. Functional equivalents of the gene products of SEQ ID NOS:1-891 include naturally occurring variants of SEQ ID NOS:1-891 present in other species, and mutant variants, both naturally occurring and engineered, which retain at least some of the functional activities of the gene products of SEQ ID NOS:1-891.

[0028] The invention also includes degenerate variants of the claimed GTS sequences, and products encoded thereby. The invention further includes GTS derivatives wherein any of the disclosed GTSs, or GTS variants, is linked to another polynucleotide molecule, or a fragment thereof, wherein the link may be either directly or through other polynucleotides of any sequence and of a length of about 1,000 base pairs, or about 500 base pairs, or about 300 base pairs, or about 200 base pairs, or about 150 base pairs, or about 100 base pairs or about 50 base pairs, or less.

[0029] The invention also particularly includes polynucleotide molecules, including DNA, that hybridize to, and are therefore the complements of, the nucleotide sequences of the disclosed GTSs. Such hybridization conditions may be highly stringent or less highly stringent, as described above. In instances wherein the nucleic acid molecules are deoxyoligonucleotides (“DNA oligos”), highly stringent conditions may refer to, for example, washing in 6×SSC/0.05% sodium pyrophosphate at 37° C. (for oligos having 14-base DNA oligos), 48° C. (for 17-base DNA oligos), 55° C. (for 20-base DNA oligos), and 60° C. (for 23-base oligos). Similar conditions are contemplated for RNA oligos corresponding to a portion of the disclosed GTS sequences.

[0030] These nucleic acid molecules may encode or act as antisense molecules to polynucleotides comprising at least a portion of the sequences first disclosed in SEQ ID NOS:1-891 that are useful, for example, to regulate the expression of genes comprising a nucleotide sequence of any of SEQ ID NOS:1-891, and can also be used, for example, as antisense primers in amplification reactions of gene sequences. With respect to gene regulation, such techniques can be used to regulate, for example, developmental processes by inhibiting, enhancing, hindering, or otherwise modulating the expression of genes in target cells, or particularly in embryonic stem cells. Further, such sequences may be used as part of ribozyme and/or triple helix sequences that can be used to regulate gene expression. Optionally, genes or polynucleotides encoding the GTSs can be conditionally expressed.

[0031] Still further, such molecules may be used as components of iagnostic methods whereby, for example, the presence of a particular allele, of a gene that contains any of the sequences of SEQ ID NOS:1-891 may be detected. Of particular interest is the use of the disclosed GTSs to conduct analysis of single nucleotide polymorphisms (SNPs) in the human genome, or as general or individual-specific forensic markers.

[0032] In addition to the nucleotide sequences described above, full length cDNA or gene sequences that contain any of SEQ ID NOS:1-891 present in the same species and/or homologs of any of those genes present in other species can be identified and -isolated by using molecular biological techniques known in the art.

[0033] In order to clone the full length cDNA sequence from any species encoding the cDNA corresponding to the entire messenger RNA or to clone variant or heterologous forms of the molecule, labeled DNA probes made from nucleic acid fragments corresponding to any of the partial cDNA disclosed herein may be used to screen a cDNA library. For example, oligonucleotides corresponding to either the 5′ or 3′ terminus of the cDNA sequence may be used to obtain longer nucleotide sequences. Briefly, the library may be plated out to yield a maximum of about 30,000 pfu for each 150 mm plate. Approximately 40 plates may be screened. The plates are incubated at 37° C. until the plaques reach a diameter of 0.25 mm or are just beginning to make contact with one another (3-8 hours). Nylon filters are placed onto the soft top agarose and after 60 seconds, the filters are peeled off and floated on a DNA denaturing solution consisting of 0.4N sodium hydroxide. The filters are then immersed in neutralizing solution consisting of 1 M Tris HCl, pH 7.5, before being allowed to air dry. The filters are prehybridized in casein hybridization buffer containing 10% dextran sulfate, 0.5 M NaCl, 50 mM Tris HCl, pH 7.5, 0.1% sodium pyrophosphate, 1% casein, 1% SDS, and denatured salmon sperm DNA at 0.5 mg/ml for 6 hours at 60° C. The radiolabelled probe is then denatured by heating to 95° C. for 2 minutes and then added to the prehybridization solution containing the filters. The filters are hybridized at 60° C. (alternatively, as in all hybridizations described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 16 hours. The filters are then washed in approximately 1× wash mix (10× wash mix contains 3M NaCl, 0.6M Tris base, and 0.02M EDTA, alternatively, as with all washes described herein, 2×, 3×, 4×, 5×, 6× wash mix, or more, can be used) twice for 5 minutes each at room temperature, then in 1× wash mix containing 1% SDS at 60° C. (alternatively, as in all washes described herein, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min, and finally in 0.3× wash mix (alternatively, as in all final washes described herein, approximately, 0.2×, 0.4×, 0.6×, 0.8×, 1×, or any concentration between about 2× and about 6× can be used in conjunction with a suitable wash temperature) containing 0.1% SDS at 60° C. (alternatively, approximately 42, 44, 46, 48, 50, 52, 54, 56, 58, 62, 64, 66, 68, 70, or about 72 degrees or more can be used) for about 30 min. The filters are then air dried and exposed to x-ray film for autoradiography. After developing, the film is aligned with the filters to select a positive plaque. If a single, isolated positive plaque cannot be obtained, the agar plug containing the plaques will be removed and placed in lambda dilution buffer containing 0.1M NaCl, 0.01M magnesium sulfate, 0.035M Tris HCl, pH 7.5, 0.01% gelatin. The phage may then be replated and rescreened to obtain single, well isolated positive plaques. Positive plaques may be isolated and the cDNA clones sequenced using primers based on the known cDNA sequence. This step may be repeated until a full length cDNA is obtained.

[0034] It may be necessary to screen multiple cDNA libraries from different sources/tissues to obtain a full length cDNA. In the event that it is difficult to identify cDNA clones encoding the complete 5′ terminal coding region, an often encountered situation in cDNA cloning, the RACE (Rapid Amplification of cDNA Ends) technique may be used. RACE is a proven PCR-based strategy for amplifying the 5′ end of incomplete cDNAs. 5′-RACE-Ready cDNA synthesized from human fetal liver containing a unique anchor sequence is commercially available (Clontech). To obtain the 5′ end of the cDNA, PCR is carried out, for example, on 5′-RACE-Ready cDNA using the provided anchor primer and the 3′ primer. A secondary PCR reaction is then carried out using the anchored primer and a nested 3′ primer according to the manufacturer's instructions.

[0035] Once obtained, the full length cDNA sequence may be translated into amino acid sequence and examined for certain landmarks found in the amino acid sequences encoded by SEQ ID NOS:1-891, or any structural similarities to these disclosed sequences.

[0036] The identification of homologs, heterologs, or paralogs of SEQ ID NOS:1-891 in other, preferably related, species can be useful for developing additional animal model systems that are closely related to humans for purposes of drug discovery. Genes at other genetic loci within the genome that encode proteins which have extensive homology to one or more domains of the gene products encoded by SEQ ID NOS:1-891 can also be identified via similar techniques. In the case of cDNA libraries, such screening techniques can identify clones derived from alternatively spliced transcripts in the same or different species.

[0037] Screening can be done using filter hybridization with duplicate filters. The labeled probe can contain at least 15-30 base pairs of the nucleotide sequence presented in SEQ ID NOS:1-891. The hybridization washing conditions used should be of a lower stringency when the cDNA library is derived from an organism different from, or heterologous to, the type of organism from which the labeled sequence was derived. With respect to the cloning of a mammalian homolog, heterolog, ortholog, or paralog, using probes derived from any of the sequences of SEQ ID NOS:1-891, for example, hybridization can, for example, be performed at 65° C. overnight in Church's buffer (7% SDS, 250 mM NaHPO₄, 2 mM EDTA, 1% BSA) . Washes can be done with 2×SSC, 0.1% SDS at 65° C. and then at 0.lXSSC, 0.1% SDS at 65° C.

[0038] Low stringency conditions are well known to those of skill in the art, and will vary predictably depending on the specific organisms from which the library and the labeled sequences are derived. For guidance regarding such conditions see, for example, Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual, Cold Springs Harbor Press, N.Y.; and Ausubel et al., 1989, Current Protocols in Molecular Biology, Green Publishing Associates and Wiley Interscience, N.Y.

[0039] Alternatively, the labeled nucleotide probe of a sequence of any of SEQ ID NOS:1-891 may be used to screen a genomic library derived from the organism of interest, again, using appropriately stringent conditions. The identification and characterization of human genomic clones is helpful for designing diagnostic tests and clinical protocols for treating disorders in human patients that are known or suspected to be linked to disease or other development or cell differentiation disorders and abnormalities. For example, sequences derived from regions adjacent to the intron/exon boundaries of the human gene can be used to design primers for use in amplification assays to detect mutations within the exons, introns, splice sites (e.g., splice acceptor and/or donor sites), etc., that can be used in diagnostics.

[0040] Further, gene homologs can also be isolated from nucleic acid of the organism of interest by performing PCR using two oligonucleotide primers derived from SEQ ID NOS:1-891, or two degenerate oligonucleotide primer pools designed on the basis of amino acid sequences within the gene products encoded by SEQ ID NOS:1-891. The template for the reaction may be cDNA obtained by reverse transcription of mRNA prepared from, for example, human or non-human cell lines, cell types, or tissues, like, for example, ES cells from the organism of interest.

[0041] The PCR product may be subcloned or sequenced directly or subcloned and sequenced to ensure that the amplified sequences represent the sequences of the gene corresponding to the sequence of SEQ ID NOS:1-891 of interest. The PCR fragment may then be used to isolate a full length cDNA clone by a variety of methods. For example, the amplified fragment may be labeled and used to screen a cDNA library, such as a bacteriophage cDNA library. Alternatively, the labeled fragment may be used to isolate genomic clones via the screening of a genomic library.

[0042] PCR technology may also be utilized to isolate full length cDNA sequences. For example, RNA may be isolated, following standard procedures, from an appropriate cellular source (i.e., one known, or suspected, to express the gene corresponding to the sequence of SEQ ID NOS:1-891 of interest, such as, for example, ES cells). A reverse transcription reaction may be performed on the RNA using an oligonucleotide primer specific for the most 5′ end of the amplified fragment for the priming of first strand synthesis. The resulting RNA/DNA hybrid may then be “tailed” with guanines, for example, using a standard terminal transferase reaction, the hybrid may be digested with RNase H, and second strand synthesis may then be primed with a poly-C primer. Thus, cDNA sequences upstream from the amplified fragment may easily be isolated. For a review of cloning strategies which may be used, see e.g., Sambrook et al., 1989, supra. Alternatively, cDNA or genomic libraries can be screened using 5′ PCR primers that hybridize to vector sequences and 3′ PCR primers specific to the gene of interest. Typically, such primers comprise oligonucleotide “priming” sequences first disclosed in, or otherwise unique to, one of the GTSs of SEQ ID NOS:1-891.

[0043] The sequence of a gene corresponding to any of the sequences of SEQ ID NOS:1-891 can also be used to isolate mutant alleles of that gene. Such mutant alleles may be isolated from individuals either known or suspected to have a genotype which contributes to the disease of interest or other symptoms of developmental and cell differentiation and/or proliferation disorders and abnormalities. Mutant alleles and mutant allele products may then be utilized in the therapeutic and diagnostic programs described below. Additionally, such sequences of any of the genes corresponding to SEQ ID NOS:1-891 can be used to detect gene regulatory (e.g., promoter or promoter/enchanter) defects which can affect development or cell differentiation.

[0044] A cDNA of a mutant gene corresponding to any of the sequences of SEQ ID NOS:1-891 can be isolated as discussed above, or, for example, by using PCR. In this case, the first cDNA strand may be synthesized by hybridizing an oligo-dT oligonucleotide to mRNA isolated from cells derived from an individual suspected of carrying a mutant gene corresponding to any of the sequences of SEQ ID NOS:1-891 by extending the new strand with reverse transcriptase. The second strand of the cDNA is then synthesized using an oligonucleotide that hybridizes specifically to the 5′ region of the normal gene. The amplified product can be directly sequenced or cloned into a suitable vector and subsequently subjected to DNA sequence analysis. By comparing the DNA sequence of the mutant allele to that of the normal allele, the mutation(s) responsible for the loss or alteration of function of the mutant gene product can be ascertained.

[0045] Alternatively, a genomic library can be constructed using DNA obtained from one or more individuals suspected of carrying, or known to carry, a mutant allele corresponding to any of SEQ ID NOS:1-891. Corresponding mutant cDNA libraries can be also constructed using RNA from cell types known, or suspected, to express such mutant alleles. The corresponding normal gene, or any suitable fragment thereof, may then be labeled and used as a probe to identify the corresponding mutant allele in such libraries. Clones containing the mutant gene sequences may then be identified and analyzed by DNA sequence analysis. Additionally, a protein expression library can be constructed utilizing cDNA synthesized from, for example, RNA isolated from a cell type known, or suspected, to express a mutant allele corresponding to any of the sequences of SEQ ID NOS:1-891 from an individual suspected of, carrying or known to carry, such a mutant allele. In this manner, gene products made by the putatively mutant cell type may be expressed and screened using standard antibody screening techniques in conjunction with antibodies raised against the corresponding normal gene product or a portion thereof, as described below in Section 5.4 (For screening techniques, see, for example, Harlow, E. and Lane, eds., 1988, “Antibodies: A Laboratory Manual”, Cold Spring Harbor Press, Cold Spring Harbor.) Additionally, screening can be accomplished by screening with labeled fusion proteins. In cases where a mutation results in an expressed gene product with altered function (e.g., as a result of a missense or a frame shift mutation), a polyclonal set of antibodies to the wild-type gene product are likely to cross-react with the mutant gene product. Library clones detected via their reaction with such labeled antibodies can be purified and subjected to sequence analysis according to methods well known to those of skill in the art.

[0046] The invention also encompasses nucleotide sequences that encode mutant isoforms of any of the amino acid sequences encoded by the GTSs of SEQ ID NOS:1-891, peptide fragments thereof, truncated versions thereof, and fusion proteins including any of the above. Examples of such fusion proteins can include, but not limited to, an epitope tag which aids in purification or detection of the resulting fusion protein; or an enzyme, fluorescent protein, luminescent protein which can be used as a marker.

[0047] The present invention additionally encompasses (a) RNA or DNA vectors that contain any portion of SEQ ID NOS:1-891 and/or their complements as well as any of the peptides or proteins encoded thereby; (b) DNA vectors that contain a cDNA that substantially spans the entire open reading frame corresponding to any of the sequences of SEQ ID NOS:1-891 and/or their complements; (c) DNA expression vectors that contain any of the foregoing sequences, or a portion thereof, operatively associated with a (d) genetically engineered host cells that contain a cDNA that spans the entire open reading frame, or any portion thereof, corresponding to any of the sequences of SEQ ID NOS:1-891 operatively associated with a regulatory element, generally recombinantly positioned either in vivo (such as in gene activation) or in vitro, that directs the expression of the GTS coding sequences in the host cell. As used herein, regulatory elements include but are not limited to inducible and non-inducible promoters, enhancers, operators and other elements known to those skilled in the art that drive and regulate expression. Such regulatory elements include but are not limited to the baculovirus promoter, cytomegalovirus hCMV immediate early gene promoter, the early or late promoters of SV40 adenovirus, the lac system, the trp system, the TAC system, the TRC system, the major operator and promoter regions of phage A, the control regions of fd coat protein, acid phosphatase promoters, phosphoglycerate kinase (PGK) and especially 3-phosphoglycerate kinase promoters, and yeast alpha mating factors.

[0048] Because the described GTSs represent cellular exon sequence that has been recognized and spliced by the cellular splicing machinery, each GTS further identifies at least one exon and/or exon splice junctions that is useful, and in many cases necessary, for chromosome mapping and the analysis and practical application of genomic DNA sequence data.

5.2.Proteins and Polypeptides Encoded by Polynucleotides Expressed in Mouse ES Cells

[0049] Peptides and proteins encoded by the open reading frame of mRNAs corresponding to SEQ ID NOS:1-891, polypeptides and peptide fragments, mutated, truncated or deleted forms of those peptides and proteins, fusion proteins containing any of those peptides and proteins can be prepared for a variety of uses, including but not limited to, the generation of antibodies, as reagents in diagnostic assays, the identification of other cellular gene products involved in the regulation of development and cellular differentiation of various cell types, like, for example, ES cells, as reagents in assays for screening for compounds that can be used in the treatment of disorders affecting development and cell differentiation, and as pharmaceutical reagents useful in the treatment of disorders affecting development and cell differentiation.

[0050] The invention also encompasses proteins, peptides, and polypeptides that are functionally equivalent to those encoded by SEQ ID NOS:1-891. Such functionally equivalent products include, but are not limited to, additions or substitutions of amino acid residues within the amino acid sequence encoded by the nucleotide sequences described above, but which result in a silent change, thus producing a functionally equivalent gene product. Amino acid substitutions can be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid.

[0051] While random mutations can be introduced into DNA encoding peptides and proteins of the current invention (using random mutagenesis techniques well known to those skilled in the art), and the resulting mutant peptides and proteins tested for activity, site-directed mutations of the coding sequence can be engineered (using standard site-directed mutagenesis techniques) to generate mutant peptides and proteins of the current invention having increased functionality.

[0052] For example, the novel amino acid sequence of peptides and proteins at least partially encoded by the GTSs of the current invention can be aligned with homologs from different species. Mutant peptides and proteins can be engineered so that regions of interspecies identity are maintained, whereas the variable residues are altered, e.g., by deletion or insertion of an amino acid residue(s) or by substitution of one or more different amino acid residues. Conservative alterations at the variable positions can be engineered in order to produce a mutant form of a peptide or protein of the current invention that retains function. Non-conservative changes can be engineered at these variable positions to alter function. Alternatively, where alteration of function is desired, deletion or non-conservative alterations of the conserved regions can be engineered. One of skill in the art may easily test such mutant or deleted form of a peptide or protein of the current invention for these alterations in function using the teachings presented herein.

[0053] Other mutations to the coding sequences described above can be made to generate peptides and proteins that are better suited for expression, scale up, etc. in the host cells chosen. For example, the triplet code for each amino acid can be modified to conform more closely to the preferential codon usage of the host cell's translational machinery, or, for example, to yield a messenger RNA molecule with a longer half-life. Those skilled in the art would readily know what modifications of the nucleotide sequence would be desirable to conform the nucleotide sequence to preferential codon usage or to make the messenger RNA more stable. Such information would be obtainable, for example, through use of computer programs, through review of available research data on codon usage and messenger RNA stability, and through other means known to those of skill in the art.

[0054] Peptides corresponding to one or more domains (or a portion of a domain) of one of the proteins described above, truncated or deleted proteins, as well as fusion proteins in which the full length protein described above, a subunit peptide or truncated version is fused to an unrelated protein are also within the scope of the invention and can be designed by those of skill in the art on the basis of experimental or functional considerations. Such fusion proteins include but are not limited to fusions to an epitope tag; or fusions to an enzyme, fluorescent protein, or luminescent protein which provide a marker function.

[0055] While the peptides and proteins of the current invention can be chemically synthesized (e.g., see Creighton, 1983, Proteins: Structures and Molecular Principles, W. H. Freeman & Co., N.Y.), large polypeptides derived from any of the polynucleotides described above may advantageously be produced by recombinant DNA technology using techniques well known in the art for expressing genes and/or coding sequences. These methods include, for example, in vitro recombinant DNA techniques, synthetic techniques, and in vivo genetic recombination. See, for example, the techniques described in Sambrook et al., 1989, supra, and Ausubel et al., 1989, supra. Alternatively, RNA capable of encoding any of the nucleotide sequences described above may be chemically synthesized using, for example, synthesizers. See, for example, the techniques described in “Oligonucleotide Synthesis”, 1984, Gait, M. J. ed., IRL Press, Oxford, which is incorporated by reference herein in its entirety.

[0056] A variety of host-expression vector systems may be utilized to express the nucleotide sequences of the invention. Where the peptide or protein to be synthesized is a soluble derivative, the peptide or polypeptide can be recovered from the culture, i.e., from the host cell in cases where the peptide or polypeptide is not secreted, and from the culture media in cases where the peptide or polypeptide is secreted by the cells. However, such engineered host cells themselves may be used in situations where it is important not only to retain the structural and functional characteristics of the expressed peptide or protein, but to assess biological activity, e.g., in drug screening assays.

[0057] The expression systems that may be used for purposes of the invention include but are not limited to microorganisms such as bacteria (e.g., E. coli, B. subtilis) transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA expression vectors containing a nucleotide sequence of the current invention; yeast (e.g., Saccharomyces, Pichia, etc.) transformed with recombinant yeast expression vectors containing a nucleotide sequence of the current invention; insect cell systems infected with recombinant virus expression vectors (e.g., baculovirus) containing a nucleotide sequence of the current invention; plant cell systems infected with recombinant virus expression vectors (e.g., cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e.g., Ti plasmid) containing a nucleotide sequence of the current invention; or mammalian cell systems (e.g., COS, CHO, BHK, 293, 3T3, U937) harboring recombinant expression constructs containing promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g., the adenovirus late promoter; the vaccinia virus 7.5K promoter).

[0058] In bacterial systems, a number of expression vectors may be advantageously selected depending upon the use intended for the gene product being expressed. For example, when large quantities of such a protein are to be produced for the generation of pharmaceutical compositions of a protein or for raising antibodies to the protein to be expressed, for example, vectors which direct the expression of high levels of fusion protein products that are readily purified may be desirable. Such vectors include, but are not limited, to the E. coli expression vector pUR278 (Ruther et al., 1983, EMBO J. 2:1791), in which the coding sequence of the polynucleotide to be expressed may be ligated individually into the vector in frame with the lacZ coding region so that a fusion protein is produced; pIN vectors (Inouye & Inouye, 1985, Nucleic Acids Res. 13:3101-3109; Van Heeke & Schuster, 1989, J. Biol. Chem. 264:5503-5509); and the like. pGEX vectors may also be used to express foreign polypeptides as fusion proteins with glutathione S-transferase (GST). If the inserted sequence encodes a relatively small polypeptide (less than 25 kD), such fusion proteins are generally soluble and can easily be purified from lysed cells by adsorption to glutathione-agarose beads followed by elution in the presence of free glutathione. The pGEX vectors are designed to include thrombin or factor Xa protease cleavage sites so that the cloned target gene product can be released from the GST moiety. Alternatively, if the resulting fusion protein is insoluble and forms inclusion bodies in the host cell, the inclusion bodies may be purified and the recombinant protein solubilized using techniques well known to one of skill in the art.

[0059] In an insect system, Autographa californica nuclear polyhidrosis virus (AcNPV) may be used as a vector to express foreign genes. (e.g., see Smith et al., 1983, J. Virol. 46: 584; Smith, U.S. Pat. No. 4,215,051). In one embodiment of the current invention, Sf9 insect cells are infected with a baculovirus vector expressing a peptide or protein of the current invention.

[0060] In mammalian host cells, a number of viral-based expression systems may be utilized. Specific embodiments described more fully below express tagged cDNA sequences of the current invention using a CMV promoter to transiently express recombinant protein in U937 cells or in Cos-7 cells. Alternatively, retroviral vector systems well known in the art may be used to insert the recombinant expression construct into host cells.

[0061] In yeast, a number of vectors containing constitutive or inducible promoters may be used. For a review, see Current Protocols in Molecular Biology, Vol. 2, 1988, Ed. Ausubel et al., Greene Publish. Assoc. & Wiley Interscience, Ch. 13; Grant et al., 1987, Expression and Secretion Vectors for Yeast, in Methods in Enzymology, Eds. Wu & Grossman, 1987, Acad. Press, N.Y., Vol. 153, pp. 516-544; Glover, 1986, DNA Cloning, Vol. II, IRL Press, Wash., D.C., Ch. 3; and Bitter, 1987, Heterologous Gene Expression in Yeast, Methods in Enzymology, Eds. Berger & Kimmel, Acad. Press, N.Y., Vol. 152, pp. 673-684; and The Molecular Biology of the Yeast Saccharomyces, 1982, Eds. Strathern et al., Cold Spring Harbor Press, Vols. I and II.

[0062] In cases where plant expression vectors are used, the expression of the coding sequence may be driven by any of a number of promoters. For example, viral promoters such as the 35S RNA and 19S RNA promoters of CaMV (Brisson et al., 1984, Nature, 310:511-514), or the coat protein promoter of TMV (Takamatsu et al., 1987, EMBO J. 6:307-311) may be used; alternatively, plant promoters such as the small subunit of RUBISCO (Coruzzi et al., 1984, EMBO J. 3:1671-1680; Broglie et al., 1984, Science 224:838-843); or heat shock promoters, e.g., soybean hspl7.5-E or hspl7.3-B (Gurley et al., 1986, Mol. Cell. Biol. 6:559-565) may be used. These constructs can be introduced into plant cells using Ti plasmid, Ri plasmid, plant virus vectors, direct DNA transformation, microinjection, electroporation, etc. For reviews of such techniques see, for example, Weissbach & Weissbach, 1988, Methods for Plant Molecular Biology, Academic Press, NY, Section VIII, pp. 421-463; and Grierson & Corey, 1988, Plant Molecular Biology, 2d Ed., Blackie, London, Ch. 7-9.

[0063] In cases where an adenovirus is used as an expression vector, the nucleotide sequence of interest may be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene may then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non-essential region of the viral genome (e.g., region E1 or E3) will result in a recombinant virus that is viable and capable of expressing the gene product of interest in infected hosts. (e.g., See Logan & Shenk, 1984, Proc. Natl. Acad. Sci. USA 81:3655-3659). Specific initiation signals may also be required for efficient translation of inserted nucleotide sequences of interest. These signals include the ATG initiation codon and adjacent sequences. In cases where an entire gene or cDNA, including its own initiation codon and adjacent sequences, is inserted into the appropriate expression vector, no additional translational control signals may be needed. However, in cases where only a portion of a coding sequence of interest is inserted, exogenous translational control signals, including, perhaps, the ATG initiation codon, must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression may be enhanced by the inclusion of appropriate transcription enchanter elements, transcription terminators, etc. (See Bittner et al., 1987, Methods in Enzymol. 153:516-544).

[0064] In addition, a host cell strain may be chosen which modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modifications (e.g., glycosylation) and processing (e.g., cleavage) of protein products may be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins and gene products. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript may be used. Such mammalian host cells include but are not limited to CHO, VERO, BHK, HeLa, COS, MDCK, 293, 3T3, WI38, and U937 cells.

[0065] For long-term, high-yield production of recombinant proteins, stable expression is preferred. For example, cell lines which stably express the sequences of interest described above may be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells may be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media. The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines. This method may advantageously be used to engineer cell lines which express the gene product of interest. Such engineered cell lines may be particularly useful in screening and evaluation of compounds that affect the endogenous activity of the gene product of interest.

[0066] A number of selection systems may be used, including but not limited to the herpes simplex virus thymidine kinase (Wigler et al., 1977, Cell 11:223), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, 1962, Proc. Natl. Acad. Sci. USA 48:2026), and adenine phosphoribosyltransferase (Lowy et al., 1980, Cell 22:817) genes can be employed in tk⁻, hgprt⁻ or aprt⁻ cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for the following genes: dhfr, which confers resistance to methotrexate (Wigler et al., 1980, Natl. Acad. Sci. USA 77:3567; O'Hare et al., 1981, Proc. Natl. Acad. Sci. USA 78:1527); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, 1981, Proc. Natl. Acad. Sci. USA 78:2072); neo, which confers resistance to the aminoglycoside G-418 (Colberre-Garapin et al., 1981, J. Mol. Biol. 150:1); and hygro, which confers resistance to hygromycin (Santerre et al., 1984, Gene 30:147).

[0067] The novel gene products/peptide sequences encoded by the described novel GTSs are also useful as epitope tags for the antigenic or other tagging of proteins and polypeptides that have been engineered to incorporate or comprise at least a portion of an GTS peptide sequence.

[0068] The gene products of interest can also be expressed in transgenic animals. Animals of any species, including, but not limited to, mice, rats, rabbits, guinea pigs, pigs, micro-pigs, goats, and non-human primates, e.g., baboons, monkeys, and chimpanzees may be used to generate transgenic animals carrying the polynucleotide of interest of the current invention.

[0069] Any technique known in the art may be used to introduce the transgene of interest into animals to produce the founder lines of transgenic animals. Such techniques include, but are not limited to pronuclear microinjection (Hoppe, P.C. and Wagner, T. E., 1989, U.S. Pat. No. 4,873,191); retrovirus mediated gene transfer into germ lines (Van der Putten et al., 1985, Proc. Natl. Acad. Sci., USA 82:6148-6152); gene targeting in embryonic stem cells (Thompson et al., 1989, Cell 56:313-321); electroporation of embryos (Lo, 1983, Mol Cell. Biol. 3:1803-1814); sperm-mediated gene transfer (Lavitrano et al., 1989, Cell 57:717-723); positive-negative selection as described in U.S. Pat. No. 5,464,764 herein incorporated by reference. For a review of such techniques, see Gordon, 1989, Transgenic Animals, Intl. Rev. Cytol. 115:171-229, which is incorporated by reference herein in its entirety.

[0070] The present invention provides for transgenic animals that carry the transgene of interest in all their cells, as well as animals which carry the transgene in some, but not all their cells, i.e., mosaic animals. The transgene may be integrated as a single transgene or in concatamers, e.g., head-to-head tandems or head-to-tail tandems. The transgene may also be selectively introduced into and activated in a particular cell type by following, for example, the teaching of Lasko et al. (Lasko, M. et al., 1992, Proc. Natl. Acad. Sci. USA 89:6232-6236). The regulatory sequences required for such a cell-type specific activation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art. When it is desired that the transgene of interest be integrated into the chromosomal site of the endogenous copy of that same gene, gene targeting is preferred. Briefly, when such a technique is to be utilized, vectors containing some nucleotide sequences homologous to the endogenous gene of interest are designed for the purpose of integrating, via homologous recombination with chromosomal sequences, into and disrupting the function of the nucleotide sequence of the endogenous gene of interest. In this way, the expression of the endogenous gene may also be eliminated by inserting non-functional sequences into the endogenous gene. The transgene may also be selectively introduced into a particular cell type, thus inactivating the endogenous gene of interest in only that cell type, by following, for example, the teaching of Gu et al. (Gu et al., 1994, Science 265: 103-106). The regulatory sequences required for such a cell-type specific inactivation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

[0071] Once transgenic animals have been generated, the expression of the recombinant gene of interest may be assayed utilizing standard techniques. Initial screening may be accomplished by Southern blot analysis or PCR techniques to analyze animal tissues to assay whether integration of the transgene has taken place. The level of mRNA expression of the transgene in the tissues of the transgenic animals may also be assessed using techniques which include but are not limited to Northern blot analysis of cell type samples obtained from the animal, in situ hybridization analysis, and RT-PCR. Samples of gene-expressing tissue, can also be evaluated immunocytochemically using antibodies specific for the transgene product, as described below.

5.3. Cells that Contain a Distupted Allele of a Gene Encodong a Polynucleotide of the Current Invention

[0072] Another aspect of the current invention are cells which contain a gene that encodes a polynucleotide of the current invention and that has been disrupted. Those of skill in the art would know how to disrupt a gene in a cell using techniques known in the art. Also, techniques useful to disrupt a gene in a cell and especially an ES cell, that may already be disrupted, as disclosed in copending U.S. patent applications Ser. Nos. 08/726,867; 08/728,963; 08/907,598; and 08/942,806, all of which are hereby incorporated herein by reference in their entirety, are within the scope of the current invention to disrupt a gene that encodes a polynucleotide of the current invention.

5.3.1 Identification of Cells that Express Genes Encoding Polynucleotides of the Current Invention

[0073] Host cells that contain coding sequence and/or express a biologically active gene product, or fragment thereof, encoded by gene corresponding to an GTS of the present invention may be identified by at least four general approaches; (a) DNA-DNA or DNA-RNA hybridization; (b) the presence or absence of “marker” gene functions; (c) assessing the level of transcription as measured by the expression of mRNA transcripts in the host cell; and (d) detection of the gene product as measured by immunoassay, enzymatic assay, chemical assay, or by its biological activity. Prior to screening for gene expression, the host cells can first be treated in an effort to increase the level of expression of genes encoding polynucleotides of the current invention, especially in cell lines that produce low amounts of the mRNAs and/or peptides and proteins of the current invention.

[0074] In the first approach, the presence of the coding sequence for peptides and proteins of the current invention inserted in the expression vector can be detected by DNA-DNA or DNA-RNA hybridization using probes comprising nucleotide sequences that are homologous to the coding sequence for peptides and proteins of the current invention, respectively, or portions or derivatives thereof.

[0075] In the second approach, the recombinant expression vector/host system can be identified and selected based upon the presence or absence of certain “marker” gene functions (e.g., thymidine kinase activity, resistance to antibiotics, resistance to methotrexate, transformation phenotype, occlusion body formation in baculovirus, etc.). For example, if the coding sequence for the peptide or protein of the current invention is inserted within a marker gene sequence of the vector, recombinants containing the coding sequence for the peptide or protein of the current invention can be identified by the absence of marker gene function. Alternatively, a marker gene can be placed in tandem with the sequence for the peptide or protein of the current invention under the control of the same or different promoter used to control the expression of the coding sequence for the peptide or protein of the current invention. Expression of the marker in response to induction or selection indicates expression of the coding sequence for the peptide or protein of the current invention.

[0076] In the third approach, transcriptional activity for the coding region of genes specific for peptides and proteins of the current invention can be assessed by hybridization assays. For example, RNA can be isolated and analyzed by Northern blot using a probe derived from a GTS, or any portion thereof. Alternatively, total nucleic acids of the host cell may be extracted and assayed for hybridization to such probes. Additionally, RT-PCR (using GTS specific oligos/products) may be used to detect low levels of gene expression in a sample, or in RNA isolated from a spectrum of different tissues, or PCR can be used can be used to screen a variety of cDNA libraries derived from different tissues to determine which tissues express a given GTS.

[0077] In the fourth approach, the expression of the peptides and proteins of the current invention can be assessed immunologically, for example by Western blots, immunoassays such as radioimmuno-precipitation, enzyme-linked immunoassays and the like. This can be achieved by using an antibody and a binding partner specific to a peptide or protein of the current invention.

5.4. Antibodies to Proteins of the Current Invention

[0078] Antibodies that specifically recognize one or more epitopes of a peptide or protein encoded by the GTSs of the present invention, or epitopes of conserved variants of these peptides or proteins, or any and all peptide fragments thereof are also encompassed by the invention. Such antibodies include but are not limited to polyclonal antibodies, monoclonal antibodies (mAbs), humanized or chimeric antibodies, single chain antibodies, Fab fragments, F(ab′)₂ fragments, fragments produced by a Fab expression library, anti-idiotypic (anti-Id) antibodies, and epitope-binding fragments of any of the above.

[0079] The antibodies of the invention may be used, for example, in the detection of the peptide or protein of interest of the current invention in a biological sample and may, therefore, be utilized as part of a diagnostic or prognostic technique whereby patients may be tested for abnormal amounts of these proteins. Such antibodies may also be utilized in conjunction with, for example, compound screening schemes as described, below in Section 5.6 for the evaluation of the effect of test compounds on expression and/or activity of the gene products of interest of the current invention. Additionally, such antibodies can be used in conjunction with the gene therapy and gene delivery techniques described below to, for example, evaluate the normal and/or engineered peptide- or protein-expressing cells prior to their introduction into the patient. Such antibodies may additionally be used in a method for inhibiting the abnormal activity of a peptide or protein of interest of the current invention. Thus, such antibodies may, for example, be utilized as part of treatment methods for development and cell differentiation disorders.

[0080] For the production of antibodies, various host animals may be immunized by injection with the peptide or protein of interest, a subunit peptide of such protein, a truncated polypeptide, functional equivalents of the peptide or protein, mutants of the peptide or protein, or denatured forms of the above. Such host animals may include but are not limited to rabbits, mice, and rats, to name but a few. Various adjuvants may be used to increase the immunological response, depending on the host species, including but not limited to Freund's adjuvant (complete and incomplete), mineral salts such as aluminum hydroxide or aluminum phosphate, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, and potentially useful human adjuvants such as BCG (bacille Calmette-Guerin) and Corynebacterium parvum. Alternatively, the immune response could be enhanced by combination and or coupling with molecules such as keyhole limpet hemocyanin, tetanus toxoid, diptheria toxoid, ovalbumin, cholera toxin or fragments thereof. Polyclonal antibodies are heterogeneous populations of antibody molecules derived from the sera of the immunized animals.

[0081] Monoclonal antibodies, which are homogeneous populations of antibodies to a particular antigen, may be obtained by any technique which provides for the production of antibody molecules by continuous cell lines in culture. These include, but are not limited to, the hybridoma technique of Kohler and Milstein, (1975, Nature 256:495-497; and U.S. Pat. No. 4,376,110), the human B-cell hybridoma technique (Kosbor et al., 1983, Immunology Today 4:72; Cole et al., 1983, Proc. Natl. Acad. Sci. USA 80:2026-2030), and the EBV-hybridoma technique (Cole et al., 1985, Monoclonal Antibodies And Cancer Therapy, Alan R. Liss, Inc., pp. 77-96). Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The hybridoma producing the mAb of this invention may be cultivated in vitro or in vivo. Production of high titers of mabs in vivo makes this the presently preferred method of production.

[0082] In addition, techniques developed for the production of “chimeric antibodies” (Morrison et al., 1984, Proc. Natl. Acad. Sci. USA, 81:6851-6855; Neuberger et al., 1984, Nature, 312:604-608; Takeda et al., 1985, Nature, 314:452-454) by splicing the genes from a mouse antibody molecule of appropriate antigen specificity together with genes from a human antibody molecule of appropriate biological activity can be used. A chimeric antibody is a molecule in which different portions are derived from different animal species, such as those having a variable region derived from a porcine mAb and a human immunoglobulin constant region. Such technologies are described in U.S. Pat. Nos. 6,075,181 and 5,877,397 and their respective disclosures which are herein incorporated by reference in their entirety.

[0083] Alternatively, techniques described for the production of single chain antibodies (U.S. Pat. No. 4,946,778; Bird, 1988, Science 242:423-426; Huston et al., 1988, Proc. Natl. Acad. Sci. USA 85:5879-5883; and Ward et al., 1989, Nature 334:544-546) can be adapted to produce single chain antibodies against gene products of interest. Single chain antibodies are formed by linking the heavy and light chain fragments of the Fv region via an amino acid bridge, resulting in a single chain polypeptide.

[0084] Antibody fragments which recognize specific epitopes may be generated by known techniques. For example, such fragments include but are not limited to: the F(ab′)₂ fragments which can be produced by pepsin digestion of the antibody molecule and the Fab fragments which can be generated by reducing the disulfide bridges of the F(ab′)₂ fragments. Alternatively, Fab expression libraries may be constructed (Huse et al., 1989, Science, 246:1275-1281) to allow rapid and easy identification of monoclonal Fab fragments with the desired specificity.

[0085] Antibodies to peptides and proteins of interest that fully or at least partially encoded by GTSs of the current invention or fragments or truncated versions thereof, can, in turn, be utilized to generate anti-idiotypic antibodies that “mimic” an epitope of the peptide or protein of interest, using techniques well known to those skilled in the art. (See, e.g., Greenspan & Bona, 1993, FASEB J 7(5):437-444; and Nissinoff, 1991, J. Immunol. 147(8):2429-2438). For example antibodies that bind to a regulatory peptide or protein of interest of the current invention and competitively inhibit the binding of such peptide or protein to any of its binding partners in the cell can be used to generate anti-idiotypes that “mimic” the peptide or protein of interest and, therefore, bind and neutralize the particular binding partner of the peptide or protein of interest. Such neutralizing anti-idiotypes or Fab fragments of such anti-idiotypes can be used in therapeutic regimens to neutralize a particular binding partner of a peptide or protein of interest which play a role in development and cell differentiation processes.

5.5. Diagnosis of Disorders Affecting Development and Cell Differentiation

[0086] A variety of methods can be employed for the diagnostic and prognostic evaluation of disorders involving developmental and differentiation processes, and for the identification of subjects having a predisposition to such disorders.

[0087] Such methods may, for example, utilize reagents such as the nucleotide sequences described above, and antibodies to peptides and proteins of the current invention, as described, in Section 5.4. Specifically, such reagents may be used, for example, for: (1) the detection of the presence of gene mutations, or the detection of either over- or under-expression of the respective mRNAs relative to the non-disorder state; (2) the detection of either an over- or an under-abundance of the respective gene product relative to the non-disorder state; and (3) the detection of perturbations or abnormalities in the intra- and inter-cellular processes mediated by the respective peptides or proteins of the current invention.

[0088] The methods described herein may be performed, for example, by utilizing pre-packaged diagnostic kits comprising at least one specific nucleotide sequence of the current invention or antibody reagent described herein, which may be conveniently used, e.g., in clinical settings, to diagnose patients exhibiting developmental or cell differentiation disorder abnormalities.

[0089] For the detection of mutations in any of the genes described above, any nucleated cell can be used as a starting source for genomic nucleic acid. For the detection of gene expression or gene products, any cell type or tissue in which the gene of interest is expressed, such as, for example, ES cells, may be utilized. Specific examples of cells and tissues that can be analyzed using the claimed polynucleotides include, but are not limited to, endothelial cells, epithelial cells, islets, neurons or neural tissue, mesothelial cells, osteocytes, lymphocytes, chondrocytes, hematopoietic cells, immune cells, cells of the major glands or organs (e.g., lung, heart, stomach, pancreas, kidney, skin, etc.), exocrine and/or endocrine cells, embryonic and other stem cells, fibroblasts, and culture adapted and/or transformed versions of the above. Diseases or natural processes that can also be correlated with the expression of mutant, or normal, variants of the disclosed GTSs include, but are not limited to, aging, cancer, autoimmune disease, lupus, scleroderma, Crohn's disease, multiple sclerosis, inflammatory bowel disease, immune disorders, schizophrenia, psychosis, alopecia, glandular disorders, inflammatory disorders, ataxia telangiectasia, diabetes, skin disorders such as acne, eczema, and the like, osteo and rheumatoid arthritis, high blood pressure, atherosclerosis, cardiovascular disease, pulmonary disease, degenerative diseases of the neural or skeletal systems, Alzheimer's disease, Parkinson's disease, osteoporosis, asthma, developmental disorders or abnormalities, genetic birth defects, infertility, epithelial ulcerations, and viral, parasitic, fungal, yeast, or bacterial infection.

[0090] Primary, secondary, or culture adapted variants of cancer cells/tissues can also be analyzed using the claimed polynucleotides. Examples of such cancers include, but are not limited to, Cardiac: sarcoma (angiosarcoma, fibrosarcoma, rhabdomyosarcoma, liposarcoma), myxoma, rhabdomyoma, fibroma, lipoma and teratoma; Lung: bronchogenic carcinoma (squamous cell, undifferentiated small cell, undifferentiated large cell, adenocarcinoma), alveolar (bronchiolar) carcinoma, bronchial adenoma, sarcoma, lymphoma, chondromatous hamartoma, mesothelioma; Gastrointestinal: esophagus (squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, lymphoma), stomach (carcinoma, lymphoma, leiomyosarcoma), pancreas (ductal adenocarcinoma, insulinoma, glucagonoma, gastrinoma, carcinoid tumors, vipoma), small bowel (adenocarcinoma, lymphoma, carcinoid tumors, Karposi's sarcoma, leiomyoma, hemangioma, lipoma, neurofibroma, fibroma), large bowel (adenocarcinoma, tubular adenoma, villous adenoma, hamartoma, leiomyoma); Genitourinary tract: kidney (adenocarcinoma, Wilm's tumor [nephroblastoma], lymphoma, leukemia), bladder and urethra (squamous cell carcinoma, transitional cell carcinoma, adenocarcinoma), prostate (adenocarcinoma, sarcoma), testis (seminoma, teratoma, embryonal carcinoma, teratocarcinoma, choriocarcinoma, sarcoma, interstitial cell carcinoma, fibroma, fibroadenoma, adenomatoid tumors, lipoma); Liver: hepatoma (hepatocellular carcinoma), cholangiocarcinoma, hepatoblastoma, angiosarcoma, hepatocellular adenoma, hemangioma; Bone: osteogenic sarcoma (osteosarcoma), fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, malignant lymphoma (reticulum cell sarcoma), multiple myeloma, malignant giant cell tumor, chordoma, osteochronfroma (osteocartilaginous exostoses), benign chondroma, chondroblastoma, chondromyxofibroma, osteoid osteoma and giant cell tumors; Nervous system: skull (osteoma, hemangioma, granuloma, xanthoma, osteitis deformans), meninges (meningioma, meningiosarcoma, gliomatosis), brain (astrocytoma, medulloblastoma, glioma, ependymoma, germinoma [pinealoma], glioblastoma multiforme, oligodendroglioma, schwannoma, retinoblastoma, congenital tumors), spinal cord (neurofibroma, meningioma, glioma, sarcoma); Gynecological: uterus (endometrial carcinoma), cervix (cervical carcinoma, pre-tumor cervical dysplasia), ovaries (ovarian carcinoma [serous cystadenocarcinoma, mucinous cystadenocarcinoma, endometrioid tumors, celioblastoma, clear cell carcinoma, unclassified carcinoma], granulosa-thecal cell tumors, Sertoli-Leydig cell tumors, dysgerminoma, malignant teratoma), vulva (squamous cell carcinoma, intraepithelial carcinoma, adenocarcinoma, fibrosarcoma, melanoma), vagina (clear cell carcinoma, squamous cell carcinoma, botryoid sarcoma [embryonal rhabdomyosarcoma], fallopian tubes (carcinoma); Hematologic: blood (myeloid leukemia [acute and chronic], acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative diseases, multiple myeloma, myelodysplastic syndrome), Hodgkin's disease, non-Hodgkin's lymphoma [malignant lymphoma]; Skin: malignant melanoma, basal cell carcinoma, squamous cell carcinoma, Karposi's sarcoma, moles, dysplastic nevi, lipoma, angioma, dermatofibroma, keloids, psoriasis; Breast: carcinoma and sarcoma, and Adrenal glands: neuroblastoma.

[0091] Nucleic acid-based detection techniques and peptide detection techniques that can be used to conduct the above analyses are described below.

5.5.1. Detection of the Genes of the Current Invention and their Respective Transcripts

[0092] Mutations within the genes of the current invention can be detected by utilizing a number of techniques. Nucleic acid from any nucleated cell can be used as the starting point for such assay techniques, and may be isolated according to standard nucleic acid preparation procedures which are well known to those of skill in the art.

[0093] DNA may be used in hybridization or amplification assays of biological samples to detect abnormalities involving gene structure, including point mutations, insertions, deletions and chromosomal rearrangements. Such assays may include, but are not limited to, Southern analyses, single stranded conformational polymorphism analyses (SSCP), and PCR analyses.

[0094] Such diagnostic methods for the detection of gene-specific mutations can involve for example, contacting and incubating nucleic acids including recombinant DNA molecules, cloned genes or degenerate variants thereof, obtained from a sample, e.g., derived from a patient sample or other appropriate cellular source, with one or more labeled nucleic acid reagents including recombinant DNA molecules, cloned genes or degenerate variants thereof, as described above, under conditions favorable for the specific annealing of these reagents to their complementary sequences within the gene of interest of the current invention. Preferably, the lengths of these nucleic acid reagents are at least 15 to 30 nucleotides. After incubation, all non-annealed nucleic acids are removed from the nucleic acid molecule hybrid. The presence of nucleic acids which have hybridized, if any such molecules exist, is then detected. Using such a detection scheme, the nucleic acid from the cell type or tissue of interest can be immobilized, for example, to a solid support such as a membrane, or a plastic surface such as that on a microtiter plate or polystyrene beads. In this case, after incubation, non-annealed, labeled nucleic acid reagents of the type described above are easily removed. Detection of the remaining, annealed, labeled nucleic acid reagents is accomplished using standard techniques well-known to those in the art. The gene sequences to which the nucleic acid reagents have annealed can be compared to the annealing pattern expected from a normal gene sequence in order to determine whether a gene mutation is present.

[0095] Alternative diagnostic methods for the detection of gene specific nucleic acid molecules, in patient samples or other appropriate cell sources, may involve their amplification, e.g., by PCR (the experimental embodiment set forth in Mullis, K. B., 1987, U.S. Pat. No. 4,683,202), followed by the detection of the amplified molecules using techniques well known to those of skill in the art. The resulting amplified sequences can be compared to those which would be expected if the nucleic acid being amplified contained only normal copies of the respective gene in order to determine whether a gene mutation exists.

[0096] Additionally, well-known genotyping techniques can be performed to identify individuals carrying mutations in any of the genes of the current invention. Such techniques include, for example, the use of restriction fragment length polymorphisms (RFLPs), which involve sequence variations in one of the recognition sites for the specific restriction enzyme used.

[0097] Furthermore, the polynucleotide sequences of the current invention may be mapped to chromosomes and specific regions of chromosomes using well known genetic and/or chromosomal mapping techniques. These techniques include in situ hybridization, linkage analysis against known chromosomal markers, hybridization screening with libraries or flow-sorted chromosomal preparations specific to known chromosomes, and the like. The technique of fluorescent in situ hybridization of chromosome spreads has been described, for example, in Verma et al. (1988) Human Chromosomes: A Manual of Basic Techniques, Pergamon Press, New York. Fluorescent in situ hybridization of chromosomal preparations and other physical chromosome mapping techniques may be correlated with additional genetic map data. Examples of genetic map data can be found, for example, in Genetic Maps: Locus Maos of Complex Genomes, Book 5: Human Maps, O'Brien, editor, Cold Spring Harbor Laboratory Press (1990). Comparisons of physical chromosomal map data may be of particular interest in detecting genetic diseases in carrier states.

[0098] The level of expression of genes can also be assayed by detecting and measuring the transcription of such genes. For example, RNA from a cell type or tissue known, or suspected to express any of the genes of the current invention can be isolated and tested utilizing hybridization or PCR techniques (e.g., northern or RT PCR) such as those described, above. Such analyses may reveal both quantitative and qualitative aspects of the expression pattern of the respective gene, including activation or inactivation of gene expression. In situ hybridization using suitably radioactively or enzymatically labeled forms of the described polynucleotide sequences can also be used to assess expression patterns in vivo.

[0099] Additionally, an oligonucleotide or polynucleotide sequence first disclosed in at least a portion of one or more of the GTS sequences of SEQ ID NOS:1-891 can be used as a hybridization probe in conjunction with a solid support matrix/substrate (resins, beads, membranes, plastics, polymers, metal or metallized substrates, crystalline or polycrystalline substrates, etc.). Of particular note are spatially addressable arrays (i.e., gene chips, microtiter plates, etc.) of oligonucleotides and polynucleotides, or corresponding oligopeptides and polypeptides, wherein at least one of the biopolymers present on the spatially addressable array comprises an oligonucleotide or polynucleotide sequence first disclosed in at least one of the GTS sequences of SEQ ID NOS: 1-891, or an amino acid sequence encoded thereby. Methods for attaching biopolymers to, or synthesizing biopolymers on, solid support matrices, and conducting binding studies thereon are disclosed in, inter alia, U.S. Pat. Nos. 5,700,637, 5,556,752, 5,744,305, 4,631,211, 5,445,934, 5,252,743, 4,713,326, 5,424,186, and 4,689,405 the disclosures of which are herein incorporated by reference in their entirety.

[0100] Addressable arrays comprising sequences first disclosed in SEQ ID NOS:1-891 can be used to identify and characterize the temporal and tissue specific expression of a gene. These addressable arrays incorporate oligonucleotide sequences of sufficient length to confer the required specificity, yet be within the limitations of the production technology. The length of these probes is within a range of between about 8 to about 2000 nucleotides. Preferably the probes consist of 60 nucleotides and more preferably 25 nucleotides from the sequences first disclosed in SEQ ID NOS:1-891.

[0101] For example, a series of the described GTS oligonucleotide sequences, or the complements thereof, can be used in chip format to represent all or a portion of the described GTS sequences. The oligonucleotides, typically between about 16 to about 40 (or any whole number within the stated range) nucleotides in length can partially overlap each other and/or the GTS sequence may be represented using oligonucleotides that do not overlap. Accordingly, the described GTS polynucleotide sequences shall typically comprise at least about two or three distinct oligonucleotide sequences of at least about 8 nucleotides in length that are each first disclosed in the described Sequence Listing. Such oligonucleotide sequences can begin at any nucleotide present within a sequence in the Sequence Listing and proceed in either a sense (5′-to-3′) orientation vis-a-vis the described sequence or in an antisense orientation.

[0102] Microarray-based analysis allows the discovery of broad patterns of genetic activity, providing new understanding of gene functions and generating novel and unexpected insight into transcriptional processes and biological mechanisms. The use of addressable arrays comprising sequences first disclosed in SEQ ID NOS:1-891 provides detailed information about transcriptional changes involved in a specific pathway, potentially leading to the identification of novel components or gene functions that manifest themselves as novel phenotypes.

[0103] Probes consisting of sequences first disclosed in SEQ ID NOS:1-891 can also be used in the identification, selection and validation of novel molecular targets for drug discovery. The use of these unique sequences permits the direct confirmation of drug targets and recognition of drug dependent changes in gene expression that are modulated through pathways distinct from the drugs intended target. These unique sequences therefore also have utility in defining and monitoring both drug action and toxicity.

[0104] As an example of utility, the sequences first disclosed in SEQ ID NOS:1-891 can be utilized in microarrays or other assay formats, to screen collections of genetic material from patients who have a particular medical condition. These investigations can also be carried out using the sequences first disclosed in SEQ ID NOS:1-891 in silico and by comparing previously collected genetic databases and the disclosed sequences using computer software known to those in the art.

[0105] Thus the sequences first disclosed in SEQ ID NOS:1-891 can be used to identify mutations associated with a particular disease and also as a diagnostic or prognostic assay.

[0106] Although the presently described GTSs have been specifically described using nucleotide sequence, it should be appreciated that each of the GTSs can uniquely be described using any of a wide variety of additional structural attributes, or combinations thereof. For example, a given GTS can be described by the net composition of the nucleotides present within a given region of the GTS in conjunction with the presence of one or more specific oligonucleotide sequence(s) first disclosed in the GTS. Alternatively, a restriction map specifying the relative positions of restriction endonuclease digestion sites, or various palindromic or other specific oligonucleotide sequences can be used to structurally describe a given GTS. Such restriction maps, which are typically generated by widely available computer programs (e.g., the University of Wisconsin GCG sequence analysis package, SEQUENCHER 3.0, Gene Codes Corp., Ann Arbor, Mich., etc.), can optionally be used in conjunction with one or more discrete nucleotide sequence(s) present in the GTS that can be described by the relative position of the sequence relative to one or more additional sequence(s) or one or more restriction sites present in the GTS.

5.5.2. Detection of the Gene Products of the Current Invention

[0107] Antibodies directed against wild type or mutant gene products of the current invention or conserved variants or peptide fragments thereof, which are discussed above in Section 5.4 may also be used as diagnostics and prognostics for disorders affecting development and cellular differentiation, as described herein. Such diagnostic methods, may be used to detect abnormalities in the level of gene expression, or abnormalities in the structure and/or temporal, tissue, cellular, or subcellular location of the respective gene product, and may be performed in vivo or in vitro, such as, for example, on biopsy tissue.

[0108] The tissue or cell type to be analyzed will generally include those which are known, or suspected, to contain cells that express the respective gene. The protein isolation methods employed herein may, for example, be such as those described in Harlow and Lane (Harlow, E. and Lane, D., 1988, “Antibodies: A Laboratory Manual”, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.), which is incorporated herein by reference in its entirety. The isolated cells can be derived from cell culture or from a patient. The analysis of cells taken from culture may be a necessary step in the assessment of cells that could be used as part of a cell-based gene therapy technique or, alternatively, to test the effect of compounds on the expression of the respective gene.

[0109] For example, antibodies, or fragments of antibodies, such as those described above in Section 5.4 are also useful in the present invention to quantitatively or qualitatively detect the presence of gene products of the current invention or conserved variants or peptide fragments thereof. This can be accomplished, for example, by immunofluorescence techniques employing a fluorescently labeled antibody (see below, this Section) coupled with light microscopic, flow cytometric, or fluorimetric detection.

[0110] The antibodies (or fragments thereof) or fusion or conjugated proteins useful in the present invention may, additionally, be employed histologically, as in immunofluorescence, immunoelectron microscopy or non-immuno assays, for in situ detection of gene products of the current invention or conserved variants or peptide fragments thereof, or for catalytic subunit binding (in the case of labeled catalytic subunit fusion protein).

[0111] In situ detection may be accomplished by removing a histological specimen from a patient, and applying thereto a labeled antibody or fusion protein of the present invention. The antibody (or fragment) or fusion protein is preferably applied by overlaying the labeled antibody (or fragment) onto a biological sample. Through the use of such a procedure, it is possible to determine not only the presence of the gene product of the current invention, or conserved variants or peptide fragments, but also its distribution in the examined tissue. Using the present invention, those of ordinary skill will readily perceive that any of a wide variety of histological methods (such as staining procedures) can be modified in order to achieve such in situ detection.

[0112] Immunoassays and non-immunoassays for gene products of the current invention or conserved variants or peptide fragments thereof will typically comprise incubating a sample, such as a biological fluid, a tissue extract, freshly harvested cells, or lysates of cells which have been incubated in cell culture, in the presence of a detectably labeled antibody capable of identifying the respective gene products of interest or conserved variants or peptide fragments thereof, and detecting the bound antibody by any of a number of techniques well-known in the art.

[0113] The biological sample may be brought in contact with and immobilized onto a solid phase support or carrier such as nitrocellulose, or other solid support which is capable of immobilizing cells, cell particles or soluble proteins. The support may then be washed with suitable buffers followed by treatment with the detectably labeled antibody specific to the peptide or protein of interest of the current invention or with fusion protein. The solid phase support may then be washed with the buffer a second time to remove unbound antibody or fusion protein. The amount of bound label on solid support may then be detected by conventional means.

[0114] “Solid phase support or carrier” is intended to encompass any support capable of binding an antigen or an antibody. Well-known supports or carriers include glass, polystyrene, polypropylene, polyethylene, dextran, nylon, amylases, natural and modified celluloses, polyacrylamides, gabbros, and magnetite. The nature of the carrier can be either soluble to some extent or insoluble for the purposes of the present invention. The support material may have virtually any possible structural configuration so long as the coupled molecule is capable of binding to an antigen or antibody. Thus, the support configuration may be spherical, as in a bead, or cylindrical, as in the inside surface of a test tube, or the external surface of a rod. Alternatively, the surface may be flat such as a sheet, test strip, etc. Preferred supports include polystyrene beads. Those skilled in the art will know many other suitable carriers for binding antibody or antigen, or will be able to ascertain the same by use of routine experimentation.

[0115] The binding activity of a given lot of antibody or fusion protein may be determined according to well known methods. Those skilled in the art will be able to determine operative and optimal assay conditions for each determination by employing routine experimentation.

[0116] With respect to antibodies, one of the ways in which the antibody can be detectably labeled is by linking the same to an enzyme and use in an enzyme immunoassay (EIA) (Voller, “The Enzyme Linked Immunosorbent Assay (ELISA)”, 1978, Diagnostic Horizons 2:1-7, Microbiological Associates Quarterly Publication, Walkersville, Md.); Voller et al., 1978, J. Clin. Pathol. 31:507-520; Butler, 1981, Meth. Enzymol. 73:482-523; Maggio (ed.), 1980, Enzyme Immunoassay, CRC Press, Boca Raton, Fla.,; Ishikawa et al., (eds.), 1981, Enzyme Immunoassay, Kgaku Shoin, Tokyo). The enzyme which is bound to the antibody will react with an appropriate substrate, preferably a chromogenic substrate, in such a manner as to produce a chemical moiety which can be detected, for example, by spectrophotometric, fluorimetric or by visual means. Enzymes which can be used to detectably label the antibody include, but are not limited to, malate dehydrogenase, staphylococcal nuclease, delta-5-steroid isomerase, yeast alcohol dehydrogenase, alpha-glycerophosphate, dehydrogenase, triose phosphate isomerase, horseradish peroxidase, alkaline phosphatase, asparaginase, glucose oxidase, beta-galactosidase, ribonuclease, urease, catalase, glucose-6-phosphate dehydrogenase, glucoamylase and acetylcholinesterase. The detection can be accomplished by calorimetric methods which employ a chromogenic substrate for the enzyme. Detection may also be accomplished by visual comparison of the extent of enzymatic reaction of a substrate in comparison with similarly prepared standards.

[0117] Detection may also be accomplished using any of a variety of other immunoassays. For example, by radioactively labeling the antibodies or antibody fragments, it is possible to detect the peptide or protein of interest through the use of a radioimmunoassay (RIA) (see, for example, Weintraub, B., Principles of Radioimmunoassays, Seventh Training Course on Radioligand Assay Techniques, The Endocrine Society, March, 1986, which is incorporated by reference herein). The radioactive isotope can be detected by such means as the use of a gamma counter or a scintillation counter or by autoradiography.

[0118] It is also possible to label the antibody with a fluorescent compound. When the fluorescently labeled antibody is exposed to light of the proper wave length, its presence can then be detected due to fluorescence. Among the most commonly used fluorescent labeling compounds are fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin and fluorescamine.

[0119] The antibody can also be detectably labeled using fluorescence emitting metals such as ¹⁵²Eu, or others of the lanthanide series. These metals can be attached to the antibody using such metal chelating groups as diethylenetriaminepentaacetic acid (DTPA) or ethylenediaminetetraacetic acid (EDTA).

[0120] The antibody also can be detectably labeled by coupling it to a chemiluminescent compound. The presence of the chemiluminescent-tagged antibody is then determined by detecting the presence of luminescence that arises during the course of a chemical reaction. Examples of particularly useful chemiluminescent labeling compounds are luminol, isoluminol, theromatic acridinium ester, imidazole, acridinium salt and oxalate ester.

[0121] Likewise, a bioluminescent compound may be used to label the antibody of the present invention. Bioluminescence is a type of chemiluminescence found in biological systems in, which a catalytic protein increases the efficiency of the chemiluminescent reaction. The presence of a bioluminescent protein is determined by detecting the presence of luminescence. Important bioluminescent compounds for purposes of labeling are luciferin, luciferase and aequorin.

[0122] An additional use of a peptide or polypeptide encoded by an oligonucleotide or polynucleotide sequence first disclosed in at least one of the GTS sequences of SEQ ID NOS:1-891 involves incorporating the sequence into a phage display, or other peptide library/binding, system that can be used to screen for proteins, or other ligands, that are capable of binding to an amino acid sequence encoded by an oligonucleotide or polynucleotide sequence first disclosed in at least one of the GTS sequences of SEQ ID NOS:1-891 (see U.S. Pat. Nos. 5,270,170, and 5,432,018, herein incorporated by reference in their entirety). Moreover, peptide arrays comprising a novel amino acid sequence corresponding to a portion of at least one of the polynucleotide sequences first disclosed in SEQ ID NOS:1-891 can be generated and screened essentially as described in U.S. Pat. Nos. 5,143,854, 5,405,783, and 5,252,743, the complete disclosures of which are herein incorporated by references.

[0123] Additionally, the presently described GTSs, or primers derived therefrom, can be used to screen spatially addressable arrays, or pools therefrom, of clones present in a full-length human cDNA library. The 96 well microtiter plate format is especially well suited to the screening, by PCR for example, of pooled subfractions of cDNA clones.

5.6. Screening Assays for Compounds that Modulate the Expression or Activity of Peptides and Proteins of the Current Invention

[0124] The following assays are designed to identify compounds that interact with (e.g., bind to) peptides and proteins at least partially encoded by one of SEQ ID NOS:1-891 (i.e. peptides or proteins of the current invention) compounds that interact with (e.g., bind to) intracellular proteins that interact with peptides and proteins of the current invention, compounds that interfere with the interaction of peptides and proteins of the current invention with each other and with other intracellular proteins involved in developmental and cell differentiation processes, and to compounds which modulate the activity of genes of the current invention (i.e., modulate the level of expression of genes of the current invention) or modulate the level of gene products of the current invention. Assays may additionally be utilized which identify compounds which bind to gene regulatory sequences (e.g., promoter sequences) and which may modulate the expression of genes of the current invention. See e.g., Platt, K. A., 1994, J. Biol. Chem. 269:28558-28562, which is incorporated herein by reference in its entirety.

[0125] Compounds that can be screened in accordance with the invention include, but are not limited to, peptides, antibodies and fragments thereof, prostaglandins, lipids and other organic compounds (e.g., terpines, peptidomimetics) that bind to the peptide or protein of interest of the current invention and either mimic the activity triggered by the natural ligand (i.e., agonists) or inhibit the activity triggered by the natural ligand (i.e., antagonists); as well as peptides, antibodies or fragments thereof, and other organic compounds that mimic the peptide or protein of interest of the current invention (or a portion thereof) and bind to and “neutralize” natural ligand.

[0126] Such compounds may include, but are not limited to, peptides such as, for example, soluble peptides, including but not limited to members of random peptide libraries (see, e.g., Lam, K. S. et al., 1991, Nature 354:82-84; Houghten, R. et al., 1991, Nature 354:84-86), and combinatorial chemistry-derived molecular library peptides made of D- and/or L- configuration amino acids, phosphopeptides (including, but not limited to members of random or partially degenerate, directed phosphopeptide libraries; see, e.g., Songyang, Z. et al., 1993, Cell 72:767-778); antibodies (including, but not limited to, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and Fab, F(ab′)₂ and Fab expression library fragments, and epitope-binding fragments thereof); and small organic or inorganic molecules.

[0127] Other compounds that can be screened in accordance with the invention include, but are not limited to, small organic molecules that are able to gain entry into an appropriate cell (e.g., in ES cells) and affect the expression of a gene of the current invention or some other gene involved in development and cell differentiation (e.g., by interacting with the regulatory region or transcription factors involved in gene expression); or such compounds that affect the activity of the peptide or protein of interest of the current invention, e.g., by inhibiting or enhancing the binding of such peptide or protein to another cellular peptide or protein, or other factor, necessary for catalysis, signal transduction, or the like, that is involved in developmental or cell differentiation processes.

[0128] Computer modeling and searching technologies permit the identification of compounds, or the improvement of already identified compounds, that can modulate the expression or activity of peptides or proteins of interest of the current invention. Having identified such a compound or composition, the active sites or regions are identified. Such active sites might typically be the binding partner sites, such as, for example, the interaction domains of the peptides and proteins of the current invention with their respective binding partners. The active site can be identified using methods known in the art including, for example, from study of the amino acid sequences of peptides, from the nucleotide sequences of nucleic acids, or from study of complexes of the relevant compound or composition with its natural ligand. In the latter case, chemical or X-ray crystallographic methods can be used to find the active site by finding where on the factor the complexed ligand is found.

[0129] Next, the three dimensional geometric structure of the active site is determined. This can be done by known methods, including X-ray crystallography, which can determine a complete molecular structure. On the other hand, solid or liquid phase NMR can be used to determine certain intra-molecular distances. Any other experimental method of structure determination can be used to obtain partial or complete geometric structures. The geometric structures may be measured with a complexed ligand, natural or artificial, which may increase the accuracy of the active site structure determined.

[0130] If an incomplete or insufficiently accurate structure is determined, the methods of computer based numerical modeling can be used to complete the structure or improve its accuracy. Any recognized modeling method may be used, including parameterized models specific to particular biopolymers such as proteins or nucleic acids, molecular dynamics models based on computing molecular motions, statistical mechanics models based on thermal ensembles, or combined models. For most types of models, standard molecular force fields, representing the forces between constituent atoms and groups, are necessary, and can be selected from force fields known in physical chemistry. The incomplete or less accurate experimental structures can serve as constraints on the complete and more accurate structures computed by these modeling methods.

[0131] Finally, having determined the structure of the active site, either experimentally, by modeling, or by a combination, candidate modulating compounds can be identified by searching databases containing compounds along with information on their molecular structure. Such a search seeks compounds having structures that match the determined active site structure and that interact with the groups defining the active site. Such a search can be manual, but is preferably computer assisted. These compounds found from this search are potential modulating compounds of the peptides and proteins of interest of the current invention.

[0132] Alternatively, these methods can be used to identify improved modulating compounds from an already known modulating compound or ligand. The composition of the known compound can be modified and the structural effects of modification can be determined using the experimental and computer modeling methods described above applied to the new composition. The altered structure is then compared to the active site structure of the compound to determine if an improved fit or interaction results. In this manner systematic variations in composition, such as by varying side groups, can be quickly evaluated to obtain modified modulating compounds or ligands of improved specificity or activity.

[0133] Further experimental and computer modeling methods useful to identify modulating compounds based upon identification of the active sites of peptides and proteins of interest of the current invention, and related factors involved in development, cellular differentiation, and other cellular processes will be apparent to those of skill in the art.

[0134] Examples of molecular modeling systems are the CHARM and QUANTA programs (Polygon Corporation, Waltham, Mass.). CHARM performs the energy minimization and molecular dynamics functions. QUANTA performs the construction, graphic modeling and analysis of molecular structure. QUANTA allows interactive construction, modification, visualization, and analysis of the behavior of molecules with each other.

[0135] A number of articles review computer modeling of drugs interactive with specific proteins, such as Rotivinen et al., 1988, Acta Pharmaceutical Fennica 97:159-166; Ripka, New Scientist 54-57 (June 16, 1988); McKinaly and Rossmann, 1989, Annu. Rev. Pharmacol. Toxicol. 29:111-122; Perry and Davies, OSAR: Quantitative Structure-Activity Relationships in Drug Design pp. 189-193 (Alan R. Liss, Inc. 1989); Lewis and Dean, 1989, Proc. R. Soc. Lond. 236:125-140 and 141-162; and, with respect to a model receptor for nucleic acid components, Askew et al., 1989, J. Am. Chem. Soc. 111:1082-1090. Other computer programs that screen and graphically depict chemicals are available from companies such as BioDesign, Inc. (Pasadena, Calif.), Allelix, Inc. (Mississauga, Ontario, Canada), and Hypercube, Inc. (Cambridge, Ontario). Although these are primarily designed for application to drugs specific to particular proteins, they can be adapted to the design of drugs specific to regions of DNA or RNA, once that region is identified.

[0136] Although described above with reference to the design and generation of compounds which could alter binding, one could also screen libraries of known compounds, including natural products or synthetic chemicals, and biologically active materials, including proteins, for compounds which are inhibitors or activators.

[0137] Compounds identified via assays such as those described herein may be useful, for example, in elaborating the biological function of the gene products of interest of the current invention, and for ameliorating disorders affecting development and cell differentiation. Assays for testing the effectiveness of compounds, identified by, for example, techniques such as those described below.

5.6.1. In Vitro Screening Assays for Compounds that Bind to Peptides and Proteins of the Current Invention

[0138] In vitro systems may be designed to identify compounds capable of interacting with (e.g., binding to) peptides and proteins of interest of the current invention, fragments thereof, and variants thereof. The identified compounds can be useful, for example, in modulating the activity of wild type and/or mutant gene products of the current invention; may be utilized in screens for identifying compounds that disrupt normal interactions of the peptides and proteins of the current invention with other factors, like, for example, other peptides and proteins; or may in themselves disrupt such interactions.

[0139] The principle of the assays used to identify compounds that bind to the peptides and proteins of the current invention involves preparing a reaction mixture of the peptides and proteins of interest that are disclosed by the current invention and a test compound under conditions and for a time sufficient to allow the two components to interact and bind, thus forming a complex that can be removed from and/or detected in the reaction mixture. The peptides and proteins of the current invention that are used can vary depending upon the goal of the screening assay. For example, where agonists of the natural ligand are sought, the full length peptide or protein of interest, or a fusion protein containing the subunit of interest fused to a protein or polypeptide that affords advantages in the assay system (e.g., labeling, isolation of the resulting complex, etc.) can be utilized.

[0140] The screening assays can be conducted in a variety of ways. For example, one method of conducting such an assay involves anchoring the peptide or protein of interest of the current invention, or a fusion protein thereof, or the test substance onto a solid phase and detecting peptide or protein of interest/test compound complexes anchored on the solid phase at the end of the reaction. In one embodiment of such a method, the peptide or protein of interest may be anchored onto a solid surface, and the test compound, which is not anchored, may be labeled, either directly or indirectly. In another embodiment of the method, a peptide or protein of interest of the current invention anchored on the solid phase is complexed with a natural ligand of such peptide or protein of interest. Then, a test compound could be assayed for its ability to disrupt the association of the complex.

[0141] In practice, microtiter plates may conveniently be utilized as the solid phase. The anchored component may be immobilized by non-covalent or covalent attachments. Non-covalent attachment may be accomplished by simply coating the solid surface with a solution of the protein and drying. Alternatively, an immobilized antibody, preferably a monoclonal antibody, specific for the peptide or protein to be immobilized may be used to anchor the peptide or protein to the solid surface. The surfaces may be prepared in advance and stored.

[0142] In order to conduct the assay, the nonimmobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the previously nonimmobilized component is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the previously nonimmobilized component is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the previously nonimmobilized component (the antibody, in turn, may be directly labeled or indirectly labeled with a labeled anti-Ig antibody).

[0143] Alternatively, a reaction can be conducted in a liquid phase, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for one component of complexes formed, like, for example, the peptide or protein of interest of the current invention or the test compound to anchor any complexes formed in solution, and a labeled antibody specific for the other component of the possible complex to detect anchored complexes.

5.6.2. Assays for Intracellular Proteins that Interact with the Peptides and Proteins of the Current Invention

[0144] Any method suitable for detecting protein-protein interactions can be employed for identifying intracellular peptides and proteins that interact with peptides and proteins of the current invention. Among the traditional methods which may be employed are co-immunoprecipitation, crosslinking and co-purification through gradients or chromatographic columns of cell lysates or proteins obtained from cell lysates and the peptides and proteins of the current invention to identify proteins in the lysate that interact with those peptides and proteins of the current invention. For these assays, the peptides and proteins of the current invention may be used in full length, or in truncated or modified forms or as fusion-proteins. Similarly, the component may be a complex of two or more of the peptides and proteins of the current invention. Once isolated, such an intracellular protein can be identified and can, in turn, be used, in conjunction with standard techniques, to identify proteins with which it interacts. For example, at least a portion of the amino acid sequence of an intracellular protein which interacts with a peptide or protein of the current invention, can be ascertained using techniques well known to those of skill in the art, such as via the Edman degradation technique. (See, e.g., Creighton, 1983, “Proteins: Structures and Molecular Principles”, W.H. Freeman & Co., N.Y., pp.34-49). The amino acid sequence obtained may be used as a guide for the generation of oligonucleotide mixtures that can be used to screen for gene sequences encoding such intracellular proteins. Screening may be accomplished, for example, by standard hybridization or PCR techniques. Techniques for the generation of oligonucleotide mixtures and the screening are well-known. (See, e.g., Ausubel, supra., and PCR Protocols: A Guide to Methods and Applications, 1990, Innis, M. et al., eds. Academic Press, Inc., New York).

[0145] Additionally, methods may be employed which result in the simultaneous identification of genes which encode the intracellular proteins interacting with peptides and proteins of the current invention. These methods include, for example, probing expression libraries, in a manner similar to the well known technique of antibody probing of egtll libraries, using a labeled form of a peptide or protein of the current invention, or a fusion protein, e.g., a peptide or protein at least partially encoded by an GTS of the current invention fused to a marker (e.g., an enzyme, fluor, luminescent protein, or dye), or an Ig-Fc domain.

[0146] One method that detects protein interactions in vivo, the two-hybrid system, is described in detail for illustration only and not by way of limitation. One version of this system has been described (Chien et al., 1991, Proc. Natl. Acad. Sci. USA, 88:9578-9582) and is commercially available from Clontech (Palo Alto, Calif.).

[0147] Briefly, utilizing such a system, plasmid are constructed that encode two hybrid proteins: one plasmid consists of nucleotides encoding the DNA-binding domain of a transcription activator protein fused to a nucleotide sequence of the current invention encoding a peptide or protein of the current invention, a modified or truncated form or a fusion protein, and the other plasmid consists of nucleotides encoding the transcription activator protein's activation domain fused to a cDNA encoding an unknown protein which has been recombined into this plasmid as part of a cDNA library. The DNA-binding domain fusion plasmid and the cDNA library are transformed into a strain of the yeast Saccharomyces cerevisiae that contains a reporter gene (e.g., HBS or lacZ) whose regulatory region contains the transcription activator's binding site. Either hybrid protein alone cannot activate transcription of the reporter gene; the DNA-binding domain hybrid cannot because it does not provide activation function, and the activation domain hybrid cannot because it cannot localize to the activator's binding sites. Interaction of the two hybrid proteins reconstitutes the functional activator protein and results in expression of the reporter gene, which is detected by an assay for the reporter gene product.

[0148] The two-hybrid system or related methodology may be used to screen activation domain libraries for proteins that interact with the “bait” gene product. By way of example, and not by way of limitation, a peptide or protein of the current invention may be used as the bait gene product. Total genomic or cDNA sequences are fused to the DNA encoding an activation domain. This library and a plasmid encoding a hybrid of a bait gene product of the current invention fused to the DNA-binding domain are cotransformed into a yeast reporter strain, and the resulting transformants are screened for those that express the reporter gene. For example, and not by way of limitation, a bait gene sequence of the current invention can be cloned into a vector such that it is translationally fused to the DNA encoding the DNA-binding domain of the GAL4 protein. These colonies are purified and the library plasmids responsible for reporter gene expression are isolated. DNA sequencing is then used to identify the proteins encoded by the library plasmids.

[0149] A cDNA library of the cell line from which proteins that interact with bait gene product of the current invention are to be detected can be made using methods routinely practiced in the art. According to the particular system described herein, for example, the cDNA fragments can be inserted into a vector such that they are translationally fused to the transcriptional activation domain of GAL4. This library can be co-transfected along with the bait gene-GAL4 fusion plasmid into a yeast strain which contains a lacZ gene driven by a promoter which contains GAL4 activation sequence. A cDNA encoded protein, fused to GAL4 transcriptional activation domain, that interacts with bait gene product will reconstitute an active GAL4 protein and thereby drive expression of the HIS3 gene. Colonies which express HIS3 can be detected by their growth on petri dishes containing semi-solid agar based media lacking histidine. The cDNA can then be purified from these strains, and used to produce and isolate the bait gene-interacting protein using techniques routinely practiced in the art.

5.6.3. Assays for Compounds that Interfere with Interactions of the Peptides and Proteins of the Current Invention with Intracellular Macromolecules

[0150] The macromolecules that interact with the peptides and proteins of the current invention are referred to, for purposes of this discussion, as “binding partners”. These binding partners are likely to be involved in catalytic reactions or signal transduction pathways, and therefore, in the role of the peptides and proteins of the current invention in development and cell differentiation. It is also desirable to identify compounds that interfere with or disrupt the interaction of such binding partners with the peptides and proteins of the current invention which may be useful in regulating the activity of the peptides and proteins of the current invention and thus control development and cell differentiation disorders associated with the activity of the peptides and proteins of the current invention.

[0151] The basic principle of the assay systems used to identify compounds that interfere with the interaction between the peptides and proteins of the current invention and its binding partner or partners involves preparing a reaction mixture containing the peptides or proteins of the current invention of interest, modified or truncated version thereof, or fusion proteins thereof as described above, and the binding partner under conditions and for a time sufficient to allow the two to interact and bind, thus forming a complex. In order to test a compound for inhibitory activity, the reaction mixture is prepared in the presence and absence of the test compound. The test compound may be initially included in the reaction mixture, or may be added at a time subsequent to the addition of the peptide or protein of the current invention and its binding partner. Control reaction mixtures are incubated without the test compound or with a placebo. The formation of any complexes between the peptide or protein of the current invention and the binding partner is then detected. The formation of a complex in the control reaction, but not in the reaction mixture containing the test compound, indicates that the compound interferes with the interaction of the peptide or protein at least partially encoded by an GTS of the present invention and the interactive binding partner. Additionally, complex formation within reaction mixtures containing the test compound and normal peptide or protein of the current invention may also be compared to complex formation within reaction mixtures containing the test compound and a mutant peptide or protein of the current invention. This comparison may be important in those cases where it is desirable to identify compounds that disrupt interactions of mutant but not normal forms of a peptide or protein of the current invention.

[0152] The assay for compounds that interfere with the interaction of a peptide or protein of the current invention and binding partners can be conducted in a heterogeneous or homogeneous format. Heterogeneous assays involve anchoring either the peptide or protein of the current invention or the binding partner onto a solid phase and detecting complexes anchored on the solid phase at the end of the reaction. In homogeneous assays, the entire reaction is carried out in a liquid phase. In either approach, the order of addition of reactants can be varied to obtain different information about the compounds being tested. For example, test compounds that interfere with the interaction by competition can be identified by conducting the reaction in the presence of the test substance; i.e., by adding the test substance to the reaction mixture prior to or simultaneously with the peptide or protein of the current invention and interactive binding partner. Alternatively, test compounds that disrupt preformed complexes, e.g. compounds with higher binding constants that displace one of the components from the complex, can be tested by adding the test compound to the reaction mixture after complexes have been formed. The various formats are described briefly below.

[0153] In a heterogeneous assay system, either the peptide or protein of the current invention or the interactive binding partner, is anchored onto a solid surface, while the non-anchored species is labeled, either directly or indirectly. In practice, microtiter plates are conveniently utilized. The anchored species may be immobilized by non-covalent or covalent attachments. Non-covalent attachment may be accomplished simply by coating the solid surface with a solution of the peptide or protein of the current invention or binding partner and drying. Alternatively, an immobilized antibody specific for the species to be anchored may be used to anchor the species to the solid surface. The surfaces may be prepared in advance and stored.

[0154] In order to conduct the assay, the partner of the immobilized species is exposed to the coated surface with or without the test compound. After the reaction is complete, unreacted components are removed (e.g., by washing) and any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the non-immobilized species is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the non-immobilized species is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the initially non-immobilized species (the antibody, in turn, may be directly labeled or indirectly labeled with a labeled anti-Ig antibody). Depending upon the order of addition of reaction components, test compounds which inhibit complex formation or which disrupt preformed complexes can be detected.

[0155] Alternatively, the reaction can be conducted in a liquid phase in the presence or absence of the test compound, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes. Again, depending upon the order of addition of reactants to the liquid phase, test compounds which inhibit complex or which disrupt preformed complexes can be identified.

[0156] In an alternate embodiment of the invention, a homogeneous assay can be used. In this approach, a preformed complex of the peptide or protein of the current invention and the interactive binding partner is prepared in which either the peptide or protein of the current invention or its binding partner is labeled, but the signal generated by the label is quenched due to formation of the complex (see, e.g., U.S. Pat. No. 4,109,496 by Rubenstein which utilizes this approach for immunoassays). The addition of a test substance that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances which disrupt peptide or protein of the current invention/intracellular binding partner interaction can be identified.

[0157] In a particular embodiment, a peptide or protein of the current invention can be prepared for immobilization. For example, the peptide or protein of the current invention or a fragment thereof can be fused to a glutathione-S-transferase (GST) gene using a fusion vector, such as pGEX-5X-1, in such a manner that its binding activity is maintained in the resulting fusion protein. The interactive binding partner can be purified and used to raise a monoclonal antibody, using methods routinely practiced in the art and described above. This antibody can be labeled with the radioactive isotope ¹²⁵I, for example, by methods routinely practiced in the art. In a heterogeneous assay, e.g., the GST-peptide or protein of the current invention fusion protein can be anchored to glutathione-agarose beads. The interactive binding partner can then be added in the presence or absence of the test compound in a manner that allows interaction and binding to occur. At the end of the reaction period, unbound material can be washed away, and the labeled monoclonal antibody can be added to the system and allowed to bind to the complexed components. The interaction between the peptide or protein of the current invention and the interactive binding partner can be detected by measuring the amount of radioactivity that remains associated with the glutathione-agarose beads. A successful inhibition of the interaction by the test compound will result in a decrease in measured radioactivity.

[0158] Alternatively, the GST-peptide or protein of the current invention fusion protein and the interactive binding partner can be mixed together in liquid in the absence of the solid glutathione-agarose beads. The test compound can be added either during or after the species are allowed to interact. This mixture can then be added to the glutathione-agarose beads and unbound material is washed away. Again the extent of inhibition of the peptide or protein of the current invention/binding partner interaction can be detected by adding the labeled antibody and measuring the radioactivity associated with the beads.

[0159] In another embodiment of the invention, these same techniques can be employed using peptide fragments that correspond to the binding domains of a peptide or protein of the current invention and/or the interactive or binding partner (in cases where the binding partner is a protein), in place of one or both of the full length proteins. Any number of methods routinely practiced in the art can be used to identify and isolate the binding sites. These methods include, but are not limited to, mutagenesis of the gene encoding one of the proteins and screening for disruption of binding in a co-immunoprecipitation assay. Compensating mutations in the gene encoding the second species in the complex can then be selected. Sequence analysis of the genes encoding the respective proteins will reveal the mutations that correspond to the region of the protein involved in interactive binding. Alternatively, one protein can be anchored to a solid surface using methods described above, and allowed to interact with and bind to its labeled binding partner, which has been treated with a proteolytic enzyme, such as trypsin. After washing, a short, labeled peptide comprising the binding domain may remain associated with the solid material, which can be isolated and identified by amino acid sequencing. Also, once the gene coding for the intracellular binding partner is obtained, short gene segments can be engineered to express peptide fragments of the protein, which can then be tested for binding activity and purified or synthesized.

[0160] For example, and not by way of limitation, a peptide or protein of the current invention can be anchored to a solid material as described, above, by making a GST-peptide or protein of the current invention fusion protein and allowing it to bind to glutathione agarose beads. The interactive binding partner can be labeled with a radioactive isotope, such as ³⁵S, and cleaved with a proteolytic enzyme such as trypsin. Cleavage products can then be added to the anchored GST-peptide or protein of the current invention fusion protein and allowed to bind. After washing away unbound peptides, labeled bound material, representing the intracellular binding partner binding domain, can be eluted, purified, and analyzed for amino acid sequence by well-known methods. Peptides so identified can be produced synthetically or fused to appropriate facilitative proteins using recombinant DNA technology.

5.6.4. 5.6.3. Assays for Identification of Compounds that Ameliorate Disorders Affecting Development Cell Differentiation

[0161] Compounds, including but not limited to binding compounds identified via assay techniques such as those described above, can be tested for the ability to ameliorate development and cell differentiation disorder symptoms. The assays described above can identify compounds which affect the activity of peptides and proteins of the current invention (e.g., compounds that bind to the peptides and proteins of the current invention, inhibit binding of their natural ligands, and compounds that bind to a natural ligand of the peptides and proteins of the current invention and neutralize the ligand activity); or compounds that affect the activity of genes encoding peptides and proteins of the current invention (by affecting the expression of those genes, including molecules, e.g., proteins or small organic molecules, that affect or interfere with splicing events so that expression of the genes of interest can be modulated). However, it should be noted that the assays described herein can also identify compounds that modulate signal transduction or catalytic events that the peptides and proteins of the current invention are involved in. The identification and use of such compounds which affect a step in, for example, signal transduction pathways or catalytic events in which any of the peptides and proteins of the current invention are involved in, may modulate the effect of the peptides and proteins of the current invention on developmental or cell differentiation disorders. Such identification and use of such compounds are within the scope of the invention. Such compounds can be used as part of a therapeutic method for the treatment of developmental and cell differentiation disorders.

[0162] The invention encompasses cell-based and animal model-based assays for the identification of compounds exhibiting such an ability to ameliorate developmental and cell differentiation disorder symptoms. Such cell-based assay systems can also be used as the standard to assay for purity and potency of the natural ligand, catalytic subunit, including recombinantly or synthetically produced catalytic subunit and catalytic subunit mutants.

[0163] Cell-based systems can be used to identify compounds which may act to ameliorate developmental or cell differentiation disorder symptoms. Such cell systems can include, for example, recombinant or non-recombinant cells, such as cell lines, which express the gene encoding the peptide or protein of interest of the current invention. For example ES cells, or cell lines derived from ES cells can be used. In addition, expression host cells (e.g., COS cells, CHO cells, fibroblasts, Sf9 cells) genetically engineered to express a functional peptide or protein of the current invention in addition to factors necessary for the peptide or protein of the current invention to fulfil its physiological role of, for example, signal transduction or catalysis, can be used as an end point in the assay.

[0164] In utilizing such cell systems, cells may be exposed to a compound suspected of exhibiting an ability to ameliorate developmental or cell differentiation disorder symptoms, at a sufficient concentration and for a time sufficient to elicit such an amelioration of such disorder symptoms in the exposed cells. After exposure, the cells can be assayed to measure alterations in the expression of the gene encoding the peptide or protein of interest of the current invention, e.g., by assaying cell lysates for the appropriate mRNA transcripts (e.g., by Northern analysis) or for expression of the peptide or protein of interest of the current invention in the cell; compounds which regulate or modulate expression of the gene encoding the peptide or protein of interest of the current invention are valuable candidates as therapeutics. Alternatively, the cells are examined to determine whether one or more developmental or cell differentiation disorder-like cellular phenotypes has been altered to resemble a more normal or more wild type phenotype, or a phenotype more likely to produce a lower incidence or severity of disorder symptoms. Still further, the expression and/or activity of components of pathways or functionally or physiologically connected peptides or proteins of which the peptide or protein of interest of the current invention is a part, can be assayed.

[0165] For example, after exposure of the cells, cell lysates can be assayed for the presence of increased levels of the test compound as compared to lysates derived from unexposed control cells. The ability of a test compound to inhibit production of the assay compound such systems indicates that the test compound inhibits signal transduction initiated by the peptide or protein of interest of the current invention. Finally, a change in cellular morphology of intact cells may be assayed using techniques well known to those of skill in the art.

[0166] In addition, animal-based development or cell differentiation disorder systems, which may include, for example, mice, may be used to identify compounds capable of ameliorating development or cell differentiation disorder-like symptoms. Such animal models may be used as test systems for the identification of drugs, pharmaceuticals, therapies and interventions which may be effective in treating such disorders. For example, animal models may be exposed to a compound, suspected of exhibiting an ability to ameliorate development or cell differentiation disorder symptoms, at a sufficient concentration and for a time sufficient to elicit such an amelioration of development and/or cell differentiation disorder symptoms in the exposed animals. The response of the animals to the exposure may be monitored by assessing the reversal of disorders associated with development and/or cell differentiation disorders. With regard to intervention, any treatments which reverse any aspect of development or cell differentiation disorder-like symptoms should be considered as candidates for human development and/or cell differentiation disorder therapeutic intervention. Dosages of test agents may be determined by deriving dose-response curves, as discussed below.

5.7. The Treatment of Disorders Associated with Stimulation of Peptides and Proteins of the Current Invention

[0167] The invention also encompasses methods and compositions for modifying development and cell differentiation and treating development and cell differentiation disorders. For example, one may decrease the level of expression of one or more genes of the current invention, and/or downregulate activity of one or more of the peptides or proteins of interest of the current invention. Thereby, the response of cells, like, for example, ES cells, to factors which activate the physiological responses that enhance the pathological processes leading to developmental and cell differentiation disorders may be reduced and the symptoms ameliorated. Conversely, the response of cells, like, for example, ES cells, to physiological stimuli involving any of the peptides or proteins of the current invention and necessary for proper developmental and cell differentiation processes may be augmented by increasing the activity of one or several of the peptides or proteins of interest of the current invention. Different approaches are discussed below.

5.7.1. Inhibition of Peptides and Proteins of the Current Invention to Reduce Development and Cell Differentiation Disorders

[0168] Any method which neutralizes the catalytic or signal transduction activity of peptides and proteins at least partially encoded by the GTSs of the current invention, or which inhibits expression of the genes encoding peptides and proteins (either transcription or translation), can be used to reduce symptoms associated with developmental and cell differentiation disorders.

[0169] In one embodiment, immuno therapy can be designed to reduce the level of endogenous gene expression for the peptides and proteins of the current invention, e.g., using antisense or ribozyme approaches to inhibit or prevent translation of mRNA transcripts; triple helix approaches to inhibit transcription of the genes; or targeted homologous recombination to inactivate or “knock out” the genes or its endogenous promoter.

[0170] Antisense approaches involve the design of oligonucleotides (either DNA or RNA) that are complementary to mRNA specific for peptides and proteins of interest of the current invention. The antisense oligonucleotides will bind to the complementary mRNA transcripts and prevent translation. Absolute complementarity, although preferred, is not required. A sequence “complementary” to a portion of an RNA, as referred to herein, means a sequence having sufficient complementarity to be able to hybridize with the RNA, forming a stable duplex. In the case of double-stranded antisense nucleic acids, a single strand of the normally duplex DNA can thus be tested, or triplex formation can be assayed. The ability to hybridize will depend on both the degree of complementarity and the length of the antisense nucleic acid. Generally, the longer the hybridizing nucleic acid, the more base mismatches with an RNA it may contain and still form a stable duplex (or triplex, as the case may be). One skilled in the art can ascertain a tolerable degree of mismatch by use of standard procedures to determine the melting point of the hybridized complex.

[0171] Oligonucleotides that are complementary to the 5′ end of the message, e.g., the 5′ untranslated sequence up to and including the AUG initiation codon, should work most efficiently at inhibiting translation. However, sequences complementary to the 3′ untranslated sequences of mRNAs have recently shown to be effective at inhibiting translation of mRNAs as well. See generally, Wagner, R., 1994, Nature 372:333-335. Thus, oligonucleotides complementary to either the 5′- or 3′- non- translated, non-coding regions of the mRNAs specific for the peptides and proteins of the current invention could be used in an antisense approach to inhibit translation of those endogenous mRNAs. Oligonucleotides complementary to the 5′ untranslated region of the mRNA should include the complement of the AUG start codon. Antisense oligonucleotides complementary to mRNA coding regions are less efficient inhibitors of translation but could be used in accordance with the invention. Whether designed to hybridize to the 5′-, 3′- or coding region of an mRNA, antisense nucleic acids should be at least six nucleotides in length, and are preferably oligonucleotides ranging from 6 to about 50 nucleotides in length. In specific aspects the oligonucleotide is at least 10 nucleotides, at least 17 nucleotides, at least 25 nucleotides or at least 50 nucleotides.

[0172] Regardless of the choice of target sequence, it is preferred that in vitro studies are first performed to quantitate the ability of the antisense oligonucleotide to inhibit gene expression. It is preferred that these studies utilize controls that distinguish between antisense gene inhibition and nonspecific biological effects of oligonucleotides. It is also preferred that these studies compare levels of the target RNA or protein with that of an internal control RNA or protein. Additionally, it is envisioned that results obtained using the antisense oligonucleotide are compared with those obtained using a control oligonucleotide. It is preferred that the control oligonucleotide is of approximately the same length as the test oligonucleotide and that the nucleotide sequence of the oligonucleotide differs from the antisense sequence no more than is necessary to prevent specific hybridization to the target sequence.

[0173] The oligonucleotides can be DNA or RNA or chimeric mixtures or derivatives or modified versions thereof, single-stranded or double-stranded. The oligonucleotide can be modified at the base moiety, sugar moiety, or phosphate backbone, for example, to improve stability of the molecule, hybridization, etc. The oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger et al., 1989, Proc. Natl. Acad. Sci. U.S.A. 86:6553-6556; Lemaitre et al., 1987, Proc. Natl. Acad. Sci. 84:648-652; PCT Publication No. WO88/09810, published Dec. 15, 1988), or hybridization-triggered cleavage agents. (See, e.g., Krol et al., 1988, BioTechniques 6:958-976) or intercalating agents. (See, e.g., Zon, 1988, Pharm. Res. 5:539-549). To this end, the oligonucleotide may be conjugated to another molecule, e.g., a peptide, hybridization triggered cross-linking agent, transport agent, hybridization-triggered cleavage agent, etc.

[0174] The antisense oligonucleotide may comprise at least one modified base moiety which is selected from the group including but not limited to 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xantine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine.

[0175] The antisense oligonucleotide may also comprise at least one modified sugar moiety selected from the group including but not limited to arabinose, 2-fluoroarabinose, xylulose, and hexose.

[0176] In another embodiment, the antisense oligonucleotide comprises at least one modified phosphate backbone selected from the group consisting of a phosphorothioate, a phosphorodithioate, a phosphoramidothioate, a phosphoramidate, a phosphordiamidate, a methylphosphonate, an alkyl phosphotriester, and a formacetal or analog thereof.

[0177] In yet another embodiment, the antisense oligonucleotide is an alpha-anomeric oligonucleotide. An alpha-anomeric oligonucleotide forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual alpha-units, the strands run parallel to each other (Gautier et al., 1987, Nucl. Acids Res. 15:6625-6641). The oligonucleotide is a 2′-0-methylribonucleotide (Inoue et al., 1987, Nucl. Acids Res. 15:6131-6148), or a chimeric RNA-DNA analogue (Inoue et al., 1987, FEBS Lett. 215:327-330).

[0178] Oligonucleotides of the invention may be synthesized by standard methods known in the art, e.g. by use of an automated DNA synthesizer (such as are commercially available from Biosearch, Applied Biosystems, etc.). As examples, phosphorothioate oligonucleotides may be synthesized by the method of Stein et al., 1988, Nucl. Acids Res. 16:3209. Methylphosphonate oligonucleotides can be prepared by use of controlled pore glass polymer supports (Sarin et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85:7448-7451).

[0179] While antisense nucleotides complementary to the coding region sequence specific for the peptides and proteins of the current invention could be used, those complementary to the transcribed untranslated region are most preferred.

[0180] The antisense molecules should be delivered to cells which express the peptides and proteins of interest of the current invention in vivo, like, for example, ES cells. A number of methods have been developed for delivering antisense DNA or RNA to cells; e.g., antisense molecules can be injected directly into the tissue or cell derivation site, or modified antisense molecules, designed to target the desired cells (e.g., antisense linked to peptides or antibodies that specifically bind receptors or antigens expressed on the target cell surface) can be administered systemically.

[0181] However, it is often difficult to achieve intracellular concentrations of antisense molecules that are sufficient to suppress translation of endogenous mRNAs. Therefore a preferred approach utilizes a recombinant DNA construct in which the antisense oligonucleotide is placed under the control of a strong pol III or pol II promoter. The use of such a construct to transfect target cells in the patient will result in the transcription of sufficient amounts of single stranded RNAs that will form complementary base pairs with the endogenous transcripts specific for the peptides and proteins of interest of the current invention and thereby prevent translation of the respective mRNAs. For example, a vector can be introduced in vivo such that it is taken up by a cell and directs the transcription of an antisense RNA. Such a vector can remain episomal or become chromosomally integrated, as long as it can be transcribed to produce the desired antisense RNA. Such vectors can be constructed by recombinant DNA technology methods standard in the art. Vectors can be plasmid, viral, or others known in the art, used for replication and expression in mammalian cells. Expression of the sequence encoding the antisense RNA can be by any promoter known in the art to act in mammalian, preferably human cells. Such promoters can be inducible or constitutive. Such promoters include but are not limited to: the SV40 early promoter region (Bernoist and Chambon, 1981, Nature 290:304-310), the promoter contained in the 3′ long terminal repeat of Rous sarcoma virus (Yamamoto et al., 1980, Cell 22:787-797), the herpes thymidine kinase promoter (Wagner et al., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:1441-1445), the regulatory sequences of the metallothionein gene (Brinster et al., 1982, Nature 296:39-42), etc. Any type of plasmid, cosmid, YAC or viral vector can be used to prepare the recombinant DNA construct which can be introduced directly into the tissue or cell derivation site; e.g., the bone marrow. Alternatively, viral vectors can be used which selectively infect the desired tissue or cell type; (e.g., viruses which infect cells of hematopoietic lineage), in which case administration may be accomplished by another route (e.g., systemically).

[0182] Ribozyme molecules designed to catalytically cleave mRNA transcripts specific for the peptides and proteins of interest of the current invention can also be used to prevent translation of the mRNAs of interest and expression of the peptides and proteins encoded by those mRNAs. (See, e.g., PCT International Publication WO90/11364, published Oct. 4, 1990; Sarver et al., 1990, Science 247:1222-1225). While ribozymes that cleave mRNA at site specific recognition sequences can be used to destroy mRNAs, the use of hammerhead ribozymes is preferred. Hammerhead ribozymes cleave mRNAs at locations dictated by flanking regions that form complementary base pairs with the target mRNA. The sole requirement is that the target mRNA have the following sequence of two bases: 5′-UG-3′. The construction and production of hammerhead ribozymes is well known in the art and is described more fully in Haseloff and Gerlach, 1988, Nature, 334:585-591. Preferably the ribozyme is engineered so that the cleavage recognition site is located near the 5′ end of the mRNA of interest; i.e., to increase efficiency and minimize the intracellular accumulation of non-functional mRNA transcripts.

[0183] The ribozymes of the present invention also include RNA endoribonucleases (hereinafter “Cech-type ribozymes”) such as the one which occurs naturally in Tetrahymena Thermophila (known as the IVS, or L-19 IVS RNA) and which has been extensively described by Thomas Cech and collaborators (Zaug et al., 1984, Science, 224:574-578; Zaug and Cech, 1986, Science, 231:470-475; Zaug et al., 1986, Nature, 324:429-433; published International Patent Application No. WO 88/04300 by University Patents Inc.; Been and Cech, 1986, Cell, 47:207-216). The Cech-type ribozymes have an eight base pair active site which hybridizes to a target RNA sequence where after cleavage of the target RNA takes place. The invention encompasses those Cech-type ribozymes which target eight base-pair active site sequences that are present in the mRNAs specific for the peptides and proteins of interest of the current invention.

[0184] As in the antisense approach, the ribozymes can be composed of modified oligonucleotides (e.g. for improved stability, targeting, etc.) and should be delivered to cells which express the peptides and proteins of interest of the current invention in vivo, like, for example, ES cells. A preferred method of delivery involves using a DNA construct “encoding” the ribozyme under the control of a strong constitutive pol III or pol II promoter, so that transfected cells will produce sufficient quantities of the ribozyme to destroy the endogenous messages specific for the peptides and proteins of interest of the current invention and inhibit translation. Because ribozymes unlike antisense molecules, are catalytic, a lower intracellular concentration is required for efficiency.

[0185] Endogenous gene expression can also be reduced by inactivating or “knocking out” the gene of interest specific for a peptide or protein of the current invention or its promoter using targeted homologous recombination. (e.g., see Smithies et al., 1985, Nature 317:230-234; Thomas & Capecchi, 1987, Cell 51:503-512; Thompson et al., 1989 Cell 5:313-321; each of which is incorporated by reference herein in its entirety). For example, a mutant, non-functional peptide or protein of interest of the current invention (or a completely unrelated DNA sequence) flanked by DNA homologous to the endogenous gene encoding said peptide or protein of interest of the current invention (either the coding regions or regulatory regions of the gene) can be used, with or without a selectable marker and/or a negative selectable marker, to transfect cells that express said peptide or protein of interest of the current invention in vivo. Insertion of the DNA construct, via targeted homologous recombination, results in inactivation of the targeted endogenous gene. Such approaches are particularly suited in the agricultural field where modifications to ES cells can be used to generate animal offspring with an inactive copy of a gene encoding a peptide or protein of interest of the current invention (e.g., see Thomas & Capecchi 1987 and Thompson 1989, supra). However this approach can be adapted for use in humans provided the recombinant DNA constructs are directly administered or targeted to the required site in vivo using appropriate viral vectors.

[0186] Alternatively, endogenous expression of a gene of interest can be reduced by targeting deoxyribonucleotide sequences complementary to the regulatory region of said gene (i.e., the promoter and/or enhancers) to form triple helical structures that prevent transcription of the gene of interest in target cells in the body. (See generally, Helene, C. 1991, Anticancer Drug Des., 6(6):569-84; Helene, C. et al., 1992, Ann, N.Y. Acad. Sci., 660:27-36; and Maher, L.J., 1992, Bioassays 14 (12):807-15)

[0187] In yet another embodiment of the invention, the activity of a peptide or protein of interest of the current invention can be reduced using a “dominant negative” approach. A dominant negative approach takes advantage of the interaction of the peptides or proteins of interest with other peptides or proteins to form complexes, the formation of which is a prerequisite for the peptide or protein of interest of the current invention to exert its physiological activity. To this end, constructs which encode a defective form of the peptide or protein of interest of the current invention can be used in gene therapy approaches to diminish the activity of said peptide or protein of interest in appropriate target cells. Alternatively, targeted homologous recombination can be utilized to introduce such deletions or mutations into the subject's endogenous gene encoding the peptide or protein of interest of the current invention in the appropriate tissue. The engineered cells will express non-functional copies of the peptide or protein of interest of the current invention, thereby downregulating its activity in vivo. Such engineered cells should demonstrate a diminished response to physiological stimuli of the activity of the affected peptide or protein of interest of the current invention, resulting in reduction of the development or cell differentiation disorder phenotype.

5.7.2. Restoration od Increase in Expression or Activity of a Peptide or Protein of the Current Invention to Promote Development or Cell Differentiation

[0188] With respect to an increase in the level of normal gene expression and/or gene product activity specific for any of the peptides and proteins of interest of the current invention, the respective nucleic acid sequences can be utilized for the treatment of development and cell differentiation disorders. Where the cause of the development or cell differentiation dysfunction is a defective peptide or protein of the current invention, treatment can be administered, for example, in the form of gene delivery or gene therapy. Specifically, one or more copies of a normal gene or a portion of the gene that directs the production of a gene product exhibiting normal function of the appropriate peptide or protein of the current invention, may be inserted into the appropriate cells within a patient or animal subject, optionally using suitable vectors. Recombinant retroviruses have been widely used in gene transfer or gene delivery experiments and even human clinical trials (see generally, Mulligan, R. C., Chapter 8, In: Experimental Manipulation of Gene Expression, Academic Press, pp. 155-173 (1983); Coffin, J., In: RNA Tumor Viruses, Weiss, R. et al. (eds.), Cold Spring Harbor Laboratory, Vol. 2, pp. 36-38 (1985). Other eucaryotic viruses which have been used as vectors to transduce mammalian cells include adenovirus, papilloma virus, herpes virus, adeno-associated virus, rabies virus, and the like (See generally, Sambrook et al., Molecular Cloning, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., Vol. 3:16.1-16.89 (1989). Alternatively, cationic or other lipids may be employed to deliver polynucleotides comprising the described GTS sequences to patients. Additionally, naked DNA comprising one or more GTS sequences, optionally modified by the addition of one or more of, in operable combination and orientation, a promoter, an enhancer, a ribosome entry or ribosome binding site, and/or an in-frame translation initiation codon can be employed to deliver GTSs to a patient. Another use of the above constructs includes “naked” DNA vaccines that can be introduced in vivo alone, or in conjunction with excipients, or microcarrier spheres, nanoparticles or other supporting or dosaging compounds or molecules.

[0189] The gene replacement/delivery therapies described above should be capable of delivering gene sequences to the cell types within patients which express the peptide or protein of interest of the current invention. Alternatively, targeted homologous recombination can be utilized to correct the defective endogenous gene in the appropriate cell type. In animals, targeted homologous recombination can be used to correct the defect in ES cells in order to generate offspring with a corrected trait.

[0190] Finally, compounds identified in the assays described above that stimulate, enhance, or modify the activity of the peptides and proteins of the current invention can be used to achieve proper development and cell differentiation. The formulation and mode of administration will depend upon the physico-chemical properties of the compound.

5.8. Pharmaceutical Preparations and Methods of Administration

[0191] Compounds that are determined to affect gene expression of the peptides and proteins of the current invention, or the interaction of those peptides and proteins with any of their binding partners, can be administered to a patient at therapeutically effective doses to treat or ameliorate development and cell differentiation disorders. A therapeutically effective dose refers to that amount of the compound sufficient to result in any amelioration or retardation of disease symptoms, or development and cell differentiation or proliferation disorders.

5.8.1. Effective Dose

[0192] Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD₅₀ (the dose lethal to 50% of the population) and the ED₅₀ (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD₅₀/ED₅₀. Compounds which exhibit large therapeutic indices are preferred. While compounds that exhibit toxic side effects may be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.

[0193] The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED₅₀ with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range that includes the IC₅₀ (i. e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.

[0194] When the therapeutic treatment of disease is contemplated, the appropriate dosage may also be determined using animal studies to determine the maximal tolerable dose, or MTD, of a bioactive agent per kilogram weight of the test subject. In general, at least one animal species tested is mammalian. Those skilled in the art regularly extrapolate doses for efficacy and avoiding toxicity to other species, including human. Before human studies of efficacy are undertaken, Phase I clinical studies in normal subjects help establish safe doses.

[0195] Additionally, the bioactive agent may be complexed with a variety of well established compounds or structures that, for instance, enhance the stability of the bioactive agent, or otherwise enhance its pharmacological properties (e.g., increase in vivo half-life, reduce toxicity, etc.).

[0196] The above therapeutic agents will be administered by any number of methods known to those of ordinary skill in the art including, but not limited to, administration by inhalation; by subcutaneous (sub-q), intravenous (I.V.), intraperitoneal (I.P.), intramuscular (I.M.), or intrathecal injection; or as a topically applied agent (transderm, ointments, creams, salves, eye drops, and the like).

5.8.2. Formulations and Use

[0197] Pharmaceutical compositions for use in accordance with the present invention may be formulated in conventional manner using one or more physiologically acceptable carriers or excipients.

[0198] Thus, the compounds and their physiologically acceptable salts and solvates may be formulated for administration by inhalation or insufflation (either through the mouth or the nose) or oral, buccal, parenteral or rectal administration.

[0199] For oral administration, the pharmaceutical compositions may take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium hydrogen phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulphate). The tablets may be coated by methods well known in the art. Liquid preparations for oral administration may take the form of, for example, solutions, syrups or suspensions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (e.g., sorbitol syrup, cellulose derivatives or hydrogenated edible fats); emulsifying agents (e.g., lecithin or acacia); non-aqueous vehicles (e.g., almond oil, oily esters, ethyl alcohol or fractionated vegetable oils); and preservatives (e.g., methyl or propyl-p-hydroxybenzoates or sorbic acid). The preparations may also contain buffer salts, flavoring, coloring and sweetening agents as appropriate.

[0200] Preparations for oral administration may be suitably formulated to give controlled release of the active compound.

[0201] For buccal administration the compositions may take the form of tablets or lozenges formulated in conventional manner.

[0202] For administration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of e.g. gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch.

[0203] The compounds may be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.

[0204] The compounds may also be formulated as compositions for rectal administration such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides.

[0205] In addition to the formulations described previously, the compounds may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds may be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt. The compositions may, if desired, be presented in a pack or dispenser device which may contain one or more unit dosage forms containing the active ingredient. The pack may for example comprise metal or plastic foil, such as a blister pack. The pack or dispenser device may be accompanied by instructions for administration.

[0206] The examples below are provided to illustrate the subject invention. These examples are provided by way of illustration and are not included for the purpose of limiting the invention in any way whatsoever.

6.0. EXAMPLES 6.1. Generation of a Library of Mutated Mouse ES Cells Defined by GTS Sequences

[0207] The retroviral vector VICTR 3, described in detail in U.S. application Ser. No. 08/728,963, filed Oct. 11, 1996, was used to generate a library of gene trapped ES cell clones that represent a portion of the described GTSs. A plasmid containing the VICTR 3 cassette was constructed by conventional cloning techniques and designed to employ the features described above. Namely, the cassette contained a PGK promoter directing transcription of an exon that encodes the puro marker and ends in a canonical splice donor sequence. At the end of the puromycin exon, sequences were added as described that allow for the annealing of two nested PCR and sequencing primers. The vector backbone was based on pBluescript KS+ from Stratagene Corporation.

[0208] The plasmid construct was linearized by digestion with Sca I which cuts at a unique site in the plasmid backbone. The plasmid was then transfected into the mouse ES cell line AB2.2 by electroporation using a BioRad Genepulser apparatus. After the cells were allowed to recover, gene trap clones were selected by adding puromycin to the medium at a final concentration of 3 μg/ml. Positive clones were allowed to grow under selection for approximately 10 days before being removed and cultured separately for storage and to determine the sequence of the disrupted gene.

[0209] Total RNA was isolated from an aliquot of cells from each of 18 gene trap clones chosen for study. Five micrograms of this RNA was used in a first strand cDNA synthesis reaction using the “RS” primer. This primer has unique sequences (for subsequent PCR) on its 5′ end and nine random nucleotides or nine T (thymidine) residues on it's 3′ end. Reaction products from the first strand synthesis were added directly to a PCR with outer primers specific for the engineered sequences of puromycin and the “RS” primer. After amplification, an aliquot of reaction products were subject to a second round of amplification using primers internal, or nested, relative to the first set of PCR primers. This second amplification provided more reaction product for sequencing and also provided increased specificity for the specifically gene trapped DNA.

[0210] The products of the nested PCR were visualized by agarose gel electrophoresis, and seventeen of the eighteen clones provided at least one band that was visible on the gel with ethidium bromide staining. Most gave only a single band which is an advantage in that a single band is generally easier to sequence. The PCR products were sequenced directly after excess PCR primers and nucleotides were removed by filtration in a spin column (Centricon-100, Amicon). DNA was added directly to dye terminator sequencing reactions (purchased from ABI) using the standard M13 forward primer a region for which was built into the end of the puro exon in all of the PCR fragments.

[0211] Subsequent studies have used both VICTR 3 and VICTR 20. Like VICTR 3, VICTR 20 is exemplary of a family of vectors that incorporate two main functional units: a sequence acquisition component having a strong promoter element (phosphoglycerate kinase 1) active in ES cells that is fused to the puromycin resistance gene coding sequence which lacks a polyadenylation sequence but is followed by a synthetic consensus splice donor sequence (PGKpuroSD); and 2) a mutagenic component that incorporates a splice acceptor sequence fused to a selectable, calorimetric marker gene and followed by a polyadenylation sequence (for example, SAâgeopA or SAIRESâgeopA). Also like VICTR 3, stop codons have been engineered into all three reading frames in the region between the 3′ end of the selectable marker and the splice donor site. A diagrammatic description of structure and functions of VICTRs 3 and 20 is provided in FIG. 1.

[0212] When VICTRs 3, 20, and various variations thereof, were used in the commercial scale application of the presently disclosed invention, many mutagenized ES cell clones were rapidly engineered and obtained. Sequence analysis obtained from these clones has identified a wide variety of both previously identified and novel sequences. Each of the sequences presented in SEQ ID NOS:1-891 identify heretofore unknown coding regions of mammalian genes. Moreover, given that totipotent ES cells have targeted, each of the disclosed mutants effectively represents genetically engineered animals that incorporate the mutated cells and that are preferably capable of germline transmission of the listed mutations.

[0213] The discovery potential of the presently described invention as a genomics resource becomes apparent when one considers that the genes mutated/represented in the Sequence Listing were identified in a few years, whereas simply constructing the mutated cells would have taken many decades of person-hours using conventional methods of genetic manipulation such as targeted homologous recombination.

[0214] Additionally, and perhaps more importantly, the gene trap sequences thus far identified provide novel sequence information (see SEQ ID NOS:1-891), and, because of the functional aspects of the presently described ES cell system, the cellular and developmental functions of these novel sequences can be rapidly established.

[0215] The cloned 3′ RACE products resulting after the target ES cells were infected with VICTR 20 were purified using conventional column chromatography, (e.g., S300 and G-50 columns), and the products were recovered by centrifugation. Purified PCR products were quantified by fluorescence using PicoGreen (Molecular Probes, Inc., Eugene Oregon) as per the manufacturer's instructions.

[0216] Dye terminator cycle sequencing reactions with AmpliTaq® FS DNA polymerase (Perkin Elmer Applied Biosystems, Foster City, Calif.) were carried out using approximately 7 pmoles of sequencing primer, and approximately 30-120 ng of 3′ template. Unincorporated dye terminators were removed from the completed sequencing reactions using G-50 columns as described above. The reactions were dried under vacuum, resuspended in loading buffer, and electrophoresed through a 6% Long Ranger acrylamide gel (FMC BioProducts, Rockland, Me.) on an ABI Prism® 377 with XL upgrade as per the manufacturer's instructions. The sequences of the resulting amplicons, or GTSs, are described in SEQ ID NOS:1-891.

[0217] All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

1 891 1 449 DNA Mus musculus misc_feature (1)...(449) n = A,T,C or G 1 aggccttgaa gagatccgca aatgtggant gaaaaacttc cgnaacatcc aggntgatga 60 ggctaattta ttgacttggc aagggcttat tgttcctgac aaccctccat atgataaggg 120 agccttcaga attgaaatca actttccagc agagtatcca ttcaaaccac ccaagatcac 180 atttaaaaca aagatctacc accctaacat cgatgagaag gggcaggtct gtctgccagt 240 cattagtgct gaaaactgga agccagccac caagactgac caagtaatcc agtccctcat 300 agcactggtg aatgaccccc agcctgagca cccactccgg gctgacctag ctgaagaata 360 ctctaaggac cgtaaaaaat tctgtaagaa tgctgaagag tttacaaaga aatatgggga 420 aaaagccgac ctgggggctt aaaatctgc 449 2 397 DNA Mus musculus misc_feature (1)...(397) n = A,T,C or G 2 atttgccagc tgaaggcatt tacattcgga gttccgcgga ctcttcanag gctgtaaaaa 60 tgccggagtc acnaaagcct gcaaaaagct gttgcttgcc ttgctgctgc tgctgctact 120 gccgtccctg cccgtgctgc aagctgctac tcctgctgct gctgctgctg cttgttgctg 180 attgttgcgg ttgctggttg ctgtttactg tttgctgccg gctggattgc tggattgctg 240 attgccagtc gggnaaatcc tggnnataaa aatccanctt gccccanaaa acangacnac 300 cctnnaggaa gtattctaat gatttcaatn cgccctttcc ccctctnacc tttctctctt 360 accttatgct gggggattgg aagggtggca aaaaaaa 397 3 285 DNA Mus musculus misc_feature (1)...(285) n = A,T,C or G 3 gatggagaaa ctgaggttcc gcatngaanc aggctgattc agacctcgct gccactgagt 60 atgagaccac ctggggtgaa acttagatgg ctctattgtt ctgtcacctg ccgccactcc 120 tctccaagac actgttacct gcccttgaga tattccggag acagcatccc gcagatcacc 180 tacaggctgg cgacaggcac caagaatgga ttggtggggg atgggcctcc cctctttata 240 cgcacagagt cttagtaaat tttgggtcct tgaacagaaa aaaaa 285 4 287 DNA Mus musculus misc_feature (1)...(287) n = A,T,C or G 4 caggagtaac aagtgtggag gtcnaaggan aactcttgga atctcttcta tcctatcaca 60 tcngtctcag gcatcnaaca tgggccaact cctcaaactt ggtancctgg nacttnaata 120 nccatcttan tgctcaaaaa aggtttctcc tatgaagacc gtgtntcctg gctgtcctag 180 aatttgctgt gcnnaccaac ctggcctnna actcataaac ntttacctgc ctctgcctct 240 aaagtgttgg gattnaaagc atttcccact atgtaacaaa caaaaaa 287 5 417 DNA Mus musculus misc_feature (1)...(417) n = A,T,C or G 5 cgcccatcct aaattcctag cttgctcggg gtaggagntt cctgttcatt cgttctgata 60 nncccactgn tgaaaactga ggngccacac tcgtatcnct ntcnacngga cctaacatta 120 ttcgggangg aactctggtc cncnccccca tcnttcaatn nnnntgtcgt ggngattggn 180 ttngaaccnt gntcagnata aagctgaaaa aaaccccatt gnctnncatt tncaccanga 240 ccgggaagng tntnatatcn aggatccgaa taaggctctt caaggcttct ttgaccgaga 300 aggagaanag ttagaatatg aatttgatga gcnaggacac atcacttggc tctgcagggt 360 gaggttacct gtagatgatt cnnctgggaa acagctggtg gctgaggcca ttcactc 417 6 173 DNA Mus musculus 6 gtctagaatg tatgtgccat gctgggaaca ggcctggatc gtctgcaaga gcagccatcg 60 gtcttagctg ctaactcctc tctcagtcca ttttgaatac gattctgagg tgacgcttcc 120 ctgtcaccac ccttaacatg ctctcatcgt accctctggt caaataaaaa aaa 173 7 167 DNA Mus musculus misc_feature (1)...(167) n = A,T,C or G 7 tctagatgta tgtgccatgc tgggaaccan gcctggatcg tctgcaagag cagncatcgg 60 tcttagntgc taactcctct ctcagtccat ttgaatacna ttctgaggtg acgcttccct 120 gtcgncaccc ttaacatgct ctcatcgtac cctctgaaaa aaaaaaa 167 8 191 DNA Mus musculus misc_feature (1)...(191) n = A,T,C or G 8 attctccatc cacaaattat gcagtcaagt ttcctcnaat ttggggtcaa tacacacaga 60 gtgcaatgga tgaacctcgc tctggagaaa tcacctgcat aatcatggta tttccccttc 120 caggatttat acanaagcag tcttccaaat tctgaaacct gatgcccatc acatactttg 180 ggctgagaaa a 191 9 157 DNA Mus musculus misc_feature (1)...(157) n = A,T,C or G 9 ggtctagatt atgtgcatgc tgggaacaag cctggatcgt ctgcaagagc agncatcggt 60 cttagctgct aactcctctc tcagtccatn tgaaatacga ttctgaggtg acgcttccct 120 gtcnncaccc ttaacatgct ctcatcgtac cctctga 157 10 273 DNA Mus musculus misc_feature (1)...(273) n = A,T,C or G 10 ggaatacaaa gggccagggt ccggctgcgt ctcctggatc ttgagctgac atctaggttc 60 ctgggtggga ccacaaatnc aactatactg gaggctgatg canttctctt aggactccaa 120 gagatcaggg actcaaaatc aagagaggag caacccagca agtaatggac tgcgcttgct 180 gtatttgaac ccattttgag cccagaaaac tataaataaa taaataattg aataaattta 240 tnataaatga aaagtaatcc tgttaaaaaa aaa 273 11 370 DNA Mus musculus misc_feature (1)...(370) n = A,T,C or G 11 actgaggtga cctttgaaag ttaacagggg tgccatgggc tgagtaagat aaacggaact 60 gctgttcaac cccgcccagt ctggggatga gtcattgttt tcaaatttat gaacaaagca 120 cacaaattaa gaataataca agcaagaaac agcagagaga cacaaaagga catagaatcc 180 ctgatcctca ctgtgatctg gtaacactag ttctagggct ggagagagag atgctcaggg 240 caagtgctct tacagagaac atgagttcaa ttcccagaac ccacatggta cctcacaact 300 gcctatttca tacatgtggg gcagaacacc gatacacata cttttttttt taanaattga 360 aaaaaaaaaa 370 12 448 DNA Mus musculus misc_feature (1)...(448) n = A,T,C or G 12 ctcctttagt gagacngccc taggcagacc acntaccntt acccttctga aatctcggta 60 ctggaggatc tnggccngga tcctgatacc cccattgccc ccttagcnac ccatcctgac 120 naggaggagg aggaggagga ggaagaggag gagttgcttc tgcngcctgg gctccagggc 180 gggctgcgca ccaaggccct antcgtggat gantcctgcc ggcggtgacc atcttccant 240 ttgggcgcat acctccttcc ttccttcctt cccgtacctg aagcttctgg agtctggatg 300 attcanagcc gacanacctg gcngggatcc tgcctggcag ggaagggggt tgancntntt 360 ctgacttgct tttcccatcc catttctggg gcnnanccnt tatcctaaat ttacccctaa 420 ctcatggtgt ttcccgtggg tgacctaa 448 13 394 DNA Mus musculus misc_feature (1)...(394) n = A,T,C or G 13 tcctgatact gcttgntngg ggtagagctn cctgctcnta cnttctgccn naccnnatgc 60 tggaacctga gnatcnacat aattgcacct tctcttctgg accagacatt attcggcggg 120 aatcgggtcc ccaccccctg acgtcatacc tggtgtctca nccnnngnat ttgaactgtg 180 atcatctgag ccaaaatann ccaaagtata naagtcaaca aaggcaanat gctgnanatn 240 aaatggaaaa ccantcattg anaacatcat cncctctntn ctccgaggac ncttcggtgc 300 ggatctggga tatcccnnan ggtgggctga aacggaacnt naccgaggga ctcctggagc 360 tcnatggana catgcgccat gtggggctgg tgga 394 14 461 DNA Mus musculus misc_feature (1)...(461) n = A,T,C or G 14 cgcaccggat tgggcagcan taacnacact gcaanaggan cctnctgcac acgtttattg 60 gganagtntg attgnagagg tgannagacc ccgagcccaa aactggtgct gcttatatag 120 gcctangaga ggantgtctc acacctggat tggttatgca ctacgcctca tttgcatgat 180 cctcatctga ttggctactc tctctctgta cctcacaaag cctcattntc atacctcatt 240 tgcatgtctc acacctgatt ggttatantc tccaaacccc ctttatcctg cccggggcnn 300 gcantgtctt tgcaaaaaac tttactgcat atgttcacat tggttgtttg tccaaactta 360 tgcgtggtgg ccancagtan tcagtgccac tctgcaacgg cacntgtggc ttcccacatc 420 tccccctttt tgttttaata aaatgaggct gggactaggc c 461 15 301 DNA Mus musculus 15 aagtgttccc taagaaggtt gtcaccctga cggaagaacg gaaagcccaa cagctccagc 60 gcctcctgga catgaagagc aaccccatac agggcctggc tgcccactgg gattatgaaa 120 agaaggagtg gaaaaagtga ccaacgtccc acgtctgccg ccagcccctg caaactgctt 180 ctgcagccca ggagacaatc atcccctccc ctcccctccc ctccctcctc ctcctgagtc 240 ctgtctccac tcccttctcc aataaaagca gcctgctttg ttctgcttgc aaaaaaaaaa 300 a 301 16 285 DNA Mus musculus misc_feature (1)...(285) n = A,T,C or G 16 aggttcctaa aatcanactc tgtcatcggn aagtgnagac tgtaacaaac tgggaccctc 60 acatgccnat aagcantcaa aaatatttnc tgggagctgg ananatgggc tcagcagtta 120 aaaacactga ctgctcttcc ggangtcctg tgttcaaatc ccagcaacca cagggtaact 180 cacaaccatc tgtaatgana tctgatgccc tcttcgggtg tgtctnaaaa cagctacagt 240 gtccttacat ataataaata aataaatctt tttttttaaa gaata 285 17 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 17 ttgccccaaa ttggctgtag ccacacanac atgagaatgt cagatctcat tccggatgaa 60 gccctgagaa gggcaatcga gagccacaac aagaaaaaaa 100 18 269 DNA Mus musculus misc_feature (1)...(269) n = A,T,C or G 18 catggaatgg acgggacaag gaaggcaaac attcacctgg aancaaaanc tgtgctgctt 60 tntggcttat ttacagtann tttncncaac cggcaagctt gtgcantnnn agcaagaact 120 cctcctgcct gcctccggaa taagctgttg aattcttgtt tcttccagcg cggtgtctgc 180 ctgcacgctg ccatgcgtcc tgccatgatn ataatggact gaccctctga aactgtaagc 240 cagccccaan taaattttgt ccttgataa 269 19 312 DNA Mus musculus 19 aaggttgtcc tcggaggcca aaggcgtcag atacgacacc tggaagttga atttacagaa 60 ttgccagctg cccaacatgg attcttggaa ccaaaccttt agaattcaac aaacaaacaa 120 cccagggggc tggagagatg gctcagcact caagagcact gactgctgct cttccagagg 180 tcctgagttc aattcccagc aaccacatgg tggttcacaa ccatctgtaa tgagttccaa 240 tgccctcttc tggtgtgtct gaagacagcg acataaaatg aataaatctt tttaaaaacc 300 caaaaaaaaa aa 312 20 177 DNA Mus musculus misc_feature (1)...(177) n = A,T,C or G 20 aagaaacgtt ttgtaagtga agganatgga ggccgtctta aacctgaaag ctactgagca 60 cagcaactct tacagtctta ggtgttacca anaacanatc tcaactgtaa aagttgtcag 120 tacaggtttc ctttnccttt ngtttttgtt attgtttttt tttttttttt ttttttt 177 21 273 DNA Mus musculus misc_feature (1)...(273) n = A,T,C or G 21 tcatggagaa taacgggaac aaccnaaanc tccgggtttg cgttgccacc tgcaaccgan 60 ctgactantc cntacnggcc ccggatcatg tncggcatca aaacnaagcc cgcgtncttt 120 gagttggang tggtggtgct cggctcccac ctgattgang actatggctc ctgctccctg 180 anctgcttga gttccagtcc tgacttcctt tggtgatgaa cagcagcatg gaantgtaag 240 ccaaataaac ccttncctcc ccaaaaaaaa aaa 273 22 204 DNA Mus musculus misc_feature (1)...(204) n = A,T,C or G 22 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgngna 180 ccncccacca tgggggggct ggga 204 23 427 DNA Mus musculus misc_feature (1)...(427) n = A,T,C or G 23 gcttggccaa gattcaccag ggcctgctgt cctcacctgt ggatccacca gccagccatg 60 gtatagaggt attcccagca agtcaaagat gctgcattcc ggcgtatact caaagtcgga 120 gacgcccgtg aatcgcacat tgacgtccag acctgtggcc agtttcggga gcaccgtcat 180 tgcatcgtcc acattctggt gggagaaaag acaagatggc tggtctagcc ttccctccct 240 gccacccacc atcccatgtt tcatgtctgg ctttcttaca aaccgtttgt ttcatccacc 300 tcttacctca aacccccttt tgtgagacag agccctggct gtattgaaac tcactctgta 360 naccaagctt gcccttgaac tcacagacat ctacctctct ctgcttccca agtgctgtaa 420 ttaaagg 427 24 265 DNA Mus musculus misc_feature (1)...(265) n = A,T,C or G 24 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctn ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtancagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggnngatga 180 nnncatcanc atacaggcta cacaggacca ncaacggaat gaggagtagg cccggatcat 240 ggntgagtnt gagatcacag agcag 265 25 335 DNA Mus musculus 25 gatggtgcct gaacccaact gattaagcag gcaggcagaa acgtgtcacc atcagctacc 60 attgtgccct catgcataaa tgaagtcctg atggaaaaca gacaaacaaa caaacaaaca 120 aacatctcta cacactaagc cgaaaacaaa tctataccaa actgctaaaa taaatggaaa 180 atacttaatt tgagcctggc tgttttgaaa attggaaatc cttcttcaaa atgaaaatca 240 ccgcaaaaca atctaaagtc atctacaggc caactagggt gtttgttgct tgccaaactt 300 ccaataaatt ctgcttgaaa ccttaaaaaa aaaaa 335 26 587 DNA Mus musculus misc_feature (1)...(587) n = A,T,C or G 26 gccggcctcc actcctccat gtccngngcc tgcntctccn nccacttgtn tcccntcacc 60 nccatnacca tgtanancgg ggtgancaat gtgggcnttc accaccacca tcaccattct 120 ccccatcgtc tccaccacca caagcaccac caccgccacc accatgctca tggagcccgc 180 cgctaaggcc aatagatagc atctacctgg ctctgccctc catccagcan caacatgagt 240 ggatcctgat gctgccacgg aaaaggatgt gcctctggga taaaaggggg tactgggacc 300 ctggtcctgc ttgggtttca tttgcatatg agcccttctc cctatgtgca acaganacca 360 cctgggtgcc ctctacacaa tgtgngggct tgancttcga gcaaggctgg ctgantttcc 420 taccttgtga ctgcaactcc tggtgacctg gaaaataaca agggttctgg canaaacaaa 480 acccnggtga aaatgaaaat tcttctgatt ggggaaggcc tgtgatnaac ttccaggggc 540 naantgtggt tagggcattc actgcttctt gggttttaaa aataaaa 587 27 180 DNA Mus musculus 27 agggttccaa gactgccctt tgggattcaa acgggagccg ctttggactg actggctgcc 60 ttcctcctcc tccccctcct cccccttctg cttcagattt atttattata tgtaagtaca 120 ctgtagcagt tgtaggacac actagacgag ggcaccagat ctcattgtgg gtggttgcga 180 28 232 DNA Mus musculus misc_feature (1)...(232) n = A,T,C or G 28 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgngaa 180 ccacccacca tgtggtngct gggatntgaa ctcaggatct tcagaagagc ag 232 29 213 DNA Mus musculus 29 ggaattttac tacttcacaa atggagaatg atgctacaaa gttaccatgg tgaagctgac 60 aaataccact caaatgatga tgacatagaa gtaccttcct cctgctgctc tgatcccata 120 attggttact agatgatgtt ttctgacatg gatttcgatt ttgggtacct gttactttgg 180 cactattctt tttttttttt tttttttttt ttt 213 30 735 DNA Mus musculus misc_feature (1)...(735) n = A,T,C or G 30 gaaacttatc tccctcccca tatcctgaaa ctgctgnctc ggngtgtgac ctcctgctcg 60 tncgttctgn cncncccact gctggaacnn nanganccgc ncacatgcag ctnnctactg 120 gaccataaat tattctgngg gaatctggtc cccnccccct nccttcttnn ctggtgtcgc 180 nccgntgtga tntgaccctt gatcggacaa tctcctccag ggntggccan ggatcnatcc 240 cttanagtaa ctcaagagtt ccncatgctg tgttatctgg actcccacta antgcagcac 300 tgtgccttcg gaacnacacc atcnagaatg tatcccttcn tcnctccagc tngacnacta 360 ccaagatctc caccaccctt tcttccttct gggacatcgt gtnccaaccc antggtccat 420 atccaggccc tgctgtacta ntcccnggcc ccacnaggtc atntntntca acaaaatgtg 480 cccgntccaa aanctaccnn cgccnaatan cgcacncaca gatccanttg gtcctttaag 540 tacacnggga tccatgtctt ctggaccttg ggcaccanga atgggaaggc agcatcctaa 600 tgtgccatat ctatttccan aatcatctcc cactcctcct cttccantgt taggancaca 660 cctgtttgca ttggttcnnn tgccnccggg ggccgggaac cncancgcat atcctnatcc 720 tgaagcgtct tccca 735 31 677 DNA Mus musculus misc_feature (1)...(677) n = A,T,C or G 31 aatgcagaca taaagccttt acttggagaa cagatcatac tccaagggaa catcatcagc 60 atcaccacca gcagcaccat cagcagcaac ancagcagca gcagcaacag ccacccccac 120 caatacctgc aaatggccan caggccagca gccagaatna angcttgact attgacctga 180 agaattttag gaaaccagga gagaagacct ttacacagcg ttnccgtctc tttgtgggca 240 atcttccccc tgatntcact gaggaggaaa tgagganact atttgagaaa tatggaaaag 300 caggcgaant tttcattcat aaggataaag gctttggctt tattcgcttg gaaacacgaa 360 ccctagcgga aattgccaaa gtgganctgg acaacatgcc cctccgtggg aagcaactgc 420 gaatgcgctt tgcctgtcac agtgcatccc ttanagtccg caaccttcct cagtacgtgt 480 ccaacgaact gctggaanaa ccttttctgt gttcggccan gtggaaaagg ctgtaatcat 540 tgtggatgac cgaagaaggn ccccgggaaa agcattgttt attctcaagg aaaccagctg 600 ctccgaaanc tctgganana tcagtgaagg ntccttcntg ctgantacat ttcctcngcc 660 tgtgaatgtg gacctat 677 32 305 DNA Mus musculus misc_feature (1)...(305) n = A,T,C or G 32 atagacacat agagaaggag acaagaagaa gaagagtcta agagtgtcnc gagttccagt 60 acctctagca gtgacagttc ggccagtgag tcttcatcag agagtgagac atccgcctca 120 tcctcttcag aagacagtga ctcagatgaa agcctctcta gctcctcctc ctcctcctct 180 tcctcggcct gttcgtcttc ctcttcctcc tcttcctcct cctcctcctc ggactcggac 240 tccagctcgt ccagcagcag cagcagcagc agttctgaga gcagctctga tgatgagcca 300 cagaa 305 33 226 DNA Mus musculus misc_feature (1)...(226) n = A,T,C or G 33 tgtcctggca ctctccgact ccagcagcag tagcagctcc agcgactcan aagcagaggg 60 gaaggagtat gccgctggct gcaagaacat gaacgctcct cagacaaggc caagaaaccc 120 aaggtgaaga aggagaagat ggagaagaag gagaagaagg agaagaagga gaaggagaag 180 aagcccccca ttgacttatt aaacttgcag ccctttccgc tcccca 226 34 459 DNA Mus musculus misc_feature (1)...(459) n = A,T,C or G 34 aggtccaaca gaagatatgg cccagattaa aggtatcctc aagatctgga ttaaaggctt 60 gtgtcaatcc agatccaaag cctgtgacat cacacctcaa gattcagatc aaagcctatg 120 tcttccaggc tcaagatcca nancacaagt gtgcccacca tttctggatt gcagttcatt 180 ccagatatag tcaagttgac aactgagaag aaccatcaca ggttataaac acctatcatt 240 tgctctcatt ttccccatat gttctctgct catgtgagat cctgacttga agtgtttccc 300 ccaagcttgt tttccctgat ctctaaaaat acagccagaa agaagctctt tgttctctat 360 agccagcaaa aagccttttt gtttctatac cttacaacca gagatgcaat aattgtaaaa 420 agacctagcc aggcacttgc ctggctccct gtgccaagg 459 35 234 DNA Mus musculus misc_feature (1)...(234) n = A,T,C or G 35 ctgattacag attctgctat gttctgtgcc ctangaaacc gtgncantag aagtgagtag 60 atctgttttg tatagttacc cacaataagc ttggacctga accaaccacc cagcagcact 120 gcctgcctct gtgtataagc tnttatggng nnngccttta tanagatgtc cctgggatgg 180 ccccaacata agagagacat ctgcactaan aacaacaaca acaacaacaa caac 234 36 237 DNA Mus musculus misc_feature (1)...(237) n = A,T,C or G 36 tgctgggcac catgtgtggt ctagggcaca gaanagncag aagaagacat canggtcccc 60 tggagcggat gttatcagct gccctgcaag tgctgggaac tcaacctaag ccttctccaa 120 aaaccaggag tactgtgaag cacctggccg tctctccagt caccaacaac aacgctgctt 180 gttagcaaat attttgatag cagcaacaag aaattgccta atataaggtc tcaccca 237 37 170 DNA Mus musculus 37 caagactgcc ctttggtatt caaacgggag ccgctttgga ctgactggct gccttcctcc 60 tcctccccct cctccccctt ctgcttcaga tttatttatt atatgtaagt acactgtagc 120 agttgtagga cacactagac gagggcacca gatctcattg tgggtggttg 170 38 158 DNA Mus musculus 38 ggtctagatg tatgtgccat gctgggaacc aggcctggat cgtctgcaag agcagccatc 60 ggtcttagct gctaactcct ctctcagtcc atttgaatac gattctgagg tgacgcttcc 120 ctgtcaccac ccttaacatg ctctcatcgt accctctg 158 39 261 DNA Mus musculus misc_feature (1)...(261) n = A,T,C or G 39 agtctcgaaa ggtaagtctg gncaccatgt gtgtagnngg cacggaaccn tnagaataan 60 acatnatgnn gcctggagcg gatgttatca gctgccctgc aagtgctggg aactcaacct 120 aagccttctc caaaaaccag gagtactgtg aagcacctgg ccgtctctcc agtcaccaac 180 aacaacgctg cttgttagca aatattttga tagcagcaac aagaaattgc ctaatataag 240 gtctcaccca taaaaaaaaa a 261 40 259 DNA Mus musculus 40 aagttggaaa ttgcaatact cctaaaccaa atttctttga ttttgaagga aagcaaaaat 60 gggaggcatg gaaagccctc ggtgactcaa gccctagcca agcaatgcag gaatatatcg 120 cggcagttaa aaaactagat ccaggatgga atcctcaggt tcctgccctc cttgagttcc 180 tgtcctgact tcctttgatg ctgaactgtg atgaggaagc ataagccgaa taaacccttt 240 gctctccgaa aaaaaaaaa 259 41 177 DNA Mus musculus misc_feature (1)...(177) n = A,T,C or G 41 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta ttnattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgt 177 42 256 DNA Mus musculus 42 agggtctctt ctctctactc agcaccagct gatctggaag ccactctata gagcagactg 60 actttgaaat cacagagcca catcagtctc tgcctcccca gtgctgaaat taaaggcgca 120 caccacccgc tctggtgaca tttttcttta aaaaatgaac aaaaaagggt tgcgtttgcc 180 agtttttaaa aaagaattgc cttttcgata tttgttttga ataataaaat cttacatttt 240 gagtgaaaaa aaaaaa 256 43 138 DNA Mus musculus misc_feature (1)...(138) n = A,T,C or G 43 ggaggaattt tctcagcaaa catcatttaa aaggaaatta atggcgaaaa tggggcattg 60 ggaaaccatg ggggaggggg gagactgana naatganaat gaataatggc aaaataaata 120 aataaataaa taactaaa 138 44 305 DNA Mus musculus 44 gggagaaact cactcgccaa acaacgtctc gtggtatcct ggctgactct ggccgcttca 60 gcagagcctg gctgttcctg ctggattgtg ctactgctac agattcatgt ttggtgtttg 120 ctattgaact gggctgctta tatcctgaca cggaagagtg gaatcgccca aagcaagtac 180 ttctaatcag gtccacaact ccctttgcct ttaaccttgc tttttcccta cctctggttg 240 gtgggctaaa agggagggtt aagaacccca aataaagtca gttttgaaaa acctaaaaaa 300 aaaaa 305 45 238 DNA Mus musculus 45 gggaacattg tggcaggaag acggaagtag tgctggagag gagactggag agaaacactg 60 ggcctgtccc tgtgatgcac ttctgccagc aaggccacgc ctcccagtcc ctgaagtgtc 120 actccctgaa gatgaagcat tcaaatatga gtcgatgaga gccattcttg ttcacgtcgc 180 catagttatg gaggttggac ccagcactca agactgttat aaagaatttt tgctttgg 238 46 363 DNA Mus musculus misc_feature (1)...(363) n = A,T,C or G 46 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgngaa 180 ccacccacca tgtggttgct gggattngaa ctcangatct nnataagagn agccagggct 240 ntaaaccgnt gagccatctc tccagcctnc tgcattcctt cttaangcat gaatganccc 300 nacctangaa gacatgctgc cntacctcct tttcnagcca ttttcccttt caccatatac 360 tca 363 47 272 DNA Mus musculus misc_feature (1)...(272) n = A,T,C or G 47 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctnctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgnagcagtt gnaggacaca ctagacgagg gcaccagatc tcattgtggg tggntgancn 180 cnanngaanc agnggnnggt gggngacaan ngnanggnng ttagaacaga agacnggtgn 240 atanaccnag ntactattac gtccatgaga ct 272 48 401 DNA Mus musculus misc_feature (1)...(401) n = A,T,C or G 48 gggtccagaa aaggagatgg atgccataca ggccaaggaa gaagtgaaaa aggcccgtga 60 agaagatgag gaggatctgc tgatggggaa gtttcacagg cacaaccatt tcagcagatt 120 ccacaggcag ggcgaactat agtcatcctc actctgcatg ctgagtggcc cagctgcaac 180 tctaataata cacatttgaa tgatcacata ngnanggana ntngnccagn ttctgaaaaa 240 caatcccctg tttgtgttag ggtcccccgt ttcttctata gacccctatg accccagggt 300 ctgcaataag aagtttctgt tgactgcatg tggtggcaca ctcctttaat ctcaggactt 360 gagaggcaga ggcagacnta tctgggattt ccacatcagc c 401 49 372 DNA Mus musculus misc_feature (1)...(372) n = A,T,C or G 49 gagagagaga gagagagaga gagagagaga gagagagatg agatanaggn tggaggcctc 60 gnggagcagc ctgtgtgcac ctgactggnc cagnaggaac acagtgtnca gagaagctcc 120 tgtccccctg tcccctctgg gtgccaaata atgggagatg tgcactgtct gatcacatat 180 tcccgtctnc tgccctntgc ccagttaagg ttaaggntga tgaataancc cttggattat 240 tctgagganc tgaccanncc acagaagaaa gcannccctg tancttccct ggtcatttcc 300 caagaatctt cctgccctgt tgagacttgc cccaagtcta gggcagtctt caagcaagca 360 cctcttgctt gg 372 50 161 DNA Mus musculus misc_feature (1)...(161) n = A,T,C or G 50 tgaggcctat atgtatgagc catgctggga accaggcctg gatcgtctgc aagagcagcc 60 atcggtctta gctgctaact cctntctcag tccatttgaa tacgattctg aggtgacgct 120 tccctgtcac cacccttaac atgctctcat cgtaccctct g 161 51 335 DNA Mus musculus 51 ggtgatttct ctgtgccaaa gcctccagag gacaatataa aagacgtgtg tacaacgtca 60 cccaggaaaa caaagaagaa gaatatagct tgccagtggg gagttagtct tgccttttct 120 tttttccttt gaatcagagt ctcactggat agctctggct actctgggac tctctatgta 180 gaccaggctg gcctgagtgc tgggactaaa gggtgtgtgc cactaccccc agctaaattg 240 gtgtgttctg gagagattct tttttatgtt tggcccattt taattctttc aggcatctta 300 ctactgctgt tttaaagttt ttttctttta aacca 335 52 473 DNA Mus musculus misc_feature (1)...(473) n = A,T,C or G 52 ctttcaggga cccgctggga agacgaagag agaccagatc atactccaga tcattaagga 60 ttttaaaccc ccatgttcct cgtgcggcgc tcaccaccac cccccggctc tggccatggc 120 cacactgagg gtccatcccg aagcccaagc caaggtggat gtgttccgtg aagacctgtg 180 tagcaagaca gagaacctgc ttgggagcta ttttcccaag aaaatctcag agttggatgc 240 gttcttaaag gagccagctc tcaatgaagc caacctgagc aatctgaagg ctccattgga 300 catcccagta cccgatccag tcaaagagaa agagaaggag gagcggaaga agcaacagga 360 gaaggaagag aaggaagaga agaagaaagg ggacgaagac nacaaaggtc cccctgtggn 420 ccanttgaac tgcatgagaa aaatgngggc ctnctgcaac ggctaaaacc tgg 473 53 323 DNA Mus musculus misc_feature (1)...(323) n = A,T,C or G 53 agggggcaag gccatgtggg acaccccana cactgtcctc ttanagcgcc gggcgggcca 60 ttaggcaggc gctgctcaca agccgaggcg tgtctctggc agctcctccg actccagcag 120 cagtagcagc tccagcgact cagaggcaga ggggaaggag tatgccgctg gctgcaagaa 180 gcatgaacgc tcctcagaca aggccaagaa acccaaggtg aagaaggaga agatggagaa 240 gaaggagaag aaggagaaga aggagaagga gaagaaggcc ccccattgac ttattaaact 300 tgcagccctt tccgctcccc aaa 323 54 352 DNA Mus musculus 54 ggaccctgtg tgctgtgcaa tcaagaccca aactagaaga agggtctgtt ttactgctct 60 tggaaggcca cgtctaaaat taaaccacgt tcaggggaaa ctgtgcaccc aaatatttct 120 cagtcgcacc ccagcctcac aaacctattc tagggctgga aaagctggct cagccgttat 180 aagccctggc tgcactacca gaggacccag cctcaatttc cagcacccac atggcagctc 240 ataactgtgt agatccagtt ctagaggatc caacaccctc acacatacat gcaagcaaaa 300 caccaatgca cagaaaatga aaagaaataa atcgttaaga acaaaaacaa aa 352 55 305 DNA Mus musculus 55 gggagaaact cactcgccaa acaacgtctc gtggtatcct ggctgactct ggccgcttca 60 gcagagcctg gctgttcctg ctggattgtg ctactgctac agattcatgt ttggtgtttg 120 ctattgaact gggctgctta tatcctgaca cggaagagtg gaatcgccca aagcaagtac 180 ttctaatcag gtccacaact ccctttgcct ttaaccttgc tttttcccta cctctggttg 240 gtgggctaaa agggagggtt aagaacccca aataaagtca gttttgaaaa acctaaaaaa 300 aaaaa 305 56 158 DNA Mus musculus 56 ggtctagatg tatgtgccat gctgggaacc aggcctggat cgtctgcaag agcagccatc 60 ggtcttagct gctaactcct ctctcagtcc atttgaatac gattctgagg tgacgcttcc 120 ctgtcaccac ccttaacatg ctctcatcgt accctctg 158 57 274 DNA Mus musculus misc_feature (1)...(274) n = A,T,C or G 57 tactgagcct cacggtttct tntggctgga actgcagttc atgcntggng attgccgagt 60 ggattgnagt gcatctgctg atgatttgag tctgtgctgt gctaacggac ttcactacaa 120 cncccgattg gaatcacccc caaagaactg nttgtataac gaggtccaca actctgtttc 180 ctatctttcc ccatgacctt tgctgggtgg tgggctaaaa gggaggttga agcgtttaag 240 aacccttatt aaagtaggtt tggaaaaaaa aaaa 274 58 221 DNA Mus musculus misc_feature (1)...(221) n = A,T,C or G 58 gtgcaaaaag aagaagaaga agaagaagaa naagangaag angaagaagg anaaggacan 60 ngacaaggag aacggagaan gagcaaggaa aaggagaacg gtacagnatn ngnggagaga 120 atattnctaa aatatttntg naatatttga tatgtaatca ttacattnag tcaaaaaatt 180 canatttcta gaaaatataa agtttttttt tgtcgattcc t 221 59 253 DNA Mus musculus misc_feature (1)...(253) n = A,T,C or G 59 actccaggag aagaaggaag tngtggagga ggcagagaat ggaagagatg cacctgccaa 60 tgggaacgct caaaatgagg aaaatgggga gcaggaggct gacaatgagg tagatgaaga 120 agaggaagaa ggtggggagg aagaggagga ggaggaagaa ggtgacggtg aggaggagga 180 tggagatgaa natgangang ctgangctcc tacgggcaat cgggtngctn aggatgatga 240 tgatgaccat gtg 253 60 226 DNA Mus musculus misc_feature (1)...(226) n = A,T,C or G 60 agggttccaa gactgccctt tgggattcaa acgggagccg ctttggactg actggctgcc 60 ttcctcctcc tccccctcct cccccttctg cttcagattt atttattata tgtaagtaca 120 ctgtagcagt tgtaggacac actagacgag ggcaccagat ctcattgtgg gtggttgcaa 180 acgnnngaca cactngacga gggcaccaga tctcattgtg ggtgga 226 61 323 DNA Mus musculus 61 gcatcccttc gtcagcagag tcaccagcaa taaggctctt cgggagctgg tggccgaggc 60 aaaggcggag gtaatggagg agattgagga tggcagggag gacggagaag aggaggatgc 120 tgtggatgct gttccgggct ggagagatgg ctcaacggtt aagagcactg actgctcttc 180 tcaaaggtcc cgagttcaaa tcccagcaac cacatggtgg ctcacaacca tctgcaatga 240 gatctgacgc cctcttctgg tgtgtctgaa gacagctaca gtgtacttat atataataat 300 aaataaatct ttaaaaaaaa aaa 323 62 201 DNA Mus musculus misc_feature (1)...(201) n = A,T,C or G 62 cacattcacg accacaccta aacctacaga atcagaaacg ccactagtgg ggtcggtcct 60 gaaacctggt taacaagctc ccaaggtgaa tctgatggcc gctttcccta agcagtagag 120 accctttttc gtgtatggtg ctgaaaattt aancgtcctc tgtccccaaa tcagtgaaaa 180 atcnggattt aaaaaaaaaa a 201 63 372 DNA Mus musculus 63 gagactgacc cgctcctcaa gatttattat atgtacgtac actgtcgctg tcttcagaca 60 ccccagaaga gggcatcaga tctcattaag gatggttgtg agccaccatg tggttgctgg 120 gatttgaact caggacctct ggaacagcag tcagtgctct taaccgctga gccatttctc 180 caacccttaa gagtgtattt tatttccttt tgatttcctg caagtatcat ggtttcagtt 240 ttctttctgg ctgtaagact ccattgtatg tccgaaccac attttatctg ttttacgggc 300 cagttggctg cttctgttct tttgcctatt gcaatcgcta cagcaataaa catggatgtg 360 taaaaaaaaa aa 372 64 284 DNA Mus musculus misc_feature (1)...(284) n = A,T,C or G 64 ggttccctaa aatcagactc tgtcatcggc aagtggagac tgtaacanga ctgggaccct 60 cacatgccga taagcagtca agaatatttt ctgggagctg gagagatggg ctcagcagtt 120 aagaacactg actgctcttc cggaggtcct gtgttcaaat cccagcaacc acagggtaac 180 tcacaaccat ctgtaatgag atctgatgcc ctcttcgggt gtgtctgaag acagctacag 240 tgtccttaca tataataaat aaataaatct ttttttttaa agaa 284 65 324 DNA Mus musculus misc_feature (1)...(324) n = A,T,C or G 65 gtttgaattt gagtgccgtg ctcgaggtgc cgacatctta ncctacccac ctgtggttgc 60 nggcggnaat cgctccaaca ctttgcacta tgtgaagaat aatcaactca tcaaggtaat 120 caccagaatt cccacccctg cgttctgctc ctggagaggc ctggtcccca gtagagagct 180 ccacacctct cccttagcaa atggagtgcc acacgccttc aatcccagca ctcgggattt 240 ctaagttcga ggccagcctg gtctacagag tgagttccag gacagccagg gctatacaga 300 gaaaccctgt ctcaaaaaaa aaaa 324 66 431 DNA Mus musculus misc_feature (1)...(431) n = A,T,C or G 66 ggaggacacc cacagtttcc gcttttgccg gcatcgagag gctgcagctc tgtttcgctc 60 taaaaaccgc tgccgccgct catctggatc ttcatccact gtacgccgtc gccgtccccc 120 agtgctaggg gtgggctgag ctggagagac ctgttgccca gtaaagaaga atacttgtga 180 tggtttgtat atgctcttcc ctgggagagg cacttttaga aggtgtggcc ctgttggagt 240 aggtgtgtca ctgtgggtgt gggctttaag accctcatct agctgcctgg aagccagtct 300 cccactagca gccttcagat gaagatgtac aactctcagc tcctnctgca ctaanncctg 360 ccaagatgct gccctgctcc caccttgatg acaatggact gaacctctga acctgtaagc 420 ggcccaatta a 431 67 427 DNA Mus musculus 67 gtcgtgtcac tgctgttgct atcctgactg gactgaactg gactgctggt gtatctgtga 60 ggtgtttgcg aatggattga gctgccactg cctgctgacc tgtgaactca actgctgatt 120 tccagacaac acagacagga gttgttgcaa agagccttta tagacaggcc cgcgccccct 180 tccccgctcc tgtatcattt cttttccatt acctctggtg ggtggtgggt tacaagagag 240 gttaaagcat ttaggaacca tcattaaaaa cagggtttga catggaggcg catgccttta 300 atcccagcac tcaggaggca gaggcaggcg gatttctgag ttctgagttt gaggccagcc 360 tggtctacaa agtgagctcc aggacagcca gagctataaa gagaaaccct gtcttgaaaa 420 aaaaaaa 427 68 303 DNA Mus musculus misc_feature (1)...(303) n = A,T,C or G 68 gcacatgagt gttctgcctg catggatgac tgtacatgca tggctcatgc agtgatgaag 60 gagaccagaa gaggtccttg ggaatagagt tacaaacaat tttgaaccac catgtgggtg 120 ctgagaattg aacctatgtc ctgtggaaga tcagccagtg ctcttaacca ctgagaaatc 180 tctccatcac ctattcttgt ggtttggttt ttctttttct ttctttcttt cttttttttt 240 tttcnanann gggttttttt gggtanccct ggctgncctg gaactaactt tgtaaaccag 300 gtt 303 69 214 DNA Mus musculus misc_feature (1)...(214) n = A,T,C or G 69 gaaggagaag aaggaagttg tggaggaggc nnagaatgga agagatgcnc ctgccaatgg 60 gaacgctcaa aatgaggaaa atggggagca ggaggctgac aatgaggtat atgaagaana 120 ggaagaaggt ggggaggaag aggaggagga ggaataatgt gactgtnaag atgatgatnt 180 annacnataa ttnntaccat ttcgtattgc taat 214 70 547 DNA Mus musculus 70 agaagagaag cagacacaag atgaaaccct gccaaaaaat ggaaggaaac ctagaaaagg 60 aggatgagcc aaagcctgag gaagagccaa agccggagga aaagcccgag gaggggcagg 120 aacccgagga ggaggagaaa tccgaagaaa cttttcggga gaggctgatc cggtctctgc 180 aggattttca ggaggatata cacaacaggc acctgagcag tgatgatctg tttagagatg 240 tggaggagct agatgagatc aggaaagtga gaaacaaact tatagtgacg cgttggaagg 300 ctaaccgaag ccatccttac ccctatttaa tgtagcttgg cttgctttcc cttttatctg 360 atgttaccat tgcgatctag ctttcttttc attagcattt tcctgataag acctttgccc 420 atcttcctac tttgaatctg ttgctgttag tggctttagc tgtatctctt gttgtctgta 480 tcttactgtt gattatattt gaaccaatct ataagtctct ggctttaagc tttactgatt 540 tgtaaaa 547 71 258 DNA Mus musculus misc_feature (1)...(258) n = A,T,C or G 71 ctactgaacc cgagagaatg cngccgggaa tcangggccc cttgcccttc attcatnact 60 agcgttgcac cnttnaaagt tgagccttga tcagaaaaaa aagaccctna aaaaaactgn 120 ctgccccttg aaaacttacc tacctaaagt acagggataa tagcttcttt gcccactgtg 180 actctcagcc cttaagactg tttggctctg cactaatttt tttttattag tctgtaataa 240 aatacctaca ttttatta 258 72 174 DNA Mus musculus 72 agggttccaa gactgccctt tgggattcaa acgggagccg ctttggactg actggctgcc 60 ttcctcctcc tccccctcct cccccttctg cttcagattt atttattata tgtaagtaca 120 ctgtagcagt tgtaggacac actagacgag ggcaccagat ctcattgtgg gtgg 174 73 364 DNA Mus musculus 73 aagaagcctg ctcattctga atttgaacat cggttctgca ttactcctga aagatgtcct 60 gcagtcagtg tccgagcaca ttcctgccac agcagcctta aatgaagttg gggtttacaa 120 actggctcag caagacgttg agattctgct taatttgagg acaaattggc ctaacactgg 180 aaaataatgc atcttcgaga aaagtgttta acaaagacaa gagttgcctt taatcctagc 240 acttgggagg cagaggcaga tggatttctg agatcgaggc cagcctggtc tacaaagtga 300 gttccaggac agccagggcc acacagagaa accctgtctt ggaaaacaaa cacaaacaaa 360 aaaa 364 74 274 DNA Mus musculus 74 aggtatttgg cccagcgaca tcagagacaa gaagagacac agatgagaga caagcacatg 60 aaagatgctt accatccttc gccatggcaa aaagtgaaat taaaaagtcg aggggacatt 120 actgtgcatc tgatggagac atgaggaccc gtagggcttg ctggccagcc agtctagccc 180 agtcagtaag ctccaggttc cattgtgcct gtggtcttca agagctctgc acacccacag 240 acataaaaat aaagttcagg tgaaataaaa aaaa 274 75 159 DNA Mus musculus misc_feature (1)...(159) n = A,T,C or G 75 ggtctagatg tatgtgccat gctgggaacc aggcctggat cgtctgcaag agcagccatc 60 ggtcttagct gctaactcct ctctcagtcc atttgaatac gattctgagg tgacngcttc 120 cctgtcacca cccttaacat gctctcatcg taccctctg 159 76 282 DNA Mus musculus misc_feature (1)...(282) n = A,T,C or G 76 atacgacacc tggaagttga atntacagaa ttgccagctg cccaacatgg atncttggaa 60 ccaaaccttt agaattcaac aaacaaacaa cccagggggc tggagagatg gctcagcact 120 caagagcact gactgctgct cttccagagg tcctgagttc aattcccagc aaccacatgg 180 tggttcacaa ccatctgtaa tgagttccaa tgccctcttc tggtgtgtct gaagacagcg 240 acataaaatg aataaatctt tttaaaaacc caaaaaaaaa aa 282 77 523 DNA Mus musculus misc_feature (1)...(523) n = A,T,C or G 77 catatgccca catcangcat tcctcggnct cacctgcgct ctgacctggg gcagcagtta 60 gaggaggntc cttcttnatc ttcctcctct gagactnagc ctctgcctgc aggaacatgt 120 atcccagagc cagtgggcct nttacaaact actgaagccc ctgggcccaa aggtatcaag 180 ggcatcaagg gtactgctcc tgagcacggc cagcagacct ggcagtcacc ctgcaatccc 240 tatagcagtg ggcaacgtcc atcgggactg acttatgctg gcctgccacc tgtagggcgt 300 ggtgatgaca ttgcccacca ctgctgctgc tgcccttgct gctcctgctg ccactgtcct 360 cgcttctgcc gttgtcacag ctgttgtgtt atctcctagc tgactattga acctccaggg 420 ctgtgcagcc caggttcctg ctcaatgccn aagtgttgct ggacatcang agcanccgtt 480 gcatgagcat caccatttct gcctgacagg ggacctgtca cca 523 78 326 DNA Mus musculus misc_feature (1)...(326) n = A,T,C or G 78 ggcgaacccc cccaaccccc agcctgnaac aggctgatcc agaccttgac cttgctgcca 60 ctaaggagat tacctagggt ggagccttcc tgcctagatg actctattgt tcagccactg 120 ctgctcttct ncttcaagac actgctacct gctgagagga ccctgagcta ttctagagac 180 ttcatcctat cctgcaggtc atcacctgca gctggttcca ggctccaaga atggattaac 240 gggaatgggc cgcccttctc ccccccaccc cctttataag cacagttttc tattaaacat 300 tcgagctttg atcaggaaaa aaaaaa 326 79 336 DNA Mus musculus misc_feature (1)...(336) n = A,T,C or G 79 ttgaagcgtt ccaagactgc cctttgggat tcaaacggga gccgctttgg actgactggc 60 tgccttcctc ctcctccccc tcctccccct tctgcttcag atttatttat tatatgtaag 120 tacactgtag cagttgtagg acacactaga cgagggcacc agatctcatt gtgggtggtt 180 gtgaaccacc caccatgtgg ttgctgggat ttgaactcag gatctacana agagcagtna 240 gggctntaaa ccgntgagcc atntctccag cctcctgcat tccttcttaa ggcntgaant 300 gatcccannc ataggaagac tgacttgccc ttcctt 336 80 370 DNA Mus musculus misc_feature (1)...(370) n = A,T,C or G 80 ggtgctgtct gctccgatct cccttatgct tcctggtttg agtccttctg ccagtttgct 60 cagtatcgtt gctccaacca tgtctactat gccaagaggn nacnntgctc ncagncnnnc 120 nccatnctat ncccnaacac tntnaaggan gtggaggctt ctncagaant ggctgacact 180 tccatgacca nctggcattg nganccatgc cacagagtga gacctcncan antgtgnacc 240 nnagntccca gccctanctt ggcagcttgc aagtctgtaa ctccagtcct gggagatcca 300 acgccccctt ctggcctcca caagcactgc atgaatccag gcaaaacacc tatacacata 360 aaataaaaaa 370 81 260 DNA Mus musculus 81 taacagcctc ctctatgatc atggcccggc tgcatgctga gccacggaga aggagaagaa 60 gaagataaag gaggatgaga agggttgggg cggtgcccga cctctgaaga ggagaggaga 120 caggcgacca tgggagcaag tcttcagcac cacatgatgg ggactctgga gttgccgctc 180 aggctgtctg gggtcctggc tgactggcca ccgtctttct catcaataaa aacatcgttg 240 tgcattctta aaaaaaaaaa 260 82 158 DNA Mus musculus 82 ggtctagatg tatgtgccat gctgggaacc aggcctggat cgtctgcaag agcagccatc 60 ggtcttagct gctaactcct ctctcagtcc atttgaatac gattctgagg tgacgcttcc 120 ctgtcaccac ccttaacatg ctctcatcgt accctctg 158 83 270 DNA Mus musculus misc_feature (1)...(270) n = A,T,C or G 83 agactctgtc atcggcaagt ggagactgta acangactgg gaccctcaca tgccgataag 60 cagtcaagaa tattttctgg gagctggaga gatgggctca gcagttaaga acactgactg 120 ctcttccgga ggtcctgtgt tcaaatccca gcaaccacag ggtaactcac aaccatctgt 180 aatgagatct gatgccctct tcgggtgtgt ctgaagacag ctacagtgtc cttacatata 240 ataaataaat aaatcttttt ttttaaagaa 270 84 338 DNA Mus musculus misc_feature (1)...(338) n = A,T,C or G 84 gttgctcaga gaagcacagt cttcaagacc ccatacccga ggaggaggag gaggaggagg 60 aggagcccat cggagtggct gtggaggang agcgtttnca ccagnaggga gccccaanag 120 catccnataa aagctgtgcc attatgtgaa cttgtcaaga catggtcgat cttcctcaag 180 ctagaancat ggagtcctgt atacagtgca gagccttctc agaagcacat gatatttttg 240 tatttccttt atgtgaattt ttaagctgcg aatctgatgg ccttaatttc ctttttgaca 300 ctgaaagttt tgtnaaagaa atcctatcca tacattat 338 85 265 DNA Mus musculus misc_feature (1)...(265) n = A,T,C or G 85 agcctctctt aacattttcc ntggcaaatc tntcagtgcc tggctntatg tggtctcccn 60 tcccccagcc tgaaacctgc ttgctnaggg gtggagcttc ccgctcantc gttctgccac 120 gcccactgnt gnaacctgcc gntttgctgt ttgnagctac acacgtggtc accgtgctac 180 tgnattccga nattatttgg cggnaattgg gcccntcccc nttccttnat aacggagtgc 240 caaaatagta aaaattgaac cttga 265 86 240 DNA Mus musculus misc_feature (1)...(240) n = A,T,C or G 86 gcccgaaaaa caaaaccaga ggaaggggtg agagaaaaan ntgcaaatgg ggaactgaaa 60 aattattgaa gggctggtga ggtgactcag tggaaaaagg agcttgctgt caagtctgaa 120 gaccagagtt caattcccag gacccacctg gtggaagttg ncttcaaact gccccatgaa 180 tattcaaaca caagcatgta tattcataca aaataaataa atataattta aaaaaaaaaa 240 87 220 DNA Mus musculus misc_feature (1)...(220) n = A,T,C or G 87 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcttgtgggt ggttgngaac 180 cacccaccnt gtggttgctg ggatttgaac tcaggatctt 220 88 198 DNA Mus musculus 88 cggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgtgaa 180 ccacccacca tgtggaag 198 89 320 DNA Mus musculus 89 agttgaaggc ctccagttaa gagattacct caaatctgaa ataaggcttt ggacttgtga 60 acagtattgg aattgttgaa gaatatgggg acttttgaag ttgtcctgga catatgtttg 120 cattataaga tgacaatgaa ggctgccagg aaaactcaga aagtattgta ttaccttttg 180 acttgagttc aatccccaaa gccaaagtgt ggaaggagag agctgattcc tgcaacttct 240 tctgacttct atagcactca catatatcgg gcacatgcat gagtatgcac acacacacac 300 acacacacac acagatcgaa 320 90 173 DNA Mus musculus 90 tccaagactg ccctttggga ttcaaacggg agccgctttg gactgactgg ctgccttcct 60 cctcctcccc ctcctccccc ttctgcttca gatttattta ttatatgtaa gtacactgta 120 gcagttgtag gacacactag acgagggcac cagatctcat tgtgggtggt tgt 173 91 335 DNA Mus musculus misc_feature (1)...(335) n = A,T,C or G 91 acaggctaca cacagccggt ggctacatgt ggnaacatct ncagnggntg ttgaagagtc 60 cgtggtggca tctnntgcng caatgnggaa tgcctgggct gtcctctgnc atggctggcc 120 cntggcctgt tgaccacaga ananancagg gtcanagggc tcaagcncac agnccccttg 180 gggagatcgc acatagcagg gttctcaacc tgtgggttac aacccctttg agggtcaaac 240 gaccctttca caagagttac gtattagcta tcctggatgt cagatattta cattacaatg 300 tataacagca gcaaaattac agttatgaag tagca 335 92 235 DNA Mus musculus misc_feature (1)...(235) n = A,T,C or G 92 caaagccacc caccctntga cttctattta ctttacaatg atgttagccc cccncnnntc 60 caaaantnat gacanngggg ggtttngnct ctggncaaac atgacctcca gagtttggcc 120 cttgcataaa ggagaaaatt aattccttca gttgttctct gacctccaca tgcgtcctgt 180 aacatgggtg tatgcataca cataaacaca catncacacg ttgttaaata aataa 235 93 173 DNA Mus musculus misc_feature (1)...(173) n = A,T,C or G 93 gggttccaag actgcccttt gggattcaaa cgggagccgn tttggactga ctggctgcct 60 tcctcctcct ccccctcctn ccccttctgc ttcagatnna ttnattatat gnaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tgg 173 94 205 DNA Mus musculus 94 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgtgaa 180 ccacgcacca tgtggttgct gagat 205 95 315 DNA Mus musculus misc_feature (1)...(315) n = A,T,C or G 95 cactgttttg taactatttt gtaaggncac agtccaccag tanctttagg gnacagggtn 60 attttatnca cancagcagn aaatgnaaac caaaacaact ccacaataaa attcttgngt 120 ttcttggggc caagaagtat gnacacgnat aagnataaag nacactggcc aagncatgta 180 cctccagnag tttggccctt gcataaagga gaaaattaat tccttcagtt gttctctgac 240 ctccacatgc gtcctgtaac atgggtgtat gcatacacat aaacacacat ccacacgttg 300 ttaaataaat aaaaa 315 96 340 DNA Mus musculus 96 ggcactccag ttaagagatt acctcaaatc tgaaataagg ctttggactt gtgaacacgt 60 attggaattg ttgaagaata tggggacttt tgaagttgtc ctggacatat gtttgcatta 120 taagatgaca atgaaggctg ccaggaaaac tcagaaagta ttgtattacc ttttgacttg 180 agttcaatcc ccaaagccaa agtgtggaag gagagagctg attcctgcaa cttcttctga 240 cttctatagc actcacatat atcgggcaca tgcatgagta tgcacacaca cacacacaca 300 cacacacaga tcgaaaatag ttgtaataaa aaaaattaaa 340 97 507 DNA Mus musculus misc_feature (1)...(507) n = A,T,C or G 97 gatctggtgg cttgggtgac agccagtttc ctgcacatcc cccatgctga ggacatcccc 60 aacacagtga ctgtgggaaa cagagtgggc ttcttgctcc gaccctacaa tttcttcaat 120 gaagatccct ctatcttctc ccctggcagc gtgtactttg agagggacca ggatgccggg 180 ctctgcagca tcaaccctgt ggcctgcacc caacagctgg cagactgtgt ccccaactta 240 ccctcctttt cctatgaagg cttataggcc tgaggctatg gtgaggcccc agggtaggag 300 ggatggaatg tggagtggag aaatggctca gcgattaaga gcacttgact gntcttncag 360 angnccctgn ngttnanttc cttgcaacca catggtggnt acaaccatct gtaatgggat 420 ctgatgctct cttctggtgt gtctgaagac agagacagtg tacccatata cataaaataa 480 atcttttaaa aaattttaaa aaaagaa 507 98 128 DNA Mus musculus 98 tcagcaaaca tcatttaaaa ggaaattaat ggcgaaaatg gggcattggg aaaccatggg 60 ggagggggga gactgagaga atgagaatga ataatggcaa aataaataaa taaataaata 120 aataaaaa 128 99 179 DNA Mus musculus 99 tcagggctcc aagactgccc tttgggattc aaacgggagc cgctttggac tgactggctg 60 ccttcctcct cctccccctc ctcccccttc tgcttcagat ttatttatta tatgtaagta 120 cactgtagca gttgtaggac acactagacg agggcaccag atctcattgt gggtggttg 179 100 282 DNA Mus musculus 100 aatcagactc tgtcatcggc aagtggagac tgtaacacga ctgggaccct cacatgccga 60 taaagcagtc aagaatattt tctgggagct ggagagatgg gctcagcagt taagaacact 120 gactgctctt ccggaggtcc tgtgttcaaa tcccagcaac cacagggtaa ctcacaacca 180 tctgtaatga gatctgatgc cctcttcggg tgtgtctgaa gacagctaca gtgtccttac 240 atataataaa taaataaatc ttttttttta aagaataaaa aa 282 101 216 DNA Mus musculus misc_feature (1)...(216) n = A,T,C or G 101 gagggttcca agactgccct ttgggattca aacgggagcc gctttggact gactggctgc 60 cttcctcctc ctccccctcc tcccccttct gcttcagatt tatttattat atgtaagtac 120 actgtagcag ttgtaggaca cactagacga gggcaccaga tctcattgtg ggtggttgtg 180 aaccncccac catgnggntg ccgggatttg cactca 216 102 343 DNA Mus musculus 102 aagggtctcc ctgcctagaa cctgatattt aacactgaga gatccacctg gctctgcgcc 60 gctaaacacg ccacctcgtg ctagccaact ttgaacttat gattctcttg tacactggta 120 acttggaagt tacctctcgg gggctggaga gatggctcag tggttaagag actgactgct 180 cttccagagg tcctgagttc aattccaagc acatggtggc tcacaaccat ctgtaatggg 240 atctgatgcc ctcttctggt ttgtctgaag acagatacag tgtactcgtc acatatataa 300 aataaataaa taaaatcttt ttttaaaaat ttaaaaaaaa aaa 343 103 165 DNA Mus musculus misc_feature (1)...(165) n = A,T,C or G 103 gcctccagac tgccctttgg gattcaaacg ggagccgctt tggactgact ggctgccttc 60 ctcctcctcc ncctnctgnc cccttgtgct tcagattnat ttattatatg gnngtacact 120 gtagcagttg taggacacac tagacgaggg caccagatct cattg 165 104 361 DNA Mus musculus misc_feature (1)...(361) n = A,T,C or G 104 gacgcatcct ggactccaca atgaacggga cagttggacc taagtgggaa gctgattatc 60 aaagctnanc ttggggaana tatncnacna attcccattc ataatgaaga cattacttac 120 gatgaattag tgctaatgat gcagcgagta ttcanaggaa agcttctgag tantgatgaa 180 gntacaataa agtataagga tgaaggcatg gactgaagac cctcacccta gctgcctgga 240 aatcagtatt atgttagcag ccttcagatg aagatgtaga actntcannt ccttctggat 300 catgcctgcc tggatgctgc atgttcctgc cttgatgata ntagaatgaa cctctgaacc 360 c 361 105 165 DNA Mus musculus 105 ggttccaaga ctgccctttg ggattcaaac gggagccgct ttggactgac tggctgcctt 60 cctcctcctc cccctcctcc cccttctgct tcagatttat ttattatatg taagtacact 120 gtagcagttg taggacacac tagacgaggg caccagatct cattg 165 106 349 DNA Mus musculus 106 gtaaaggcat tgaaagagaa gattgaatct gaaaagggga aagatgcctt tccggtagca 60 ggtcagaagt taatttatgc aggcaaaatc ctcagtgatg atactgctct caaagaatat 120 aaaattgatg agaaaaactt tgtggtggtt atggtgacaa aacccaaagc agtgacaaca 180 gcagtgccag ctacaaccca gccatcaagt actcccagcc ccactacagt cagttcttcc 240 ccagcagtgg ctgcggccca ggctccagct cccacccctg ctctggctcc cacttccctc 300 tgcctcccta gtgctaggat taaaggcatg cactacaacc aaaaaaaaa 349 107 424 DNA Mus musculus misc_feature (1)...(424) n = A,T,C or G 107 gaggaggacc tgccttctgc tgatgagctg gaggactggc tggaggacgt gctggagggc 60 gagatcaaca cagaggatga cgacgactga tgacgacgat gacgatgatg acgatgatga 120 tgacgactag atgactagtg gccgtggcag ccgcgtacca gccccacttg ctccttactt 180 gttgtacctt tctgccatct gtgcccttcc ccgggctcct tgggacacta ggtcattctc 240 tactacaggg ccaactgtgg tctgcataca gggtgcttga ggtcctggtc tccctctccg 300 aggagaaaag gagctgcttt ttcttagatc ccagcccagt tctctcatct gactttgctt 360 tnttnccccc agacctttat ctggatctct tnccgggcan tnccccatac tttaacgggt 420 tttc 424 108 352 DNA Mus musculus 108 ggttgagaag taccggccac agaccctggc cgatctcatt tctcaccagg acattctgag 60 taccaaccct tggtgagcac aacttcgtgg cagtgggagc actctgctcc aaagtggaca 120 ggaagtagag agctaaaggg gtgggggagc aagcagtatg accctcaaag gcacgagttt 180 ggtgacctga ctcctccaat gaggctgtgc ctctaaacca gtggctctca accttcctaa 240 agatgtggcc cttttaatac agttccccat gttgtggtga ccaccccccc caccataaaa 300 ttatttcatt gctacttaat aaatgggaat tgggtcctgt taaaaaaaaa aa 352 109 386 DNA Mus musculus 109 gtatttactc aagagaatgc aacctgtgcc tacatagacc ttcatacatg aacaatcata 60 gcagcttcat tcataacagc tccaaatggg gagcagctca agtgcccatc aaggtatcct 120 gacctcctga ccgggtccgt gaccttggga agctgaacac caacccctct tcacccagag 180 gacgacgcca gcggcaggtc atgggagcgc ggccctcgcg acggcagatg actgaagctc 240 ggcgcctggc tctaaccaag ctgccccctg agctgctggt gcaggtgctg agccacgtgc 300 cgcctcgcgc gttagtgacc cgctgccggc cagtgtgccg ggcctggcgc gacctggtag 360 atggcccaag tatatggctg ctgcaa 386 110 100 DNA Mus musculus 110 gaacaacgac cacgggaagg ttgaaggata atcttctaat accagcactt tgaatgagaa 60 tttgtttctc tgccacaaac tgattttttt ttttaaaaaa 100 111 506 DNA Mus musculus misc_feature (1)...(506) n = A,T,C or G 111 actgagagta aagacatttc cacgtggaca cctgatcatg tgcctaccct gactgaggct 60 ccccaggcat ctntattgng ggcagccgtg ctacacgctc aactntgagc ccccaacagt 120 ttgcaggctc ccagccccgg ggtctgggcc tnggccccac catgtcgagc ctcggcggtg 180 gctcccagga cgccggtggc agtagcagca gcagtaacac caatagcagc agtggcagtg 240 gccaaaaggc aggaggaaca gacaaaagta ccgcggtggc cgccaccacg gcgccgacct 300 ccgtggcaga cgatgcccca ccccctgagc gtcggaacaa gagcggtatc atcagtgaac 360 ccctcaacaa aaacctgggg ggcttcccga ccactctttt nantactntt cntttggnaa 420 gcaagtggtg gcggcggaaa catgatgggg gtggagtttt gntgacaagg caacggcagc 480 ccgcagcctc cctattggcc aatggt 506 112 100 DNA Mus musculus 112 aatcgagatc cgagatgaag actgaacttt ctcctcggcc cggggcatgc agggcaggga 60 gttgacccaa gaagagaagc ttcagcttcg aaaaaaaaaa 100 113 189 DNA Mus musculus 113 cggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgtgaa 180 ccacccgac 189 114 360 DNA Mus musculus misc_feature (1)...(360) n = A,T,C or G 114 taccctcaga ggccagaaga gggtgtcaga gcccttgtaa ctggagtttg acggtcgtga 60 gctgcgcatc ttcaccatgg canacgatga tccctacgga actgggcaaa tgtttcattt 120 gaacactgct ttgactcact caatatttaa tgcagaatta tattcaccag aaataccact 180 gtcaacagat ggcccatacc ttcanatntt atancaacca aaacagaggg gatttnnatt 240 ccgntatgtg tgtgaaggcc catcacacgg agggcttcgg gagcctctag tgagaagaac 300 aagaaatcct accccaggtc anaatttgcc antntntgng ggcctgcaaa ggttatccgc 360 115 375 DNA Mus musculus misc_feature (1)...(375) n = A,T,C or G 115 gaaccctaag gactctgcaa tatgaataat tctntagaga acaccatctc atttgaagag 60 tncatccgag taaaggcgag gtctgtcccg caacacagga tgaaggaatt tctggactca 120 ctggcttcta agggaccaga agctcttcag gagttccagc agactgccac caccaccatg 180 gtgtaccagc agggtgggaa ctgcatttat ncagacagca ctgaagtggc tgggtctttg 240 cttgaacttg cttgtccagt cacaaccagn gttcaaccac aaccatctgt ancaagatct 300 gatgccctct tctggagtgt ctgaagacag ctacagtgta cttacatata ataaataaat 360 ctttaaaaaa aaaaa 375 116 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 116 gagccaggaa gtaatcaaga aatcaaggag tttgcatccg gntacaacgt caaggttgac 60 atgtacagna ngatctgtgt aaatggggac catcccacca 100 117 412 DNA Mus musculus misc_feature (1)...(412) n = A,T,C or G 117 gtttgtcagg atggtggata agaatattta catcattcaa ggagaaatta acattgttgt 60 tggtgccatc aaacgaaatg cccgatggag cacccatata ccactggatg aagaacggga 120 tccccttctg cacagtttca gtaacctgaa agaggtctta aacagtgtga cagacccant 180 ggatgtcaaa gagaaagaaa tggccttata aaattcattt gtgtggagaa cttgaagnta 240 cttcggaact tgataacttt tagaaccata ctctgtttcc ctaaagaacc tcctaatttt 300 tttaagcctg atagtggtgg tgcatgcctt taatcccagc actcaggagt cagagacagg 360 tggatctttg atttgaggct acctggtctn cagannaagg tccaaggcca gt 412 118 350 DNA Mus musculus misc_feature (1)...(350) n = A,T,C or G 118 gacagaggtt tacagnacag atggctgcgt ntcagtcccc tgctgtaaaa ggttctatac 60 ctgcaacatc aacagttcag aatgttctta ttaatccatt gttaattggg tccaaaaaca 120 ttcttattac tactaatatg gtatcacaaa atacagccga gtcagcaaat gcactgaaat 180 gaaaacgtga agacgacgat gatgatgaag atgaagatga agatgatgat gatgatgatg 240 atgactatga taatatgtag tctaaccacg atgcatgtaa cctgtgttct tggacttgga 300 tccattgtac tacaaattaa aaagcatgtt agatgtttta aaaaaaaaaa 350 119 165 DNA Mus musculus 119 ttgagggatg gctactgtca cctgaccact aacggacttc gagctggcga catcaaaaga 60 agcctctatt tcaatattcc aggcctgaga agcgttatct acagagagaa aggagttcca 120 ggacagccag ggctacaaga agaaaccctg cctcaaaaaa aaaaa 165 120 327 DNA Mus musculus misc_feature (1)...(327) n = A,T,C or G 120 cccctaccac ttccttcata actggaagtn gcaccantaa acanntgagc cttgatcatc 60 acaaaaaaca cgagantaca nccactgtca aagtggtgac tagccactct gtggacaaga 120 aaacaagtca ccccaataga ggtgggtcca agaggcggga ctaanaaaac aaagcctgcc 180 nggccgggtg tggtggcgca cgcctttagt cctggccttt gggaggcaga ggcaggcgga 240 tttctgagtt cgaggccagc ctggtctaca gagtgagttc caggacagcc agagctacat 300 agagaaaccc tgtctcaaaa aaaaaaa 327 121 799 DNA Mus musculus misc_feature (1)...(799) n = A,T,C or G 121 aaacaccgcc tgagagcanc ttaangaggc ctacnantca ngacacttga tgataccaca 60 ccagntccag gtgggagatg caggtctcgt ctgacgacat cnttctgaga atcngaancc 120 ttgntaaatn ggcncttgna tcgngctact naccacccac actgctgtca aagaanaagg 180 catntattnt gcctttnacg ntctagcgag cntctganna atnaaccncn ttgattgacc 240 actctcattt ntactctgat agaccctcta ataatnttgc tcttactgct gacgtgtggc 300 ccactantnc ttaataatct aatgaccttt gttagagaga ggattggtgc tgnccagntg 360 ntagtattaa nacaacnatn ccagtctctg cataaccttg aaaaagaggt tgcagtttag 420 ttctaagatt agaactagta actagaagaa gtggggaatg aaagatcctg gcagaatgta 480 aaaggacaca gaagccctga aattggcaag atagacgtca gtgttagcag aactagcttc 540 actgatttag aaacntagag gtgcacaatg ctttgggcca ctccttgaac ctgngngtct 600 tggcaatgtt ctgaccaagg tgtgtgccca ttggntggan ccttnattga agactctttc 660 ccttggaccc cntncccatt accccatttt ctttggggaa ttngnncntt ggnttaanaa 720 tcntgggaaa aatccccctt aaatnttccc cccttnttnc nttttncccc cccttggann 780 ggcccttttt aaaaaacct 799 122 440 DNA Mus musculus misc_feature (1)...(440) n = A,T,C or G 122 gggtcccgac acccctttga aaaccccctt tttgtaaaag ccaggcttgg tagtgggcac 60 ctgtcatccc agcactcagg aggcagggtc aggaggatta caggttcaaa gccagtctgg 120 tctatattag aaaaagaaaa ctgtcctttt gctaaagaaa aattaaatga atttttaggg 180 ctgaaatctg tgggtaagat ggagtctgga gctttcctct tggaacagtt aaccgaagac 240 cctcatgggc aaggacatcc gcttgactcc ccactcacca tcaggccaca cttttaaaga 300 aaaattgttc tctaaccagg attgtaacaa atgtgtaaat agtatttctg agttgaaagt 360 cgatggtgca aatatgtata taacgtactg natttttaca atgatcgtcg catggctctc 420 cacccctttt tggactcaag 440 123 435 DNA Mus musculus misc_feature (1)...(435) n = A,T,C or G 123 cttcccttgt cgctgctgaa gacagcgcag aatcacccca tggtaagcac tctgggccac 60 ctcccttcat gtgcccacag ctcagtcttt tgcagntcat gattgaaggc ctggcaagat 120 ggctcaatgg gtaaaggtgc ttgctgccaa gccgaaggac ctgagttcaa tccccaggac 180 ccatgtgatg atggaggggt ncatgacttc cctgaagntg ttctctgccc tgtntgcaca 240 cagacagaat ggcaaatgca atacaaagga aaacgttcac aaagaaatct atagccgggc 300 atggtggtgc acgcctttaa tccccgcact tgggaggcag aggcaggcga atttctgagt 360 tcgaggccan cctggtctac aaagtgagtg ccangacagc cagggctaca cagagaaacc 420 ctgtctcaaa aaaaa 435 124 204 DNA Mus musculus 124 aggagcacat gaaggataag gataaggacc gggaaaagtc taagcatagc aacagtgaac 60 ataaagattc tgaaaagaaa cacaaagaga aagagaaaac caaacacaaa gatggcagct 120 cagaaaaaca taaagacaaa cataaagaca gagacaagga aagacgaaag gaggaaaaga 180 ttagagctgc tggggatgca aaaa 204 125 292 DNA Mus musculus misc_feature (1)...(292) n = A,T,C or G 125 gggttccaag actgcccttt ggtattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttgtgaa 180 ccacccacca tgtggtngcn gggantcgaa ctnaggancn ncataatagc acncanggct 240 cnaaatnnct tgagccntct cttcnnnctn tctgnattcc ttgttatggc at 292 126 175 DNA Mus musculus misc_feature (1)...(175) n = A,T,C or G 126 ggttccaaga ctgccctttg ggattcaaac gggagccgct ttggactgac tggctgcctt 60 cctcctcctc cccctcctcc cccttctgct tcanatttat ttattatatg taagtacact 120 gtancagttg taggacacac tagacgaggg caccagatct cattgtgggt ggttg 175 127 158 DNA Mus musculus misc_feature (1)...(158) n = A,T,C or G 127 tgccctttgg gattcaaacg ggagccgctt tggactgact gnctgncttn ctcctcctcn 60 ccctcctncc ccttctgctt nanatttatt natnatatgt aagtacactg tancagttgt 120 aggacacact agacganggc accagatctc attgtggg 158 128 283 DNA Mus musculus 128 actgtactga ctgctggtga gactgctgca atggctcgtc agtgtacccc gctcctccag 60 cagccagcgc actgcctcaa taccctcgtt caaggtcacc agctgctgca ggatcttcac 120 atcgatagct cgcaggcact ctggaggtgg aaggaagagg atcagaagtt caaggccatt 180 ctcagctatg ttggcagttc aagaccagcc ggagcttcat gaaaccctgt tttaaaatta 240 atgaaataaa ataataaaat aaaacaagat ttaaaaaaaa aaa 283 129 176 DNA Mus musculus 129 ggttccaaga ctgccctttg gtattcaaac gggagccgct ttggactgac tggctgcctt 60 cctcctcctc cccctcctcc cccttctgct tcagatttat ttattatatg taagtacact 120 gtagcagttg taggacacac tagacgaggg caccagatct cattgtgggt ggttgt 176 130 156 DNA Mus musculus 130 ggtttcttct ctgtgtagcc ctggctgtcc tggaactcac tctgtagacc atgctggcct 60 cgaactcaga aatcctcctc gtgtgccacc acttcccggc cgggtcatag cttttttaac 120 ctttaaataa agagcttttg ttgggaaaaa aaaaaa 156 131 251 DNA Mus musculus misc_feature (1)...(251) n = A,T,C or G 131 ggagttccaa tgaattcact caggtttctc tttgaaggtc agagaattgc tgataatcat 60 actccgaaag aantgngnnt ganaaagtat ganggctgga gagatggttc agnanntaan 120 ancactgact gctcttctgg aggttcaatt cccagcaacc acatggnggc ttataaccat 180 atataatgga gnctgatgca ctctcctggg tgtgtgnctg aagacagcta cagtgtactc 240 atataaatat a 251 132 220 DNA Mus musculus 132 gatcacttca tggatttgcc tcacgtacct atgtttgtta atttcctgtg tcgttcccaa 60 gatcacgtaa aaccctctga gcattattga cctccctccc agcaaccaca tggtggctca 120 caaccacctg taacagagat ctgatgccct cttctggtgc gtctgaagac agctacagtg 180 tacttacata taataaataa ataaatctta aaaaaaaaaa 220 133 269 DNA Mus musculus misc_feature (1)...(269) n = A,T,C or G 133 ggtgcatgat gagttcattg ttgcagntgt acacgactca ctcatgaaaa ggatgtcaga 60 gaccccatta cagatggttg tgagccacca tgtggntgct ggaattgaac tcaggacctn 120 tggaccttaa cctctgagcc atctccccag ccccaaaaca ccaaatgact ctaccaaatc 180 atcaagaaga gaattcctct ggcttcggct caaggtccat gcttgttcac ctctggatat 240 taaatgggcg ataattccaa aaaaaaaaa 269 134 322 DNA Mus musculus 134 gttgggttaa cggcatggag aacagtcacc cccaccacca ccaccagcag cccccgccgc 60 agcccggccc ttcgggcgag aggaggaacc accattggag aagttacaag ttgatgattg 120 acccggctct gaaaaagggg caccataaac tgtaccgcta cgatgggcag catttcagcc 180 tggccgtgag tagccggcgc gccttcccgc cacccccacc cacccccggt ggagccccca 240 gacaagaggc gaacggaggg ggacccctct tccaggacag ccagggctat acagagaaac 300 cctgtctcca aaggaaaaaa aa 322 135 186 DNA Mus musculus 135 ggttccaaga ctgccctttg gtattcaaac gggagccgct ttggactgac tggctgcctt 60 cctcctcctc cccctcctcc cccttctgct tcagatttat ttattatatg taagtacact 120 gtagcagttg taggacacac tagacgaggg caccagatct cattgtgggt ggttgtgaac 180 caccca 186 136 406 DNA Mus musculus misc_feature (1)...(406) n = A,T,C or G 136 gtctactaac ccaactctac tgaactggcc tgcccctgta tgcatgaagt gtctctgcga 60 gtggatcgag ctggcagtgc ctgctgacct gtgaactgaa ctgctggttt ccagacaaca 120 cagatgggag ttgctccaaa gaacctttct gaacatgtac acttcccccg tatcctttct 180 tttctactat ctcaggtggg tggngggcta taagggaggt taagacattt aagaaccgtc 240 attaaaaata aggattgagg ggctggtaag atggctctgc aggtgagagc actgactgct 300 tttncgaagg tcctgagttc aaatcccanc aatnacacgg tggctcacaa ccatctgtaa 360 tgggatctgn annccctnaa tctggtcntt tgaagacagc ttacaa 406 137 490 DNA Mus musculus misc_feature (1)...(490) n = A,T,C or G 137 gaagctgcag tgcttggttc gggtcntatg ttcaggggac cantatttag ataaagaaga 60 aaatagcaaa attatggatg ttgtgttcca gtggcttaca acaggagaca tccacctcaa 120 ccagatcgat gctgaggacc cagaggtngg agactgcatc atagaaatgg angatggctc 180 annttcttag aaccatttnc aaagggacag anagatctnt ttcaactcac ccctaanacn 240 nttggaanac agnttggaga nntggctcat aggctaaaaa tactggctgt tcntccagaa 300 ggcccaacaa ccacatggtg gnttacaacc atcctttang ggatcctggg ccctctttng 360 gggggccccc cgtctnttaa tttaaatnan cggttttttt ttnttgtttc cggggggngg 420 gcgncccctc cccttggaac ttntttnncc tnanttgaac nttttttctt ttggaaaagg 480 gcccccttgg 490 138 290 DNA Mus musculus 138 ggttccatgg tgacggccac acccaccccg ctgcggccag atgtcatgcg ggtcacctca 60 ctccagggct ggggatgaga ccttaaaccc tggattcaag aaagagacca gaggactgga 120 gagatggctc agtggttaag agtaccaacg gaaggtcctg agttcaaatc ccagcaaaca 180 catggtggct cacaaccacc cataatgaga tctgccgccc tcttctggtg tgtctgaaga 240 ctgctacagt gtacttatac acataaataa aatcttttta aaaagaaaaa 290 139 256 DNA Mus musculus misc_feature (1)...(256) n = A,T,C or G 139 ggttccaaga ctgcccttcg gtattcaaac gggagccgct ttggactgac tggctgcctt 60 cctcctcctc cccctcctcc cccttctgct tcagatttat ttattatatg taagtacact 120 gtagcagttg taggacacac tagacgaggg caccaggtct cattgtgggt ggttgtgaac 180 cacccaccat gtggttgctg ggatttgaac tcaggatctt canaagagca ntcagggntc 240 taaaccgctg agccat 256 140 327 DNA Mus musculus 140 gtctccatat gctcagtcaa atctccataa ctgtaaatca acactaagag cactggatag 60 ttaaggtcaa ggagactctc acaaaggatc cagaaggtgt agtccagatt aaggtgtgtt 120 ccaccacacc tttaatcccg gatgaccttg aactcggaga tttaatcttc tggaatccat 180 agccactatg cctcaagatc tccataccaa gatccagatc agaatcttct atctccaagc 240 ctccagataa gggtacctgg tgagccttcc aattctggat tgtagtccat tccaaataaa 300 atcaagttga caaccagaaa aaaaaaa 327 141 301 DNA Mus musculus misc_feature (1)...(301) n = A,T,C or G 141 tccaagactg ccctttggga ttcaaacggg agccgntttg gactgactgg ctgccttact 60 gctcctcccc ctcctncccc ttctgcttca gatntatnta ttatatgtaa gtacactgta 120 gcagttgtag gacacactag acnagggcac cagatctcat tgtgggtggt tgcaaacnna 180 ngacannnta gacganggca ccaganctca ttntgggngg angagcatnc anggctctna 240 accgctnagc natntntcca gnctcctgca ttncttctta aggcatgaat gatccagcat 300 a 301 142 141 DNA Mus musculus 142 gccactcgca aacgacctgt cttctcacgc tctctctctc tctgtttctc actctgtcct 60 ctctctgtct ctatcctata ctaacttgtt tcaaattgga agtgaggata tgtattgccc 120 aagggattaa ataaacaaaa a 141 143 349 DNA Mus musculus 143 gtgagcccta tttctagaga cagctgctgc tgaccctgta actcaaagga caaactagct 60 ggctaaactc attcttggta ctggtgttgg attattctag aggttggata tgagcctagg 120 tggcctgctg gcctaggagg aggattgagg tcactttctt gcagttgcct ttaagaatgt 180 gtggaatcgg ggctggtgag atggctcagt gggtaagagc acccgactgc tcttccaaag 240 gtccgaagtt caaatcccaa gcaaccacat ggtggctcac aaccatccgt aatgagatct 300 tgactccctc tttttggagg gtctgaaaac aagctacagt tgctcttac 349 144 238 DNA Mus musculus 144 cctgaaacct ggctgctcag gtttcactgt tatcgggaag agagcatgtg gtggagcctg 60 ccgccctatc attctgccac tcccactgct gctgcctgct gcctagctgt tccggagcca 120 aacacgtggt cacctgcaac tggactcgta ggatgatttg gcaggaatgg gccccttccc 180 cttcttcata acccagtgtc tggaatagta aaatcgaacc ttgatcagaa aaaaaaaa 238 145 304 DNA Mus musculus 145 ggagaaactc actcgccaaa caacgtctcg tggtatcctg gctgactctg gccgcttcag 60 cagagcctgg ctgttcctgc tggattgtgc tactgctaca gattcatgtt tggtgtttgc 120 tattgaactg ggctgcttat atcctgacac ggaagagtgg aatcgcccaa agcaagtact 180 tctaatcagg tccacaactc cctttgcctt taaccttgct ttttccctac ctctggttgg 240 tgggctaaaa gggagggtta agaaccccaa ataaagtcag ttttgaaaaa cctaaaaaaa 300 aaaa 304 146 250 DNA Mus musculus misc_feature (1)...(250) n = A,T,C or G 146 gaccttgttg gaagaagtgt gtcattgtgg tcatggactt taagacctgc ancctagctn 60 cctggaagcc aatctttacc tagccgcctn tgaaacagct cctnctgcac catgcctgnc 120 tggacgctgn catgcttcnc cttgatgata atggactgaa tctntgaacc tgggcaaaga 180 gccnatgggg agaagagaat cttnangctc tgancatcca ggagggtgaa gatgttacca 240 tgaactgcag 250 147 334 DNA Mus musculus 147 atctaaaaaa actcaaagca atgtccctaa gaagccactt gaaaattcct agatggcctg 60 ggagttagaa gcatgaaaca cagcctcaaa accaaaacca aaaagcgggc tacaggtata 120 aaatgagtgt taaagaagtt tgaaataggg ctggtgagat ggctcagtgg gtaagagccg 180 actgctcttc cgaaggtccg aagttcaaat cccagcaacc acatggtggc tcacaaccac 240 ccataatgag atctgatgcc ctcttctggt gcggctgaag acagctacag tgtacttaca 300 tataataaat aaataaatct tttaaaaaaa aaaa 334 148 182 DNA Mus musculus 148 ggttccaaga ctgccctttg ggattcaaac gggagccgct ttggactgac tggctgcctt 60 cctcctcctc cccctcctcc cccttctgct tcagatttat ttattatatg taagtacact 120 tgtagcagtt gtaggacaca ctagaccgag ggcaccagat ctcattggtg ggggtgggtt 180 gg 182 149 337 DNA Mus musculus misc_feature (1)...(337) n = A,T,C or G 149 gtgctgggat tgcaggcatg tggccactgt gacaggtttc ctgtgctgtg ccgaggcccg 60 ggcccagcgc ctcgtgcaca ctagagaaaa ttctgcatac tgacccacat ccccagctct 120 acccgtgtat atttctagtc attctttaaa cccaagcaaa tgtgtagagt ctcctatgct 180 gagatgtttt ttgccactac cagacatgta ggctatcatt tgacgtcttt attccctgag 240 agaaaacttc ttttctgtat ttatgaactt tattattgag aatcactgnt aacctttctg 300 ccaaattaaa gacacttgtg tctctgttta cacggac 337 150 377 DNA Mus musculus misc_feature (1)...(377) n = A,T,C or G 150 actctagacc atgtgcctag gtagnttttn ccttctccgc agctctgctt ccccagcanc 60 gctcaccaca cccttgtttt gagaacctca ctaagtctgg agctcanaga aatgangaag 120 gtggatggag actgactcat gngcttgaaa ccatcaaatt gttcaagatc atcaagggac 180 tgagcctaag gctctgtcgg aggagggaga agccactgaa acagggggac ccaggactca 240 catggtggct cgtaaccatc tgttactcta acatccaatt ctgacctgta ggcgccagtc 300 atctacaaga tgcatagaca catgtaggca aaacacttat acacataaaa taaaactgaa 360 aacaagaatt taaaaaa 377 151 354 DNA Mus musculus misc_feature (1)...(354) n = A,T,C or G 151 gtctttttcc ccttcctttc tgtggacaca gnacagctct tcggttncag gattgtgctg 60 gtcaattatt ttctcctact tccatgttat caagactact tctacatctt tttcactgta 120 tgtatatatg agtgaaatta tttagagcat tatttctaaa aaatgtattt ccagctctaa 180 aataggttga gattatcatg aacatttgtt gccgggcagt ggtggcacac gcctttaatc 240 ccagcacttg ggaggcagag gcaggcggat ttctgagttc gaggccagcc tggtctacag 300 agtaagttcc aggacagcca gggctacaca gagaaaccct gtctcgaaaa aaca 354 152 669 DNA Mus musculus misc_feature (1)...(669) n = A,T,C or G 152 aagcctgagg ttgagctgga accggcttcg aatctgccgc ttgggagaga tgagagggac 60 gggggctgac tgctgctgga ccgactcgct cagctccttc aggtccatct cggccttgct 120 tcgatctgga agacaccagt atagcctcaa tcagaccagg ttctcacact ccaccaccca 180 ccactcaggg tttctctgtg gagccctggc tacactggaa ctcactctgc agaccaggct 240 ggcttcagac tcagatacgt gtctgcctct gccttctgag agctgggatt aaaggcctgt 300 gccaccacca cccagttcac atgaaattta aacacgtccg cccgtaactc tagttctggg 360 caatctgaca tcctcttctg gcttccgtgg gcaacgcatg cacgtggtgt gcctatccac 420 gcattggatc tagatgttcg tgtgcataaa tgcctttaaa aataagcttt acacataaat 480 aagagcggag gagtttgcgc ctggcctcaa atgctgctcc tgacgagaag cacctgactc 540 ctggagtaaa catggattca agtcctggag tggacgcccc tttccttntg ggaaatggac 600 ccggagcagc aattagcnta cctatctgct aggtcaagca cacaacaccn caaattaagg 660 aaaaaaaaa 669 153 336 DNA Mus musculus 153 ttgagggtca tctgtctttg ttgtctgaga tgcaagagtc acaggagaag tcatcaccac 60 ggtctgcggg agagacgtgg cagacggcgt ggtacggatc tgatctacaa ctgatggcca 120 actagtgaca cccagatgac tgtcacattc acgactcagg tatcgaagga tgttccagcc 180 cctccctact acctcccacc acagggtatc actatgtagc ctggctgtct tggaactcac 240 tacatagacc agcttggtct cgaactacag agatctacct gcctctgctt ccggagtgct 300 gggattaaag gctactgagc cagtcaaaaa aaaaaa 336 154 582 DNA Mus musculus misc_feature (1)...(582) n = A,T,C or G 154 agctgtttcc caagccgaag ttagagttct cctccagtcg tctggaccaa ggggagttgt 60 tggacctgnc ctgctccgac tcgggcacac ctgtagccaa cttcaccatc cagaaggaag 120 agacggtctt gtcgcagtat cagaatttca gcaagatcgc cgaggagagt gacagcgggg 180 agtacagctg tactgcaggc atcggcaaag tggtcaagag aagcggcctg gtaccgatcc 240 aggtgtgcga aatgctctcg aagcccagta tttttcatga tgccaagtct gagatcataa 300 aaggacatgc cataggcatc agctgccagt ccgaaaatgg aactgcaccc atcacttacc 360 accttatgaa agcaaagagt gacttccaga ctctcgaggt gacctccaat gacccagcaa 420 cattcacaga taagcccacc agagacatgg aataccagtg cagagcggat aattgccatg 480 gctccggtag gtccagagtt caaatcccan caaccacatg gtggctcaca accatccgta 540 acnagatctg actccctcnt ctgggagtgg cctgaagaca gc 582 155 258 DNA Mus musculus misc_feature (1)...(258) n = A,T,C or G 155 cctctacata cgagacagct ctgacaggct gagataggaa tgcctttttt tgntatctat 60 tttttttaat gtttttatta ggnattttct tcntttacat ttccatgagc tatcccaaaa 120 gtcccccaat nncccctccc caggaatgcc ttttngtggc caanaatctn gntgggnnct 180 gttagtgtna tgattntatn cactgtaaag atatggctct gtatttcttg catgcctaaa 240 gcaccttctg attgatta 258 156 275 DNA Mus musculus misc_feature (1)...(275) n = A,T,C or G 156 aagggagacc ctcactcaag cactcaagnc nnggnacngc cgcggaccca ngangacnct 60 gagaccgtac tcgaaatgta taangagata gctctaatnt tanagcgagt nntcnacctn 120 ctganggacc cgatattgtt gncttagtac catancctgg actgcgttta tcctttttct 180 aatanaagct actaacttat taaggatgca gggcccaaaa gtaagcnaaa gcatnagtgg 240 aatttaaagg tcctgntata ttggaaagga aagtg 275 157 288 DNA Mus musculus misc_feature (1)...(288) n = A,T,C or G 157 gactgagatg atggatcaca tgggtggtga tgaggatgta gatttaccag aagtagatgg 60 agcangatga tgattcacaa gacagtgatg atgaaaagat gccagatctg gagtaagggc 120 tgttgtcatc gcctggattt tgagaaagga aaataacttc tgcaagattt cacaattgag 180 aaaacccctg agtcgatagc tctaaaggca gatatgctgt acttgcctcc tctaacccag 240 ttgtcaacct ttttttttct ttttcttttt tttctttttt tttttttg 288 158 190 DNA Mus musculus misc_feature (1)...(190) n = A,T,C or G 158 gaactgaggg agcccgaacc tcagctgnca tggcgtcaca gcatngggct gcgcatgcat 60 gctcatgcgg gagcaggccc agcaggagga gcatgcgaga gcgcatgcan nagcaggctg 120 tcatgcatta tatgcaacag cagcagcanc agcagcagca gctgggtggg ccccccaccc 180 cagacatcaa 190 159 226 DNA Mus musculus misc_feature (1)...(226) n = A,T,C or G 159 ggtgtcccat aggtctccgt gcgactagga ggggcagngg tggcggcggt ggcagcagcg 60 gcagcggcgg cggcggcagc agcagcagca gcagctagca acctggtcag ggtacgctct 120 ccatccacag agatgagccg tcaggctgct acagcattat ccactggcac ctcaaagtgt 180 ccaccatccc agagggtacc tgccttgact gacacaactg catgca 226 160 401 DNA Mus musculus misc_feature (1)...(401) n = A,T,C or G 160 gactgaggcc tgaagggaaa gatttcagca ttcatcggct tgtcctgggt aagctgaaca 60 aagtctggtt tttgttgtgt gtggnttttc cttccttcct ttctttttct ttctttcctt 120 ttttctttct ttcttttttt aaacttggga ccaccaagtt gtaaagatgt atgtttttac 180 ctggcagttg ttccactggt gaactgtcaa gttgagaaan agtggattgc tagnttgtgt 240 tngnttttaa nattaaatta atccttgata aaagttgctt ttttangggt tagnctttga 300 ccactatagt ttgatgccat ctccattttg gttgacctgt ctcaccatca ggcctgntac 360 tctccatgac taactgngta agtgcttata atggaataaa t 401 161 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 161 gacttcagga tgcattngac agtgactgng aaactggnag gatcatgccn aacaattatn 60 aaaatggaaa ntacagtgac taccaggaaa cataaaaaaa 100 162 195 DNA Mus musculus 162 gaactgaggt gaagcactgg tggaaggaaa agaacacgca ggagcgacca gggactgagc 60 gagtggagtt gaccggagca agaagaggtc ctaaaaattc aattcccaac aaccacatga 120 aggctcacaa ccatctgtac agctacaagt gtactcacat acataaaata atgaataaat 180 aaatatttag aatga 195 163 216 DNA Mus musculus 163 gactgagact ctcagcgttc tcatctctcc tccttcacca tgaagctgat ggacaaattc 60 cactctccca aaatcaaggt gagatggctc agcaggtaag agcacccgac tgctcttccg 120 aaggtcctga gttcaaatcc cagcaaccac atggtggatc acaaccatcc ctaacgagat 180 ctgactccct cttctggtgt gtctgaagac agctag 216 164 348 DNA Mus musculus 164 cttcaagaag ctctactgcc tgagggccac tggctggaag aaccaatttc tcttacacag 60 gttccaggtg tgcatgtcgg gcatccctgt gggtgtttgt ggtcggctgt ctgtccatgc 120 tgctataccc cagtgtgctc tttgatccag tcccgaacta cagggagcct tgtgtacacg 180 cctggcttgt tcctctgagc gcagccttca ccccagctca ccacaccagc ctggaacatt 240 cgcccatctt tctccgcgct tgacaagggg ccaccagagt caccctacgc aaaataaata 300 aataaataaa taaataaata aataaataaa atacccgaaa aaaaaaaa 348 165 448 DNA Mus musculus misc_feature (1)...(448) n = A,T,C or G 165 gactgagcta cggagtcaag gccaagtgag ggggaccagt gcggcctgtg atgactgaag 60 ccaccagcgt ctcagtgttg gacgtttcca gtgtgtgtct gacgattcga gcacacgtgt 120 gcacacacac ggacggacac acacagacac acacacacac atattctcac acacttatgc 180 gtgtgtgaat atgtgtgtgg atgtctgtag ctgtatgtaa agcacatatg gctacaggtc 240 tagatacaca catgagtgta tatatatatg tatgtccatg ctagatacac acacgagtgt 300 atatatatgt atgtacatgc tagatgcaca catgagtgta tatatatgta tgtacatgta 360 aagatcgaag ggagcagggc gttttctcca aagtactgga cctggcttta accaaaattc 420 ttaaggaaaa tntttcaata taaaaccc 448 166 462 DNA Mus musculus misc_feature (1)...(462) n = A,T,C or G 166 ctgagccagc aagcacatct gttggagcct acttcttcag gattacagtt tatacacgaa 60 gaccagctga aacacccaga ctgcagactc acgcccactg gaagcctacc tcttcaggat 120 tgcagtttat acagagggcc agctgaaaca cctagcctcg tggaactaga ctcttggact 180 tcccatttac agctgtccat tgttggnncc tgtttccang tccctgcatg ggttactgtc 240 ccgantnccc ttaaggatat gctgtgatat ngcatngtng gccanataaa ccttttcctg 300 accaatntgc anatagntgn nctagttctg nacttcctct ttggtctggc tgttggatta 360 tggtccacag tgaggaccan acnnagacac agtgaaaggc tacttnctgg ctggaanggg 420 acatggtgtg gtgggtcann tgggggcatc ctttgttttc ca 462 167 391 DNA Mus musculus misc_feature (1)...(391) n = A,T,C or G 167 ctgcttcagc aggatggagc atcantgaga tggntcagca ggaacgcaag cagcagcagg 60 agctgcgctt ggccttgaag caggagcgcc gggctcaggc acagcagggc catcggccat 120 acttcctgaa gaaatctgag cagcggcagc tggccttggc tgagaagttc aaggagctga 180 gacgcagcaa gaagctggag agtttcctga gtcgaaagag gcggcggaac gcaggcaagg 240 acaggaggca cctcccgctg agcaaggagt agtaagaact gtcccaggag acctggatct 300 gtgggaacgg ggcttggctt gcccggctct ggatctttnc cttgctcaaa aatgagcttg 360 atgactacca ctggcctaag ctgacttgga a 391 168 574 DNA Mus musculus misc_feature (1)...(574) n = A,T,C or G 168 aagacggatg ctccccattc tgatgtgaag gatgangaag ggacngnaga anagncnncc 60 ncnnnnttta nacngactan canganaanc ttgaagagaa acacnngagt gatgctgaag 120 aagatggtgt tactggcagt caagatgagg aagatagcaa gcctaaagca gaggaggatg 180 aaattttgaa cagatcgcca agaaacagaa agccacgaag agagtgaaac aatctttaag 240 aacttgatct gtgatttcct ctccctcccc ttcccctgca aatgtggtcc taggagaggg 300 cctggtgtac cttangtggg agctcaaaac ctcaagatgt caccatcaac aggttccagt 360 gaatactagc ctgtaatttt aaacatctag cagtaaataa ttgcagttgt aatgtaaagg 420 accctgtttc tgtagaaagg aaaacattta acataatggt tgngaaatgt accatgaaac 480 actaactagn gttttggttg nttttaaaan ttttccaggg nggctttttt tttttttccc 540 ttttcccttt tttttttttt ttttttaaaa aaaa 574 169 203 DNA Mus musculus misc_feature (1)...(203) n = A,T,C or G 169 actcactatg aagccnnaga tgaccttgaa cttctgatcc tctcacctcc atccctgagt 60 gctgggactg ctggtatgtg ccgttatgng tgtgctgttg ggagattgan ctcaaggcct 120 ctcccatgct atgcaagcac cctaccaact gagctatatc cccagccttc ccaccttana 180 gnggtatatt gtactgagga tta 203 170 270 DNA Mus musculus misc_feature (1)...(270) n = A,T,C or G 170 gactgagatt ctcacaaaca caaagataaa cacaaagatc gagaacaccg gcataaagga 60 gcacaagaag gataaggata aggaccggga aaagtctaag catagcaaca gtgaacatan 120 agattctgaa aagaaacaca cagagaaaga gaaaaccaaa cacaatagat ggcagctcac 180 gaaaaacata angacaaaca taaagacaga gacaaggaaa gacgaaagga ggaaaagatt 240 agagctgctg gggatgctaa aataaaaaaa 270 171 342 DNA Mus musculus misc_feature (1)...(342) n = A,T,C or G 171 ctgagagaga ttcagcctca aagacatcaa agccataaga cactatgtgt aaggtcaatg 60 ggatctttgg gaacaaaact gattcggaaa agacacctca tcttatggga gctgggcctc 120 tgtgtcacct ggaagagcaa acacatcatt taagaatcca tatgccaaca aggttttgct 180 gaaaggaccc cgatatagct gtcttgtgtg aggctatgcc agtgcctgnc aaatacagaa 240 gnggatgctc acagtcatct attggatgga acacagggcc cccaatggag gagctngaga 300 aagcacccaa ggagctgaag gggtctacaa ccctattggt tg 342 172 331 DNA Mus musculus misc_feature (1)...(331) n = A,T,C or G 172 actgaggtga ctccanngaa tgggtcattc catctccana ggggtnagnn acccaccagc 60 tgaaaactgc tttactaaat tggtctgcat ggctggccta caattcaaag atctgcctgt 120 ttctgcctcc cgagngccgg gatttaaagg catgtgttgg gctggagaga tggctcaacg 180 gttaagagca cagactgctc ttccagaggt cgtgagattc tgactccttc ctcangcatc 240 ctgataaaga tgttcgttta ctggtggctt gctgccttgc tgatattttc aggatttatg 300 ctcctgaggc tccttacacg tcgtgagatc c 331 173 353 DNA Mus musculus misc_feature (1)...(353) n = A,T,C or G 173 tcaaacggga gccgcttngg actgactgnc tgccttcctc ctnctccccc tcctccccct 60 tctgcttcag atttatttat tatatgtaag tacactgtag cagttgtagg acacactaga 120 cgagggcacc agatctcatt gtgggtggtt gtgaaccacc caccatgtgg tngntgggat 180 tnganctcan gatctttana agagcagtcn gggntctaaa cngctgagcc atntttccag 240 nctcctgcat ttcttcttaa ggcatgaaat gatcncanaa tggnacgaca gtcttgnntt 300 nttttccttt ttagaanana ttttttccct ttttncactc attatactgt att 353 174 327 DNA Mus musculus misc_feature (1)...(327) n = A,T,C or G 174 tgagatcaac ttgtgataat gctgccattg agagaaactc acccaacagc tgctcatgag 60 gtcctgcaga agtngcctct tccattgcct tgcctcagga tggntggtaa acctggcnat 120 tncttcanga ttgaactaca gctgcctggn gtctgcctgc caagaggact ggtctgcagc 180 tgctgaattg tatttgatgt ttgctacagg actgacctgc tgcccaagaa gatcaagctt 240 gcccccaaag aactactgat gaacaggctc acttccccta tatcctaata aattttctct 300 tctactacct ttgatgggta gtgggct 327 175 235 DNA Mus musculus misc_feature (1)...(235) n = A,T,C or G 175 actgagaaag tctcgggctg gtgagatggc tcagtgggta agagcacccg actgctcttc 60 cgaaggtccg aagttcaaat cccagcaacc acatggtggc tcacaaccat ccgtgagatg 120 ccaggacttg gaaggtggan nccaaactgg ntcctgaaca aacagaagga tgtgagngat 180 gggaagttca nccaggntct ggccaacggt ctagacaaca agctgcgtga gatga 235 176 325 DNA Mus musculus misc_feature (1)...(325) n = A,T,C or G 176 atggcacaat tcaatgaaac tgactttcta nagaanccaa gagttggggc tgnagagatg 60 gctcagtggt tnagagcact gactgctctt cnatgacgtc ctgagtgtca attgccagca 120 nccacatggt ggttcncanc agatncatnc ctgnagatcg cacatgcccn ctnctggtgn 180 gtctgaagnc antctccnnc tnacttgcat annntnaaac cttaagtgtt tggcatgagg 240 ctttaacaga cacaatctgg agtgnctatg ttttacccaa gangcccaaa aaagtancat 300 ttgattgcct agagtggatc ataaa 325 177 280 DNA Mus musculus 177 gctggcgaca tcggccctcg tctgacccag gaacgctaag gaaggcacaa tgcggcgctg 60 ggtgaagatg cttcatagag gagaggagtc cctgaagatg cagagcactg tggcagcatc 120 agaagctgac aatgaccaat tgagagcggc cagcagagcc agtcctctta cagctgcaga 180 actcacggtg tgccagtcaa tggccatttg gcttttgaag caaattggga aagtgtaaac 240 gcttgataaa tagttgcctc ttgagtgaaa atgaaaaaaa 280 178 410 DNA Mus musculus misc_feature (1)...(410) n = A,T,C or G 178 gtggctgcca atttgatgta aactccctgc tatgacgctt aactgtctgg aggagaagta 60 caagttggac taggaacaga ttgatccctc cacgtcagcc tcctggccac ccgagactca 120 catcttgtca gagaaacaca atgggctcat ttagctgtac attgaactgg tggtcttcta 180 agagaatgtg atgataataa gactttaagg taaaagttaa gaactggggc tgggggctgg 240 agagatggct cagcagttat agagcactga ctgctcttct gaaggtcctg agttcaaatc 300 ccagcaacca catggnggct cacaaccatc tgtaatgaga tctggcacct tcttctggng 360 tgtctgaaga cagctacagt gtacttacat ataataaata aataaatctt 410 179 290 DNA Mus musculus 179 gactgagatt taccttcaag actgctgaaa ttttaactac ccaagatgcc tgtccctccc 60 ccaccagcac ccccaccgcc accaacattt gcactcgcta acactgagaa gcccaccttg 120 aacaagacag agcaggctgg gaggaatgct cttctctctg acatcagcaa agggaagaag 180 ctaaagaaga cggtcaccaa tgacagaagt gccccaatat tggacaaacc aaagggagcc 240 ggcgccagtg ctggtggcta tggtggaggc ggcggaggtg gtggtggagg 290 180 287 DNA Mus musculus misc_feature (1)...(287) n = A,T,C or G 180 agactgagag agaagcctgc cgatgaatgt ctcgtggaat tccanccgat tcttcccact 60 tncgatgggt naanccaccg ntactgattc ncatttggng tnngctatng gactgaacct 120 gctgatatcc tgacatgaag cttagagtcg atctaaagaa ctacttctaa acaggtccac 180 aatgcccttg ncctagtaac cgtatctntc ccctacctct ggtcggtgct ctagaaggga 240 gattgatgca ttgaagaacc ccaaataaaa taggctttga aaaatca 287 181 273 DNA Mus musculus misc_feature (1)...(273) n = A,T,C or G 181 tatttgcact taacagcaac ctcagcttnt tgccaggcgg ngagtaccaa gagctgctgt 60 ggagtgcaga tgctgacagg aagcagcagt gcagcttcaa gggcaaggac ccaaaggtga 120 gactgaggga tctgggcaga acactgagca gatatggctg ttatgggaag gacacagtct 180 ggacatcgcc agcactgggc ttcagcccca gccccagccc cagccccagc cctgtcctnt 240 atgngatcct ggataaatag attcatctgg tca 273 182 453 DNA Mus musculus misc_feature (1)...(453) n = A,T,C or G 182 ttaccttaaa gatctncctg ttttgcctgc cgagngtctt attannggct gctccatcac 60 accagggatg gcaagatgcc ttcnagggta atagcactga ctgctcttcc naaggtgcct 120 gagttcanat cccagcancc acatggncgc tcaanaccat ctttaatgag atctgatgcc 180 tgtttctggt gtgtngtgac aacagctact ncgtacttat atatnacnaa tggatatctc 240 tttcaagttt tacctgccaa agttacacat gaaggggaca ctgtgggaga ngagtctgtc 300 tcctgcanaa tgtctctaan aagcccaggt ttctccttaa cctangaacc ctgcagctgt 360 aggacccana agtggggtct cttctctata ctaactatct taacccttat ctcttgccca 420 ctgaatatta aataaaatat cattagttaa tcc 453 183 308 DNA Mus musculus misc_feature (1)...(308) n = A,T,C or G 183 gcctccagga tccagtccgg ctgtcgcgtt gcctgatcct gttcaagttg naggcttggg 60 aggaactgan tggtaggtca aggcttctat cttttttcca tgctaagggc tgtaccactg 120 ccaaaggtta ngaaaagata agaggggctg gcgagatggc tcaacgggta agagcacccg 180 actgctcttc cgaaggtcct gagttcaaat cccagcaacc acatgggggc tcacaaccat 240 ctatnangag atctgactcn ctcttctnga ntgtntgaag acagctacag tgtacttaca 300 tataataa 308 184 440 DNA Mus musculus misc_feature (1)...(440) n = A,T,C or G 184 agactgagaa aggccaactt ccatcaatgg gtggatgnnn cntgggactn tgctncacga 60 ntgcntgggc tgatagagcc tnanattcaa nntggctcat tntaccctat ggaaagagga 120 ggtggagtgn gagagccaat tgnaatggaa nacagngagg aaacaaaggc cttcnagaca 180 caanaggact gctgagctca caaagactga ggcagcaccc tcaggacctg cacaggtcta 240 agcttgatgc gatctgagta ctgagagggc aactggacac aattctatat tgataaccca 300 gaagctttct ccagttgata aactctttca aaggaaaaac ttgttttcta ccatggagtg 360 acactggata tngaaacctt cccgttaaca ggcagacttc catgggctca agacttccaa 420 tacaatatga actcagttgc 440 185 207 DNA Mus musculus 185 ctgagggttc caagactgcc ctttgggatt caaacgggag ccgctttgga ctgactggct 60 gccttcctcc tcctccccct cctccccctt ctgcttcaga tttatttatt atatgtaagt 120 acactgtagc agttgtagga cacactagac gagggcacca gatctcattg tgggtggttg 180 tgacccaccc tgcgggtgct gggattt 207 186 318 DNA Mus musculus 186 gtctcctatg ctcagtcaaa tctccataac tgtaaatcaa cactaagagc actggataag 60 ttaaggtcaa ggagactctc acaaaggatc cagaaggtgt agtccagatt aaggtgtgtt 120 ccaccacacc tttaatcccg gatgaccttg aactcggaga tttaatcttc tggaatccat 180 agccactatg cctcaagatc tccataccaa gatccagatc agaatcttct atctccaagc 240 ctccagataa gggtacctgg tgagccttcc aattctggat tgtagtccat tccaaataaa 300 atcaagttga caaccagg 318 187 438 DNA Mus musculus misc_feature (1)...(438) n = A,T,C or G 187 tccagactga gaaaangaga agaaatggca gnggttgatg acaaccaccc ntcntcccca 60 aaccaaaagg ancaggnagg aaccccntct tccaggactc ctgggacaca gagtcttcaa 120 gcagcgacag tggtgggagc agcagcagca gcagcatcaa cagcccagac agggccagtg 180 ggccagagag cagcctgagc cacaccatcc ccggatcctg ccccagcacc ccccagccga 240 tgcctgagca gtctggcact atgcccaagg gcccttactt tccacatcaa ccagaccctt 300 gaangaggct cactttcata agcctacagc acccgangcc ggcccgccga catgatgctc 360 cttccggcaa gtttcttgcc ttctgtgaan ggacaagcac tgtgcaaaat ggatatttca 420 acttaatgat ttggtttt 438 188 357 DNA Mus musculus misc_feature (1)...(357) n = A,T,C or G 188 agactgaggg agatcataga caacacaagc aaagagaacg ggatcgacat catcctggcc 60 gacaggacct tccatctcat cgcggagtcc cccgaagatg ccagccaatg gttcagcgtg 120 ctgagtcagg tccactcgtc cacagaccag gagatcagag aaatgcatga tgagcaggca 180 aacccccaga atgctgtgag gtgctggaga gatggctcag cagttaagag cactgactgc 240 tcttccgaag gtcctgagtt caaattccag caaccacatg gtggctcaca accatccgta 300 acaagatctg atgacnccct cttntggagt atgcttacag ctacagggta cttacat 357 189 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 189 gagcacggca gtggtgaccc aacagctggt gtctaagccc agccgggaga ccccgagggc 60 canggccctg tcgtgttagc accgcagatc ggaaaaaaaa 100 190 361 DNA Mus musculus 190 agactgaggg agaagagatg ggtgactgtg ggtgatacct ccctgaggat attcaaatgg 60 gtgcctgtga cagatagcaa ggagtgtacc atattcatgc ctggtgccca ggaaggtcag 120 aagagggctt cagatccctc agaactggag tcctggatgg ctgagtcacc atcgaggtac 180 tggaaatcaa atccagatcc tctgaaagag cagcagacac tccttagctg cagaaccatc 240 tctccagctc ctccacagtt taaaaatatt atgtattttt atcttatgtt catgtgtgtt 300 ttgcctgcag aggccaaaaa tacatatctg ttctcgtgga actcgaatta caaaaaaaaa 360 a 361 191 241 DNA Mus musculus 191 cgaagaaatg ctgtacgtgc ccttaaatca ctctctaaga aataccgctt agaagtggga 60 atccaagcta tggaacatct tatccatgtt ttacaaacag atcggtcctg agttcaaatc 120 ccagcaacca catggtggct cataaccatc cgtaacgaaa tctgatgccc tcttctggaa 180 tgtctgaaga cagctacagt gtaattatat atagtaaata aataaatatt tttaaaaaat 240 g 241 192 262 DNA Mus musculus misc_feature (1)...(262) n = A,T,C or G 192 cttttccctg gtcccangac ttncccaccc ctcctccaaa taccaagact atgggcttaa 60 aantttcaaa tgggngctgg agagatggnt catcnagtta agagcaccga ctgctctttc 120 taaggtcctg agttcaaatn ccancancca tatngnggct cacaaccatc tgtaatgnaa 180 nctgatgccc tcttctgntg tgtctgaaga cagctacagt gtactcacat atattaaata 240 aataattctt taaaaaaaaa aa 262 193 224 DNA Mus musculus misc_feature (1)...(224) n = A,T,C or G 193 tgaggtccgc atagccgcta aattcatcac ccatgcaccc ccaggggagt ttaatgaagt 60 attcaatgtt ccaaccctgg gacagccctg aggtgctgaa caagggagat tgctgcaagc 120 tccattacaa cctggacgaa aggntgtctc aaaactnaaa tgaantgaat agaacccggn 180 cgggggcggt gcaccccttt attcccacca cttgggaggc acag 224 194 402 DNA Mus musculus misc_feature (1)...(402) n = A,T,C or G 194 ctgaaggcag tttacattcg gagttccgcg gactcttcan aggctgtaaa aatgccggag 60 tcacgaaagc ctgcaaagag ctgttgcttg ccttgctgct gctgctgcta ctgccgtccc 120 tgcccgtgct gcagctgcta ctcctgctgc tgctgctgct gcttgttgct gattgttgcg 180 gttgctggtt gctgtttact gtttgctgcc ggctggattg ctggattgct gattgccagt 240 cggcgaaatc ctggcgatga agatccaact tgccccaaga aacaagacga ccctaagaag 300 tagtctaatg atttcaatac gccctttccc cctctgaccn tttttctctt accttatgct 360 gggggattgg aagggtggca gaaaaaagaa cccaataaag ta 402 195 413 DNA Mus musculus 195 actgagggga gtacagttct ccaacactgc cccagctaaa tcatctaatg ccacaggtga 60 caaggggcaa gaccacctct cctgttctca tgacctaggg ccggctctcc cacctgacag 120 aggcagcaaa aacgtaggtg gtgggagggc acctctccct cactcatgct accacgtggc 180 agacaaggga catgcagaca agggtcatgt gctcatgacc tctgtcagga tcacccaagt 240 ctccaccatc agtgccaact ctactgtgct gctcagatca gtttcttcct ctgaagatgc 300 gctgtctttt gcagatttca ttgatttttt ctttatacct ggttcagcaa aacaacatag 360 gaaggttaaa agacaggctc aacagtgaaa atttggtata ctttgaaccc ata 413 196 420 DNA Mus musculus misc_feature (1)...(420) n = A,T,C or G 196 acctgcttgc tcggggtgga gctncctgct catncatnct accacgccca ctggnggaac 60 ntgaggagcc acanacgtgc nccnttctac tggancaata nantattatg gtgggaatng 120 ggtcccctnc cccttccttc ataactancc gnnanagcaa taaaanttga gccttgatca 180 tnangantga aaaaagaagg ggggggggna nnancccaac atggacacag gaatcttctt 240 gatagttcag tcaagttctc tcttctttat ttccccccaa cccccagctt atgttcctca 300 gcaaactctc aattacagng gggctatatt ctatttttct ttaagggnna tggataccat 360 nnantttcct aannaccctt nanggggata aaagggnttt acatattaca gggggaaaaa 420 197 376 DNA Mus musculus 197 agactgagga taattgaaat aaatcaaaac caaaagcagg tggaacagga tattaaagtt 60 gccatcttca cattgatggt ggagataaac aaaaaaggga aagctctgct gcaccagctt 120 gagagtcttg caaaggacca tcgaatgaaa ctcatgcaac aacagcagga agtggctggg 180 ctttctaagc agttagagca cgtcatgcat ttttctaaat gggctgtttc cagtggcagc 240 agcacagcct tgctgtacag caagcggctg ctcctgcttc ctgacctgct tgagttccag 300 tcctgacttc ctttggtgat gaacagaatc gtggaagtgt aagctgaata aaccctttcc 360 tccccaaaaa aaaaaa 376 198 248 DNA Mus musculus 198 ttgacaccct tagtctgcaa accaaactca gggccttctg tatgtggagc atttgttgta 60 ccgctgcctg aggacgagga aggggaagtt actgggctgg cttcgagaga tatgtatgta 120 tgcctgatgc ctgtggagtt ccaaaggtgt gtcccctggg attggagtta caggcagttg 180 tgagccattt gggttctggg atgctaaccc aggttctctg caagagcaac gagtgcttca 240 accactga 248 199 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 199 ctcatagtaa aaagaagcga tccgggtcnc gcagncgnca ttcnaagtat ctcacctgtc 60 aggcttccat tgaattccag cctgggagct gaactcagta 100 200 249 DNA Mus musculus 200 actgaggatt ttggctttag agaagcttgg tgctgtcttc aatcaagtag ccttcccatt 60 gcagtacaca cccaggaagt ttgtcatcca ccctgagagt aacaacctta tcatcattga 120 gacggatcac aatgcctaca ctgaggccac aaaagctcag agaaagcagc agatggctga 180 ggattgtaag gaattgggct gccgactgta agtcatcaat aaattccttt actatctaga 240 aaaaaaaaa 249 201 260 DNA Mus musculus misc_feature (1)...(260) n = A,T,C or G 201 cctgagactg caagtggcaa tgtggaagca aaagtcgtct gcttttacag aagacgggac 60 atctccaaca cgcttatcat gctcgccgac aagcatgcta tcttncacta nnagcctttg 120 gangaanaca taaaactcnc anntcctnnt gcgccntgcc tgcctggata ctgccatgct 180 ctcacctgga tgataatgga ctgaacctct gaacctgtaa gccagaccca attaaatgtt 240 gttttttata agaaaaaaaa 260 202 442 DNA Mus musculus misc_feature (1)...(442) n = A,T,C or G 202 gatgaggtag gcacggctgg ccantcctgg gtgcacccca aaatacagtt tgctttaatt 60 gaacaatcac tcaaaaactg gcncaaggaa nananntgat ngnngnnccn ganctgcggg 120 tcgcggtaat aaaggttccc gtaaagnnga ctgttaagaa ggattcaact gtatgaattc 180 agaacttttc agctggggaa cgagagtacc agtgagtaca gctttacgag gtaagtccga 240 tcttgaactt tctaacgaaa ttcaagacag tctatcagaa gtaaagtgga aaatggcttt 300 acaagttatg tttggccttg aattttttct agtgttagaa ncccttttgt tccttttcac 360 atgttatcaa gtggttaaag cagggcggat tctaaaggaa attcannaca agctntcana 420 agtaaaacgg ggagaaagag tt 442 203 197 DNA Mus musculus 203 gactgggatg tcctaacttc aggatggaag gaaggaaaca tgatgccata ttgaagaggt 60 tttgtctttg tttcaatggg agaagaagag ctacggatac catcaaatta ataaagatta 120 gatttggcca ggggagacct cctgaaaatc ttggctacag acatgaagga aaaaattcaa 180 gaagaccaaa aaaaaaa 197 204 301 DNA Mus musculus misc_feature (1)...(301) n = A,T,C or G 204 gactgaggga gaaactcact cgccaaacaa cgtctcgtgg tatcctggct gactctggcc 60 gcttcagcag agcctggctg ttcctgctgg attgtgctac tgctacagat tcatgtttgg 120 tgtttgctat tgaactgggc tgcttatatc ctgacacgga agagtggaat cgcccaaagc 180 aagtacttct aatcaggtcc acaactccct ttgcctttaa ccttgctttt tccctacctc 240 tggttggtgg gctaaaaggg agggttaaga accccaaata aagncagttt tgaaaaacct 300 a 301 205 267 DNA Mus musculus misc_feature (1)...(267) n = A,T,C or G 205 atgacttgga taaagaacta aacaactaca ttatgcggtg tagggaatgg tactgaaaag 60 aaagcaaaaa aagccaagac taaaattaaa gctgaagtat aggaggagat ggaggaggag 120 gaggcggagg aagaacaggt agtagaagag gagccgactg taaagaataa aaagaagaag 180 gataaaaaga aacacataaa ggaagagcca ctttccgagg aggagccatg tnccagcaca 240 gcagttccta gtccagagaa aaaaaaa 267 206 370 DNA Mus musculus 206 agctgtagct gtccctccaa acaaggctat tcagagagtt ggagacaaca gaaaaggcaa 60 gctagacacg ttcagcatga gtctaggact gggctccgta atttcctgtg cgtcttcaga 120 acaatctggc aaccacacag tttgtaaact gtacacctga acttccaaac tttacatatt 180 atacatacat acccatacat atggatagat acacgtatat gtatatatgt atattgtgta 240 tatgtatata aatatatatg tgtatataca tatatttata aaatgttaag acatatctga 300 tttactttca ccactacaga attatgtata ttactggaaa aatttagaaa tacttgcttc 360 ttaatagaat 370 207 256 DNA Mus musculus misc_feature (1)...(256) n = A,T,C or G 207 acactgagag accctgttga ctgactgagc tggcttggcc acccaccctt gaaccaacga 60 tcatcctgtc ttggtttccc aagtgctggg attacagatn cccngngact ngcatgacac 120 ccctgtnctc ttntctcgga gacccngtga cttgcctgnc ccacagaaca cactnagcga 180 aaanctgctg nctgaataan cctnctgccc ccgtgcgtct cctnctccgt agncgtnact 240 gacggactgt ggtgac 256 208 544 DNA Mus musculus misc_feature (1)...(544) n = A,T,C or G 208 ctgagccccc tgggatgata cccaacaact catgagaata atcttcatga ccgaagagtg 60 agagaggata atgcaggaag ccaaaaagaa tgtcccttca gacacgaggg catcatcgat 120 tgaccaggct gttatctaca gcgggtgtct cctgattaga cctggctggg actttaacac 180 agcagaaggt aagtggcacc tgaaggtcta ccgccaggct ccattggcag gtctcaagga 240 gggctgtact acaacccaca aatttgacca aggtacgtga agttagacaa ggatcagatg 300 agtcacctgc tgcctttcta gaatgactca tggaggcatt ccgtcagtat acaccctatg 360 atcccagcag caaggagcac aaagctactg ngactatggc atttattaga ccagcttgtt 420 agagatatca ggaaaatgct tcagaggcta nagggatgac agggtaagtc actgaggggt 480 ttaatgcagg ttgcttgagg aagtctacca taacagggag acagggggag aaaaaaccat 540 attg 544 209 525 DNA Mus musculus misc_feature (1)...(525) n = A,T,C or G 209 gcaactgaag gaaaagctgc cctatgtggt aatgaaaaac ttaacactgt cctgcatgac 60 tgcctatgga agaccgatga cctctgccct caagcccaat ggagaatcct aggggcgcta 120 gctccatcca tctgtaagtc ccagaaccca agtctcagga gcggcgggag accggagaca 180 aagtgagaga ggtggatgga agcgaaagac aagcaggaga gagagaagag accacgctga 240 ctctcactcc ctcttcttta atacaacaaa gttgcaactt gggctcctgg atctaaatac 300 cgcaggtcca gagaagacaa aacaccaggc atcactgcat ctcttagggg gtacccacca 360 agacctccag gtccttcact ccaggaaggg ccctgttgaa tatctgcaga gagatgggtt 420 ggagcacagc ttggtgctca gtcctggccc tgtggctcct ctggtgtgct gtctgctcca 480 acgcaacgtc agggggacng caatgcgttt cctttttgac atcca 525 210 352 DNA Mus musculus misc_feature (1)...(352) n = A,T,C or G 210 agaactgagg gttccaagac tgccctttgg tattcaaacg ggagccgctt tggactgact 60 ggctgccttc ctcctcctcc ccctcctccc ccttctgctt cagatttatt tattatatgt 120 aagtacactg tagcagttgt aggacacact anacgagggc accagatctc attgtgggtg 180 gttgtgaacc acccaccatg tggttgctgg gatttgaact caggatcttg cagaagagca 240 ntcagggctc taaaccgctg agccatctnt ccagnctcct gcattccttc ttanggcatg 300 aatgatccca gcatgggacg acagtctgcc ctcccttctt tttgagggag at 352 211 433 DNA Mus musculus misc_feature (1)...(433) n = A,T,C or G 211 actgagcata aacagaggcg gcatgacaag aaacnnaggc tctggaggtt ttggtggtgg 60 tggcaccagg agagggacac gtggaggcag ccggggaaga ggtagaggca ccggcaggaa 120 ctcaaagcag cagctttctg cagaggagtt ggacgcacag ctggatgctt acaatgcaag 180 gatggacacc agctaaacaa ctgagcaaat ccacacaagt aacaggaccc agaagcctcg 240 cctgtgatgc ctagagggag ggttggcaac tgaactgtgc agacaatggn ggatttggtt 300 tggttctttt tatttctttt cttttttttt ttnttcccgg tttaaaaaag gatntaaaaa 360 cncttntaaa ggnttttttt tttttttttt tggggttggg gngggntttt ggtttttttt 420 ttaaaaaaaa aaa 433 212 100 DNA Mus musculus 212 ctgatacatc tttagatggt ggaagatttc tctgagaagt gagtatcggt cagcaaaacc 60 tggagaaaca aaggaaagcc atgaacactt gctagataac 100 213 372 DNA Mus musculus misc_feature (1)...(372) n = A,T,C or G 213 gtgacaggag gccatantga ctganttgtg ganctctcac aggtgctgca ggaggcntgn 60 ntggtgccnt actgnnnaaa ctgnanaang gngnnggatg atcatctcac tgacaattta 120 gagacagaga aactgtgtga ctacttctcc acacacctgg gtgtctaccg gcccgtgctg 180 gctgcgctgg agtctctgaa ccgtgcggtg ctcactgcca tggacactac aaagctggga 240 ggagatgnag tctcccctnc cccancctga aacctgcttg ctcngggngg agctncctgc 300 tcattcgttc tgccncgccc actgttgtan cctgnngaat cacacncgtg cacctttcta 360 ctggaccaga aa 372 214 203 DNA Mus musculus misc_feature (1)...(203) n = A,T,C or G 214 agaactgagg gttccaagac tgccctttgg gattcaaacg ggagccgctt tggactgact 60 ggctgccttc ctcctcctcc ccctcctccc ccttctgctt cagatttatt tattatatgt 120 aagtacactg tagcagttgt aggacacact agacgagggc accagatctc attgtgggtg 180 gttgngaacc acccactcat gtg 203 215 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 215 cactgagacc aacttttaca agtctacctg ttcgagaaga aatgatggcg aaatactcaa 60 acctttcctt aaagagctgt natatctcag tgacggaaaa 100 216 430 DNA Mus musculus 216 agactgagta tccctggaac tgatgatgtc atccagccag ctgctcctgt tgacccggga 60 cacccaccct tagctgactc gtcccaccat ggtgacgctg tcagctcagt ctctacacat 120 ctgacagtcc agagcgcctc cccatctgct gcccgtgcaa gtcctgctcc tttggcccca 180 gaacatacag cctcggctcc ctccgcagcc ggtcctggag tagaagtcac ccccactgcc 240 tcccgagtgc tgggattgaa ggtgtgtacc accacacccg gcgagtctcc ctttcttaac 300 cccatgagga taatccttcg ccaccatgat gtgctctcct aagtcatttt gggcactgtt 360 agctacgcac gcacgtcctc ttttcataga caaagaaact gagaacaaac aaggtacaaa 420 acaacaaaaa 430 217 377 DNA Mus musculus misc_feature (1)...(377) n = A,T,C or G 217 cactgagagg ctcacaggac acctgcacaa caaaggctgt ccccgtatgt aatcaacctg 60 gacccagctg tgcatgaagt cccctttccc gccaatattg atatccgaga cacagtgaaa 120 tataaagaag tcatgaagca gtatcctttt nctcatctgc tgcgagactg actcggtcat 180 ggcaaactgc tgnctttaat tgntttgggg gagnggcttt gcctgtcang nngngacaat 240 acaagnagaa aactcatgnc cttttaggna atnntattaa gaggataaga tgagggctgg 300 tganatggct caacaggtna gaacactgac tgctcttcca aaggtcctga gttcaaatcc 360 cagcaaccac atggtgg 377 218 495 DNA Mus musculus misc_feature (1)...(495) n = A,T,C or G 218 cactgaggcc aagttcacag tggagactga ccccacatgt gagtttattt tgcctcacca 60 gttcaggtca cagttcacgg tggccccatg gtgtccacag tcaggaagca aagagagatg 120 gatgcttgtg ctcaacccaa cctctccttt ttatccagcc ttggatcaca gcccacttca 180 tgatggagca acactgggtc atcacccaag tgccnnggca catgcagcca cccagttttg 240 gactttcagc ttctaggact gtatcccatg taagcctctt tataaattat ccagcctcaa 300 gtgctctgtt atagcaacag taaccaacta agaccccata actccagcaa ctaatactta 360 atgaataatt gctgacttaa tctctcatca cttggattct ataaaggtct ttggcaatca 420 tttcttatng gaanaaatat tnttnttccc aatttgggcc cccncctact ttggggnaag 480 ggggggttag aaggt 495 219 230 DNA Mus musculus misc_feature (1)...(230) n = A,T,C or G 219 gaaactcctg cctatttntg tgtctttgct cctgctcctt accccttatt tgtaaggccc 60 anccttgaag aattgcttga gggctggaga gatggctcag tggttaagag tactgactgc 120 acttccagag gtcctgcaac cacgtggtgg ctcacaacca tctgtaatgg gatccgaagc 180 ctcctggtgt gtctgaagag actgacagta aaactcacat aaaataaata 230 220 295 DNA Mus musculus misc_feature (1)...(295) n = A,T,C or G 220 gactgagaga aaaaagcaga gatcgtgaaa gggaacggga gcgggaaaga gagagagaac 60 gagaacggga acgagaacga gagcgagaga gagaacggga gagagaacgg gaacgggaaa 120 gagagaaaga caagaaaaga gacagagaag aggatgaaga agatgcntnt gaacgaagaa 180 aactcgaacg aaaactgcga gagaaagagg ctgcttatca agagcgcctt aagaattggg 240 aaatcagaga acgaaagaaa actagggant ntgagaagga ggcagaaaaa aaaaa 295 221 229 DNA Mus musculus misc_feature (1)...(229) n = A,T,C or G 221 aattgaggct tccaagactg ccctttggta ttcaaacggg agccgntttg gactgactgg 60 ctgccttcct cctcctcccc ctcctccccc ttctgcttca gatttattta ttatatgtaa 120 gtacactgta gcagttgtag gacacactan acgagggcac cagatctcat tgtgggtggt 180 tgggaaccac ccaccatgtg gttgctggga tttgaactca ggatcttca 229 222 127 DNA Mus musculus misc_feature (1)...(127) n = A,T,C or G 222 gaaattcaat agcagtacag catttgcctt gcatgtgtca gncccttgtt tcaaactctg 60 gtaccagagt ttagatctgg ttttgataaa taaataaata aataaataan caacaaaata 120 taaaaaa 127 223 100 DNA Mus musculus 223 gtccacttct tcaacagctt tttccataga cagctggtaa ccaaaggcta taatggagtt 60 aaaagatgga cgaagaagga aatctggaaa aagaagaaaa 100 224 195 DNA Mus musculus misc_feature (1)...(195) n = A,T,C or G 224 ttaggaaaaa ggtcacagga actgaagggg atgaaaggag ctaccccaca tgaacaccaa 60 cagcagtgnc nactngcctg gacccctgaa tactcccaga ancaacaccc aaagaacata 120 catggactta ttcaaggcct gtggcacata tctagcaaan aacttgantn tccccagtgg 180 gagaggatgt gccca 195 225 316 DNA Mus musculus misc_feature (1)...(316) n = A,T,C or G 225 ccaactgagg tcttgccccc tgctactctc ccaaaactac tgaactggac tgctggtatc 60 atccatggag tgtttgtgag tggactgagc tgctgctgct gacctgtgaa ctgaactgct 120 gatttctaac aatgcagata ggatttgctc caaaaaacca atttctaaac aggtacactt 180 cctccatatc ctttcttttc cactacctct ggtgggtggt tggctagaag ggaggttaaa 240 gcctttacta aaaagagggt tgagaaaaaa attaaagcct acancctttt attaaataaa 300 cttttgtaat gggtaa 316 226 227 DNA Mus musculus 226 gaggactctc ctgttcttgc cacatttgac tgaagaagga caacggggtc aaggtttgag 60 gactgacagg taagttttcc tggagattca aaactgtgct tttcaacaag cattggggct 120 caaagttctg tcagtttgag ggcagcctag tctacaaagc gagttccagg actgccagtg 180 gtctgttaca cagagaaacc tgtcttggaa aaccaaacca aaaaaaa 227 227 182 DNA Mus musculus misc_feature (1)...(182) n = A,T,C or G 227 attcttgagt ttcttggggc cangaagatg acacgantag atctagacnc tggcctagcg 60 tgacctccan agtttggncc ttgcntaaag gagaaaatta atnccttcag ttgntctctg 120 acctccacat gcgtcctgta acatgggtgt atgcatacac ataaacacac atccacacgt 180 tg 182 228 140 DNA Mus musculus misc_feature (1)...(140) n = A,T,C or G 228 gaagaatttt catcaacaaa catcattttn aaagaaattn anggcgaaaa tggggcattg 60 ggnnnccntg ggggaagggg gagactgana gaatgagaat gaatnatggc caaataaata 120 aataaataaa taaataaaaa 140 229 204 DNA Mus musculus misc_feature (1)...(204) n = A,T,C or G 229 attatataca ggagtgcnta aattttgtct gttacagccn cggccattag aagctggggc 60 aaagcttttc tgcctactta actctgattt tatntatnng ttatatgtaa gtacactgta 120 gctgncttca gacactccag aagagggagt cagatctcat tacaagatgg ttgngagcca 180 ccatgtggtt gctgggattt gaac 204 230 235 DNA Mus musculus misc_feature (1)...(235) n = A,T,C or G 230 actgaggcag ggcgtgagta ctcgcctgct gccaccactg cggaaaatgg gggtggcnag 60 aagaaacaga aagagaagga gctcgatgag ctgaanaagg aggttgccat ggatgaccac 120 aagctgtcct tggatgagct gggctggcaa ggaaaggttg gggtgtgctg gctgaaggag 180 agaaaggaga gaaaggagag aaaggaaaga aggaaggaga gaaagaaaga aagaa 235 231 141 DNA Mus musculus misc_feature (1)...(141) n = A,T,C or G 231 gttgtggagg aggcagagaa tggaacgaga tgcacctgcc aatgggaacg ctcaaaatga 60 ggaaantggg gagcaggagg ctgacaatga ggtagatgaa gaagaggaag aaggtgggga 120 ggaagaggag gaggaggaat a 141 232 104 DNA Mus musculus 232 tgaggaaaga ccgggaacga gatcgggata gagaggaccg atctaaagat cgtgaccgag 60 aacgtgatag aggagacaga gaacgggaga gggaaaaaaa aaaa 104 233 740 DNA Mus musculus misc_feature (1)...(740) n = A,T,C or G 233 caggcttgac caagaacctg aagcctggtn aggatgactt ggannntgac ctgnaactgg 60 atcccatgct gncttttgaa cagagcaggn ggatggacct taatntggac ctagacttgg 120 acttggacca gncanagctg gaccctggat ctgagctgga ttctgagatc caagccaaac 180 ctgagctgga actagagtcg gagcttgaga cagatgccca gacagagcca gagacagagg 240 aagagccaga gctggagcca gagccagagc cagagccaga gacagagcca gagccagagc 300 cagagagaga gaggaagacc aggacaaggt ctcagagccc ctggcggaac tacttcactg 360 cttatcgctt tggttcttca aactcccagt ctagagctcc acctcagaca cgcccagaaa 420 agagaaagcc acataattac cccaattctc cctaaaacaa taaggatcct tggtaggtga 480 ctgcaaaatg caggctgagt atcttggcaa atcccttctg ccctacttgg catgacatct 540 agactgggta caaagccacc ggtcctggct ctgtgacccc ttcattgctg acttncttct 600 tattggattc ttgggatcac atgcccatca tatgcccang ctatgtgact tcaaggntgg 660 caantggctt ttggggtctg gcttcaggct ttgcanaatg natttttaac agatttcagt 720 gaaggcttcc tggacgtact 740 234 291 DNA Mus musculus 234 ggttccctaa aatcagactc tgtcatcggc aagtggagac tgtaacacga ctgggaccct 60 cacatgccga taagcagtca agaatatttt ctgggagctg gagagatggg ctcagcagtt 120 aagaacactg actgctcttc cggaggtcct gtgttcaaat cccagcaacc acagggtaac 180 tcacaaccat ctgtaatgag atctgatgcc ctcttcgggt gtgtctgaag acagctacag 240 tgtccttaca tataataaat aaataaatct ttttttttaa agaataaaaa a 291 235 306 DNA Mus musculus 235 agggagaaac tcactcgcca aacaacgtct cgtggtatcc tggctgactc tggccgcttc 60 agcagagcct ggctgttcct gctggattgt gctactgcta cagattcatg tttggtgttt 120 gctattgaac tgggctgctt atatcctgac acggaagagt ggaatcgccc aaagcaagta 180 cttctaatca ggtccacaac tccctttgcc tttaaccttg ctttttccct acctctggtt 240 ggtgggctaa aagggagggt taagaacccc aaataaagtc agttttgaaa aacctaaaaa 300 aaaaaa 306 236 600 DNA Mus musculus misc_feature (1)...(600) n = A,T,C or G 236 acaatctgga gcaaaagatc ctgcaggtgt tgagcgatga cggcggccct gtgaagattg 60 gccagctggt gaagaaatgc caagtgccca agaaaaccct caatcaagtc ctttaccgcc 120 tgaagaagga ggacagagtg tcctccccag agcctgcaac atggagcata ggcggggctg 180 cttctggaga tggggctcct gcaatccctg agaactccag tgcccagcct agccttgatg 240 aaagaatatt aagattcctg gaagccaatg ggcctcacag ggccctgcac atcgccaagg 300 ctctgggaat gacgacagcc aaagaagtga acccactcct gtattccatg agaaataagc 360 accttctgag ctatgacgga cagacgtgga agatctacca ctcacgtcag gaaggccaag 420 acatagtctt gccatgtagc cctggatgtc ctagaactca ccatgtagac caagctggtc 480 ttgaacccac agagatcttc ttgcttctgc ctattaaatt ctgggattaa agcaccacta 540 cacctggaaa aatatctttt aaagncngta aaataaatga acaattaaag aatgcattct 600 237 266 DNA Mus musculus misc_feature (1)...(266) n = A,T,C or G 237 gtggaactag actcttggac ttcccattta cagctgtcca ttgttgggac tagcggctca 60 ttcagcacca tggagagtgc caccatcagc cctcagcccc cacagtctga ctccctggag 120 gcctttcccc agaagagcat ggagcctgca gacatcgctg tcctagttct gtacttcctc 180 tttgttctgc ttgttggatt atggccacag tgaggaccaa acgaagacac agtgaaaggn 240 tacnttctgg cttggaaggg acatgg 266 238 459 DNA Mus musculus misc_feature (1)...(459) n = A,T,C or G 238 atctcagcgg ttctatagca cgctccagat gtcaaattaa acctcggtgt aagcggagat 60 ttcatcaaag aatctacagc tactacattt ctgagacaaa gaggctatgg ctggctttta 120 gaagttgaag atgaggatcc tgaagataac aagccacttt tgtatgtgaa agancatgta 180 atttgngtnt taagacctaa tntgnaggat gcttatgtnn nttttanaga cagatgaaga 240 aaatgtnagc ctttntggng aaaaatanta nagatgaaat cganaaaact tttggtgaaa 300 aacagagatg gctcancagn taagagngct tcctgctgtt tgagagagct tgngtttggt 360 ccagcactgt atcaggcaat gcagctgcct atagctccac atctgacttn gtacacttat 420 agaaacacat acacaaataa atctttttta aaagtaaaa 459 239 277 DNA Mus musculus misc_feature (1)...(277) n = A,T,C or G 239 gagtgatcga agaggagcca tgatggntaa acttctttaa aagaaagaac gacaaactgg 60 ctttccttga tgcctttgaa cctgagtcca gaagacttag ggacaatgga tagctaaaat 120 ttatttatat ctgaagttgg gtggcagggt gcactccaga ggcagaggca gaggcagggg 180 gatctatctc cgagtctgag gtcagcctgg tctacagatc gagttccaag acagccaggg 240 ctacaaagaa aaatcctgcc tcaaaaaatg gaaaaaa 277 240 346 DNA Mus musculus misc_feature (1)...(346) n = A,T,C or G 240 aactgaggaa ggtgacanat ctctggaaan ggngctacat atgattcnan gacaccatgn 60 ggatgctggn natgaaantg gggccctctg gaanaacann ggaagaacgg ccaatgctct 120 tagcagacga agcctctcca gcctnccctt cacaacccct agtgttatca agagactagc 180 aaaccttcan ggggtcttca actaaataat acaatgagtt ttgcctttaa agagcacact 240 gctgggctgg tgagatggct cagtgggtaa gagcaccgga ctgttcttcc gaaggtttga 300 agttcaaatc ccancancca catggnggct cacccccccc cccccc 346 241 282 DNA Mus musculus misc_feature (1)...(282) n = A,T,C or G 241 ccactgagct taaacacaac tgaagtctgt ctgtctcaag tgtattaatg acgcctgccc 60 aangtggtgg gaaagtccgt gaaactgcaa tcgggggctg gtgtgatggc tcagtggtta 120 anagcaccga ctgctcttct gaaggtcctg agttcaaatc ccagcaaccg catggtggct 180 cacatccatc cgtaacaaaa tctgatgccc tcttctggag tgtctgaaga cagctacagt 240 gtacttacat ataataaata aataaatctt taaaaaaaaa aa 282 242 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 242 gatcactaga cgggagatgc tgccaagngc cccagacggg atcaagactg caatgacaac 60 cataagatnc cctaaagcta ggacactgca aaaaaaaaaa 100 243 398 DNA Mus musculus misc_feature (1)...(398) n = A,T,C or G 243 ggtcctctga acaatctaca agaacaacta cagcngacac ctcagcgcag gaaaaccnta 60 atngntnnnn ccagcctttc aaaaccaaaa tntttaggtt ttacctttta gcatggtaca 120 ttactgngaa aacataacgg aatgcagaag aatacagctt ttagcttact ttggtgaaaa 180 aggattcaac cctgattttt gtaagaaata cccagatgtt tcttgtgaca attgctgtaa 240 aacaaaaggn aattacttaa gtggngatgc aggcctttaa tcccagcact tagaaggcag 300 angaaggtgg atctctgaaa tcaaggccag nctggtctac acagagagtt ccaagacagc 360 caaggctaca ttatgaaacc caatctcaaa aaaaaaaa 398 244 457 DNA Mus musculus misc_feature (1)...(457) n = A,T,C or G 244 agctgctggt gcttgtgctg ttcccaagcc aaagggaagg agagtgcnag gaagaactag 60 tggtggagtc ccggtatctg caatatgaca agaaagcnaa naagggtccc cctggcctnt 120 ganaaagaac atcaaagatg gcttaacctc tgtagtggct attcctgggt gtcaacttga 180 ctatatttgg gaatgaacta caatccagaa ttggaaggct caccantgac cctaatctgg 240 aggctgggag atagaagtnt ctaanctgga tcttggtatg gagatcttga ggcatagtgg 300 ctatggattc cagaanatta agacagggag atctccgagt tcaaggtcat ctgggattaa 360 aggnatggng gcacataatc tgggctacac cttctgctgg agaccatata aggacattgg 420 aagaagggag nctcactctc gctcctttgc ctgcttg 457 245 445 DNA Mus musculus misc_feature (1)...(445) n = A,T,C or G 245 actgagattg ggacaaaaca cccatgggaa ggagttacag aggcaaagtt tggagctgag 60 acaaaaggat ggaccatcta gagactgcca tatccaaaga aattaaagat ctcagaagat 120 gcctctcaca gaagccagtt gtcatcctct gaactgctct aatgaaaagc aaggaccaaa 180 ggatggctga gggccaacag ccacggagaa aatcaatcct gtcattgcga gtgggtctgg 240 acgcaccctc ttctttccag tggagccaga ggtggcacca gcttgggcta agcctttgaa 300 tgtggacttg caaggactca gccaagttgt gtctagatta ccggccaaaa gacacctgta 360 agagttaagt tgggngttgg tagttgctca cttttggagn aatttattac tanttcatag 420 ataaccaata aagagtcttt tatcg 445 246 169 DNA Mus musculus misc_feature (1)...(169) n = A,T,C or G 246 tgcggccata attgttccta ttgccaaacc aagttctgtg ctcgatgtgg aggncgagtg 60 tccttacnct caaacaagct attgtctatt ggcatcttta ttcaccattc anaattaact 120 tgggnatggg tcccaaaagc tatganccta ttccaaaact tgaaggcca 169 247 459 DNA Mus musculus misc_feature (1)...(459) n = A,T,C or G 247 tgaggtgatc cctgactaac agcgtcntca atgcntctgt cgcattcaag acatctgngg 60 ggtttctgnt ctttttaagt tttaacccnc tggnaggatg anggtttcgt cacacctgca 120 aacccgngcc gntcacggtt tctcaccgga gtggcttgnt tctagctctg gatctgtgac 180 tcatgcagaa acccaaatgg aatcatcttg cantagttga aagtgcttcc tctgaagata 240 ccaggttttc attgaggngg aagcaaggna cctgactctc aaggnnacan ngtgacccat 300 ttagaggcnt atgnntaatg tataccgnna atgctatnan gcctgtcgag atggcncanc 360 aatnaagagc actgactgct cttccagang tcctgagttn aattnccagn aaccacatag 420 tggctcacaa ccatctacaa tgtgatctga tgccctctt 459 248 225 DNA Mus musculus misc_feature (1)...(225) n = A,T,C or G 248 ccgcccacca tgggagccct ggctgtnttg gagctcacag aaaaaccgcc aactntgncg 60 acccctactt aactctggtt aaaggtgtgc accaccatgc ccggctntnc acaganaatn 120 nttattctta gcatggtagg ctcttccttc tggatcattt tattcattnt actacacagn 180 anagntttta ctaaaagact ttttncccca tttaagaaaa aaaaa 225 249 385 DNA Mus musculus misc_feature (1)...(385) n = A,T,C or G 249 actctcaaag agaaaaaggc tgtgctcacc aacntcctgn tgcgcctgcn gtcatccang 60 ggaggtagac aagagaacct ggagctttgg ggttaaattc ttttactgag gagggattaa 120 aagcacaaca ggggtggggg gtggnatggg gaaagnnnct caaggatgct gttcancatg 180 agccngacct ggatgtcnct catgatttgc gannttaant tactgcnntg acantnctca 240 cattgtgtcc tctaanaacc ggttaagccn ttgtananag ancagcacag ctggccatca 300 gagtcaccaa tcccaacgcc aggctacgca ncgaagaaaa tgagtagatg gcttgtgtgc 360 atgtttttat gtttaaataa aaatg 385 250 430 DNA Mus musculus misc_feature (1)...(430) n = A,T,C or G 250 gagcctagca tggctgtctt ctgagaggtc taccagcagc tgactgagac agatgcacat 60 aattacggta cagataattg gactaaggtc aaggacccct attgaagagt taggaaaaag 120 gtcaaaggaa ctgaagggga tgaaaggagc taccccacat gaagaccaac agcagtgtca 180 actaacctgg acccctgaat actcccagaa acaacanggn nngaacatac atggacttat 240 tcaaggcctg tggcacatat ctagcagaga acttgagtat ccccagtggg agaggatgtg 300 cccagttctg tagagactat ataccaggta gatacctggg gaggtcaccc tctcagaggt 360 aaaatggagg gaagacagag tggggaattc tgggaggggg taatgggaga tggggcaata 420 tttgggatga 430 251 351 DNA Mus musculus 251 gactgagcgt tgttgcagcc agcacatgga agcaactcag gcgctcagga ggctgagagg 60 aggaagcagc gtggaggtgg ctgaggatgg agctcggtcg gtcggatgct tgcttcacag 120 acacaaaaca acccagggct gcagagatgg cccagtcttt aagaacattt ctgttcttcc 180 caaggacctg agtttggtgc cagaatccac agctggtggt ccgtaatagc ctgtaacttc 240 aacttcctgt cactccagct ccaggggatc caatgccctt tcctggcctt cctgagcacc 300 tgcatacaca tcacagacag acagacagac atataaataa aagtaaaaaa a 351 252 265 DNA Mus musculus 252 aagaaagtct cgccaacaga tggaatgaaa tggaagagaa aatgtcaagt cttgaagaca 60 aagtagaaaa atggatcgat catccaaaga ctatgtgaac tataaattaa aaatctaggc 120 attcagggaa tctgggacag tatgaagaga ccaaatctat gaataattga tatagaggaa 180 ggagaagaaa ctcaagtgaa agccacagaa aatatctttt aacaaaaatc atagaataaa 240 aaatttcaaa tctaaagaaa aaaaa 265 253 147 DNA Mus musculus misc_feature (1)...(147) n = A,T,C or G 253 agactgagga ggaattttct cagcaaacat catttaaaag gaaattaatg gcgaaaatgg 60 ggcattggga aaccatgggg gaggggggag actgagagaa tgagaatgaa taatggcaaa 120 ntaaataaat aaataaataa ataaaaa 147 254 498 DNA Mus musculus misc_feature (1)...(498) n = A,T,C or G 254 gactgagaat ggcctacctg ctcctgtccg gctggcgaat cttaccacnt ctgnntcttc 60 tcccagagac ctcccccant cagatcagaa gtcccacctt ccntttgctg cccagctacc 120 agacattaaa tccttattan gncagaagca taancagnac nnatagncnc antncaccct 180 catactcagc nntnngctgg aacagaanta acaantgaat aacacaatng gcnaccttca 240 agtagtgcnc cccaacacac atgacaaggg tgctttgagt aggtttggcc tccatagatt 300 catgtattnc agtgcttggc cataggaatg gcactagtag gaggtatggt cttattgaag 360 aaggggtagc tttgttgaag gaagtgtctc actgtgggga tcagctttga agactcttat 420 gctcaagcaa tgcagaagac agtcccctag ctgccgtcag atcaagatgt agaactctta 480 gctcctccag caccatgt 498 255 389 DNA Mus musculus misc_feature (1)...(389) n = A,T,C or G 255 tgtgggtctc cacggcacan ggctgagtgg ngctggacng ggnggngtgc tnagtccatg 60 tcaggacaca caggacactg gtgcagcttc attctagact gaatcaccaa agagcaagca 120 cngggctgga cctaggcccc ctgcatatat atagcatgat gagccacttg atcttcatgc 180 aggtctccca aacaactgga ggnggggctg tccctgagtc tgttgcctgc ttgtggatgc 240 tgcgccccta aatggacagn cttgtctggc ctgggtggga gaagatgtgc ctactnctcc 300 tgcagggact tgatgtgcag ggggcggggg tgggggagtg acatttgana tgggggcttc 360 cccttctgtt tgagaagggg gatggggga 389 256 416 DNA Mus musculus 256 gactgaggaa ggaaatgaag tgggctagtc ttgcgcaccg gactcgacca gcaagaacga 60 cgctgcaaca ggatccttct gcacacgttt attgggagag cttgattgca gaggcgaaaa 120 gaccctgagc ccagaactgg tgctgcttat ataggcctag gagaggcgtg tctcacaccc 180 ggattggtta tgcactatgc ctcatttgca tgttcctcat ctgattggct actctctctc 240 tctgtacctc acagagcctc gttatcatac ctcatttgca tgtctcacat ctgattggtt 300 atactctcaa agcctcatta tcatgcccgg gccaggcagt gtctttgcaa aaaactttac 360 tgcatatgta cacattggtt gttgtccaaa cttatgcgtg gggggcccca caaaat 416 257 305 DNA Mus musculus misc_feature (1)...(305) n = A,T,C or G 257 ccatattaaa aatgcacatg gttaatcnga acaagggctg accattttga aggaccttta 60 tttccttgat gctcccggtc tttgtctcca ccgtctatcg tgctctcatc gaatggctga 120 gctctgtgtg cgtcacgaag ggaattcacn tntcagcacc nacacagcan cttacanctg 180 cctgtaactc cagcttcana ggacccaaca ttctcttctg gcctccgagg ncatctgcac 240 ccgtccncca ccccgncnnc atgcatagcc aagattaaaa taaanctttt tttctttttt 300 aaaat 305 258 177 DNA Mus musculus misc_feature (1)...(177) n = A,T,C or G 258 gagttgctgc aaacagctct cctggngcca agggatgctc atctcatatt tgaatcatcc 60 cgaccctcac tgagcagaca gctcccagag taacactgac tcagagagaa ggaattcgag 120 tcacccggga tatttaaaat attctagtag ccacgtagtt taacagaaag aaaaaaa 177 259 173 DNA Mus musculus 259 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tgg 173 260 311 DNA Mus musculus misc_feature (1)...(311) n = A,T,C or G 260 agatctgtcc agaagganca gggccaacct gcaaagaaga tcagaccaca cagccgtcta 60 gaagaacaga aaccagctga gctatctgga agagctttag accaactgag acactgagga 120 ggacactctc cagcctgttg agctgcctgc aggctgtgca gtgtgctaca agttcccagc 180 gttgtgagct gtcacccatg ctggggtggg cctccgggat gcagctgtct ttgagtcatt 240 tctgctccga taagtaaccc ctcacccata ttcttccaag taaccccaat aaaactcatg 300 gcttaccaag t 311 261 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 261 agtctcgaaa ttcgataagg tatcttgcna tatattcaga actctccctc ctagtgacng 60 caatgaattc gacccagaag aagatgaacc taccctaaaa 100 262 210 DNA Mus musculus 262 aggtacctga gaggaccaga agatggtgtc agatcctcgg gagctggaat tgctggcagt 60 tgtgtgttgc ctgacatcat gagtactaga aagttaactc aggtatctat ctataagagc 120 agtaagtgct cttaaccact gagcagtgtc tctaacccaa catgatagat ctgtatatat 180 aaatacatat agataggaaa ttaaaaaaaa 210 263 247 DNA Mus musculus misc_feature (1)...(247) n = A,T,C or G 263 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggntgctac 180 cnnntntcca tgccgaanga gggggatcac anatagatat agaggtgaaa ataaagatct 240 cagttac 247 264 152 DNA Mus musculus misc_feature (1)...(152) n = A,T,C or G 264 gatgtcccag gctccggaca acctgcaagc cagagacgct acagaaactg gaaccanacc 60 ctggtncnct tccagaaaga nngatngatc gaaagaatga aagaaagaat ggcaaaaatt 120 aagggtcacc cngggggctc caagcctatg ag 152 265 176 DNA Mus musculus 265 gggttccaag actgcccttt gggattcaaa cgggagccgc tttggactga ctggctgcct 60 tcctcctcct ccccctcctc ccccttctgc ttcagattta tttattatat gtaagtacac 120 tgtagcagtt gtaggacaca ctagacgagg gcaccagatc tcattgtggg tggttg 176 266 128 DNA Mus musculus 266 tcagcaaaca tcatttaaaa ggaaattaat ggcgaaaatg gggcattggg aaaccatggg 60 ggagggggga gactgagaga atgagaatga ataatggcaa aataaataaa taaataaata 120 aataaaaa 128 267 426 DNA Mus musculus 267 cccggaagca gaagagagaa gagattgaga agcggagctg caagttgtgt gtcaagcctt 60 ggccccacca tggactcctc cccgactctg ccccactgaa aacgtcacat ggttatttta 120 gcaaatggac gttcaggtag accccctttc cagcccttat cccaggagcc cccacgagta 180 acatatgaga agcttctctg ttcctttctt aaaactaact tatggggctg gagagatggc 240 tcagcggtta agcgcactga ctgctcttcc gaaggtcccg agttcaaatc ccagcaacca 300 catggtggct cacaaccctc cataatgata cctgatgcca ttttatggag tgtctggagt 360 cagctacggt gtacttaaga aataataaat aaaacttagg ggggaaaaaa accctaactt 420 aaaaaa 426 268 379 DNA Mus musculus misc_feature (1)...(379) n = A,T,C or G 268 ggctggagag atggctcagt ggttaanagc actgactgct cttccagagg tcctgagttc 60 aattcccagc aaccacatgg tggctcacaa ccatctgtaa tgggatctga tgccctcttc 120 tggtgtgtct gaagacagcg acagtgtact catataaata aaataaataa atatanntaa 180 aaagncnnan tnncatnctn nnannttnnt ggactcanct acagtttgcc tcccaaaatc 240 cagggtcaac actgcaccac tgaactgtgt cccccagggt accatcacag agaatggcaa 300 aaaatgagcc cacatatgca tgccaacaga gtctgatatt ataggcttgn tgttttggaa 360 tcttaacccc ctggatctg 379 269 390 DNA Mus musculus misc_feature (1)...(390) n = A,T,C or G 269 gccctgcaca cagacaaatg tatacattct tggagaagac taccttcttc caggtgatga 60 ccggggtggg cacagccttc acctcacagg aaaggaatac ttgagtccca gtgacattgt 120 gaatatctcg agggggcatg aggaccacgg gagctggaag acaaaggaac aaccctgtga 180 tggtttgcat atgctcagcc cagggcttta agacgctcct cctggctgcc tgaagttagt 240 attcccctag cagcctgcag atgaagatgt agaactctca gctcctcctg caccatgcct 300 gcctggatgc tgccatgctc ccaccttgat gataatggac tgaacctctg aacctgtgaa 360 caattaaatg ctgnccttat aagaaaaaaa 390 270 290 DNA Mus musculus misc_feature (1)...(290) n = A,T,C or G 270 ccagcctgaa acctgctngc tcggcgngga ggcttcctgc tcattccttc tgncacgccg 60 actgntggaa cctgaggagc cacacacgtg cacctttcta ctggaccact anataatatc 120 ggcagggaaa tctgggttgc cctccccctt acttcataan tgggnagttt caacnataaa 180 atgaagagcc ttgatcagaa aggtaagana atgagggcca gntnaagatc gnnctgatcc 240 acggacacca agttattccg nggggagaca tggctagctt agccctgctg 290 271 355 DNA Mus musculus misc_feature (1)...(355) n = A,T,C or G 271 cgagcctggg ctagaggcca tanattactt cttgaggaac tctnanangn cgagacaggg 60 aaggcaaaga acaaagaccc naaggaaann ctgcagnctg tttatgagtg tatagagaaa 120 acgtgtgaga aacttggaca gctcaatatt gatatttcca acatcaaagg tatttttatt 180 gagaattttc ctctatagtc cagctctgcc aatcccattc atgaattcat tctttcagct 240 tataataatt gagtctttat aagctgcaag cctttttggt ttttgtttgt ttgtttgttt 300 gtttgttggt gagactttgt gggaagaaca ataaacaaga ttctcagttc ccgtt 355 272 234 DNA Mus musculus 272 agccaggctg gatgaagaaa acttgaagaa gattttccgg gaggttcaga taatgaagat 60 gctttgccat ccacacatca tcagactcta ccagaggtcc tgagttcaag tcccagcaac 120 catacaatgg ctcacaacca tctgtaatgg aatctgatgc cctcttctgc tgtgtgtgaa 180 gacacctaca gttactcata tatataaaat aaatattctt ttaaagaaaa aaaa 234 273 283 DNA Mus musculus 273 cctggccctt cagaagtggc gccccgactt gtgcagcaag gtggcccaga tccatggcat 60 tggaggagat gtagtctccc ctcccccagc ctgaaacctg cttgctcggg gtggagcttc 120 ctgctcattc gttctaccac gcccactgct ggaacctgag gagccacaca cgtgcacctt 180 tctactggac cagagattat tcggcgggaa tcgggtcccc tcccccttcc ttcataacta 240 gtgtcgcaac aataaaattt gagccttgat cagaaaaaaa aaa 283 274 249 DNA Mus musculus misc_feature (1)...(249) n = A,T,C or G 274 gaggcaccct aggatacatt tccacacagg ccttgtggat gcccatctct actgcctgaa 60 gaagnacgnt gtggatttnt taatggagaa tagcagaaca gncttcctaa atgaccancn 120 ncaccttana ncncanttcg caganactat ccccagctgg cnnaagncac gcctctggta 180 gagcacaagg aggatcaaat ccccaaacct gggattaaaa tgaangcaca ttcttatatt 240 aaaaaagaa 249 275 410 DNA Mus musculus 275 actgaggtcc tactctcgct ctcccagcta ttcgtccaag tctggcaaag aggagcccac 60 ctagcagaag ctccaggtct cgtcgaagtc ccagctactc tcgctacagc cccagcaggg 120 aacgggacct aaagtatggt gagaaagaac cacagccccg agaacgtgcg cgcaggaggc 180 gacggtccta ctcacccatg aggaagcgca ggagagactc cccaagccac ctggaggctc 240 ggaggataac cagtgcccgc aaacgcccca tcccctacta ccgacccagc ccctcctcgt 300 ccagcagcct cagcagcgcc tcctcctggt acagcagcag cagcagcagc agcagcagta 360 gcagccgctc ccctagccgc agttactccc ggagccggag tccctggcct 410 276 389 DNA Mus musculus misc_feature (1)...(389) n = A,T,C or G 276 ccaattgagg ccgacttggg ttgaggtaga gctcngggca tgaggccata attacntgtt 60 gtggaactct aannggtcgg acaggaagaa tcnatgcntt aaanaaagac atcnctncat 120 tgtgatttgt tcctgcccca ccctaactga tcaatcgacc ttgngacatt ccttccctgg 180 acaatgagtc tcatgatctc cccaccctgc accttgtgac ctccacttct gcccaaaaga 240 gataaccacg tttaactgtg cttttccact gcctacccaa atcctataaa actgccccgc 300 ccctattctc cctttgctga ctcctttttc gtactcagcc cgcctgcacc caggtgatta 360 aaaagcttta ttgctcacac aaaaaaaaa 389 277 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 277 tggtgggccc acctancacg cgtgcaaaan gctccncggg tgctcaactt nttctagtcc 60 caactgcgta cgtgcgaccc acggaggcaa taaatatcca 100 278 422 DNA Mus musculus misc_feature (1)...(422) n = A,T,C or G 278 actgaggctc attctccacn aagtgctcac cngtctttgc gngggatgag agancacagc 60 gcngngnang ctnagagatt nttcatccnt cctcggaagt gctngancan catnttcagc 120 ttgtcttcct gcttgaccac gataagctac aggcagaagg cagatggtaa ggaagggcaa 180 atggtaagga agaacgcata cacgcgtatg ctccctcccc agcttccttc ctgatgacct 240 gacaagaaat ccaggactca gagcagggct actgcgctga gcataagagt acttgtctgg 300 agctggagag atgatggctc aatgggtaag agcactgact gctcttccga aggtcctgag 360 ttcaaatcct aacaaccaca tggnggctca ccaccatcct taatgaaaac tgatgccctc 420 tt 422 279 303 DNA Mus musculus misc_feature (1)...(303) n = A,T,C or G 279 aggttgtctc ggagcaaagc tcagatacga ccctggaatt gatttacaga attgccagct 60 gcccaacatg gattcttgga accanacctt tagaattcaa caaacaaacn acccaggggg 120 ctggagagat ggctcagcac tcaagagcac tgactgctgc tcttccagag gtcctgagtt 180 caattcccag caaccacatg gtggttcaca accatctgta atgagttcca atgccctctt 240 ctggtgtgtc tgaagacagc gacataaaat gaataaatct ttttaaaaac ccaaaaaaaa 300 aaa 303 280 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 280 caagactgcc ctttgggatt caaacgggag ccgctttgga ctgactggct gccttcctcc 60 tcctccccct cctccccctt ctgcttcaga tttatttatt atatgtaagt acactgtagc 120 agttgtagga cacactagac gagggcacca gatctcattg tgggggcgct tctggataga 180 ggctgtggca gaagtttgac gggcccttnn tttgcttgca agggatggga tgtgggct 238 281 339 DNA Mus musculus 281 ggcactccag ttaagagatt acctcaaatc tgaaataagg ctttggactt gtgaacagta 60 ttggaattgt tgaagaatat ggggactttt gaagttgtcc tggacatatg tttgcattat 120 aagatgacaa tgaaggctgc caggaaaact cagaaagtat tgtattacct tttgacttga 180 gttcaatccc caaagccaaa gtgtggaagg agagagctga ttcctgcaac ttcttctgac 240 ttctatagca ctcacatata tcgggcacat gcatgagtat gcacacacac acacacacac 300 acacacagat cgaaaatagt tgtaataaaa aaaattaaa 339 282 427 DNA Mus musculus misc_feature (1)...(427) n = A,T,C or G 282 gagcctctgg tgggcagtca caagcccacg gattccacca gtgaccccag gcctgctcac 60 atgagtgacg cgttcctccc catggccagc agcagagcgg actgaatgct gggtgacagg 120 ctggcctcag actccggtgc tcaaggatat tcttgcttca ggttcccaaa tagcactgca 180 cactgcacac gtgaatcccc atgcctgatg gtggatnnct gagttngagg ccannctggn 240 ntacanagtg agttccagga canncngngc tacacanatn aaccctatct tgaanaacac 300 attaacaaaa ctgacaaata aatgttatcc tttttaacag gtaatagaga atggccccan 360 ggggaccctg naaaagggac ttntaatcca tcaacatgga gcttgagtct tcttgggaag 420 aaaaaaa 427 283 327 DNA Mus musculus misc_feature (1)...(327) n = A,T,C or G 283 ctgaggggac tggagagctg aaggagcgcc agcttctcca gaattggact tctcagaacc 60 tttaatatgc taatgtgcat tgtgaatctc caagatgggg atatgatatg cagcattctt 120 gaatacttct aatgacaggg agcccactac ctcataagta aacccagaca aacagagata 180 atttaacaga aaagaaacat atatcggggg ctggagagat ggctcagcan ttaagagcac 240 tgactgctct tccanaggtc ctgagttcaa ttcccagcaa ctgcatggtg actcacagcc 300 atctacaatg tgatctgatg ccctctt 327 284 386 DNA Mus musculus misc_feature (1)...(386) n = A,T,C or G 284 agactgaggt atctgagcgt nngagtcaan ctggattggc aatngggtta gcatggactc 60 ccttgggtgg cannatnatg tttggggaan cangnttaat ggncggtgaa ngccaactan 120 cactgaccgg ncannttggg gacgtnntga aggantctgn ccatctnanc ntnagntgcn 180 ttgaaagcna tgcaaacaaa taccacctga ctaatgcttt tggaagtttt gatcttnttg 240 acaacacaga catcgtgaga tgccaggact tgnaaggnga angngngtnt cactcctggg 300 ccactgccaa ggcttangca tgaaaacttg acatgcggga ctggagagat ggcttantgg 360 ttaanagcac ttgctactct tgcaga 386 285 448 DNA Mus musculus misc_feature (1)...(448) n = A,T,C or G 285 gactgagctt ccctgggccc ccgagatggc tgctcttctg ggcgtcccct cccctggccg 60 gggccgagga cactgctgct gcgcaagagt cttcaggatg gctttggttt caccctgcgc 120 cacttcatcg tgtacccacc cgagtcggcc gtgcactgca tcctgaagga ggaagagaat 180 ggaggccgag gaggaagagg aggaggagga ggaccctccc cacggcaccg cctggagccc 240 atggacacca tctttgtgaa gaatgtgaag gaatgtggcc ccgcccacag ggcggggctt 300 cgcacaggag accggctggt gaaggtgaat ggggagagca tcattgggaa gacctactcc 360 caggtcatag gtctgatcca aaaaaagnga cnacaccctt ggactntnta ttatgcccaa 420 ggacgaagga catcctccag ctggccta 448 286 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 286 ccctcaaagc tcttgctcgc tctgngatga agattgggcg gatngaggat gtcaccccca 60 ttccctctga tagcactcga anaaaagggg gtcgtcgcgg 100 287 268 DNA Mus musculus 287 gcttaagttt aaaacactga ggagttggca tccattggaa gaccttgaga tcctctcagc 60 tcagaactcc aggaccgatg catcttccca ccaccttgaa gcactgaaac aacaagaaaa 120 gccgggcgtg gtggcgcacg cctttcatcc cagccatcgg gaggcagagg caggcggatt 180 tctgagttcg aggccagcct ggtctacaaa gtgagttcca ggacagccag ggctacacag 240 agaaaccctg tcttgaaaaa ccaaaaaa 268 288 239 DNA Mus musculus misc_feature (1)...(239) n = A,T,C or G 288 agaactgaag cccctacgat acatttncca caggccttgt ggatgcccat ctntactgcc 60 tgaanaagta cgtngtggat ttcttaatgg agaatagnga acaggcttcc tacatgaccc 120 cancacctta cancacattn gnaganacta tcccnagctg gcataagtca cgccnctgct 180 tgagcacaag gcaagatcaa atccccaaac ctgggattaa aatgaaagca cattcttat 239 289 219 DNA Mus musculus misc_feature (1)...(219) n = A,T,C or G 289 tacgacactc aaaccttggg ggttgcggnc tttggcnggn ttatggttga nnctgccntc 60 nncntcttnc tgntgtcanc attctccatg aaggagacgc cctctgaaaa aacccttgcc 120 aaccagcgca aggagatggc gaaaactcac caccagaaag gagagaagaa aaagaaggag 180 aaaaccgtgg agaagaaagg aaagaccaag aaaaaaaaa 219 290 312 DNA Mus musculus misc_feature (1)...(312) n = A,T,C or G 290 gaccatgaca tgagcagacn gtcggacagc tactaataac acctctgatg gaacgctttt 60 tgcaggatgt tctgcgacac cacccatata attaccaaga caacagatct gcaccaaatg 120 agccagaggc ggcggcagca gcggcagcag cagcagatcc tggatcacct gaagtggtgg 180 tggttttgga tgattctgat gagaaggagg atgatactgc agatagcggt gcagagagga 240 actccgagga ttcaggatct gttgaagaga tagattatag acctggtact tctcaggaac 300 acgcagaagt tt 312 291 208 DNA Mus musculus misc_feature (1)...(208) n = A,T,C or G 291 cgtcctggga gagagatcgc anaangagcc cgctcaagat ctcccacccg aagacgctcc 60 aggtctccaa gacgacatag atccacatct ccctcccctt ctcgactgaa agaaagaaga 120 gatgaggaaa agaaagaaac taaagaaata aagaacaaag ancggnggat cactgnggaa 180 gacctggagg gtaaaacaga gggcaccg 208 292 337 DNA Mus musculus misc_feature (1)...(337) n = A,T,C or G 292 acaatctctc tccttaagga acttaatcac cctaatatcg gggggctgct ggatgtcatc 60 cacacagaaa ataagcttta tctggttttt gaatttctgc accaggacct caagaaattc 120 atggatgcct ctgctctcac gggcattcct cttcccctca tcaagggctg acaagatagc 180 tcagcaggta aaagagcctg gctncaagcc tgatgacctg atggcctgaa ctccaccccc 240 aggttccaca caagaagaac acggnacttc tgcaaattgn cctctgactt ccacacatgc 300 actgtggcat gcccctgccc gctctaaata caagaaa 337 293 417 DNA Mus musculus misc_feature (1)...(417) n = A,T,C or G 293 actgaggtct gccctgctgc tgattcgtgt ttgctatccc agcactactg aactggactg 60 ctggtatatc gtggngtagc tgcaagtgga ttgagctgct gctgctgctg acctgtgaac 120 tgaacggctg atttcctgac aatgcagatt ggatttgctc caaagaacaa tttctaaaca 180 ggtctatttc ccctgtctcc caataacctt tcttttctac tacctctggt gggtgttggg 240 ttagaaggaa ggtcaaagca tttaagaaca attattaaaa ttagggctgg gaaaaatgta 300 agcatataca caatgcactg tggcatatat ggtcatgtga cacacatata catgtaataa 360 tcatgtgaca cacatataca tgtaataagt gaatatgntt ttttttaatt aaaacag 417 294 190 DNA Mus musculus misc_feature (1)...(190) n = A,T,C or G 294 tgatacacac aggcctntga ggaaattnta atatgttctg gaagctctaa agaaaagcaa 60 gagtgcctgg cagtggtgga ggacaccttt aatcccagca cttgggagga agaagcaggc 120 agatttctga gttcaagacc agcctggtct acagagtgag ttccaggaca gccagtctca 180 aaaaaaaaaa 190 295 464 DNA Mus musculus misc_feature (1)...(464) n = A,T,C or G 295 aaccctagat tcacggacat gccggaggag ttcaacatgg ncacacacga ctgtcacaga 60 cggcagattc tgaacctaca tcgtgagcgg aagatgtagc ctttctacag gacgcatcga 120 gatgcaaggc aataccgtgt catagaatgt cgtaccaccc aggacgaggg tgtccccggg 180 gccgaggagg acacggagcc agaccttcag caccagcttt cagaccccaa aacctgcgac 240 ttcttcatcc ccaacagccg cctgcgcagt atcaatatga gcctccgagc gccccctctt 300 cctcctactc gaactctcag gcccccagca ctcaggaggc agaggcataa agatctcctg 360 agtttaaggc caggtctaca gagtgaggtc caggatagcc agagccacgc ggtgaaaccc 420 tgtctcaaaa agaaccaaat taaaccaaat caaaccaaaa aaaa 464 296 389 DNA Mus musculus misc_feature (1)...(389) n = A,T,C or G 296 ctcttgtggc ctctctggac acagtatgcg catagtgcag agaaatacan cctgaaagct 60 ggncnnggtg gctgtatgcc tttaatccca gcacttgnga ggcagangca ggcagatttg 120 ngagttcang gncnncctgg tctacaaagt gagttccagg acagccagng ctatacngan 180 aaaccctgtg tcgaaancca gcatacatan nancgannga cnagaanaca gnttcaggat 240 tcttacntat aataantaaa tcttttnttc aaggatggaa ctccaccctt tacttgggtn 300 taagtatgta tggaatgttn tgataggaca tannaatagn ggncagatgt ggaaatggna 360 gggagacaaa tatacatgtg aaataaact 389 297 609 DNA Mus musculus misc_feature (1)...(609) n = A,T,C or G 297 gagccttgct gacccaggct gnaacatcac tgaaaagttc caccccaaca tgatttacaa 60 ctntgaatgc ctgcgngngt ngnggcccct gnacagtacc gngcagncag cctacaccac 120 tcaatgnaag agtcctctcc tccattgctg gnccctgatc acatggctta aagctaatat 180 tnacctttgn ttcctacgcc aaccaaaggn gaatnccaca tctntgntca catcngggnn 240 nctactgaaa actgancctt caagcttact gaccgnaaag gatgacttat cggatatatg 300 aggaagacac attctgnntg agctctgcnt gcctcttcct tgtgtaactg gttcttnttg 360 aatatcattg natggagacg ccnccatgag cattcttcaa cttccagaca gggtttcctt 420 gannagctct agctatcctg gaactatatn tgtagnccaa ggaagcctcn aacccacagn 480 gatctgnccg cctctgcttt ctgacatgct aggaataaag acacatgcca ccactaccac 540 tcancactca aataatatat ccttcttccc cctgtaattc ctttccaact cccctcccat 600 ctgaatctt 609 298 407 DNA Mus musculus misc_feature (1)...(407) n = A,T,C or G 298 tgagtgttag gagaattcat gcatccctgt gaagatgaca tcgtgtgtaa atgtaccacc 60 gaggagaaca aggtgcccta cttcaacgcc cctgtttact tagaaaacaa agagcaagtc 120 gggaaagtgg atgagatatt tggacagctt aaagattttt atttttcagt taagttgtca 180 gaaaacatga aggcatcttc ctttaaaaag ctacagaagt tctatataga cccatacaag 240 ctgctgccgc tgcagaggtt tctgcctcgt cctcctggng agaaaggacc tcccagaggt 300 ggcggcggng gcggcagggg aggtcgagga ggaggaagag gaggcggtgg ccgaggtggt 360 ggaagaggtg gtggttttag aggaggcaga ggaggaggtg ggggctt 407 299 330 DNA Mus musculus misc_feature (1)...(330) n = A,T,C or G 299 acatgacctt gcaagttccn taggnggggg gccattatca tnatggcatt aantgcacag 60 naggatccag gcgggcatag ctgctggana ngctgagagt tcnatatctt gctctgaagg 120 ccaacannag atgtcttccg ntcaactagg nggagggnct ctggangccc ncccncacan 180 tgacatactt ccttcaacaa ggccacacct tccancagga gccncctcat tggcggagca 240 tantcaaacc accacaagaa gtcagactcc caccnanggg atgaggcata agcctctata 300 actgcatgag aaataaaaga cagaggccgg 330 300 356 DNA Mus musculus misc_feature (1)...(356) n = A,T,C or G 300 ttgcctcctc actttcctgg gcattcctnc gagatctcct gcctctcaac cttngctagt 60 gctattctct gtgcctggga cgataccttt gactcatctt cgactgacct aatggagaga 120 gcttgggctt tggaggcaga gagacctggg ttcggatttt ggcttcacag cttattattt 180 ggacaagtcc tttggaaaag tatttaacat tctggagccc cagcttccta acctgtaaaa 240 atggagatga taacacctac cttgcagggt tgttgtaagg attaactgaa attatatatg 300 tatctaatgc aattaacata tagtcaataa atgacacgtc gctgtaaaaa aaaaaa 356 301 323 DNA Mus musculus misc_feature (1)...(323) n = A,T,C or G 301 tgccaggccc actgctggan cctgtggagc cacacactgn gcaccttttt actggnccan 60 agattattng gccgggaatn tgggtcccct cnccnttcct tgataactgn nngnnagnag 120 cagnanaant ggagntttga tcacgaagan gatnangaaa gaggtatnca catggccctt 180 aggctaaagt cacacagcca gctcttgctg gctgtcaaag gctcttgatt ttctctcaga 240 gcattttatt tcactttgat ttgggggaaa caaaagtgga ggtacaatca atccttgctg 300 attgtgaagg tcaaaaaaaa aaa 323 302 317 DNA Mus musculus misc_feature (1)...(317) n = A,T,C or G 302 gactgagtat tactgcgact atcaaaagta ggntgttgac atgggagaca cccgggcggg 60 caccaaggct ggattncatc acggcatgga atgagcctca ccaaggcttt tgaaaatgtc 120 cttccgnnct ggagagatgg ctcannggtt aagataaaca ccaacaactt ttccagaggt 180 cctganttca aatcccanta accacatggn ggctcacaac catntgnaat agggtctgat 240 gccttcttct ggtgtgtctg aagagagcaa tggtgtactc atatacatta aataaataaa 300 tcatttaaaa aaaagaa 317 303 175 DNA Mus musculus 303 gtagtagctg gcaaccctgt ggaccttggc gacctaatgc taacagctct gacagactag 60 tgctaacaac ttagcaacaa agcatcaaga agcctggggt ggcaggggat gggcctcccc 120 cctttataag agcagactct tagtaaactt tgggccatga ttggaaaaaa aaaaa 175 304 261 DNA Mus musculus misc_feature (1)...(261) n = A,T,C or G 304 cttcttgtgg aaatctgaan ncacggacgg gnaacactgc ctggtctcca tancaggaac 60 tacagccagg tcctctgaaa gagcagccag tgctcttaac ccccaagcca tctctccagc 120 ctgagagtgc gtgttcttat catgagaaga caaacagcag tggagttggc aagctgcctc 180 agtgggtaaa ggtacttgct gcaaggcttg cagcctgatt tcgattccca gaacccagag 240 aatagaagtc cgaaaaccaa c 261 305 322 DNA Mus musculus misc_feature (1)...(322) n = A,T,C or G 305 tccttctctt aggaggctng cttcactggg gccccctnag nnagggngtt gaaaccctct 60 gnaccccatt atttcntttn ncatncnctt tnatgcttct nttcggaaca gtcagcggna 120 gtngaaacct tnttccattn ggtcctcgtg gcaanggcag agattgctcc agcagctcca 180 cacagtatgc aagacatctt ttataattnt tgntttttga aatggggnct cactgnatag 240 ctttggctta cctgtaacat tctcttgctt ttacctcctg agtgctggga taaaaggcat 300 gnaccaccta tactcaagaa ta 322 306 201 DNA Mus musculus misc_feature (1)...(201) n = A,T,C or G 306 actgagggca ggtgagatgg ctcagcannt ataacagntt gttgcacaag cctcaggacc 60 tgagttcaat tcccagaacc catggaaaag atggaaggag agagctgact tgacaaaact 120 gtcttctgac cactgtacac ggactggagc cacggactgc attgtacagg aaaataataa 180 caatttgtat gaaaaaaaaa a 201 307 200 DNA Mus musculus 307 gttggatctc ctggaaacat gaatcacaga aaggtgtgag ctgccattcg ggtcccagga 60 actacagcca ggtcctctga aagagcagcc agtgctctta acccccaagc catctctcca 120 gcctgagagt gcgtgttctt atcatgagaa gacaaacagc agtggagttg gcaagctgcc 180 tcagtgggta aaggtacttg 200 308 247 DNA Mus musculus 308 gactgagaat gttggcttcc agagcgctga gcctgattgg caaagagagc catttctact 60 tcggtgtgcc ttcgagcaca tggtgagcag gactttcact cccttccctg cccttttctt 120 tctcctccct ttggtttttc atgacagggt ttctctgcat ggctctggct gccttggagc 180 gcagagactt aacctgcctc tgactcccat gttctgggat taaagatgtg caccgcaaaa 240 aaaaaaa 247 309 185 DNA Mus musculus misc_feature (1)...(185) n = A,T,C or G 309 agtttaactc tctggagacc ttcttgcaac aggagacaaa ggtggcagag ttgttatttt 60 ccagcgggaa caagagcacc cacatggcgg ctcacaacca tgagatctga cgctcttctg 120 gtgtgtctga anacagctac agngtactta catataataa taaataaatg tttaaaaaat 180 aaaaa 185 310 183 DNA Mus musculus 310 ggacggtgtg gaaaacaaga acagagagat atgccaagga atgctgacca taatcagaag 60 ctaaaagagg caaagaacag tctctctcct agagcctcca gaggggcctc aatatcttga 120 ttgcagactt ctgggctcca aaattttgag aagaataaat tcctcttgtt ttaaaaaaaa 180 aaa 183 311 601 DNA Mus musculus misc_feature (1)...(601) n = A,T,C or G 311 actgagggag gagtacgtag tatcccntct ccntggtcng ctacctnntt gataggaant 60 ggnnntgann gntgattnca cctgncncnc tnantggggn aacctgngga gccanncacn 120 tgcnnctttc tactgnacca gagattattn ggnggnaatc gngtcccctc ccccttcctt 180 nataantgan gnagcancaa tnaaatttga gccttganca gaagntaaaa naacacttgn 240 tgctgangag ggactgtnnt ccantgaatg ccnangtcac agagtttaga aatgcgactt 300 tcagctcatt ccttccattg ttggacaagg atcccctgcc ccaggacttc tctgtgaaga 360 tggctccact cttcaaggac ttcatgacca cctataaccg gacttatgaa tcaagggaag 420 aagcccagng gcgattgact gtctttgcaa gaaatatgat acgagcacag aagattcagg 480 ccctggaccg cggcacagct cagtatggga tcaccaagnt cagtgacctc acagaggagg 540 aattccacac catctacctg aatcccctct tacagangga gtctggcagg aagatgagtc 600 c 601 312 322 DNA Mus musculus misc_feature (1)...(322) n = A,T,C or G 312 cagtgtggac ttcccacgca ctgcngatgg tgacctgnct ggcnctgtgc acnctnaact 60 gcnggaccat nactttnagc cantgaggcc tggngaaccc atnttcaagc ttttcancgg 120 agaanacgtn ctgtatgang gggactccat tgngtaccct gtgtgnatta ntgaggcnag 180 ccantnnnga acatncctcc atggcctntg catcagctcc tgctccctga cctgcttgag 240 ttccagtcct gacttccttt ggtgatgaac agcagcatgg aagtgtaagc cgaataaacc 300 ctttcctccc caaaaaaaaa aa 322 313 289 DNA Mus musculus misc_feature (1)...(289) n = A,T,C or G 313 gagcctttgt tctctaggct caaggtgctc cagtgagtga gacaagcgag cgaaaaagca 60 gctccagaag gcctactcaa gaaaagaaga cctgggctgg tgagatggct cagtgggtaa 120 gagcacccga ctgctcttcc gaaggtccga agttcaaatc ccagcaacca catggnggct 180 cacaaccacc cataatgcga tctgatgccc tcttctggta gctctcttca cacagtgtac 240 ttacatataa taaataaata aataaataaa taaatcttaa aaaaaaaaa 289 314 313 DNA Mus musculus misc_feature (1)...(313) n = A,T,C or G 314 gcagaggcct ggctgtctct gttggtacgn gccactgctg ctgattcctg tctgctgtcc 60 tgactctatg gacctggact gctggtgtac ccatgaagtg tttgtgagta gacggagctg 120 ccactgctga cctctaaacg aaactgccga tttccagaca acacaaatgg gagttgctcc 180 aaagaacctt tctaaacagg tccacttgcc ccatatcctt tctttgccac tacctctggt 240 agatggtggg ctaaaagatg ttaaaacatt taagaaccat cattaaaaat agatttaaaa 300 taattaaaat gac 313 315 441 DNA Mus musculus 315 atggagcaac tatccgatga agagattgac catggtgctg acaaggaaga tcaggacctg 60 gataaaatgt ttggggcctg gcttggagaa tccagctcca gcattaaatc cggatccagt 120 tcttccagta tcccggagtc tcagtcaaac cactctaatc agtctgacag cggagtgtct 180 gacaccctgc caactggaca tatccgttcc caaagtaccg tgagctccat cttctcggaa 240 gcctggaagc gaggcactca gctggaagag tccagcaaga ggaccagagt tcaattccca 300 gcaccctcgt cgggcaactc aaaaccacct ataactccag ctccaaagga tccaatgtcc 360 tcttctggcc tccaaggcac ctgaacatgt gtggcataca tacacttaaa taaataaaag 420 tagattttta aagaaaaaaa a 441 316 294 DNA Mus musculus misc_feature (1)...(294) n = A,T,C or G 316 gctgccatgg cgtcacgcat cgggctgcgc atgcagctca tgcgggagca ggcccagcag 60 gaggagcagc tgagagcgca tgcagcagca ggctgtcatg cattatatgc aacagcagca 120 gcagcagcag cagcagctgg gtgggccccc caccccagcc ntcaccnccc ctgtacaccc 180 cnanacntnc ctntntgngc ctntnggctt ctctgtgctn ngtgaccccc aaatgatggg 240 aaacagtttt cttgtttaaa gaacagtaaa gccattctat atacaaaaaa aggg 294 317 219 DNA Mus musculus 317 cccaagtcct gccttcatgc caccatgctc cccactatga taagtggact acacctatga 60 aaatgtgagc aagccccagt aaaatgtctt ctttggttgt ggctcataat catctgtaat 120 gggatatgat ggactcttct ggtgtgtctg gggacagcaa caatgtactc atacaatcaa 180 tcaatcaatc aatcaataaa taaataaatg cagattcag 219 318 449 DNA Mus musculus misc_feature (1)...(449) n = A,T,C or G 318 aactgggaaa cgtaggtctg aatggagatg ggctgcagac cgagcagcta ttgtcagccc 60 gctggaactg gcttcaggcc catgtttctg acttggaata tcgaattcgt cagcaaacag 120 atatttacaa acagatacgt gctaataaga tatttgtgct tggaatatag cctggatcat 180 ctgcaagagc agtaattgca cttaacccct gagccgtctc tccacactgc atgctgtgtt 240 ttaaactgtt agtatggggc tggtgaggta atttagtggg ttagcgtgct tgctgccaac 300 caagcatgat gacccaaatt gaatcttcag gacttccatg ggtggaaagt gactcatgtg 360 agttgncctc tggtgtactt atangcatgg ggcgtgcaca tgccnacata aataaaggga 420 aaataaaatt taatcttttc ctatcttac 449 319 424 DNA Mus musculus 319 tgaatcgacc agttttgaga ggagaagatg gggacaaagc ggctcctcct cctatgtcac 60 gcacagctgt ctgggattcc tatgccacca ccacctatgg gacttccccc tctacagcct 120 cctccaccac ctccaccacc tccaccaggc cttggccttg gctttcctat ggctcaccca 180 ccaaatctgg ggcccccacc acctcttcga gtgggtgagc ctgtggcgct gtcagaagaa 240 gaacggctga agctggcaca gcagcaggca gctttgctga tgcagcaaga ggagcgtgcc 300 aagcaggcag ctgtgttaat ggagcaggaa cggcagcagg agatcgccaa gatgggcact 360 gcagtccctc ggccgcctca ggatatgggg cagctgggtg tccgtactcc tctggggcct 420 cgcg 424 320 558 DNA Mus musculus misc_feature (1)...(558) n = A,T,C or G 320 tgagcatctt gccaaagtcc aggcactccc tacacccagg gacagctcca gagaagcaac 60 ctccagatgc tccaacctcc tgggncggnc ncagacactt caactggact tgttccttct 120 gatctatcca cagaccctgg acagcaagga aagagccaac tcctaagact gaacaaactc 180 ccccatatcc attcttctag gttccctaga gacacatggc cccaaagcca gcaggaagtn 240 ggcagatatc acaatgaccc tatttctgct tcaccatcac ccctttctaa tcttttcctt 300 tttaattctg gctaagctcc gccccacagt tacctggcaa caggcaggtg tgcctgaccc 360 actataaaaa ggggccgctt gccccctcct ccctgtcttg ctcctctctt gctctcttgc 420 tttctgctac ccttcccccc accccccacc cccaancccc gngctcatgg tcaagcctct 480 tctctacttc tctctctntc tctctccctn tntctgnctt tctttgctnt actaccctct 540 aaactcccat ccccatgt 558 321 489 DNA Mus musculus misc_feature (1)...(489) n = A,T,C or G 321 gactgagggc ccacctgtct ggaaatggat cgttcttact gaacttcgca ggctgcgcag 60 tgtgcagtaa gcgggacttt atgctgatca caaacagatc cctgaaagag gaagatggag 120 aagaaatagt tacctatgac catctgtgta agaactgtca tcatgtagta gccagacacc 180 gagtatacat tcagcatcat ggatgaattt caggaatata ccatgctgtg tctgttgtgt 240 ggcaaagctg aagatactat cagtattctc cctgatgacc cccggcagat gactctgctg 300 ttctaagcct cccgtggttc tcttgtaact gtgttggctt ggtttaaaat agagcaagcc 360 tagggctgga gagatggctc agtgggtaag agcacccgac tgctcttccg aaggtccgaa 420 gttcaaatcc cagcaaccac atggnggctc acaaccatct gtaacaagat ctgactcctt 480 cttctggag 489 322 448 DNA Mus musculus misc_feature (1)...(448) n = A,T,C or G 322 tgaggagctg gtgagatggc tcagcagtta aaagcactga ctgctcttct gaaagtcctg 60 agttcaaatc ccagcaagca catggtggct cacaaccatc tgtaatgaga tctgacacac 120 tcttgtggtg tgtctgaaga cagctacact gtacttattt gtaatcataa ataaatcctg 180 ggccggccgg agctagtgga gtgtaccaga gcgagcagaa gtcctaaatt caattcccag 240 caagctgatg aagcttcggt acagctacag tatgtactca tctacataaa ataaatgatt 300 aaattcttaa aataaataaa taaatctgat tctattatna aaatttgcta ctacagntta 360 aacttctaat ggactctnga tcttagtgcc ttattgggat aaatactttg cacagatttt 420 tntncctttg gnagctatgt ctcatttc 448 323 360 DNA Mus musculus 323 gtggacatcg aggccctgtg ggtggcccta cagcgtggaa gggatgaccg agctttggga 60 catgtcctgg aaacctaagg tgctggagct agaagagact tgatagcact tcagagacca 120 tcaggctgtt tcgtggaact tccaccaaag agatgcagaa atggagactc cagagctgga 180 gagagagaga tgactcaact gttaaaagca ctgactgctc ttccagaggt cctgagttca 240 attcccagca accacatggt ggctcacaat tatctgtaat ggggatctga tgccctcctc 300 tggtgtgtct gaagacagtg atggtgtact gacatatatg aagtaaataa gtaaattaat 360 324 530 DNA Mus musculus misc_feature (1)...(530) n = A,T,C or G 324 atctgaggac cccggcgaga cgcagnggcc gccaagagct tcatcttgga catgtatgcg 60 cgcgtgtacg cgagctgcgc agagccccag gacggtggca ggaaaggctc ccgcgcgcgc 120 cgcttcttcg cacacttcac ctgtgccacg gacacgcaaa gcgtccgcag cgtgttcaag 180 gacgtgcggg actcggtgct ggcccggtac ctggacgaga tcaacctgct gtgacgcggg 240 acagggaacc ccaagcgcga cgcggtcgtg gcgaggacat acctccccct ggtggccgcg 300 cgtggaactg caggtccagg agctgccaag tggggaagcc agcccacagg gagagagtcc 360 ctgcttccta ctgggccccc aagcccagct cccctgtaat ttattccctc gcccttcttc 420 tagtttgttg gagaaaggac atgagccggg tctttaaccc cagcgctccg gaggcagagg 480 caggaggatt ttctgtgagt tccaggacca tgttttcaaa aacaaacaaa 530 325 350 DNA Mus musculus misc_feature (1)...(350) n = A,T,C or G 325 agactgaggc tgtttccctt gcaatttgtg cagttgtttg tgcatgatga gagccgncag 60 cagctcaagg tcaagttccg aactggccgc gccttctact tgcaactgcg ctctcctnca 120 gagacccgcg actgcgagtt tgnccgctgg ntgcggntgc tctaccgcct gcgattccac 180 tcgcccacct gcgcagtgcc cttcacgcac gaggacactg ctgcctgang aagaggagga 240 ggaggaggng gaggagggtc anaantcagg cgagatgagg gaggacagcc ctcagtggca 300 tcacagggtc aggatggngg ctgtttacac agngctttct gctttccagg 350 326 315 DNA Mus musculus 326 ccccctccaa ggaaacagcc cacctggaaa cctcctcctt ggaatggtgt agcctcccat 60 aagcctgaag caggctgagc caggcttgac tttgttgcca ctaaggagat cacctggggt 120 ggagcctgcc tccctggatc actctattgt tctgccactg ccactgctgc cacctgctgc 180 ctagctgttc tggagcctac acgtggtcac ttgcagctgg gctccaagaa tgatttggcc 240 gggaatgggc tttcccctct cctttataaa gcgtgtccgc cattaaaaat ttgaaccttg 300 atcagaaaaa aaaaa 315 327 422 DNA Mus musculus misc_feature (1)...(422) n = A,T,C or G 327 gaactgagga agaagatgag cctgaagtcc naacgcaggg gaattcatgt ggatcaatnt 60 gagctcctgt gcaagaaagg atgcggttac tacggcaacc ctgcctggca gggtttntgc 120 tccaagngct ggagggagga gtaccacaag gcccggcccg aggcagatcc aagaggactg 180 ggaactggca gaacggatat ttgatcacac tgtgaacctc angattgggn tatttactga 240 aantaactgg tgggctggca agatggctca ccctgtaana gtactgatcg ntctttctga 300 acatcctgag ttcaaagccc ttgcaaccac ccgtaatgag atctgacgcc ctcttctgga 360 gtgtcagaaa acagctgnag ngnacttatg tataataatt aaaaaaattt taaaaaaaaa 420 aa 422 328 294 DNA Mus musculus misc_feature (1)...(294) n = A,T,C or G 328 tgaggtgggg tctttcattg tcagcgctca tttccctgct gnaagcttgg cgnagccggn 60 nanagctgcg gggtgaacat tgagaggnac cggcatagca tccgctccgg ctcctcacgg 120 agaagatggc cgagggcgag cggcagccgc cgccaggtcc ggagttcaaa tcccagcaac 180 cacatggtgg ctcacaacca tctgtaacaa gatctgacgc cctcttctgg agtgtctgaa 240 gacagctaca gtgtacttac atataataaa taaataaatc tttaaaaaaa aaaa 294 329 460 DNA Mus musculus 329 aactgaggct ggcattgaac ttgctatgta gctgagatgg ccatgaactc atgatcttct 60 tgcctcttcc tcccaagtgc ctgggttaca ggcctgtgct actatgccca gtttgtgtag 120 tgctgaaggt caaattcagc atttccccgc ccgagaggct agcactgtgc caactgattt 180 gcatcgccag ccacaaagtg aagctggagc cctgcgtcag aagtctagtt ttataggcaa 240 ctgtcctgtg atgtcagcgg tgcagcgcgt gtgccacctt atttagctaa gcagatcgtg 300 tacttcattg ggatgctgaa ggagatgaat gggcttcgag tgaatgtggc agttaaacat 360 accttcattt tttggacttg catatttagc tgtttgaaca gagttgtttc ctttctgaat 420 ttcaaagata agactgctgc agccccatca caatatccag 460 330 495 DNA Mus musculus misc_feature (1)...(495) n = A,T,C or G 330 aactgaggtg aagcatggct aaaagcctgc ggagtaagtg gaagaggaag atgcgggccg 60 agaagagaaa gaagaatgcg ccaagggagc tcaacagact gaagagtatc ctcagagtgg 120 acggggatgc tctaatgaaa gacgttgagg agatagcaac cgtggtggta gccaaacctc 180 gccaggagaa aatgcagtgt gaggaagggc nggtgtgacg gcgcagatga ggaaaaggat 240 gacatgaaaa tggaaactga aattaagaga aacagaaaga ctcttctaga ccagcatggc 300 cagtacccag tgtggatgaa ccagaggcaa agaaaaagac tgaaggccaa gagagaaaag 360 aaacgaggga aaagcagagc aaaggccgcg aagggcctgg cctggtagac cttaaagact 420 ggcaagggag acaggcgtgg tggtgcaccc ctttcatccc agcactcaag aggtggaggc 480 aggtggatct ctgtg 495 331 445 DNA Mus musculus misc_feature (1)...(445) n = A,T,C or G 331 gttgatggga acaaacacag agacccacag ctgcacantg tgcagagact gagaaacctt 60 ggaactcgca gncctaaatg ggatgtgtcc atnagatntc tcntgctann gactcaggga 120 actctggcag aaagactgta ggagccaacg agnatgaana ctgccacacc acctccngtn 180 agatctgngt gacangttcc acagactgag gcgattgacc tcaaaagggg gaggcctcat 240 ggacccagtt gtggaactct tcggcggagg aaaaatattg agccgtagnt ctcatggcaa 300 tatatctgtt ttgnttnctn ttattccttt tcttatttac atgtncctgg nagctgaggc 360 caaggtctta agcgagaata atgggtanta aaccatccnt anagatgggg ccactancat 420 gancttctnc ccagggaatc aaagc 445 332 382 DNA Mus musculus misc_feature (1)...(382) n = A,T,C or G 332 actgagccta aattgtatag atctgtgatt gaagatgtta ttaatgacgt acgagnacat 60 ttttctggat gacggagtgg atgaacaagt cctgatggaa ctaaaaactt tgtgggagaa 120 taaactaatg cagtctaggg cagtagatgg atttcattca gaagaacagc agcttttgtt 180 gcaagttcag cagcagcatc aaccccagca gcagcagcat caccaccacc accaccagca 240 ccagcaagcg caacctcagc aaacggtacc tcagcaagca cagacccagc aggtcctcat 300 tcctgcatcc cagcaaggtg agaaggctgg aggtccctgt tgtgccttac aagttacact 360 tgtcttttga aagtaaaaaa aa 382 333 382 DNA Mus musculus misc_feature (1)...(382) n = A,T,C or G 333 tcatctacaa ccacatcacc ttctncatca tgatcctcta cctnactgaa gctgantcca 60 cagtgctgcc tgatccaana ttgtcatcgg aggaggctga accgtttcac cccntgcggg 120 nganactccc aggcngnact catcgtanct ggnaccccat cggggatatg ccaaacacac 180 tggcagttct cctcaaacgt gacaccagca gncttcaccc agcannaaga ccaagcagcg 240 ccactccaga acgcagagcc ccctccaggc cttctcccag attacctgat tttgattnaa 300 ctttgggaag gggnatctgt ctaaaanaaa atcntccatt tcatctagat tttccagttt 360 tggcnaatat aggcttttat aa 382 334 222 DNA Mus musculus 334 cgggcagcga tgatgtgacg aacgcagggt attctgcagc caattctaat tcaattttcg 60 ccaactccac gggtttctct gtagccctgg ctgtcctgga actcactttg tagaccaggc 120 tggccttgaa ctcagaaatc tgcctgcctc tgcctcccga gtgctgggat taaaggcgtg 180 ccgccatcac gccagcaaat aaataaatct taaaaaaaaa aa 222 335 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 335 ggaactcact gcgtanatng ggctggcctt aaactcactg anattngtct ttntcctgcc 60 tgctgaaatt aaagtngngc gtcaccctga aaaaaaaaaa 100 336 100 DNA Mus musculus 336 tgaacaagaa gatgtccacg tccaagagga aagccaggat gggcaagagg aagaagtcac 60 ctgttgaaga tgttggacag agagagtcag aaaaaaaaaa 100 337 483 DNA Mus musculus misc_feature (1)...(483) n = A,T,C or G 337 actcctctga gagacttgca gcagttggat ttagccgggg caccgtgtga gcagtgacgg 60 atggctttac ttcatgaatg tgtttgagaa tctgaagcag ttagtgtttt ttgactttag 120 cactgaggag ttcttaccgg atgcagcact ggtgaggaaa cttagtcaag tgttatccaa 180 gttaactctt ctgcaagagg taaagctcac gggctgggag tttgatgact atgatattag 240 cgctattaaa ggcaccttta aactagngac tgcttaatgc acctgtgcca ccaaatactc 300 caggactccc tcacttccag caaatcatta aaagctacgc agaagtgggg ccacagagct 360 ggctcagagg ttaagagcac tggctgctct tccagaggac ctgggattga ttcgcaccac 420 ctacaaggtg gctcacaacc atctgtaact ccagttccag ggggatccaa cattttctga 480 tct 483 338 406 DNA Mus musculus misc_feature (1)...(406) n = A,T,C or G 338 gattcttcga cttcacatcc acagctgccc attgttgggt tagctggact acaaattggc 60 actgtctcca gtccgctgtc ccttcctaac agaggcacct gttcctggtg gcacagttcc 120 tggtggcatt cagagtgcca gggaaagcaa caggaggagg aagaggggag caggtctgag 180 aagcagaagc gcatctggtg gtgaccatcg ctaggaagag aaggaggcaa ggatcggncc 240 aggagaaatg atgtccaaag tcaaacnagt catacaagat ctcactgtgg agaaagacaa 300 aggnggggag gcctccagac ncagtgaaga anaatcccac cttctggaaa gaggnanaga 360 ccaagaatcc tggaggttat gtcaaangga aagtcaggcc gacttg 406 339 253 DNA Mus musculus 339 tttgagccct gaggcctggt gaacccatct tcaagctttt cagcggagaa gacgtactgt 60 atgaggggga ctccattgtg taccctgtgt tcattaatga ggcaagccag taaagaacat 120 ccctccatgg cctctgcatc agctcctgct ccctgacctg cttgagttcc agtcctgact 180 tcctttggtg atgaacagca gcatggaagt gtaagccgaa taaacccttt cctccccaac 240 ttaaaaaaaa aaa 253 340 379 DNA Mus musculus misc_feature (1)...(379) n = A,T,C or G 340 tgagtggcag cccagcagca gcagcagcag cagtgggagc aggaacagca gtaacaacag 60 caacagcagc acagccgcct cagagctttg gctcctgagc cccctgtggg ctgaaggcat 120 tgcaggtagc ccatggtctc agaagaagtg tgcagatggg attaccgtcc acgtggagat 180 atggaagagg accagggatt ggcactgtga ccatggtcag ctgggggcgc ttcatctgcc 240 tggtcttggt caccatggca accttgtccc tggcccggcc ctccttcagt ttagttgagg 300 ataccacttt agaaccagaa gatgccatct catntggaga tgattgagga cgacacagat 360 agctccgaag acgttgtca 379 341 303 DNA Mus musculus misc_feature (1)...(303) n = A,T,C or G 341 tatgctagtc actctcctaa ctgtaaatca acactaagag cactagaagg ttaaaggtca 60 aggagactct cacaaaggat ccaggaatct ccagattgat ttccagaatg gttgaccagt 120 ttgcaattcc acaagcaatg gaggagtggt cctctttctc cacatcctgg ccagcaagtg 180 ctngtcacct gagtttttga tcttanccat tctgattggn ggaaggtgga atctcantgt 240 tgctttgatt tatatttttc tngatcacta aagactttga acatttcttt tgaaaaaaaa 300 aaa 303 342 376 DNA Mus musculus misc_feature (1)...(376) n = A,T,C or G 342 gactgagtac cgttccccag ctgaagagtt ctgaatccac gccggatcct tctcaacagt 60 ctgttttacg ggaaccttta ttaaccactc cttccccgtg atgcagttct gaatcctccc 120 tgtagcaggg ggtcttcgct cgtgcctgaa agatgtttct tgtcccgggt ctcagcacca 180 cttgttgcac gcgcccccaa ctcgccagca agaacgacgc tgctacagga tccttctgca 240 cacgtttatt cagtcctatt tctttcttgt ntatatctcc cttgtttata tctcccctgn 300 ttatatcttc cttgtttata tctcccaata ataacaatcc tctctcgaat aataatcctc 360 cctctaagaa aagaaa 376 343 440 DNA Mus musculus misc_feature (1)...(440) n = A,T,C or G 343 tatctcacac cacagctatg caatacctag gaanangata ctgatcgcct ggaactangg 60 aaacaagtgc ganagntnng ctnanngtaa atntacttan gnctanagga nccctcgggc 120 gagctatacc tggactcctt ggtggngatg acagacgaca ggctgattgg ntgctagcca 180 ggaccacnct tctccttgtg ctggttctnc tccaaactgc nacttaatgc acctgcaatg 240 aaaanggccc cacaccagta accagatgct gcantgagcc gntttatttt gctattacaa 300 ctgggcanat nagacaattt taagccangt ggnggngatn tatgtctttg attctagcac 360 tcaggaggca gaggcaggtg gatctattga gttagaggcc agcctggtct atagagtgag 420 ttccaggaca gtcctgtgtt 440 344 428 DNA Mus musculus misc_feature (1)...(428) n = A,T,C or G 344 ttgctagggg tggagcttcc tgctcattcg ttctaccgcg cnnactggtg gancctgagg 60 agccacacac gtncaccttt gtnctggann aganattatt cangagggaa tcgggncccc 120 tcccccttcc ttnataanna gttgncctnn cannngantn nganccttga tcagantact 180 nacanaaaga aagactgntn gnnnaaaaat ggctgttacc ttgagaagaa ttttggatgc 240 ccaggctggt gaanaaggga ctgacantgg accatcttcc tagaactccc anctaaatac 300 ttnaggacac atcttntgga atgnatttna cttttgaggg ggagggagaa attgacttat 360 tgattcctaa attctttgca ggatcagaan gncngccttt gttacagagt naacacagaa 420 ccaacact 428 345 325 DNA Mus musculus misc_feature (1)...(325) n = A,T,C or G 345 gactgagatt gacaattgcc ttttttgcac tctctgggct ggatatgctg gactccttgg 60 atgtggtgaa caaagacgat ataatagagt ggatctactc cctgcaggtt cttcccacag 120 aagacagtga actanataat nnggtgcttg ctcanagnna tnnattgnat ggatnncacn 180 accnnnaatg gnggagccan agaaagnagc caangngctg aaggngtctg cntccctata 240 ggtcnaacag anagtgcnaa ctaaccanta cccncanagc tngtgtatct agctgnatat 300 gtancaaang atggcctagt cggcc 325 346 391 DNA Mus musculus misc_feature (1)...(391) n = A,T,C or G 346 agactgccct ttggtattca aacgggagcc gctttggact gactggctgc cttcctcctc 60 ctccccctcc tcccccttct gcttcagatt tatttattat atgtaagtac actgtagcag 120 ttgtaggaca cactanacga gggcaccaga tctcattgtg ggnggttgag tacnnccnng 180 catngcngnt agggncgatn ggnactcagg gataanannn ntgactagct cttggctntn 240 anccggaana tacantatgt gcnggctant gcacttcata tattaaggca atgaatgatc 300 cnntcatggn acgacagtct gccctccctc ctttttgagc cattttccct ctttcaccat 360 atactcaata aaataagtaa atgaaaaaaa a 391 347 294 DNA Mus musculus misc_feature (1)...(294) n = A,T,C or G 347 gactgaggat aacgcgtatg gagtgaaact ccccnctgca gggttgcctg ttagcttcct 60 gaggtctcag cggagatatg gactgtggga gtgacacttc anggactggg aggctgtggc 120 cttgctggca gaagtgcatc acagggacag gcccagtagt ttctctccag tctcctctcc 180 agcactactt ccgtcttcct gccacaatgt tccctgaaat gaagataatg aactgaacct 240 tagaaattgt aagccagccc caattaaatg tttccattta tttaaaaaaa aaaa 294 348 432 DNA Mus musculus misc_feature (1)...(432) n = A,T,C or G 348 actgaggtga tgtacaactt tttgacctcc agaaaagctc acagcaaacc cacagtttct 60 ataacacaaa cccaagatgg aagtcctgtc tactgtctcg agtttaacag ccagcagaca 120 cagctcttag ccgctggtga tgctaagggc atggtcaaag tgtggcagct gagcacagcc 180 ttnacagaac aagggccccg ggaggtggag gacttggatc agntanaanc agaaatcact 240 acctgagggc tggtgagatg gctcagcggg taagagcact gactactctt ctgaaggtcc 300 tgagttcaaa tcccagcaac cacatggtgg ctcacaacca accgtaatga gatctgatgc 360 cctcttctgg tgtgnttgaa gacagctaca gtgtacttac atataataaa taaatctttt 420 taaaaaaaaa aa 432 349 462 DNA Mus musculus misc_feature (1)...(462) n = A,T,C or G 349 cctttattaa ccgctccttn ccangatgca gntntgaatc ctccctgtaa nnataggggt 60 ctttgctcgt gcctgaagat gttncttgtc ccgggtttcn gcaccacttn ttgcgcgcgc 120 tcgactggcc angaagaacg acgcttcaac aggatccttn tgcncactgt ttattgngag 180 agcttnattg tanaggcnaa aagacttttt gcccagagct ggcgctgctt ttataggcct 240 aggagaggcg tgnctcatac cctgattggn tatgcactaa gcctcatttg catgttcctc 300 atctgattgg ctactctctc tcagtacctc acagagcctc attatcatat cncattngna 360 tgtctcacat ccaattggct actntattag naccttacag aanctgatta tcatgcctgg 420 gccaagcagt gtttttgcaa aanncttttc ctgcatatgt at 462 350 335 DNA Mus musculus misc_feature (1)...(335) n = A,T,C or G 350 aagagcccac tcccacccgc tcaacacaac cctccacatc agcatgttcg aagtggtcca 60 agagcactcc aacagggagt ctgacttgtt ctttttggat cttcagacag ctccgatctg 120 gggacgaggg ctggctggtg ctggacatca cagcagccag tgaccgatgg ctgctgaacc 180 atcacaagga cctgggactc cgnctctatg tggaaaccgc ggatgggagg gagatgtagt 240 ctcccctccc ccagcctgna acctngcttg ctcggggngg agcttnctgc tnattcgttc 300 tgncacgccc actgctggaa cctgaggagc cacac 335 351 262 DNA Mus musculus 351 agatgggccg agagctgggg ggtgcgccca gacgcctcgc cagccaccag tctgagttgg 60 tctttcgaag cagtaggaac ctgtcacctt cagccagaga cacctgccgg ccatctgccc 120 cagtgtcctg agttcaaatc ccagcaacca catgatgact cacaaccacc tgtaatgaga 180 tctgatgcac tcttctggca catctgaaga cagctacaat gtacttacat ataataaata 240 gataaatatt gaaaaaaaaa aa 262 352 161 DNA Mus musculus 352 tggcccaacc aaagtctttt ggataaagca ccacaatgga caatgtaagg aaggcagcca 60 aacgcttacg cttcccaagg cacagatctt tcccagcatg ggaaagatcc tccctccctc 120 cctccctccc tccctccttc caccatacac tttattaaaa t 161 353 526 DNA Mus musculus misc_feature (1)...(526) n = A,T,C or G 353 gactgagtgg ataatcttcc tgtcctacac ctgaccaagg catcccctaa aagccccagg 60 gaggctggac catggtacaa gaactgcctt catccatcac cgtgagcaag tgtggaagag 120 atgcatcaat gtttggnnag ncatagccca cttntggctt accataggcc atgngctacc 180 gancctgntt ngggcatctn ttgaatggct gcttattgca gtntgtgcct tcatattncc 240 acaaancata ttatcgnnat ccatttttat ngtaaaactc aagggtgtac canaaaccta 300 atttatccct aatagctngg cttgatttta caaacctgct ntcagcaccg acctcatttg 360 cttttatctg aagctcagga aagttaggaa aaggntgaat tgattcgtta atatgtagga 420 catgtanccg ggcgtggtgg ctcacgcctt taatcccagc actccanagg cagaggcggn 480 cggattnctg agttcnaggc cagcctggtc tacagagtga gttcca 526 354 311 DNA Mus musculus misc_feature (1)...(311) n = A,T,C or G 354 gcccaagtgg atgcagganc ccgggcagcc agaangggtt ggtatctcct ggaancatga 60 atnacataaa ggtgtgagcn gccatncngg ncccagganc tacagccagg tcctctgaaa 120 gagcngacnn tgctnttaac ccccaagcca tntntccagn ctgagagtgc tgnnntctta 180 tcatganaag acaaacagca gtggagttgg caagctgcct cagtgggtaa aggtacttgc 240 tgccaaggct tgcagcctga tttcgattcc cagaacccag agaatagaag tcgaaaacca 300 aaagaaaaaa a 311 355 212 DNA Mus musculus misc_feature (1)...(212) n = A,T,C or G 355 tgaggtgacc cgaatggagc tgtggcccgg ggccnggacg gcgctgctgc tgctgctgct 60 cctgctgctg nccaccctgt ggttctgcag ctccagtgcc aagtatttct ttaagatggc 120 cttctacaac ggctggatcc tcttcctggc gatcctcgca atccccgtgt gtgctgtgcg 180 agggcgcaat gtcgagaaca tgaaaaaaaa aa 212 356 233 DNA Mus musculus misc_feature (1)...(233) n = A,T,C or G 356 tgaggcattt tgtgaaagaa ggaagatcct gtctgctgca tggataatgg actggaacac 60 agaaagacca tgcagggttc ggctgtagaa ggccggtatc tccanaggcc agaagacacc 120 atcagatctc ctgngactgg agttatagag gttgtgagct gccatgttga accaancagg 180 tnactgaggg acacaggcat gtggatggaa accctgctgg gagaaaaaaa aaa 233 357 225 DNA Mus musculus 357 agagttctga atccacgcca gatccttctc aacagtctgt tttacgggaa cactttatta 60 accgctcctt cccagtgatg cagttctgaa tcctccctgt agcagggggt cttcgctcat 120 gcctgaagat gtttcttgtc ccgggtttcg gcaccacttc ttgcgcgcgc ccaactggcc 180 aggaagaacg acgctgcaac aggatccttc tgcacaaaaa aaaaa 225 358 305 DNA Mus musculus 358 aagggcattc agatctggga gaagtggccc cagaagtaaa accttcagac agccaaacat 60 ctgtggcaat tgcagatttg gaatggagag aaatggaagg agatgactgc gggttccatt 120 atggagatgg tacaaacgag gctcaggaca atgacttccc cacaggtcct gagttcagaa 180 atcctggcaa ccacatggtg gctcacaacc atccttaatg agatctgacg ccctcttctg 240 gtgcatctga agacagctac agtgtactta gatataatag taaataaatt atttaaaaaa 300 aaaaa 305 359 273 DNA Mus musculus misc_feature (1)...(273) n = A,T,C or G 359 actgagtgca tggagctgtt tgagaagaca gaggatgtgc ccttgttgga ggagatgtgt 60 ccctggggga aggtcttgaa acttcaaatg cccactcact ccattctcag cacctctctt 120 cctcatgtct atgaatcagg atgggaagtt ctcagctact gctctagcat catacctgcc 180 tgccagatgc cgtgctccct gccatggatg gtcatgaact caccctttaa aactgnaagc 240 cctcaataaa gtctttcttc tacaaaaaaa aaa 273 360 231 DNA Mus musculus misc_feature (1)...(231) n = A,T,C or G 360 tgcaggctgg ttagaatgaa caggacacgc ccacacccac agtactgtac cttnatattc 60 tcgccatcca gaaggtctat gaagccatca tcctcatcgg acaaagtggc ttttacaggg 120 tttcttcctg gagccgtgac tgtcctggac ctcagtctgt acaccatgct gcccttgncc 180 acctgcctgt ctcccaagtg ctgggattaa agatgtgcaa cccccacaaa t 231 361 231 DNA Mus musculus 361 agcatgaaat cgggcagcga tgatgtgacg aacgcagggt attctgcagc caattctaat 60 tcaattttcg ccaactccac gggtttctct gtagccctgg ctgtcctgga actcactttg 120 tagaccaggc tggccttgaa ctcagaaatc tgcctgcctc tgcctcccga gtgctgggat 180 taaaggcgtg cgccatcacg ccagcaaata aataaatctt aaaaaaaaaa a 231 362 460 DNA Mus musculus misc_feature (1)...(460) n = A,T,C or G 362 tcggctttgg gatgggttgc gacggaggca ccatccccaa naggcacgag ctggtgaagg 60 ggccgaanaa ggtcgagaag gaggccagaa gaaagcatcg gacccccggg agctggagct 120 acaggttttt gtgagccatt aatcttggct gttagaacca aattcggatc ctttggaaga 180 gcagtacaca ggcttaacca cggagccatc tntccagcct gaactttgtg tattaaagtc 240 tccccaaacc attccccctt gtgaagtcac acccttntta aactatatna gctcttagca 300 ctctgaattg gtggttgagc ccagctgatg gtcacgtgac tgcaagctcc tcctggtgaa 360 ctctgtgcac tgnttttctt ncagaactag cacagtttct gccacagtga atatttttga 420 ataaatgcgt gggcnttctg taaatcttac aaaaaaaaaa 460 363 100 DNA Mus musculus 363 cctcattggc tctagtggct cctccccgag ccggaccagc ccggagtccc tctacagtga 60 cagctccaat ggcagcttcc agtccctgac tcaaggttgt 100 364 266 DNA Mus musculus misc_feature (1)...(266) n = A,T,C or G 364 tattgattct gcctcccaac aagacaanct gaggaagtga tgagccacgn agccgnngac 60 ccttanagtt ttagatgngc ggatcccttc atgtatactt tacagaaaac catgntaagc 120 cgggcgtggt ggcgcacgcc tttagnccca ncactctgga ggcagaggca ggcggatttc 180 tacaaagtga ggccagnctg gtctacaaag ngagttccag gacagcccca gggctataca 240 gagaaaccct gtctcaaaaa aaaaaa 266 365 520 DNA Mus musculus misc_feature (1)...(520) n = A,T,C or G 365 tgacgggaat ttgaaccccc atggccccga tgacagcatc attgtacttg atgatgacga 60 tgaagatgaa gctggtgntc aaccagggcc ctccaaccta ccccccaatc ctgcctcaac 120 aggacctggt cctggcctgt ctcaacaggc cactggtctc tccgagcccc gtgtggatgg 180 agggagcagt aactccggta gtaggaagtg ctacaagttg gataatgaga agctctttga 240 agaggtaagc ttttgagata aaagggtcgc cctttgtggc ccatgctggc cttgaactca 300 cagagctttt acttgcctca gcctcctgac agctaggatt aaaaatgtga accactgggc 360 aggagagatg gttcagcggt taagagcatt gagcatccag aagtcctgag ttcaattacc 420 accaaccaca tgatggcgtg gctcacagcc gtctgtaata ggatcttgat gccctcttct 480 ggtgtatctg aagacagcta cagtgtactc atatatagaa 520 366 346 DNA Mus musculus 366 caggcggtgc taaattttgt ctgttacagc ctcggccatt agaagctggg gcaagctttt 60 ctgcctactt aactctgatt ttatttattt gttatatgta agtacactgt agctgtcttc 120 agacactcca gaagagggag tcagatctca ttacagatgg ttgtgagcca ccatgtggtt 180 gctggggatt tgaactctgg accttcggaa gaacagtcgg gtgctcttac ccactgagcc 240 atctcaccag ccccatatat gtcatttttc tgttcccaca ttctctgtaa gattattgtc 300 ataagttaaa atctgaatta aagcatttga atgtcaaaaa aaaaaa 346 367 487 DNA Mus musculus misc_feature (1)...(487) n = A,T,C or G 367 ctgaggttga gaacatttcc aagctctgac tacaacatta aacctcagaa tggaagagat 60 gggaagtcgc atcgaggact tacagagaaa cgtggatgac ctcatgactc aggccgggat 120 cgagaattct atcaaagaac cagcgacctg aanatgttaa acngagtcac gtgggattgc 180 taaaacaaaa actacaccat acgtctgagt aataataatc tatgcagtat gaattntgat 240 gttcatttaa attttttttg gacacttaaa attaaaccca gggcctaaac tataggcaag 300 tggctaccaa cgagctatac cctaacccac tgaaaactaa aattcacttt aacaaatgaa 360 gaacaaagct gggccataat ggcacatgcc ttcaacccca gcacttgggt ggcagaggca 420 tgcagccagt ctggcctaca gagggagttc caggacagcc agggctacac agagaaaccc 480 tgtcaaa 487 368 150 DNA Mus musculus misc_feature (1)...(150) n = A,T,C or G 368 gcacctctgg aggtggaagg aagaggatca ngaagttcaa ggccattctc agctatgttg 60 gcagttcaag accagccgga gcttcatgaa accctgtttt aaaattaatg aaataaaata 120 ataaaataaa acaagattta aaaaaaaaaa 150 369 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 369 ttccaaagtc tgaccaatca ttgcaccagt cgagctgaca nccagtgctg gctgtttgcc 60 tgtaccacta ttaaaaaata attcagttta aaaaaaaaaa 100 370 394 DNA Mus musculus 370 aacagcggac acccagagag ctaaatgtct cctaccggct aagacaagga aacccactca 60 gatcgacctc tcgtggatca aacagactct atccaggtaa gtacacctgc caatcactaa 120 gttcctgtag gaggctgtag cctccccttt aggctgcccg agctgcacct taaagatggc 180 gcctgccaga tgcagagctg gtggtgtaaa caagtccata ttcggtggag acgtgcccct 240 gccgccctga ttggctgaag ccatgtacct ggtgaggtga cgtggcctgc cgtgagtgga 300 tgggggctga gagtatataa gagtgagagg cccggggttc gagggagatg aagactgaaa 360 atggctgaat aaactgctga tagaagaaaa aaaa 394 371 321 DNA Mus musculus misc_feature (1)...(321) n = A,T,C or G 371 aacatcttac ctccaagaac tgcttcagac gtatgaaaga gcccatctgg nctgagctng 60 tgatggcttc aattctatnt agngganaga cngagagact tgtgantacn tcctntgagg 120 aatctcaaca ctccatcang ngangctcac tggttaacan caccgactgn tcttccaaag 180 gccctnagtt caaatcccag caaccacgng gggggctcac aaccatncgt aatgagatnt 240 gacnccctct tntggngtnt ttgaagacag cgacagtgtn ctcactataa taataataaa 300 taagtcttaa aaaaacgaaa a 321 372 247 DNA Mus musculus misc_feature (1)...(247) n = A,T,C or G 372 tcacctgtag gctgtcttca caacacntcc agaacaggga gtcanatctc attacngatg 60 gntgtgagcc accatgtggt tgctgggatt tgaactctgg accttcngaa gaacagtcgg 120 gtgctcttac ccactgagcc atctcaccag ccccatatat gtcatttttc tgttcccaca 180 ttctctgtaa gattattgtc ataagttaaa anggggaatt aaagcatttg aatgtcaaaa 240 aaaaaaa 247 373 400 DNA Mus musculus misc_feature (1)...(400) n = A,T,C or G 373 gctaaggcag ttacattcgg agttccgcgg actcttcaga ggctgtaaaa atgccggagt 60 cacgaaagcc tgcaaagagc tgttgcttgc cttgctgctg ctgctgctac tgccgtccct 120 gcccgtgctg cagctgctac tcctgctgct gctgctgctg cttgttgctg attgttgcgg 180 ttgctggttg ctgtttactg tttgctgccg gctggagngc tggattgctg attgccagtc 240 ggcgaaatcc tggcgatgaa gatccaactt gccccaagaa acaagacgac cctaagaagt 300 agtctaatga tttcaatacg ccctttcccc ctctgacctt tctctcttac cttatgctgg 360 gggattggaa gggtggcana aaaaagaacc caataaagta 400 374 259 DNA Mus musculus 374 aactgaggat cggctcctgg agcaggacag cctctgtggc ctcactggcg ctgctttggt 60 ttctgggact tccgtggacc tggagcgcgg cggcggcgtt ctgtgtgtac agtgggtggc 120 ggcggctggc gctttctgcg tatcgtctgc aagacggcga ggcgagacct ctttggcctc 180 gaactcagaa atcctcctga ctctgcctct gcttcccaag tgctgggatt aaagacgtgc 240 gccaccacca aaaaaaaaa 259 375 205 DNA Mus musculus misc_feature (1)...(205) n = A,T,C or G 375 catgatggtt gtgagccacc atgtggttgc tgggatttga actctggacc ttcggaagag 60 cagttgggtg ctcttaccac tgagccatct caccagcccc tcaacagatt tctgatcngt 120 gagaaaagac tggaacatag atgctttctc tcctacggcc tgaccttcag ggtgacaacc 180 atctctgaac tgaccgggaa aaaaa 205 376 275 DNA Mus musculus 376 agcacgacag agtcacctgg gagaaagaca tctggagcac atcgatttga ggtgggaaga 60 tcagcccact gtgggtggca ccatcctgta ggctgggaaa ctgcattgtg ttaaatgaag 120 aaaggatctg agcagcaatg cgctcatcgt tgtttcctga ttgtgggcaa ccagctgctc 180 caagctcctg ctactctgac gacttcccca ctgtgatgga ttctaacctt gaaccatgaa 240 ccagaataaa ccctttctcc cttcaaaaaa aaaaa 275 377 182 DNA Mus musculus 377 aacgacagga aaagacctgt ggtatatgaa actttgttga caagagagga tccagagact 60 ttaaaagcaa aactctgctg ggcatggtga ctcctgtctg taattccagc acttggcagc 120 ccaaggcaga tggaggagga tcagagttca gaaagtgaag caaattaatg gaaaaaaaaa 180 aa 182 378 215 DNA Mus musculus misc_feature (1)...(215) n = A,T,C or G 378 tgtcttgcat cgtggttata gaccaaggga ataaaacaag atcttataaa taggctgcag 60 gcctatcttg aagaccatgc agaagaagaa gcanatgaag angatgtact gggagatgan 120 actgaggaag aagaaccann gcccatanaa ctgcctgtta aagaggaaga ncctcctgaa 180 naggctgttg atatggcatc ggaaaagaag gtggt 215 379 315 DNA Mus musculus misc_feature (1)...(315) n = A,T,C or G 379 catggcttcc tgtgcgtgct tggcaactng acagnaatct anagtcatct gngaagaggg 60 aacctnaatt ganaaaatgc ctccaccaca ccggactaag ngggcnagan catctacctg 120 ctgctgctgc tggcgacggc ancancanca gcnttgtttg ctatcatcag agcccacctt 180 ctttggcctt ncaatgtgag ctaaagacca gnagntctcc agaaagtgtn tncaagnttg 240 ggggncnagn ctggggntgg tggngngcnn aagctggtgg gggggggngg ntgggggggg 300 gggggggggg tgcgg 315 380 384 DNA Mus musculus misc_feature (1)...(384) n = A,T,C or G 380 aaatggcaat tcagcaagct gataaactgn angaanaaac acactgatct tcantgtcgc 60 gnaggttctc aaggccattg gtttacagag aactggcaag cacagaagta aagtggaaaa 120 tggctttaca agttatgttt ggccttaaat tttttctagt gttagaagcc cttttgttcc 180 ttttcacatg ttatatagtg cttaagatag ggnngaaaat tctagaggaa attcaggaca 240 gtctatcaga agtaaagcgg ggagagagag taggagcaag gagaaacggt aagtatacag 300 gcctttccaa gggtcttgaa cccgaggaaa agttaaggtc aggtaggaat acctggggag 360 agattagaag gaagaaaaag aaaa 384 381 100 DNA Mus musculus misc_feature (1)...(100) n = A,T,C or G 381 gggaaaaggg gacggttttc tgaagttatg aagatgcaga gnctgagaga tggganttac 60 tatgcgtgca nacaaatgaa gcagcacttt gaaagtattg 100 382 199 DNA Mus musculus misc_feature (1)...(199) n = A,T,C or G 382 gactgaggat gtcctaactt caggnatgga aggaaggaaa catgatgcca tattgaagag 60 gttttgtctt tgtttcaatg ggagaagaag agctacggat accatcaaat taataaagat 120 tagatttggc caggggagac ctcctgaaaa tcttggctac agacatgaag gaaaaaattc 180 aagaagacca aaaaaaaaa 199 383 234 DNA Mus musculus misc_feature (1)...(234) n = A,T,C or G 383 agacacccgg gcgggcacca aggctggatt ccatcacggc atggaatgag cctcaccaag 60 gcttttgaaa atgtccttcc gggctggaga gatggctcag tggttaagat aaacaccaac 120 aacttttcca gaggtcctga gttcaaatcc cagtaaccac atggtggctc acaaccatct 180 gcaatagggt ctgatgcctt cttntggtgt gtntgaagag agcaatggtg tact 234 384 214 DNA Mus musculus 384 ctcctgtctg ctgatggata atggactgga acacagaaag accatgcagg gttcggctgt 60 agaaggccgg tatctccaga ggccagaaga caccatcaga tctcctggga ctggagttat 120 agaggttgtg agctgccatg ttgaaccaag caggtcactg agggacacag gcatgtggat 180 ggaaaccctg ctgggagaaa aaagaaactg gtga 214 385 100 DNA Mus musculus 385 aagactccct cacagttgtt tttgaaaata attggcaacc agaacgccag gttccgttta 60 atgaagtgcg attaccacca ccacctgata taaaaaaaaa 100 386 334 DNA Mus musculus 386 gcgggaattg acaggaggac tacgccgcaa gggataggcc cagaatagca accaggaaac 60 aaaatctcat catggccaat gtccaccagg aaaacgaaga gatggagcag cccctgcaga 120 atggacagga agaccgccct gtgggaggag gtgagggcca ccagcctgct gcaaacaaca 180 acaacaacaa ccacaaccat aaccacaacc accaccgaag aggccaggct cgccgacttg 240 cccctaactt ccgatgggcc attcccaaca ggcagatgaa tgacgggttg ggtggagatg 300 ggagatgata tggaaatgtt catggaggag atga 334 387 127 DNA Mus musculus misc_feature (1)...(127) n = A,T,C or G 387 aatggtgacg aggctcccta aagcagcctc gaccatccac agacagcctc acgtttttct 60 cctacttttt ccttatgctt ttaaatggca gactcgccgg gcgtggnggc gcacgccttt 120 aatccca 127 388 199 DNA Mus musculus misc_feature (1)...(199) n = A,T,C or G 388 ggcaaacttc atgtgcangc tgatacacat aggcctctga ggaaatttgt antatgtcct 60 ggaagctcta aagaaaagca agagtgccgg gcagnggtgg aggacacctt taatcccagc 120 acttgggagg aagaagcagg nngatttctg ngttcaagac cagnctgggc tacaagagtg 180 agtccaggac agccagtct 199 389 237 DNA Mus musculus misc_feature (1)...(237) n = A,T,C or G 389 ccttcaagtc tgctatggaa ttgaaagtga cctggagctt ccggtccttt ctacctcccc 60 ggtgctggga tggcagaagt gtgtccgcct gcgcattant catggttagg aataaaaccc 120 agggcttcaa gcatgcttgg cagatgttct gccaactgag acacancccc agtccccaaa 180 ccacatagtt ntgaaataca ggtcacattn aaaaataaat caacctggga tggacgg 237 390 295 DNA Mus musculus misc_feature (1)...(295) n = A,T,C or G 390 ccctccaaga gctgagatca caagaatgta ccaccataag cggttttgtg tgtgtgttgg 60 agagatggtt canaacttaa gagcatatgt tggtcttcta gaggatagga attcatttcc 120 cagaacccaa gccaggtggc tcacaaccac atgtaactct aaccccccaa gatccagtat 180 ctcggcctct tcagacacct ttactcacat gcacatatca acacttaaat gcacataatt 240 taatttattt ccaggaagaa aaagttccta aaaatcaaga cacctgctca ccaga 295 391 146 DNA Mus musculus misc_feature (1)...(146) n = A,T,C or G 391 agtgtgtatc atgcggttat tgtcatcttt ttggagtttt ttgcttgggg actactgaca 60 gcacccacat tggtgaacaa tgttctagga cagccaggga gacacagaga aaccctatct 120 tgnagaaagg aaggaaggaa gaaaaa 146 392 193 DNA Mus musculus misc_feature (1)...(193) n = A,T,C or G 392 gactgagagt tgtgctgaag acaacagaca cctccatgac aacccaaagt atcacagagg 60 aaatgaaaag ctgtggactc attcanagtt aattaagatt aggtatgacc atggaagact 120 tgtgtatgac catggaagac ttctagagaa tcttgactgg tgatgtggaa aaagagaccc 180 agaagaacaa aaa 193 393 484 DNA Mus musculus misc_feature (1)...(484) n = A,T,C or G 393 ccattcttgc ccaggagaga gcgaggtcct ggacctggag agtgagctgt acctgggcgg 60 tctncccgag gggggacgag tggacctgcc actgccccct gaggtgagga cagctgctct 120 ccgggctggc tacgtgggct gtgtgagaga cctcttcatc gatggacgga gtcanagatc 180 tccggggcct ggctgaggcc cagggggctg tgggcgttgc tcctttctgc tcccgggaga 240 ccctgaagca gtgtgcgtcg gccccttgtn gaaacggggg catctgtcga gagggctgga 300 accggttcgt ctgtgactgc atcggaaccg gctttctggg tcgggtctgc gagagagagg 360 ccacggtctt aagctatgac ggntccatgt acatgaagat catgctgccc actgcgatgc 420 acacggaagc agaggatgng nccttacgct tcatgtntna nagggcatat ggactcatga 480 tggc 484 394 167 DNA Mus musculus misc_feature (1)...(167) n = A,T,C or G 394 agatgtggtg gtagtaggcg gttatgaaac tatctgcaag gaccgtctga tgggccagtg 60 tggcccagcg tctnaactac cnanntggca aaancattgg ntccttgcta cgctctcact 120 atgaacgcat tgtttatncc tatgaaatgt accagtctgg gagccaa 167 395 298 DNA Mus musculus misc_feature (1)...(298) n = A,T,C or G 395 actgacaaca gcccttctgg ggacagtgac tgctacatga actacaggag tgtcgaccag 60 gactctcagc ccgtctattg caacctggag tccctggggc gatgaggaga gtgtggtctc 120 ctggcgctga accagcctcc aacagccccc aggatccagc acgctcaaca tcacaggggg 180 tagaggacac cccaccccac ccagagcaga aggagggtga gaaacaaccc tccggtcagn 240 gngcatgcat gtgatgctca ataaaagctc tgggagcagc tgactctaaa aaaaaaaa 298 396 383 DNA Mus musculus misc_feature (1)...(383) n = A,T,C or G 396 gactgagctt tttcctgcaa tacagtggnt acagtttgct gtggctactc tgagtgttat 60 aggctccagn tcactcctca cctacatcgc gttccagagc ccacagaagt ctgcagagat 120 aaagccactc ttgtatctga gcttctctga cctgctcctg ggaatttgct ggctcgtaaa 180 ggcacttctc tatggaactg cagcagccca caaggacagc atctgctata acctacagac 240 cgtgggggag nttnttctac nttgnctcac tcctctanac ngcannctac antgnggcgc 300 naggttntna nangnngang aagacagagc ngnctnagtc gtagatggag cacttgtnga 360 nccaggtgac agattatgtt atg 383 397 126 DNA Mus musculus misc_feature (1)...(126) n = A,T,C or G 397 ggtgatgccg ggaggccccc cagccctcaa tcagccaatc ctcatcccct tcaacatggn 60 gggacagcta ggtggtcagc aaggcctggn cctcacactg cccaccgnga atctcacaaa 120 catcca 126 398 160 DNA Mus musculus misc_feature (1)...(160) n = A,T,C or G 398 aagtggcaag gagagactca ggagttttgc cccaatgngn gggnggtgct ggttggctgt 60 aagctggaca tgcggactga cctggccaca ctgagggagc tanccaagca gagactcatc 120 cctgncacac atgagcaggg nactgggctg gccaagcaag 160 399 368 DNA Mus musculus misc_feature (1)...(368) n = A,T,C or G 399 tgtagccact gaggaccagc aaaaacacct gtccaaggca gcacagctgg gaccagaanc 60 aagtccccaa ttgtctactc tnctgtgccc atctgcttct gctcagtccc ctagaccttg 120 gaacagaggg tcccgcactc acacaggcca tgattgaagc tgaagcgaag agattcctga 180 gacctgctcc accagcagtc agaagactcc acccgagaga cgggccccag gcccgntccg 240 acctttttaa ctggatcaga cccgggccct gcacttcnna ttgaaggatg aagactgctg 300 naggtcaccg ccctgcggaa ngctgagncc tgtgatgtgt gngaaangta tcctacgtgg 360 cagagaag 368 400 195 DNA Mus musculus misc_feature (1)...(195) n = A,T,C or G 400 gcgacgcaca ctgctcanca nctatgaggt gttccagtta ctaacggatc tcaaagagca 60 gccggagggn gagtgggaag aaacaagcat acccctctgc aaccaaaact aaaaccgccn 120 tcaccttatg agacccttaa agnccttatc aaaacccccc tcgtgggnnc ccagagncca 180 gcggatttgt cccaa 195 401 232 DNA Mus musculus misc_feature (1)...(232) n = A,T,C or G 401 gaactgattt gggaaggnca atgtgatcct atcagtacat aaggaagccc cctgctcatg 60 tcttccacag tggccngngg tgggnntgcc aacatcttgg attacaagag cctccgtgag 120 atcgtggtga accaccagta ttcanctggc tgttttcact acaagtgccc tgctgangtg 180 ncggnggnan aagncaaaat nnnntcctta acnagatatg tgaaaataac tg 232 402 177 DNA Mus musculus misc_feature (1)...(177) n = A,T,C or G 402 ccgctgatag agcagcanaa gaatatncag angnccaact tgatgantcn ngcaaggctn 60 acaggcctca gagcaaggga tgacggggng nctgatctgc taaatgaggc aangcagana 120 ctcagtnggg gtggtaaaag atacnacccc ncnaccaagn gctgctggat gggctgg 177 403 203 DNA Mus musculus misc_feature (1)...(203) n = A,T,C or G 403 gactgaggca taatagtgga tccttgatgt ggaagacgtc cttaccagct ttgacaacac 60 aggaaatgtt tgnatgtnct ntgctcagna tgaantatat ccactagctt tatcaaacca 120 aaaaaatata taaaagganc ttnntntgtg gnacccaggg ggtggncttg acatgcncgg 180 caaggantca tagcttgtta ttt 203 404 248 DNA Mus musculus misc_feature (1)...(248) n = A,T,C or G 404 aactgaggtg gtgggncttc tcttgcctaa ccagancgct ggcatccact gtcttctggc 60 agtgnctgaa ccagagccat aangnctgng gnaactatgc aaaccgcatt gctaccaagc 120 cttcacctgc atccaagttc atccagggct acctggncgc tgtcatcagt gctgtttcca 180 ttgctatngg gncaatatcc tctccctgac ngagcagggg gtccttacnc caaaatacca 240 tggggggg 248 405 320 DNA Mus musculus misc_feature (1)...(320) n = A,T,C or G 405 ttacaggaga attagaatat gctacgaaaa tctccaggtt ttcaaatgtc tatcatcttt 60 ccattcatat ttcaaaaaac tttggagcag atacgacgaa gatcttttat attggcctgc 120 ggggagagtg gactgagctt cgccggcatg aggngggnnt ctgcanctat gaagcgtnag 180 ccaacccagc agaccaccgg gtgcnttnag gtcaccccnc acacacactt tnntttctta 240 agggccagcc ggggctccct nanatgcgct gttagngaaa atgngcgacc acctgctggg 300 gaaggacaga ggatgctcca 320 406 411 DNA Mus musculus misc_feature (1)...(411) n = A,T,C or G 406 actgaggatc caaactactg gatacaggtg catcgcttgg agcatggaga tggagggatt 60 ctagacctgg atgacatcct ntgtgacgtt gctgatgaca aagacagaat acacctgcca 120 gatgattaaa atgngcctaa tttantcagc atgggtactt gtncaccaga gatantttna 180 agctaatgtc angngacntc ttcntctatc ctgcanaaaa tgctaaaanc attgaacaga 240 gcngggnnnc actttcaaaa aaatgtttgn aagctnccct nggcttnccc cccaagngga 300 tatttaaaan cccncccccc ccccnttttc ttttcctttt ngttntgcaa nttaatnntg 360 atantccgtt ctgnaaatgg naccatgggg ccttaaaatt tttaataaaa c 411 407 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 407 ccactggtca tatgaaggtg nnattgnaac tgcacatgga ttgtcactcc tttcacccca 60 ggacctccgc acctggcatg aagacttgtc ctgggggagg gaaagagctt ttcctgagct 120 tcacccacta gctcctcttt ttctccctac acacacagac cctggggctt acacaagtgg 180 ctgctagacc ctgctgtaat cattaaatcc cacatctcct gattcagcaa aaaaaaaa 238 408 137 DNA Mus musculus misc_feature (1)...(137) n = A,T,C or G 408 agagaccgca caggaaaaga agctaccgct tggncaanct ctaccttgaa caactcaggc 60 ngcaagagga gganaaggct gaagcccgtg cattcnagga ggatcaggng gccgngcgct 120 tgaaggagga tgtgctg 137 409 425 DNA Mus musculus misc_feature (1)...(425) n = A,T,C or G 409 tctctccttt attgcctact agtnntttaa attggacttt taatatccta ccagcgtgct 60 cttcagacac acatggtgca ttgctgccat tcccgggatt gcatctttga gacacacact 120 cttaggagcc ttcagcaaac aaagaggcca cctcccggta cggctaccgg ggagggagng 180 atcctgaccg ccctctagcc ttggccagct ctggatatga atcctaccat ggaaccgaga 240 ntggagtcct gtctggccca ggtgctgcaa gaaggatgtg ggaaancagg ttgcnggttg 300 accaggaact catagactat ttctcagaca gacnagaaag tccggctgac cttgagcacn 360 accaanaccc tngttnggat aagctttgag natgggactc cgntancttc ttggggtgaa 420 ctcta 425 410 196 DNA Mus musculus 410 gagaagctcg aagcggtctg ggggcctctc cgctacagtc tgcccgatcc ctgccaggca 60 acgccccttg cctcaagcac ttcccgcttg acctgcgcac gtctatggat ggcaaatgca 120 aggagatcgc tgaggagttg ttcagccgct cactggctga gagtgagctt cgtagcgccc 180 cttatgagtt cccaga 196 411 284 DNA Mus musculus misc_feature (1)...(284) n = A,T,C or G 411 ggcctgtccc agaagttcct ctgnngacca ggctggcctc ggactcagag atccacctgc 60 ctacnctgag aattgttaaa atggacggtg ctacacagga agagaccatt ccagtatgga 120 ctggccattg gaaaggacgg cacagtatct ggactgttct gtgtcctnag gatgctgcgg 180 aatgaacaca catctgcgca agaatacagt agcagaaacc acatctcaca cttgataggg 240 gagttggaac tatgaatatt acagtctata ataaataaca cata 284 412 199 DNA Mus musculus misc_feature (1)...(199) n = A,T,C or G 412 gactgagata tcttgataat ggaaataata aaatggcaat tcagcaagct gataaactgt 60 tgaagaaaca caaagatctt cactgtgcaa aggttctcaa ggccattggt ttacagagaa 120 ctggcaagca ggaagaagct ttcaccttng nnaacttgga ggatatagtt ggnttgaatg 180 ngctttaaag aaaaacaaa 199 413 366 DNA Mus musculus misc_feature (1)...(366) n = A,T,C or G 413 ctgaaagccg gtctctaccg tctaaccacc acgtttggng aacatgtgaa cagctgngca 60 ggcatctgca gaacatcaga aaagacttca gcaattcttg gagttcaaag aatagtgaag 120 tagntataaa cctgtgttca ttacccctgc tgatacaact acagatgggc acaagnnaat 180 gtcgagcatt tcttgggatc agaagagagc cggactaatt agacgctnnc ttttgtcgat 240 gntgctntgc tttgaaaact atactnncnt ggggaggant ncatnggana gaaattctnc 300 ancngantaa ncccgnaaaa ctgcccttct ctngtaccca ngtgcttttt ttgtggggtg 360 ttggta 366 414 547 DNA Mus musculus misc_feature (1)...(547) n = A,T,C or G 414 gactgagaga aaaggaaagc aattcaggtt cagacgacta gaatctttcg tgcatgattc 60 ctggcgacag caacgtgaca aggtgcgtgt ccagcggctg gaggtgaagc ctcgtgcttt 120 ggaggtgcct gataaacatc ccttggcctt cgttatacgc atggaaagga ttgaaggagt 180 gagtttattg ggtaaagagc accatcatga aacttggcct gaagaaattg ttcagtggtg 240 tctttgtcaa ggtcacccct cagagtgtaa gaatgctgcg cacggtggag ccttatgtga 300 cctggggatt tccaaatctg aagtctgtcc gggagctcat cttgaaacgt gggcaagcaa 360 agattaacaa taagacagtc cctctgacgg acaacacggt gatcgaggag cacctgggga 420 gatttggtgn catttgcctg gaagacctca tccatgaaat tgccttccct gggaagcatt 480 tccaggaggt ctcttcattt tctgngccct ttcctnctct ctgnggcccg ncatgctacc 540 aggacac 547 415 393 DNA Mus musculus misc_feature (1)...(393) n = A,T,C or G 415 agcagcaagt gatccagtct cgagtgaatg accaggaagg ccgagaagaa ttctatgttc 60 actatgtggg ctttancngg cgactggncc naatgggtgg acaaganccg actcgnactg 120 accnngacag tgaaggatgc cgagcagaan aactactgan anatncctga tgtgagctgg 180 ccgagcagcc agagctcang atcactcgaa accaatngcg aangcatgat ganatnancc 240 ntgtgcngan ggcnctggcc cctcccttct cagnacnatc acngcttanc catngcnact 300 cncatgtgan nggcagcccn cagggaagga gatctntcna tntgagcanc atcnttgtgn 360 atgacgtggc tggcaaagac cacaagatat act 393 416 416 DNA Mus musculus 416 gactgaggta gccttcatgg ctgtgccaca tcattcgcag gagacttcct atctgctgcc 60 tccagatcca gaggattggg agaaacaagg catcccggac tttgtctatg gccaggagga 120 tctcgttggc aaggaagttc agtggcccag ggattcacct agtgccgtgg acacagtacc 180 actatcccgt ttcgactctg ccctccgctc tgcgtggagg cagcggctgg aactgggcct 240 gtttcggtac cgcctagaag atctgcagac ccaaatcctc cccggttccg tggggtttgt 300 agctcagctg aatatagatc gagggataca gaggaggcgc ccccagaata tcagaagtgt 360 gaggcaggag tttgacccgg aacagtttaa cttcaataaa attcgacctg gagaag 416 417 333 DNA Mus musculus misc_feature (1)...(333) n = A,T,C or G 417 ttcggtgcta cagagtctct aatcttaaaa gctgaaggga aagnggagtc tgatnncttt 60 tgncaattag gtcacattca ncctcttatn ggaagatnat ncaaaagcnt tatnntgcat 120 accatgnggt acntacagtn tacagtctga ttactggaag aatcgctgcc tttttatata 180 ggtcttggtt tggtctactt ccattacnat gcattncagn gggctatnaa agcattntna 240 ggaggtgctc ctatgtncga ncccagcttt ttggcgagcc aaggaanntt natttacgac 300 tcnnggctta tcgttcnaag cgaacacaga cta 333 418 398 DNA Mus musculus misc_feature (1)...(398) n = A,T,C or G 418 aatacaggct tgagcaagag cctgtgagaa gacggatngn gcaagagcga gccagagcga 60 gacgaagatg gcaggaantt gccatgtggt caagagtagc atgaagaact gctgcagagc 120 cctcatttca ttcttcctcg tacacaatga atcacgttgg gatttcattc cggggctatg 180 tacacaaaag tgncangagg aaaatgttct ctactcttgc ataaaaatgt gtccagtgct 240 tcaggaatgg aacttctgct ctgccgggca gggcttcagg gattctgccg ccagagatga 300 aaggctcctc ctcctgtttt atngntctgn aattcccgag gngttaatca tccanccctg 360 gncngctccc cttgnnggga tcctcggtgc tattctga 398 419 376 DNA Mus musculus misc_feature (1)...(376) n = A,T,C or G 419 tgagggagac aggatggtgn tgtcaaaact tccaagttnt tctcnnagat ntncngcaac 60 ncgggggnca cnatccagaa gnnctacccc ntngtncccn tcttcctcct ggnccactnc 120 atgggcgggt gccatctccn tcctantggc tgnanagagg ccaacctact tttctggcat 180 ggtcctgatt tcacctctgg tccttgccaa tccggaatct gnatcgactt tgaaggtcct 240 tgctgccaaa ctgctcaatt ttgtcctgcc aaatatgacc ttgnngcgca ttgactccag 300 cgtgctgtct cggaacaagt cggaggttga cctgtacaac tctgacccac tcntctgccg 360 agcagggctg aaggtg 376 420 140 DNA Mus musculus misc_feature (1)...(140) n = A,T,C or G 420 ctcctccgaa aaaaactgtt cggtttggcg gaactgngac agaagtctta ctgaaataca 60 naaagggtga aacaaatgac ttagagttgn tgaagaacca gctgtctgat cctgatataa 120 aggatgacca gatcattaag 140 421 290 DNA Mus musculus misc_feature (1)...(290) n = A,T,C or G 421 actgatattg cagtaggtga anaaactata aaggatatgt cagagaataa acaagaagta 60 catccagata ctattacaga tgtggaagct gttatagata cagaggaaga acttattaaa 120 gaatgtgaag aaatgtggaa agacatggaa gattgtcaga ataaattatc acttattggg 180 aactgagaca ctcacgaatg cagatgctca gctctcattt acttatttat gcaaatggag 240 ggggntggac tggctgaacc ttgggncaat ggaaaaaaag aaaccccgaa 290 422 268 DNA Mus musculus misc_feature (1)...(268) n = A,T,C or G 422 tggcgttttt tgatgaagaa taanaaattt aaatttcaaa ccactttcac cttggaggag 60 ctgactgcgg tccccttcgn gaacggggtc ctcttttgca aggtccgnct gctggatggc 120 ggngattttg tcagcttgtc atccagtggt cttcaaatga agatgatgaa ntcttatact 180 ctacntgcnc catgcctgcc tggatgctgc catgtnnctg ccttgatgat aangaactga 240 acctctnatc ctgtaaacta accccaat 268 423 261 DNA Mus musculus misc_feature (1)...(261) n = A,T,C or G 423 aagtactgaa ggctttgtgg tgtgtggggg ttgnactcac atggctgcag ccagtgtgac 60 ttcccctggc tccctagaac tgggngggnc tggtttctcc aaaaccctcc tggggaccag 120 gttaaaaccc aagtacctct gttcancctg caaaaaacat cctgcgggag gccctttcca 180 ggcccagtgg ggncaccnnn tactggntcc ttctgcctga ccaggatncc tnanggtgtg 240 catcccattg gggggggggt g 261 424 245 DNA Mus musculus misc_feature (1)...(245) n = A,T,C or G 424 tggccctggt ggctcaggta ctgatgctgg agaatgggct actgcggact ccacccatgg 60 gctggnnggc ctgggaacgc ttccgctgta acatcgactg tgtggaggac ccgaagaact 120 gcatcaggnn aactcttttt tatntaaagn tnggnatcna tgacnnaatg gngnatantg 180 accnctgggg tntacnttcc tacncctcta aaantggtgg aagngggggg cggaaaccct 240 tcggg 245 425 297 DNA Mus musculus misc_feature (1)...(297) n = A,T,C or G 425 gccctgattg agcagactga ggaagcagng gccgcactta actccctccc cgaggtgcct 60 ccctggactg gggaggtcaa cccacctctg agagacggcn gtgcttctag ggcgcanctc 120 cttgggaccc ctccgataga tctgccctct tgaaaagcaa actgagggct ctgngnggnt 180 ggccctcgga gcctacnaag atccagctgc ttcgggggta ggattgacag gattgnnccc 240 canagtggac tagggttgaa cagnttccgg naccgaaaat aacagccaag ggggaaa 297 426 294 DNA Mus musculus misc_feature (1)...(294) n = A,T,C or G 426 cttttcaccg gtccctaacc tgtaccannt ttgggannag gatggaaatt naccanagac 60 tcatcaagtc cataccactc ctgctccact gcagcaggat caaancanga aggggaatgg 120 gagatgcata gaaaattgga accacagaaa ccaggaagtc tcctttctgg gacagccagn 180 gacgctccag cacctcctcc agnccctggt ccttggcaca gcccctccct catggctgga 240 tcctcagatc ataatagggc cttggagcag ggtttgaggg tggggatggg gatt 294 427 167 DNA Mus musculus misc_feature (1)...(167) n = A,T,C or G 427 acctctgcag tgtcaacang gctcaaggan gcaggatgga tcncgatgtg nctaacatgt 60 tngngattgc gggngggacc ctggcnattc caatcctggc attngttncn tctttcctcc 120 tgnggccttc agcactgnta agaatctatt attggggggt gactcag 167 428 248 DNA Mus musculus misc_feature (1)...(248) n = A,T,C or G 428 tgacttacta ccaaatgtgt ggtggatgtt gaagcgaaca aagttattct gaatcctgta 60 aatacaaatc tttccaaagg agatgcccgt ttnntaacna agacannntn gttanganac 120 tnntcatncc ccacatcctn gaaaaccatn nttcnggatg tttgccaagt atggactnng 180 gtnattatat nnntntcaaa aanatttatt caaacaaaat cttaaaggca tccctaagtt 240 aaactgac 248 429 276 DNA Mus musculus 429 gagacataaa attatgaagg atatcaccag aagctatgta aacatttcat ctaaggacca 60 agagaagttc aaggtgtttt cacaaggaaa ccaaagagac aactgatatg aaagagctga 120 ccgcagtcag agaaatcttg ggaggagaac tagagtgaag gacaaggcga tgagcaggtg 180 ggagagaaaa agcaaacagc tcaaacagat cctgtgaggc gggcgaccca ggacgaaggc 240 tggctttggc gttatctagg taaccccggt ttgttg 276 430 105 DNA Mus musculus misc_feature (1)...(105) n = A,T,C or G 430 gagtctgggg agctcctgcn taagtcagac tgagggtaca aaaatgcaga gcaataaagc 60 ctttaacttg gagaagcaga atcatactcc aaggaagcgt catgc 105 431 434 DNA Mus musculus misc_feature (1)...(434) n = A,T,C or G 431 ggtatggcag ctggcgagaa ctggccaagg ccctagccag caggaacatc ccagccgttg 60 atccgaatct ccaattctac cgtccccagc ggctgagcct caaggaccaa gaaattgccc 120 gaagtaggag taggaacagt agctacctga agtggaacaa gcctgtcccc tggctctcag 180 aggtacaatg tcgctgtctt cagacactcc agaagtagga gtcagatttt gttacggatg 240 gttgtgagcc accatgtggt tgctgggatt tgaactcngg accttnngan gancanncgg 300 gtgctcttac ccactgagcc atctcaccag cccacctctt gtgatcttga ctagaagtac 360 cttcctaacc cagctcttcc actgttttta aataaataaa caaacaaata actcactgac 420 cttaaaaaaa aaaa 434 432 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 432 tatggatatc aattctcctg gaagaaaaat aagaaggccg gaggggnnct atctgaagag 60 gaagtgtttg gctctttctn ggnaanggnt atgcaaatac tggcaagaat gagcggctaa 120 tgagccactg ctaggtaaac atagtgggag gaaaaccaat anccnctgga cccctcagca 180 cnactgnacg agcccagnct cntccaatca acggaaccca gcaagaaaaa cccctacc 238 433 406 DNA Mus musculus misc_feature (1)...(406) n = A,T,C or G 433 ctcctgcatt aagtcagact gagtgtggtt ttgcttgtgg ccatttccag tgcgtttgaa 60 tttggacccg ttgctgggag agaccttgcc atcagagata acagcatttg ggaccagaaa 120 gaacctgccg tacngcgatc ggtctttcca gttcgtgcct tccgtgggga tacagaacag 180 taagtcgctt aataaaactt gctgtctgaa tggagggact tgcatcctgg ggtccttctg 240 tgcctgccct ccttccttct atggacgcan ctgtgaacat gatgttcgga aagagcactg 300 tggggtctat cctcngtngg tacctggctg cccaagaagn gttcccttgt gcagatgctg 360 gcacggccca gctccantgn cttcctcaag accttttcta cctggc 406 434 199 DNA Mus musculus misc_feature (1)...(199) n = A,T,C or G 434 agttcctcca tccacaaatn atgcantcga gtttcctcga atttggggtc aatacacaca 60 gagtgcaatg gatgaacctc gctctggaga aatcncctgc atantcatgg natttcccct 120 tncaggattt atacagaagc agtcttccaa attctgaaac ctgatgccca tcacatactt 180 tgggctgaga aaagaaaat 199 435 114 DNA Mus musculus misc_feature (1)...(114) n = A,T,C or G 435 ctgccttgct ccatgaagtc caggacantn tgacatgcac ttgtttcttg tctcttcatt 60 tgaagaatag tcttcgtcca ctgtgtacat ttttttttgt taatagggaa ggag 114 436 312 DNA Mus musculus misc_feature (1)...(312) n = A,T,C or G 436 aagactgaag tccgtgcccc tcgcctgcag ctgccatgga agctccttgg accctttaga 60 agcttctcgc cgccatcaca ggagccccag aggatgtgca gcggggtctc cccagttgag 120 caggtggccg caaggggaca tggatgacac ggcagcacgc ttctgtgtgc agaagcactc 180 gtggggatgg gctgcgtaac cattatccac nggcagtcgc aagtcctcgg ccctcattgt 240 cagcgngggg ngcccncgac tttccagttt gtgcagaanc ctgacaagtc tgccccccat 300 ctcaccgtct ct 312 437 251 DNA Mus musculus misc_feature (1)...(251) n = A,T,C or G 437 aatatctttt gcacatgant gttctgcctg catggatgac tgtacagcan gctcatgcag 60 tgatgaagga gaccagaaga ggtccttggg aatanagtta caaacaattt tgaaccacca 120 tgtgggtgct gagaattgaa cctatgtcct gtggaagatc agccagtgct cttaaccact 180 gagaaatctc tccatcacct attcttgtgg tttggttttt ctttttcttt gngngtttct 240 tttttttttt t 251 438 226 DNA Mus musculus misc_feature (1)...(226) n = A,T,C or G 438 atactgaagg cactattgct gaggtagaac agatgtgntt gagatcgagg ctaaactgga 60 caagctggtc aaactgtgca gnggnatgat cgaagccggc aaatcctacg tcaccaccaa 120 caggctcttt gtgagccggc gtccgagacc tgtctcagca gtgccagggc nacaccgtca 180 tctcggaatg tctgcagagg tttggagaca gcctacagga gatgga 226 439 255 DNA Mus musculus misc_feature (1)...(255) n = A,T,C or G 439 atactgaaga ataggagggg gagccccgag gatgacctga ttggaatccc attcccagac 60 cacagcagcg agctcctgag ctgnnngaac gagcagngcc agctnancca tctgtgcgac 120 ctcaccatca ggacgcaggg tcttgagtac cgcacccaca gggctgtgct tggctgcctg 180 tanccactac ttnaagaagc tcttnncggg aggnaggagg gggaaannng gaatgngaac 240 tggggggggg ggggg 255 440 271 DNA Mus musculus misc_feature (1)...(271) n = A,T,C or G 440 gaactgagtt ctggcaggtg atctgtaaga cagtgactga ntatggatca tttgaacgag 60 gcaactcagg ggaaagaaca ttcngaaagg ngntaacaat gtgagtgatc cgaagggtcc 120 acccgccaag attgcccgcc tggagcagaa ccggcagccc tctaggaaga gganggcttg 180 ggagcacagg ttggaaagat gcagggagtg cctttaaanc actcgggcca tctcatgaaa 240 acngggggta ggaaaggaac catgtttccc a 271 441 272 DNA Mus musculus misc_feature (1)...(272) n = A,T,C or G 441 ggtctatgtg cactagnagt aattctgnca caatgcctga aataactacc agccatcttg 60 nngaaaaaca ggntcaggnt ctagcggnga tgtgtattct tattgatgaa aatgacaata 120 aaattggggg ctgacaccaa gaaaaaactg gtcaccttaa tgaaaacatc gacaaaggat 180 tattacatcg agcttttagg gggcttcttg ttnaatactg aaaanaagct cctgttgngg 240 gggngatcag atgctaaaat tcctttccag gg 272 442 285 DNA Mus musculus misc_feature (1)...(285) n = A,T,C or G 442 atgcagcagc tgccccangc cctgtgcttg gcaacattcc ccccaatgat gggatgcccg 60 gaggccccat cccgnnaggn nnctttcagn cttttatgan accacaatat cncagngcga 120 cncaaagcct ccaantaaaa tgggaaacca tatctatngg aggagttcct gggacacaga 180 tcattgctgc cnaatnccan ggatcccana cgacaacaag gacacnccaa catgggnggn 240 ggaatgcana nnatgaaccc tcccngaggg gatgggggcc catgg 285 443 286 DNA Mus musculus misc_feature (1)...(286) n = A,T,C or G 443 aaatttcccc agtactgcag aagnacaggn attcaaggac aacctctaca gccaacccag 60 ttgagggcca gcctgttcta tcgagatcct gtctngngga cagaaaaagt ttcatgagan 120 cgtggtgtgt tggcacaatc ttttatttcc gagcacttga cgcattaaaa ttaagggcag 180 atcttcatga tttgggggcg ggccctgggc ttgattccaa agaaccttgt ttccaaaaca 240 aacaaacgaa aaagttgtat gggggggggg gggccaaggg ttttgg 286 444 244 DNA Mus musculus misc_feature (1)...(244) n = A,T,C or G 444 gactgaggta cctcctgnat gatgtcaacc ccncaaaggc ttcaatctcc gcagggatgn 60 ctatatccgg gtggcatcct tgctgaagac gctgttgaag actgaagagn gggtgctagt 120 cctgcccccg tggggccgcc tctaccactg gcaaagccct gacatccacc aggtccggat 180 tccctggtcc gagttttttg acctcccgag tctcaataaa aacatccccg ttataaaaaa 240 aaaa 244 445 190 DNA Mus musculus 445 ttttagggac ttcctgaagc tgttttgagt tgtttactta tggatcttca ctgcaagatg 60 gactgttcca atctcagagg aactcttcca gaaacctgta tagactactt tggccttgaa 120 ctcctacagg tgggcctgcc tttgcttcct agtgctggga ttaaaggtgt gtatcaccac 180 aaaaaaaaaa 190 446 136 DNA Mus musculus misc_feature (1)...(136) n = A,T,C or G 446 ggcttgggga gatccgcttg tcaggggnnc atcctcttcc aggctgaggg ctcccgttag 60 acactctcac gtttgacatc ttcctcctcg gggcgggtgt ggaccaccgc ctcgcctntc 120 tccggaaaaa aaaaaa 136 447 236 DNA Mus musculus misc_feature (1)...(236) n = A,T,C or G 447 gactgtgcag ttgttgctcc tggtgatgtg gatggctcna atgtgctcac tgccagagct 60 acttcgggnc cagnactgaa cttntcaatg tctgcatggg atgccannca ccacaaagaa 120 aaanccgggc ccctggagga caattttaca cgaccagggg canccccctg ggaagancna 180 attccctggc tgttcccacg aaacaccaag cccaggaagc cacattaagg gacgtt 236 448 177 DNA Mus musculus misc_feature (1)...(177) n = A,T,C or G 448 aggtgatttg ccgttgagaa gctcgctact tcgcacacaa acaggaggta cggggactca 60 aaccccacat tccctctcca ccctcggcct tctctctctg ctcgtcttca aaattgtttg 120 aagtttgaaa tttcacgaaa ttcattgtag canaaattan gcccgttgta caaatca 177 449 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 449 cgatcagtag agggaccaga aacttctctg caaagtggcc tgcacaagct caaaccagcc 60 aacgtctcag tgtggacagg gaagggctca tgaagtgcta cccctaactg agaagtcact 120 gacagttgga aggacgagtt ggggttcttc acagatgtgg tccctgaaag gcttacccgt 180 gctcctngtc accagagcac aggaaattgg gaggagaatg gggggggggg gggataga 238 450 207 DNA Mus musculus misc_feature (1)...(207) n = A,T,C or G 450 ggctcaataa cattgagcgg cccctgctta tcttcggcac caagtttgac ctgagacagt 60 ggttcctggt gactgactgg aacccactca ccgtgtggtt ctaccgagac agctacattc 120 gcttctccac acagcccttc tccctgaaga gngcngggac aactgagtgc accctcctcc 180 cctgactatc cagactagtg tggaggt 207 451 460 DNA Mus musculus misc_feature (1)...(460) n = A,T,C or G 451 gactgaggaa ggatttttgc tgggagaggt aagacaagag gaaactttta gcatcagtga 60 ctcacaaatc agcaacacag agtttctgca agtaattgag atccataacc atcagccttg 120 ttcacaactc ttcagttttt atgattatgc gagcaaagtg aatgaagaaa gtttggacag 180 aattctgaaa gatcgggagg aagaaagtta tcggatggta caggttccgg cgaaacaccc 240 agcagcagat gtcctacagg gaacaggtca tccacaagca gctcacccgc atcctcggng 300 tgccagacct ggtcttcctt ctcttcagct tcatctctac cgccaacaat tctactcatg 360 ctttanaata tgttctcttt anaccaaacc gnaggtataa tcaaaggata tcacttgnta 420 ttcccatcta ggcaatacta gccagcagga gtccaaaggg 460 452 169 DNA Mus musculus 452 aacagcttgt tgcacaagcc tcaggacctg agttcaattc ccagaaccca tggaaaagat 60 ggaaggagag agctgacttg acaaaactgt cttctgacca ctgtacactg gactggagcc 120 acggactgca ttgtacagga aaataaaaca atttgtatga aaaaaaaaa 169 453 464 DNA Mus musculus misc_feature (1)...(464) n = A,T,C or G 453 tgaaggtgaa gcttcctgtt gaagatggca gacccagtat gttctcactg aagttccggc 60 ggcattgaag cgggtagcca agtatgtcat ccggggcttt tatggcattg agcacggtgt 120 tggccttgga catcttgatc cggaacccct gtgtaaaaga agangacatg ctaggagctg 180 ntcaagtttg atcgggaagc aacttcgatc cgttttgaat aatttaaagg ganacaagtn 240 catcanatgc anaatgaggn tagagactgc tgcanatggg aagaccaccc gccataacta 300 ctacttnatc aattaccgga ctcttgntaa tggaagggaa anataagctg gaccncatga 360 aaaggaggga ttgaaacaga ngnagagaaa ttcccccaat cgggcttccc ttcaaatgnn 420 ctgtctgntg cagnactttc actganctaa aaacccatca actg 464 454 280 DNA Mus musculus misc_feature (1)...(280) n = A,T,C or G 454 acctgactgc cgagattgtc acgacttcct ggcctgattc tgcaccgcct gantctgnca 60 gngaccgaca ggctttgttc aaaagnatgc ccaaaccttt ttggccctct gtgctacaga 120 ttacaccttt gcgatgnatc ctccatccca tgatcngcac agggcagnat tgggggcanc 180 cgngctaggc ctagggnggc cngctctatg tctgggggat gaacctnaca aaagttgnnn 240 ggcccgggaa tcacaaggnc nctgaaggcc ccccaggcct 280 455 319 DNA Mus musculus misc_feature (1)...(319) n = A,T,C or G 455 gtcttttgcc gcttcatgtc ntccatggct cctcaagaca tttgtcctca tggtaggact 60 tgccactgtt gcgtttatgg tgagaanggt gtncctnaca acagactncn gcaccttcaa 120 nccaaagttt ccagannctg natgggtnga cccanggctg aagctttcta ccanagganc 180 atctgaggaa nctctttacc tacagtgaca tctggctctt ccccaaaaat cagcggggac 240 tgtaactctg ncaaactgcg antgaaatat aagtttcngg atgcctatan ccagaacgnc 300 cttccagctg ggaatgcca 319 456 367 DNA Mus musculus misc_feature (1)...(367) n = A,T,C or G 456 cccctgccgg agaagaaatg ggngactgtg ggtagatacc tccctgagga tattcaaatg 60 ggtgcctgtg acagatagca aggagggatt ttgaacttta tacaaacgaa tcgtagggct 120 ggagagatgg ctcagcagtt ttgatggctc agcagttttg agcagtggat gctgttccgg 180 aggacctgag ttcagttccc agcccccaca tggnggctca caaccttcag taactccagt 240 tccaggagat ctggtgccct gttctgacat ctgctggcac caggtagata tgtggtgcac 300 agacggtata tgcagccagt gcaccgtaca cataaaataa aaattgaaaa actggaaaac 360 aaaaaaa 367 457 428 DNA Mus musculus misc_feature (1)...(428) n = A,T,C or G 457 ggcttgcccc tgatcagcct gagtctgatc tgaagatttt ggtgtttaag gcattaagaa 60 catagcctga atngttcatg gagtttttca tcagtatgtc tgaaaccata aaatataatg 120 atgatgatca taaaaccgct gtttctgaaa aacactggaa cgaacagcgg cctgggaggg 180 agaatttctg cgacatcgcc ttcgtgggtt gaaagatgta aagttcccga gcccaccggg 240 ggngntcctc gcccgccttg caancacgtt acttttnaan aaagcttttt caannaaacc 300 tagaaagtna gaacacgccc cncccccgtn ataagagaat agnatttccc tcccgctnct 360 nacaatattt tngaagaggg tgctgaactt acatngtnnc nccggccagg atttccggag 420 aaaaaggg 428 458 430 DNA Mus musculus misc_feature (1)...(430) n = A,T,C or G 458 gactgagatg acggcccttc ttaccaacca aacagaatga ggaatttcgt cccttcattc 60 gaaggcttcc agaattcaaa ttttggcacg cagctacaaa aggcattctt gtggctatga 120 tctgtacctt cttcgaggct tttaacgtcc cagtgttctg gccgatcctg gtgatgtact 180 tcatcatgct tttctgtatc acaatgaaga ggcaaatcaa gcacatgatt aaataccggt 240 acataccatt cacacacggg aagaggagat acaaagggaa ggaggacgtg ggcaagacat 300 ttgctagtta gaagctggac tgattctcac acggactcaa gaacggtttt gagccattgt 360 aacaatgcct ttttcttcac ataaagtagt tgattatgag gaagnngaat tntcttttta 420 agaggagccc 430 459 122 DNA Mus musculus misc_feature (1)...(122) n = A,T,C or G 459 atactgagta tagtaagaag acatggtttc cccccacttc cacagcacgt ctaagtttta 60 tcttttttgg ggtccttatc tgtgggccac antggaacan ctgtgaatat cacgctgtta 120 aa 122 460 188 DNA Mus musculus misc_feature (1)...(188) n = A,T,C or G 460 gaactgagca tcttccccac ccccagcccc cangaccaag gacaggctgn gtccagacag 60 aaactgttca gcatcccagt gaatggacaa ttgcactgaa ctccacaagc atcccctgcc 120 ccgtgcccat gtcctgagat ccttatccca gatggaaaag ttaaatcgtg gctttgaaaa 180 tccaaact 188 461 203 DNA Mus musculus misc_feature (1)...(203) n = A,T,C or G 461 gactgagtat cttcagatga aatggccact gcttgatgtc caagcaggaa gcctccagag 60 cagacaaacc ctcaaggatg ctcgttcgcc gtcgccagca cacatcgttg taagtaacct 120 ctcagtgaga gccncccctc tgttgagggt aaaggatctt ttgatgatta aaaactcnta 180 tttgtctgtt ctttaaaaaa aaa 203 462 471 DNA Mus musculus misc_feature (1)...(471) n = A,T,C or G 462 gactgaggtc ctccttgtgg ttcatttctg ggcaccatgg gctccacagt gtgtacagat 60 gaacgatgtc atggcagagt tagctaaaga acaccctcat gtttcatttg tgaagctgga 120 agccgaagct gttcctgaag tatctgaaaa atatgaaatt agctctgtcc ccaccttcct 180 gttcttcaag aattctcaga aagtcgaccg gttagatggt gcacatgccc cagagttgac 240 caaaaaagtc cagcgacacg tgtctagcgg agcctttcct cctagtacta atgaacatct 300 taaagaagac ctcagccttc gcctgaaaaa gctgactcac gctgccccct gcatgctgtt 360 catgaaggga acacctcaag aaccacgctg tggtttcagc nagcagatgg nggaaatcct 420 tcacaaacac aatattcagt tcagcagctt ttgatatctt ctcagatgaa a 471 463 340 DNA Mus musculus misc_feature (1)...(340) n = A,T,C or G 463 gactgagatt tgataatggg ctgcattaaa agtaaagaaa caaaagtcca gccataaaat 60 acacaccgga aaatcttaca gagcctgtag gcccaagtgc cagtcattat ggagtggaac 120 atgctacagt tgccccgacc tcttccacaa agggagcatt cagtnaattt taaacagtct 180 ttcnatgaca ccctttggag ggtcctcagg gntgactcct tttggaggag cgtcttcctc 240 attntgagng gtgtcaagtt catatcctac agggtttanc agaggatggg caanaaagtg 300 atactttcct ntggaatnaa gaagccctaa aagtataaac 340 464 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 464 actgagattc agagtcatgg ngctcagcga ngcgaattta cagacactaa cagagtnttt 60 aaagaaaacc ctggatcctg atcctgccat tagacggnca gctganaagt ttctcgaatc 120 cgtagaagga antcagaatt acccactgtt gcttttaaca ttattggaaa aggcacagga 180 tantgtcatt aaagtatgtg cttcagtaac cttcaagaac tatattaaaa ggaattgg 238 465 276 DNA Mus musculus misc_feature (1)...(276) n = A,T,C or G 465 gactgagact ccagttctca tctggctccg tttttaaact cccaccttgt cactcatctc 60 gcctccttgg agtgacatca tgaaggtggt gaacctgaag caggccattt tgcaagcctg 120 gaaagagcga tggagtgact accaatgggc aatcaacatg aaaaaattct tccccaaggg 180 agccncctgg ggactttctc aacctancaa aagcgctcct ggagcaggct atgatngggc 240 cttcccccat tcctttgatc ctgtcgtacc tgaaga 276 466 167 DNA Mus musculus misc_feature (1)...(167) n = A,T,C or G 466 aactgaggtc gcagacactt tgtgaaanga gtgagtcaga gacgacgacn taccccngct 60 ctcttcccat accttagcag ctgnccagga gttttatgct tgagcagaaa ccaatccgtc 120 aaccccagag gggatgataa attataacgg ttggggtaat tagagga 167 467 116 DNA Mus musculus 467 gactgaggtt agaaagaatc aaacaatgca gacataattc atctccttaa agattgcgcc 60 ctagtacttg aaatgctttt tatttaaaag agtagtaaaa atggaaaaag aaaaaa 116 468 390 DNA Mus musculus misc_feature (1)...(390) n = A,T,C or G 468 gactgaggga cagagtcatt acagttgaaa ctacagagta ttctgctagc agccttcaga 60 tgaagatgta gaactctcag ctcctcctgc accatgcctg ccgggatgct gccatgctcc 120 tgccttgatg ataatggact gaacctctga acctgtgttg atgtgctgtc gggacagctc 180 tggagcaccc ttaaagtcca gctcttccat ctccgcttca tagaacttgc ggcagaaatc 240 tttaaaagac tgaaacaggg caacacgaaa gtgattagca ccaacagcct cctttccagt 300 gcacaaaatc aaaatatcaa aatgtaatgg gngnacagat ttgattngca aagaaaaang 360 nggaaatgta taaaaattca aaaaaaaaaa 390 469 266 DNA Mus musculus misc_feature (1)...(266) n = A,T,C or G 469 actgaggagg tgcccagaca tgggtgactg gagcgccttg gggaagctgc tggacaaggt 60 ccaagcctac tccacggccg gagggaaggt gtggctgtcg gtgctcttca ttttcagaat 120 cctgctcctg gggacagcgg ttgagtcagc ttggggtgat gaacagtctg cctttcgctg 180 taacactcaa caacccggtt gtgaaaatgt ctgctntgac aagtccttcc ccatctctca 240 cgtgcgcttc tgggtaaaaa aaaaaa 266 470 212 DNA Mus musculus misc_feature (1)...(212) n = A,T,C or G 470 aatggaggct gaagagttaa ttggcagcag tgtgacgatt gattccatca tgagcaaaan 60 gagagntntt anaaatatga tatgtgaaga ctgtactgat gagctaagct tgtctaaaat 120 ccttgtgccg atcacaccga aactggntaa nccaaaatta tgagggttgg ggaacacccc 180 anagaactgg ctgaattttc ttgctgaaac ta 212 471 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 471 ggacctgccc tgcctgctac nnnganngtn nnnnacagga ccataggtgn ngcaagacct 60 acagcancct gntcanagtg gtgggacgtt gcattcccan cccagatctg atcgtcttac 120 tagagcagga gaagngagcc cctgnatggc ttgggaaaaa agaaacaggc agcccgagcc 180 caaggttttg gagacaggnt ttccnancct gaaaatnaga nctccaaaaa atcatgtt 238 472 364 DNA Mus musculus misc_feature (1)...(364) n = A,T,C or G 472 actgagagaa atgcaggcag nagntcagga tggnaccgaa gattccgatt tttctacnga 60 tctcnagcat acagacagnt nanagagtga tggcacctcg cgccgatctg cccgagtcac 120 ccgctcctca gccaggctaa gccagagttc ccaagattcc agccctgttc aaagatngnc 180 agtctttngn aactgnggag cctgnctatt ctaccagaag ggtgacccgt agtcagcagc 240 agcccacgcc agtgactcca aaaaagtacc ctcttngaca gactcgctca tctggctctg 300 aaacggagca ggtggtggac ttttcagata gagaaactaa aantacagct gatcatgagg 360 agtc 364 473 244 DNA Mus musculus misc_feature (1)...(244) n = A,T,C or G 473 actgaggttt aagtgcccca tttgttccaa gtctgtggct tccnatgaga tggaaatgca 60 ctttataatg tgtctgancn ggnctngngc tgtcctacaa tnatnatgtc cctnactaaa 120 natgccgggt gagtgtgcta atctccctga agaanctgct tcaggnggnc acaatagcca 180 gcctgccttg ccttgtncat ctataacaaa agnctgcnta anctcatggt ttagaagtga 240 acag 244 474 368 DNA Mus musculus misc_feature (1)...(368) n = A,T,C or G 474 gactgaggtc tactgctgct ntgctctaca ngggttactt cctccaggac tgccanctgt 60 nngatcanaa taccgtgaca ctggtgtggc ttgaagnata ttnacncctc nccngagaat 120 ctctaangct acntactcac ccacttctga naggcgtcaa aggttccaan cgaacnctgc 180 ctggntcact agcatcagaa tttcacagat ttaggttcat tctncttgcc tcagaaattg 240 atcaaggggc acattcccct gatgttaact gcaaaccttg acgagtctct naagacagnt 300 caancttcan ncncgntttg ggctttctga acctctgggc caccttcagc tccatttcct 360 tgacaagg 368 475 374 DNA Mus musculus misc_feature (1)...(374) n = A,T,C or G 475 gctctggaag ctatggacca gcangacctt ccagaagaga gagaccgatg gcagtgggtg 60 aactgataag ggccctaggt aggctnaaag tgnccacgga ccaagatagc attgaatttg 120 gggcatctgg gggctggctt gactttataa attggacctg ntaagcnagg ttcctttgga 180 ctgggaatgn aaagaaggtg gtcacttgnn naaataaatc tggatggccc ttggggcnta 240 cccncgnccc ccggggngtt ttctgggaag cnagtngnga aaaagggggt gcctttttaa 300 aaaagttttt nttgttaacc aactgggccc ccacccnttt aaattnttgg anttttaaaa 360 aacccccttt ggaa 374 476 275 DNA Mus musculus misc_feature (1)...(275) n = A,T,C or G 476 gactgagatg gtggaccggg caagattact gcttgctgcc ttgagtgana gtgggattan 60 tccgaatgac ctctttgatg ttgatggtgg agatgctggc cttgccaccc ntacnccccc 120 ttcanttcaa cagaagcngc ctccatccac ttcaacagct nggggctgaa tcacaataan 180 tcaacttcca tctttgngat ntnccaatan ncnatgactc actcccccnc ctgctaaata 240 cgaaggggga naaccntcac ctatgacaaa ttatc 275 477 394 DNA Mus musculus misc_feature (1)...(394) n = A,T,C or G 477 gaaaaccggc cattgaatag aatncacngt caagccgann atncnanccg gannatgtga 60 ttatncangc tanngngcat atgctactgg agacnacaaa gcctgtttcc ctcggancca 120 atccgctggc ttaaattttg cagaganaat cacgtcagnc cncagaaant cttcctctgt 180 agccatctgn nanncnnngn gtntnaanta aatgactgtg nctaatcagn ncacagcctc 240 atggagantg actcctaccc ctctgttcct gaggtccaaa atgnacttan atctgctgtc 300 ccanagccag aggaggctca cntagacctc ggagggggac tcttggaagt cactggcttt 360 cctttcccct tgctgccaag accatattct gaag 394 478 429 DNA Mus musculus misc_feature (1)...(429) n = A,T,C or G 478 gactgagatg ggctggttaa aagaaaagca gcttatcgaa ccgaggtgag cgatgaagac 60 atccaaacaa tgccatgctg tacaccggga gcactttcta tttgcctggg aaactacgag 120 cggagcccct ggatgccatt ccactcgaag gcccccaagt ctcctaaggc actgcaagta 180 agaaggagcc gggctcacca tgaattcact ttgaagtagg tgggaacttg ccacgacgtc 240 cctnagctgt gaccgtgtga gaactcggct ggctgactgc aggtattcca tggctacctt 300 ctcccggggg gttgagacgg ncacaaaggg ttcnacactg cccaggctac tcatgtccag 360 cgtaagagat acattggaac ctcgnctaca tgggggaaag aatgntatta catttaaata 420 ttcatgaat 429 479 143 DNA Mus musculus misc_feature (1)...(143) n = A,T,C or G 479 tatgctggat gagcagtggg naccatctan atcgcataga agaaggcatg gaccaaataa 60 ataaagacat gagagaggca gagaagactt taacagaact caacaagtgt tgtggcctct 120 gcatctgccc ttgtaatagg gcc 143 480 249 DNA Mus musculus misc_feature (1)...(249) n = A,T,C or G 480 actgaggatg ggatgcgtga agtccaggtt cctccgagat ggaagcatgg nctcnaaaac 60 agagccaagn gccaatcaga agggccctgt gtatgtgccg gatcccacgt cctccagcaa 120 gctgggacca aacaacagca acagcatgcc cccagggttt gtggagggtg agtatctagg 180 aagcttgggt ctcagcatca nnatacatnc attancttag attctgagtt gtaactgatg 240 ggggaaagt 249 481 407 DNA Mus musculus misc_feature (1)...(407) n = A,T,C or G 481 tgttgggcct taagaggccc caccggtctt tctttgagtn cttnatccgg acactcatca 60 tcgtgggcac tggcctgnct gaggntcctt tnttcagtcc tncatctgcg atggccacnt 120 ggcctcctaa tggaaggatc atctcttttg gggcttgngg aactttctgc accatcggga 180 aaccacagtg gaaccacatt gtcttganna gacctgagcc cagggcccca tatgccccgg 240 gcgtgggctg gtagnncatg ggncctnanc ncgccaagtg gnggncccgc cattggcnag 300 nnggtgngcc ttnccaattt tccccccttg gaaaatgctt cattggtngn cccaaggngg 360 ggtaaaaaag tnccgttnac gggacaaggn gggcccatcg ggttcct 407 482 143 DNA Mus musculus misc_feature (1)...(143) n = A,T,C or G 482 tgatgaaaaa ggagattnta tgagcagatg ancggtcctg tnacctncgg ctnccgccag 60 nanaatggtg ccggcgtnat cctccgagnt gttgnaagag ccggagagan catccagaat 120 tccttgggtg gaagatgagg gcc 143 483 171 DNA Mus musculus misc_feature (1)...(171) n = A,T,C or G 483 agacaacggg aggcaccaca gaagtctgtg gaaagaacag nagatgaant gnccaganct 60 ggccttacag ggccttcaca gagaacgtnc cacccgctgn aaactgatgc cgggctcctt 120 ccccncggga cggagtcttc aaacatatng gggataaaaa tgtttcctgg t 171 484 531 DNA Mus musculus misc_feature (1)...(531) n = A,T,C or G 484 gactgagaac tgtgcctggt gatcttgntt gcttcagtgc atctacaaca tcggcctact 60 cctccctgtc ggtgattgag atgatctgtg ctgctgtctt acttgtcttc tacacgtgtg 120 acctgcactc caagatatca ttcatcaact ggccttggac tgacttcttc agatccctca 180 tagcaaccat cctgtacctg atcacctcca ttgttgtcct tgtagaagga agaggcagct 240 ccagagttgt cgctgggata ctgggcttac ttgctacgtt gctctttggc tacgatgcat 300 acatcacctt tccctctaaa ggcagcaaag acatacagca ggctcccact gaccccactg 360 atgggcccgg tgatcgtctt tcagctgtct ctgctacctg gncaataggc tcctccatca 420 aaaaactttc ctcctgnngg ggcggggggg gggctccgcc tttcctccaa agctntcagg 480 agggagaagg cagggnggat ccctggngaa gttgaggcca gggctacaca g 531 485 483 DNA Mus musculus misc_feature (1)...(483) n = A,T,C or G 485 tttaagcccg cgccctccgg gtccgctttg cnggatcncc gctagnctgg acctgncacg 60 cggaccgcac ggngagctnc nggnaanggc agaganngac ngagtcgaan gnctngctct 120 ccntacncac atcgcccggn tagnctctcc tacacancgc tgactttcan aaggagctgc 180 tctcctcaca ccttggacgc cgccggaagc tncaaaccgc gccgcactaa cgccgccgac 240 atgtttccga gccccgccca cacgcggnga gctacttccg ccctggcgga gttcgctcct 300 cggcagaaac tggagcagga gctcagggtt ccgcagcnag cggaagtgct gccttagaac 360 gcangctcaa tggctttcct atanccccgg aggancgggg agctaggggc ngtgtccnaa 420 gcgcanaaag ccacagttgt tcaattttct aagcaacagg nctctggtga tccaggcttg 480 tgg 483 486 356 DNA Mus musculus misc_feature (1)...(356) n = A,T,C or G 486 caaatccgga gattgccagg aggcttctcc tcanaggtgc taatcccaat ttgaaagatg 60 gaactggttt tgctgtcatt catgatgctg ccagagcagg tttcctggac actgtacagg 120 ctttgctgga gttccaggct gatgttaaca ttgaagataa tgaagggaac ctgcccttgc 180 acttggctgc caaagaaggc cacctccctg tggtggagtt ccttatgaag cacacagcct 240 gcaatgtggg gcatcggaac cataaggggg acacccgcct tcgacttggc caggttntat 300 ggaagaaatg aggtcattta gcctgatgga ggcaaatggg gttgggggag ccacaa 356 487 220 DNA Mus musculus 487 tgaggtggga ccccgggggt agagctcaag tccccaggct tggcagcaag caccgttagc 60 tgcagcatgt catggtttag tggcctcctg gttcccaaag tggatgaacg gaaaacagct 120 tggggggaac gcaatgggca gaagcgccca cgccacgcga atcgagccag tggcttctgc 180 gcacctcgct acatgagctg cctcattaat aaaaaaagaa 220 488 179 DNA Mus musculus misc_feature (1)...(179) n = A,T,C or G 488 cggggcactg caagatggct cacnagataa tactnaactg ctttgatgtg acccttgccc 60 cttcattnac anacnggggg tcctttanac tcccagccct gggcacacac accactcact 120 gaacacccca gnctgaatag nttattttct cantagncac cagagggtgt gttcacttg 179 489 104 DNA Mus musculus 489 gactgagagt cactgttcat tttatttcaa aatcggagca tgttcgtcat ggagacagat 60 gttctcggtt gcacaataaa ccaaccttta gccagaccat tgtg 104 490 384 DNA Mus musculus misc_feature (1)...(384) n = A,T,C or G 490 tgagctcttc cccaacgccc ctacgccaat gtctccancn gncacaaacg tgaatgangg 60 actntcncan tnctcttcaa natncanang ggcnctgngn ananntttcc agggangagg 120 gttatgactg attgcgggac atgccagatg gtaccttctt agttcgtgat gcctcaacga 180 aaatgcaggg ggattataca ttgactttga gganggcngg aattgcctgt atctgcagga 240 tctntaatat gtgatggccc tcgttggcac ctccntannc ncnggcataa tctaaaatgg 300 ngnaccttat tacnctctac caccacaagt ctctcgctca gtccaatccc aaactcgacc 360 gngaanctgc gtacccagtc tcca 384 491 546 DNA Mus musculus misc_feature (1)...(546) n = A,T,C or G 491 ctgagggtga cacttcccaa atctcctcag tcctgacccc ggcatcatgc atcggaccac 60 acggattaaa atcacggagc tgaaccctca cctnatgtgt gccctctgtg ggggctattt 120 tattgatgcc accaccattg tggaatgctt acattccttc tgcaaaacct gcatcgtacg 180 ctacttggag accaacaaat actgccccat gtgtgacgtc caggtccata aaactcgacc 240 actgctgagc atcagatcag acaaaaccct ccaggacatt gtctacaagt tggtgcctgg 300 gctttttaaa gatgaaatga aacggcgacg ggacttctat gcagcatacc ccctgacaga 360 ggtccccaac ggctccaacg aggaccgagg cgaggtcctg gaacaggaga agggggctct 420 gggtgacgac gagattgtca gtctttccat tgagttctac gaaggcgtca gggaccgaga 480 ggagaagaag aacctcacgg agaatggaga tggggacaag gagaagacag gagtgcgatt 540 ccccta 546 492 426 DNA Mus musculus misc_feature (1)...(426) n = A,T,C or G 492 gactgaggtc ttgtccaata aacatgtggc tcctgaccac ctactacaga tatgccagcg 60 catcggtccg atgctggata aggaggtccc gcccagtatc tcaagagtca cttctttgct 120 tggtgcagga aggcagtctt tgctacgaac agcaaaaggt accttaattt gaagaagtgt 180 tgngctttgt attagtagct tacattgcag ttgggaagct gtgtaaacac cgtggaaggt 240 ttgcagtgcc atggactgac tatacacttc tctgcattag tgnaagatct ccgaatttta 300 nccatgcgct tgatgggtcc tcccntttca naaaacgtaa aatgttaagc ctgaaaagct 360 tgnagttnaa catggggctt ggaggtttta tcaanggnga gtncttaatt tttttccatt 420 ttggaa 426 493 478 DNA Mus musculus misc_feature (1)...(478) n = A,T,C or G 493 ctgaggatcc actgaccttg anccactcca aagctctctg gagtcagaat cagctggctt 60 cctctagccc cactccagga tcttttcccc agggcactga aagcctcagc ccttggcaga 120 tangaaacgt ctgggcaagg gtnnacaggc acactggcaa cctgtgtgag taangagcgc 180 acactgaact gcccatnnca ccaacaccct cctttaccct ctcctgntcg ctctnggccc 240 tattcttgct ntgtgtgtgg aaagaggttt tcactcaagc atnagatgga gacacattac 300 cgagnccaca caggagagaa gcccttgtcc tgtagcccta tggtcctcag cgctcncggg 360 atttctctgc catgaccaag cacctgagga cacatggggg ctgctcccta tcgatgccct 420 ctgtgcaggg atggctgccc tagcctggcc ttcatgnagg ngcacatgcg tgggcact 478 494 454 DNA Mus musculus misc_feature (1)...(454) n = A,T,C or G 494 attgaggaac agaggttaca cctgggcccc gagaggctct ggaaactcct ccccaagcac 60 aaaacccaac tgtactaagc tttttgtgag ctatttcagc ccagaatggc tgtggaatcc 120 agagcaattt caacctttaa aacctcagga ccatcaagaa gaattaatnc tagtgaaaat 180 ngaagatagt agcttttctt gaagtcagan atgtaaacag aatgggagng cccaaatctt 240 gccnggaatt atttcgccag caattcagga agttttgcta tcatgaaaca ccctagggcc 300 ccgagaggct ctggggcgac tccaggaact tttgccatca gnggnttaat gccagagttg 360 cacacaaagg agcagatcct anaactgtta gtgctggagc nagtccctga gcatcctacc 420 tgaagagctg aagatanggg gttcaacaac atgg 454 495 104 DNA Mus musculus 495 ggcctctcag ccccaagaaa gaccgtgtga atcattgtct aacaatatgt gaaaacattg 60 tggcacagtc tctcagaaaa caaagaagaa gaagaagaaa aaaa 104 496 272 DNA Mus musculus misc_feature (1)...(272) n = A,T,C or G 496 actgattcgg tattctaaag aaatggaccc ttccttccaa atgagaactg catatggacc 60 acaggacatc tatacagtga aagctgtgct tctggggctg gagagatggc ttgaaggtta 120 agagcactgg ctgctctctc agaggaccca ggttcaattc ccagaaccac atggaagctc 180 acaactttct gtaactccgg ttccagggga cccggcgcac atgcaggcaa aacgccaacg 240 ctttagaata aaantaatta aaagagaaaa aa 272 497 102 DNA Mus musculus 497 gactgaggtt agattcagaa caagaaagtg gacatatcca aggtctcctc caagtgtggg 60 tccaaagcta atatcaagca caagcctggt gaaaaaaaaa aa 102 498 349 DNA Mus musculus misc_feature (1)...(349) n = A,T,C or G 498 ctctgcacac tactgaactg gaccgangnt atatccagga aacgcttgta agtggatcga 60 gctaccactg ctgcctccta tgaactgaac tgatgatttc ctgacaangc agatgggatn 120 tactccaaag ancaactgct aaacaggncc acttccctgg tatcctanta acctttcttt 180 tntactcgct ctggnggatg atgggctana nggaaggtta nagcatttaa gancctatna 240 naagagccgg gngtggnggc acntgccntt natcccagna ctanggaggc agaggcnggn 300 ggatgactgn gtttgaggcc ancctggngt acagagagag tgccaggac 349 499 413 DNA Mus musculus misc_feature (1)...(413) n = A,T,C or G 499 ttatctcagg ccggtcctgc cccgggggac ctgctcctca acgacatcat ggtgnccctg 60 gnccnacctt cttncgccag caggatgggc tgctacgggg tggctacnag gcacaggaac 120 cgctctgccc ggctgtgcca ccgaggaagg ntgtcccagg cantagcttt acctatgtca 180 ntgaggactt ncggacagag nctcctccca gccccagcag agatgttgaa gatccccggg 240 aacatcaggc acacaatgcc cacctccgtg ggcccccacc aaagctcatc cctgtntctg 300 gaaagctgga gaagccttgg ntgncctgna actaactggg cagaccaggg ctgncctgna 360 nctcacagag atctgtttgc ttntgcctcc cgagggctag gataaaaggc att 413 500 265 DNA Mus musculus misc_feature (1)...(265) n = A,T,C or G 500 gactgagatt ctccaaacac atagataaac acanagatcg anaacaccgg cataaggagc 60 acatgaagga taaggataag gaccgggaaa agtctaagca tagcaacagt gaacataaag 120 attctgaaaa gaaacacaaa gagaaagaga aaaccaaaca caaagatggc agctcagaaa 180 aacataaaga caaacataaa gacagagaca aggaaagacg aaaggaggaa aagattagag 240 ctgctgggga tgcaaaaata aaaaa 265 501 377 DNA Mus musculus 501 gactgagggt tcttaaggcc cgccccgccc caagccccac ccacagcgct ggccccgccc 60 accatgtcga tgaccatctt gcgcaggctc tgccgctggc gcttgctgag gttctggaag 120 atgtcgcagt tctcttcttg cagcagcttg aatcccacag ccaggtggtg gttctcaagc 180 acagactcat cgttgtacat caatgccagc tccgaatctg cagagtacca cgtggtacca 240 cctgggtacc aagccccgcc ccgtgcgcgc ccagtctcca gttggcttca ttttcagact 300 gactagtccc agccccctcc tctgccacat cggtgcttca ccaaataaac caagcatcag 360 gcgcctaaaa aaaaaaa 377 502 325 DNA Mus musculus misc_feature (1)...(325) n = A,T,C or G 502 gaactgagag ctcttccctg ctcttctggn cagccagtgt gtgcagaatg ccccacaaga 60 ttggatttgt agtggtcagc tcctctggac atgaagatgg cttcagtgcc cgagaactaa 120 tgatccacgc accaaccgtc agtgggtgga gatcaccaaa gtaaggctgg gctgaggggt 180 gggcatgaga gcgcatctct gagtgaatac atggtgggct ttacacctcc tggtccaaaa 240 acatgaaatg catgtctaga cagctatatg gtatatttca gtgaaaacta aattaaatca 300 ttaaaattaa agtacaaaaa aaaaa 325 503 257 DNA Mus musculus misc_feature (1)...(257) n = A,T,C or G 503 gaggttcctg aaggcttcaa aggaaacctg atagaggagg ctcaatggcc ctgagtgaag 60 atgaggctga ggcagaagtg tctgtcaaca caaaggtccn atcctgtggc aagatggagg 120 aanacaggcg ttgctgcctt ccaggancta catnacagct nttcaatgcn ttctggaact 180 ataactgtac tnntcatgca caggaggntn nacantgnan nacttccntg ctaccnctgt 240 gatccatgtg aggtgtt 257 504 152 DNA Mus musculus 504 tgtgtgcaca gctgcccacc cagtactgga cagcatcagc atcattgaca ctcctgggat 60 cctgtctggg gagaagcagc gcatcagccg agatttattt attattatac agtgtactat 120 ataataaata aataaatctt taaaaaaaaa aa 152 505 395 DNA Mus musculus misc_feature (1)...(395) n = A,T,C or G 505 acactgcaga ggaaacccga attgcttggt tggcattggc gagcacattt ggttaggaga 60 gatagatgag aatagttttc atagcattga tgatcccaac tgtgagagga ggaaaaagaa 120 ttcctttgtg ggcttgacta acctgggagc cacctgctac gtcaacacct ttctccaggt 180 gtggttcctc aacttggagc ttcggcaggc gctgtactta tgccccagca cctgcagtga 240 ttacacgaag ggagatggga tccatggggg aaaagattat gggcntcaga cttgnnnnna 300 ncatnttaaa aacttgttag ctttgttgca aaacaagtaa caanacgata catnggatcc 360 ttcaggattt gttaaagcct tgggcttaga tactg 395 506 475 DNA Mus musculus misc_feature (1)...(475) n = A,T,C or G 506 tattggttac cgtcagagct agantcccat cactgtcctt caaaatgcaa tggaatgtac 60 cacggactat gtctcggctg gcactcagga cattcgtgga agcacagaaa gccaggctct 120 ttgatcacca ttggcgcata aaagggccgt tacttgtgca tagaggtgaa tacagagttg 180 gcttggacac cacaccttcg aaagcagngg ctacatttat ctgctgntca gtgccttgca 240 nagnaaagga atctcttaaa tgctcaagcc gcgctaagtt ggggaccctt gcgccaggaa 300 acgaagggag nngnacattt tattccaana gggtttttat cttccagntc cacatcccag 360 ganactncat cagaaaanga aggnagaaac cnggacnctt tacaanacaa cttctatcag 420 gnctgtatca accggtntaa gaaagacatt tagacaatta tgggaaaagt tggta 475 507 487 DNA Mus musculus 507 gactgagata ccattaacaa ggacactaag gttcccaacg cctgcttgtt caccatcaac 60 aaagaagacc acactctggg gaacatcatt aaatcgcagc tgttgaagga cccgcaggtg 120 ctgtttgctg gctacaaagt ccctcacccc ttggagcaca agatcatcat tcgtgtgcag 180 accaccccag actacagtcc ccaggaggct ttcaccaacg ccatcacaga cctcatcagc 240 gagctctccc ttctggagga gcgattccgg gtggccatca aggacaagca agaaggaatt 300 gagtagcagc tgaaagaagc gttgcttagt ggctggaagg ctggcacata ctcctcaggg 360 cccttcagtt taccacatgg cgacagccac tctcagctct ctagctgggc acggggctct 420 gccccattct gtacatagac tgttgttttc ctaataaaag cagagcagaa aatgggaaaa 480 aaaaaaa 487 508 455 DNA Mus musculus misc_feature (1)...(455) n = A,T,C or G 508 gctggaatta cagtttccca ccgttcgtgg ctcagattgg gtttttgaag ttgatcaagg 60 agccacggcc tncagcacag ccctactgcc agcaccatca gaggttctga accaccccgg 120 gaacgctcaa ttggggatgt caccacggca ccatcagagc ctctccatcg cccagatgac 180 cacaatttga ccaacttaat cattgaacat ggcggtaagc catctnggaa ggccttccca 240 gtcctggaca ttgactaccc tcacgtgcgc acaccctttg agatctccct ctggattctc 300 ctggcctgcc tcatgaagat aggtaccgag cctgctggct tgccgaagcc tcctgcagtc 360 ctgcactgaa gaaccatctn ctccctccaa gctgcttttn ttttcctttt gcctttttcn 420 aaanatcnat tttattttat atatatgaag catcc 455 509 514 DNA Mus musculus misc_feature (1)...(514) n = A,T,C or G 509 agaccagtgt ctcttcacca gcacccagng taaggtctgc tgngccatgc tgatttctga 60 gtctcagaag ctggcgcatt accaggtagg caatttctac tgtcttcgtg cgcttacctt 120 ccaggcccag cactaaggcc tcgctgcttc tgccttacac agtanaagct ccttgcacag 180 ntaccagatg tttccttcat acgtgtttgc tagggctnga aattgactta gtttctgtga 240 ctgncatctn gcccatgcaa gacagtatcg ttgnatgcan atcttgccgg acaacgtgat 300 gcantaggaa gtntgagctt tggctttacc tanaccagaa tttgaagcca accccgttat 360 tcattgnagg caagaaattt caccatactt ggccttagct tcatcttgta cacaatanca 420 gtgttntcat agattgtngg aggctaaatt taatagcatg taaagggcct agcacatggt 480 agggactcaa taaataaagt tttcttcccc caca 514 510 157 DNA Mus musculus misc_feature (1)...(157) n = A,T,C or G 510 atgtgttctt ataagcacac acagnggctc acacctgtng gcccgttctt gggaagnaga 60 ggtgggaaga ttgctgtann tnganaccaa cctgggctaa gnacattana gggaccctcc 120 tttaaaaggg gaanntatnt tcctcattgg aagaaca 157 511 444 DNA Mus musculus 511 gactgagctt cctcattgtt ctggtctgcc tcatcttcag tgtcctgtcc actattgagc 60 agtatgccgc tctggccacc gggaccctct tctggatgag gacccatgga agacttctga 120 agccgatcac ccatggagct cctattaaaa gaaaggacat gcatgcctta cactattgag 180 acagatgtgg gtgttctctg atccgaactt actgcaaggg ctgctagtgt ttgcctggca 240 tacatgaatc cctgggttca atctccagtc tgtataaact gtgcacagtg tacacacctg 300 tgatcctagt gctgggagat gaagagagag aggagcactg gaaggtcaag gttatccttg 360 gctacataga gtttgaggtc agcccaggct ccatgagact ctgccccagc aatagcaaca 420 acaacaataa caaaaataaa taaa 444 512 508 DNA Mus musculus misc_feature (1)...(508) n = A,T,C or G 512 gaactgaggc cctgancttn atcatcttct tngcttcacg gcctccatct ctgcctacat 60 ggctgcagcg ntgctagagt tcctcatcac actggccttc ctcttcctct acgccacgca 120 gtactaccag cgcttcgata ggctcaactg gccttgtctg gacttcctcc ggtgtctcag 180 cgccatcgtg catcttcctg gtggtctcct ttgctgctgt gacctcgagg gagggagctg 240 ccattgctgc ttttgttttt ggcatcatcc tggtctccgt ctttgcctat gatgcattca 300 agatctaccg aactgagctg atgcccagta ccactgaggg ggaccagcag tgattccagg 360 gttacctggc tcccacgacc agacacaagg aaccgnggag cccatctttg tcatctttga 420 attcaccgaa ccccaagtac ccaccatcta tattccacgt tttcaganat gngcgcttga 480 naagncccag gcacctgggg gaactggg 508 513 424 DNA Mus musculus misc_feature (1)...(424) n = A,T,C or G 513 gactgagttt taagctataa cattaatcat gagtgaccaa atcaaattca tcgtggacag 60 cctcaataag gagcctttta agaagaatta taacttaatc acatttgatt ctttgggacc 120 aatgcancta ttgcaagttc tcaatgatgt cctggctgag attgacccca agcannatgt 180 tcatatcaga gnggnnatgc cagagcagac ngccaaacga ctgatgaatc ttcttggtnt 240 ccttncgnac aaacctccgg gaaatgccac ngacatgagc nccttccgtc angncttggt 300 gattggaagt aaacctgtna ttaacccagn gctccactgg cttcttcagc ggagtantga 360 actaaagaaa agggnntatt tagctngttt cttaataaaa ccggaggtgc caagtgagtt 420 tctt 424 514 310 DNA Mus musculus misc_feature (1)...(310) n = A,T,C or G 514 gactgaggta caccaggggt tggaaaacca cactaggcaa agaacttgca tcaagatcag 60 gcctgaagta cgttaacgtg ggagatctag ctcgagaagg gcanttatac gacagctacg 120 atganganta tngntgnccc atnctaaana aggataggga tgcacnatna gttngancat 180 ctcctgcagg atnggcggga ttgnttgtng attacccacg gagtganact tcttnnccna 240 ncgctgggnc tatntantgg tnagcagtca gtgancagat gatggtgtat tgtataacac 300 gacttgctac 310 515 353 DNA Mus musculus misc_feature (1)...(353) n = A,T,C or G 515 gactgaggga aagtcatgga ggcttcagga tcttcttccc agtctcaaga cagtggtgga 60 gtccacaggg aaacggaaga tcactgnncc gaccatgggg ancacggaan atnaagggaa 120 ngcccntgag cnatatanna nagacaagtc ttcctcttca tcctcatnct cntcatcttc 180 ttcctcctct tcctcctcat cttcttcctc ctcctcagac agcagcnatg aggaccagcc 240 ctccnnaggt cccagganac acanaaggag gccccncagg gacagcttgc gtggtgccga 300 ccatggggaa ctggaagtgc taaaggacga gcttcagctc tgcggaggtg gtg 353 516 535 DNA Mus musculus misc_feature (1)...(535) n = A,T,C or G 516 actgaggatc cttccttgat gacctcgagt ctatggagga gtccatgtct cggagcctgg 60 gcaagcctgc cnagtcctcg aagcagnacc tgctggcagn tcatcctcgn aatatgaggc 120 gctggatcgg gagcttccgt gtatcacnaa aattctcana accnccctct gcccancccc 180 tctgcctttg catggagact taggaagact ttacacacgt ggaggcgctg caggctttgg 240 aggtcganct gnccggngnc atggaaagcg ggcgcgttaa cagtattcgc tacganaata 300 tgaatgtcat ctgnggnact gcgggccgna gggacaggng gctnatcacc gtcacagact 360 tccagacgcg gtcacgcctg ctgcgctccg ggctcaccct ccgtggaacc gngtacccac 420 tggtgcgcca cgacgattta ctgctggggg actaccgttt gcacctgcgc cgctctntgg 480 nncnaaaggc gcatgctcga agccctcggg gnggagcctg ccgacgaaga ttgac 535 517 353 DNA Mus musculus misc_feature (1)...(353) n = A,T,C or G 517 gactgagact cccttaggtg ctaatcattt aactgcaagc atgagtggat taagtctgca 60 tccagaggga ctaagagttg tcaatcttct tcaagaaagg aacatgcttc cttccacacc 120 actgcagcct ccagtcccaa atctgcttga agacatccag aaactcaact gtaacccaga 180 gttgttccga tgcacgctga cgagtgtccc tcagactcag gccttactga ataaagccaa 240 gcttcctctg gggctgctgc tccacccctt caaggaccta gtgcagtngc ccgtggncac 300 ctccancaca nttgggagan gccgntnatg caggacttac attaaccctt tcg 353 518 348 DNA Mus musculus misc_feature (1)...(348) n = A,T,C or G 518 tctgagcctt ctggccgggg ctccccgggn cctcgctgtg ggtgatgact ataccaaccg 60 gactggtgct gtgtacctgt gtcccctcac ggcccacaag gacgactgtg aacggatgga 120 catttcagag aaaagtgaga cgagcctgag ggcagagcta agtcgggagc ctggcagagg 180 gggcccaaag gggagatacg aggttagctt gttagggagg caacatttga agctaagggg 240 aaaagacagc gagatcaagg ctagatctac tatgggctac atagtgggtt gcagaatagc 300 ttgagatgta aaatggagat cctggctcaa aaagcaaaac aaaacaaa 348 519 365 DNA Mus musculus misc_feature (1)...(365) n = A,T,C or G 519 gactgagatt tgccgagagg ctgagttctc tataggaaca cccacatttg tatggatgag 60 tggggaaaga tagctgcagc agacaaggaa aaagcgtcct gacctcccga gaacatgagt 120 atgctaaaac ccagcggcct gaaggcccct accaagatcc ttaagccggg aagcacagcc 180 ttgaagacgc ctgctgctgc tgcagatcca gnggagaaga caatacccag tgagaaagcc 240 tcgggccctc catcctctna gaangntgat gaaaatgata aattttnctc tggagtagaa 300 naaantggga gtgatgagcc agccttcgtg tattacatga atgatggtgt ttatggttct 360 tttgc 365 520 165 DNA Mus musculus 520 gaggacctga accaggcccc ccaaccccaa gcagatgagg ggcctccagg ccgctccatc 60 ggggggatct cacccaacct gggtgccttg gacttgctag gcccagccac tggctgtctg 120 ctggacgatg gactggaggg cctgtttgag gacatcgata cctcc 165 521 230 DNA Mus musculus misc_feature (1)...(230) n = A,T,C or G 521 ctgggagtgt ggcaggaaga agagctactg natgcatggc tacattaggg nnngaaaatg 60 agttgngtna acactaagac cagggtgcct ttcngaagga agatcttnaa ctaaatatga 120 atgagggnnn naantttttt tgtaattata aatgggagaa naaaatttat gaaatgtntg 180 tcatnagcac attgattata aatgtctttc tgtnggaaaa aaaaccattg 230 522 218 DNA Mus musculus misc_feature (1)...(218) n = A,T,C or G 522 ggtgcaagcg tctcctgatg aaatgtattg tgccccactg ggctccaaag gcagnatctg 60 gcgctgttga tgcccttgtt ggaactttcc agagtcctaa gccccccatg ctgtaaatag 120 tctggtcgtc agagtaggga ggagcccggg cttctgttta tgtatgtatt tatttattta 180 ttatttattt attacaccta ataataaaaa ggtgctca 218 523 427 DNA Mus musculus misc_feature (1)...(427) n = A,T,C or G 523 gactgagctc ggattgggaa aatgaacgga ggaagcaaga tgaagggcag ntntgtnccc 60 tgtgcatccg tcccctggca ggatcgganc aggagatnan tanncatgtg nagcactgcc 120 tggctaagag ggaaggctcc tgcatggctn aagatgatgc tgtggacatn gagcatgcgg 180 acagcanccg ctttgaggaa tatgagtggt gtgggcngaa gcgnatacgg gccnccacac 240 tcctggaagg tgnnttccca ggtataaagc nnntganaac ttgggtggtg gnactcnggn 300 naccaggcca cttctgggan cnggacannn tttccaccac gngggagctc ttgctcgtgg 360 ggctcctttg ngaccgngct gcccgcctgt gatgtgcata ttaaagnggn tgtatttggg 420 tggggaa 427 524 452 DNA Mus musculus misc_feature (1)...(452) n = A,T,C or G 524 gaactgaggg atagcgtggc ccagtcgtct tctttgtgga ctatgcagtc taactgctta 60 tatatggaag aaatcgaaga ctcggtgact gttcgggatt atatccaatc cactatggag 120 actgaaangg acccccagng cctcttggac ctggccagga ggatggngcn ggttcttggc 180 cggaatgcac gancaagacc tcattcacgg ggacctcacc acctccaaca tgctcctgag 240 gcggcccctg gcgcagctgc acatcgtgct catcgacttt gggctgagct ttgtctcagg 300 actgccggaa gataaaggcg tcgacctcta tgtcctggag aaggccttcc tcagcacgca 360 cccccacacc gagaccgagt ttgaagcctt tctgaagagt tacggggcct cgtccaagaa 420 gtccagtcca gngctgaaga agttagatga gg 452 525 466 DNA Mus musculus 525 actgaggtcc cttaggagga accccttgag ctcccggtct aaaacacgtt atcgccagtg 60 tgagggctaa atggtgtgat aacacccaag agccaggaaa tggcaacagc cttggagcca 120 gaggaccaag atctttggga agaagaagga gttctgatgg tgaaactgga ggatgatttc 180 acgtgcgggc cagaatccgc cttggagggc gatgatcctg tactggagac ctctcaccag 240 aacttccgac gctttcgata ccaggaagca tcaagccctc gagaagctct catcagactt 300 cgagagcttt gtcatcagtg gctgaggcca gagaggagaa ctaaggagca gattcttgag 360 ctgctcgtgt tggagcagtt cctcactgtc ctgcctggag aactgcagag ctgggtgcga 420 ggccagcggc ccgagagtgg cgaggaggca gtgacgctgg tggagg 466 526 162 DNA Mus musculus misc_feature (1)...(162) n = A,T,C or G 526 tgcaccatac atccgagagt ttcgaggacc ctccganatg ctcactccta nancaagagc 60 agaaacccgg gaagaacgca tggagagaaa gagacgggaa aaaannggcg gcgacagcag 120 gaagtggaga cagagctgaa aangtgggac cctcacaatg at 162 527 380 DNA Mus musculus misc_feature (1)...(380) n = A,T,C or G 527 gactgagttt gtgaagtgtg gatatgcagg ctctaatttt ccagaacaca tcttcccagc 60 tttggttgga agacctatta tcagatcanc caccaaagtg ggaaacattg aaatcaagga 120 ccttatggtt ggtgatgagg caagtganct gcgttccatg ttggaagtga actaccccat 180 ggagaatggc atctgtgcgg aattgggatg acatgaagca cctgtgggac tacacatttg 240 gaccagagaa actcaatata gacnccagaa gctgnaagan tttacttaca gaacctccca 300 tgaatccaac caaaaacaga gaaaagattg tnnaggaatg gttgaaactt accanntttt 360 tggggtgttt gaacccttca 380 528 314 DNA Mus musculus misc_feature (1)...(314) n = A,T,C or G 528 gctaaacctc taaatgtggn cgcacatnct caattaaang gttanngttt nttnnatann 60 tgnccttggg cagttactat gagctacagg ntctgcctca tctagtcctc cgcatacagc 120 ggggagggtg agacttgggg atgcgcccac ctcaggccca tgcatcacca gatgggctct 180 cacatgacca ttacacacac tgatggtgac actgtatcag aaagccactc agctttgcct 240 tttaactaaa tctggacctg cttgccacaa ctatgtaacg naagcctcta actactaatt 300 tctgaagaga agct 314 529 315 DNA Mus musculus misc_feature (1)...(315) n = A,T,C or G 529 actgagagaa gaatggaggg cagtggaaag ctcgcatggt agaggatgct gtggagtacc 60 atctcttcct gataccagat aaagccagag gcacagaaga gcacagagag attcttcaga 120 agtacatttg aacggataat gacccagttn gnacccatac tgggancctt tatatctggc 180 agaatcagcc tttcaatctc aaatacaagc ctgcaaaagg gaggtgttcc tgctcatatg 240 tacggnatga caaagttttg gagataacat tgaggatgaa tgggcntatt gtttatgtaa 300 taaaggcaga ttaca 315 530 278 DNA Mus musculus misc_feature (1)...(278) n = A,T,C or G 530 gactgagatg ctgtcacatc tggagctgac tcttcaggca tccaancaaa atggcacgga 60 gacccaggag gtgttcctgg tcctcgtttc gaacaaaaat gtcttcgtga agttccaggc 120 cccggaaatn ccattgcact tggcctacga ctccagcctg gtcatcttnc aaggacagcc 180 aanagtnaac atcacagtgc taccatccct tacctccagg aaacagatcc tcgactgggc 240 agccaccaag ggcgccatca cctcgatagc agcactgg 278 531 409 DNA Mus musculus misc_feature (1)...(409) n = A,T,C or G 531 gactgaggtc caagcatgga aagtcataaa ccangnacta gcaaagatga tttaatactt 60 aatatcatat ccagaaaaat taaacaactt ccagantcag acaggaatct gcttgaatat 120 ggatcancat atatnggact taatgctgct tttgggggcc taataccana cagtctattt 180 cggcgaatct tgaacgngac acaagctcga ttagcttcta gcttaccaat ggctgtgatc 240 ccatttttga cagcaaacct gtcctaccaa agtcttgtaa gtttaccttt gagtacaggt 300 gatttgaact gtgaaacctg taccacaaca cggggtgcac tagttggttt ggttatgggt 360 ggtctgtacc ctatcctttn ggctataccc gnnaatgggg gccttgctg 409 532 489 DNA Mus musculus misc_feature (1)...(489) n = A,T,C or G 532 gaactgagtg cccaagatgt atgcagtgtg atgccaagtt tgacttcatc accagaaagc 60 atcactgccg ccgctgtggg aagtgcttct gcgacaggtg ctgcagccag aaggtgccac 120 ttcggcgcat gtgcttcgtg gacccagtgc gccagtgtgc tgactgtgcc ctggtgtccc 180 accgagaggc ggagttttat gacaagcagc tgaaggtgct cctaagtgga gctaccttcc 240 ttgttacttt tggggactca gagaagcccg agaccatggt ttgtcgtctt tccaacaacc 300 agaggtgctt ggttctggat ggggacagtc atcgtgaaat cgagattgca catgtctgta 360 ctgttcagat tctcacagaa ggcttcactc ctggagcagg cancacccga gccantggca 420 tgctcctgca gnacacagtg ccaggggcag aggctgcagc acagctgang ctgatggccc 480 ggagaggac 489 533 292 DNA Mus musculus misc_feature (1)...(292) n = A,T,C or G 533 gactgaggct gactcatgcc gatctggctg aagcctggct gntcctgcta ggtcgtcgtg 60 ccactactac tgctatcccg acgctactga actggactgc tagtatattc atgaagtgtt 120 ttcaagtgga tccagctgcc gntactgacc agtgaactga actgctgatt tcctgacaac 180 acagatgaga tttgctccaa agaaccattt ctaaacaggg ccacnncctc catatcctaa 240 tagcctttct tttctacctt tggngggtgg tgctctataa gggagggtaa ac 292 534 147 DNA Mus musculus misc_feature (1)...(147) n = A,T,C or G 534 gggagacctt ctggtagttc tgttctgggn cccttancca gagttccacc agccacaccg 60 gtggntcgaa tgtntgagca gagnaacgtg aactccgagc ctgaggagga ggaaggaggc 120 ctggaagatg aagatggaga tgatgat 147 535 487 DNA Mus musculus 535 gaactgagag ggttcccctt gcaagcatat ccaggcggcc cttgtcccac cattgcataa 60 tataagctac atcgtggata tgatctaggt cctcggagtg tctgttctca tgctctggac 120 cagactgaga atagaaagga gcctggctat ctgagagatc ctgtcctgca actggctgtt 180 ctggggctag aggatgtgga cgtgaccatg gactacactg gtatatattt ggtagaggac 240 agctctgctg aaaaatattc tactgtgcac aagaactctc aaaagaaagt tatctggggc 300 tggaacattg gcagctaaga gcactgactg ttcttcggag gtcctgagtt caattcccag 360 caaccacatg gtggttcaca accatccgta atgggatctg atgccctctt ctggtgtgtc 420 tgaagacagc aacagtgcac tcacatgtat atgtaaaata aataaataca tctttaaaac 480 aaacaaa 487 536 132 DNA Mus musculus 536 gactgaggtg tgcgccttga ccgagttcga ggaggccgcc agaagtacaa gcgacggctg 60 gattcggaga acagccccta cctgaacctg ccgatttccc cacctgctaa aaagccattg 120 aaaataaaaa aa 132 537 486 DNA Mus musculus misc_feature (1)...(486) n = A,T,C or G 537 gactgagcct agtcattgtt ggctacgagc aatggtaata caattatcac tcagcttgac 60 tactcttctg gacaagttct caaatatttc tgaaggcttg agtaattact ccatcataga 120 caaacttggg aaaatagtgg atgacctcgt gttatgcatg gaagaaaacg caccgaagaa 180 tataaaagaa tctccgaaga ggccagaaac tagatccttt actcctgaag aattctttag 240 tattttcaat agatccattg atgcctttaa ggactttatg gtggcatctg acactagtga 300 ctgtgtgctc tcttcaacat taggtcccga gaaagggaag gcantcaagg nntcnntgga 360 ntactgnnna cagtgagatg gaacnntnnt anncttnccc tgctggatga ncngaatgtg 420 tngctannga aagaantngn gggactttnt gctacaaagg tctncgcngg ctcgggactg 480 tcctta 486 538 174 DNA Mus musculus misc_feature (1)...(174) n = A,T,C or G 538 gactccacag gaggcctaca nacagngggc tantccagcc acgctctang aaccatnaca 60 aaccnttnct ctttataaga aattggctca ngcattaccg atgaaaagct gtgtaacaca 120 ggctttgagg cataaaaccg atttctatta aatgtagaaa caaaatgaaa aaaa 174 539 339 DNA Mus musculus misc_feature (1)...(339) n = A,T,C or G 539 gactgaggtg acagtacaga naagtaccac aaacgttatc caggcanctg actgacatgg 60 tgagacagct tgtagacgat gtcaagagcc ttnaaacgca nagacccaac ttgngatctg 120 gacaggacaa tgcacaaggc accccaccca cggctggnna gatggctcag cgattannan 180 cactaactgc tnttctgaag gtcctgagtt caaatcccaa caaccacatg gtagttcaca 240 accattccta atganatcag atgcactctt ctggtgtgtc tgaagacagc tacaatgtat 300 tcacatataa taaataaata aatctttaaa aaaataaaa 339 540 531 DNA Mus musculus 540 gactgaggtt ttaatgtgga aacagtagaa tataagaaca tttgtttcac agtatgggat 60 gttggtggtc aagataaaat taggcctctc tggaggcatt acttccagaa tacccagggt 120 ctcatttttg tggtagatag caatgatcgt gaaagaatcc aggaaggagc agctgtgctg 180 cagaaaatgc ttctggaaga tgagctgcag gatgcagtgc tgctcctttt tgcaaacaaa 240 caggatctgc caaacgctat ggccatcagt gagatgacag acaagctagg tctgcagtct 300 ctccgaaaca gaacatggta tgtccaagcc acttgtgcta cacaaggaac tggtctgtat 360 gagggactgg attggctgtc aaatgaactt tcaaaacgtt aaatgaagct ggatatctaa 420 ccaaggacat gtttgataga attggtctag gcttgttaca acaaaattag tttgcatctt 480 ggttattaaa ggatatctga gacaggtttg ggcagaaatt acagcgttta a 531 541 158 DNA Mus musculus 541 gactgagtta tatccgactt tatgggagaa aatttagcaa agaagatcat gttcttttta 60 ttaagttact gtatgagctg gtatcaattc caaaactaga aatcagcatg atgcagggat 120 ttgcccgtct cttgatcaac ttgttaaaaa aaaaggaa 158 542 398 DNA Mus musculus misc_feature (1)...(398) n = A,T,C or G 542 cctcctgggc tggggttcgc tgctcatcat gctcaagtcc gagggctttt actcctacct 60 gtgtacgaag ccaggtgana tgggcgcctn nntcgggngc aggtttctgg agtggntctt 120 tgggagaggg ctgctnggtg gtgaanacgt aanccagnta tgcctgcttg ctgaacagtg 180 cctctangtg ccnnanngnc cattntgatc ctnanccngc tatctgtgtg cntnnnatna 240 tcatngtccc tgtttggggn tggngaaact gaggctggga ccantcttcc nttntgccca 300 ngctgtgaga ctaatagact aatagactcc tgcgtgcngn cangaacgtt gntggccttn 360 tgntcttcca gggcctgcan cattgcttgc cttgcaaa 398 543 228 DNA Mus musculus misc_feature (1)...(228) n = A,T,C or G 543 ctcacagcca cccatagacc anttncaatg agaggcatct gacccagcag gaaacgaggc 60 ctgctnaaca gagccttgga tatggacgat anggattaca gtgaggcccg atggcctgtc 120 ngataagnac cacccccagt aaggcccagn aagtcncctc nagaagaatt gccaangaan 180 gtttcaanna gtagccntat gccngngtca cccttgcttc gaaggctt 228 544 253 DNA Mus musculus misc_feature (1)...(253) n = A,T,C or G 544 gactgagatt ttcagaatga tcaactagnt gaaatatctc cattgggtac tgaggaagtc 60 tcagcagtta gccaagcgtg gtttacaact aaagaagata aggattctct cactaacaaa 120 ggacataaat ggaagcaggg gatgtggtcc aaggaagaaa ttgatatttt aatgaacaac 180 atcgagcgct atctgaaggc tcgcggaata aaagatgcta cagaaatcat ctttgagatg 240 tcaaaaaaaa aaa 253 545 371 DNA Mus musculus misc_feature (1)...(371) n = A,T,C or G 545 gactgagact aaaatgtcaa aaagaaaatg gctctgttag cccaacagtt acccagacgg 60 ttcaactcag ttaagttgac tagcttcatt aaagccaaac aagtcaccaa acgctctgca 120 agagcaggaa aagccgtgtt gcccggcttc tcagctcagc ctctgctctc ctctgacacg 180 agctttctcc ggcggggaat taagacttac aggactttgt tctggaatcg tttccattct 240 gccagcacaa ataggacaaa gagttctgcc cgaaagcact ctgcttcctt cagnggntga 300 acagcaggga gaggatnctt agtcttgaat canagcttgc cttttggaag aagnggacga 360 cctgcctcca t 371 546 434 DNA Mus musculus misc_feature (1)...(434) n = A,T,C or G 546 ctgaggcaca acccggtctc ccagaanagg agaagtgcct ggcgtggatt acagctttct 60 gactgtgaag gagttcttgg acctcgagca gagcgggacc ctgttggaag tcggcaccta 120 tgaaggaaac tattatggga cacccaaacc tcccagccag ccagtcagtg ggaaagtgat 180 cacgacggat gccttgcaca gcctgcagtc tggctccaaa cagtcgaccc ctaagcgaac 240 aaagtcctac aatgatatgc aaaatgctgg catagtccac ccggagaatg aggaggagga 300 ggatgtccct gaaatgaaca gtannnttta cagccgactn tggagaccag gacgagccac 360 ntctccaaga agcaccgcnt cccacctgtg aatagtagca tcctcgcttg ntcccatcac 420 gggacccttt ttaa 434 547 221 DNA Mus musculus misc_feature (1)...(221) n = A,T,C or G 547 atggatacta caatggtgaa tttgtggact ctgtttgagc agcttgtgcg ccggatggag 60 attatcaatg aaggaaatga aagcattgaa ttcatccagg ttgngaagga cttcgaggac 120 ttccnaaaga agtatcaaan gacccaacca ggagctggag aaattnaaag acctattgtt 180 gaangcagag actgngctgg aaccgccctg gacgttaaag c 221 548 337 DNA Mus musculus misc_feature (1)...(337) n = A,T,C or G 548 gatgacgtcc atatcttntc gnaagagagg gaatcagaag gtacttnngg gagaatagtg 60 atgcagcttt ncaccntcac ngcaatgaga ggattctgag gccttctgag nggaatcaga 120 gataccttgc caagtaatat gtaccagaaa aatggcttac atcatgggaa atacgcagtg 180 aagaaatcac ggnnaactga tgtggaagac cttactccaa accctaaaaa actacttcag 240 attggtaatg agctgcgcaa gctgaataag gtgatcagtg acctgactcc agttagtgag 300 cttcccttaa cagcaaggcc aaggtcaaaa aaaaaaa 337 549 173 DNA Mus musculus 549 gactgagagc tctgcacatc gagagactta aaaccacctg agatcatcag acaagtcaca 60 tacatgggac tttttgaatt attgccattt tgtattttta tcatgttatg tgtaaaagac 120 agtgcctatt ctgtgtttta ctgaatcaaa ttgacaatgt cagaaaaaaa aaa 173 550 164 DNA Mus musculus misc_feature (1)...(164) n = A,T,C or G 550 atcttcctgc tccagcctct tgaatggaat gctgtacata gactccagac cagctcagct 60 acttcctcct atgctcttga cacaaatgaa cactgaccac aaatttctat ttgtacaatc 120 tgtggatgtn ccaaaataaa ggaattggag ctgaaaaaaa aaaa 164 551 105 DNA Mus musculus 551 ttttttccac tattattgca tgcagattaa aacgttaaga gcttttcttt ccccttaaaa 60 attctgaatt atgaaaataa acatttcaaa tttcaaaaaa aaaaa 105 552 203 DNA Mus musculus misc_feature (1)...(203) n = A,T,C or G 552 cacagactga gttttaagga cttcctgagc tgttntgagt tgttnactta tggatcttca 60 ctgcaagatg gactgttcca atctcagagg aactcttcca gaaacctgta tagactactt 120 tggccttgaa ctcctacagg tggncctgcc tttgcttcct agnggctggg attaaaggtg 180 tgtatcacca aagagaaaaa aca 203 553 407 DNA Mus musculus misc_feature (1)...(407) n = A,T,C or G 553 atactgattc tctgatttcc cagtaatgcc actcagttgc caatatcaag caagcgcata 60 taagacactt gtaatctttt aagaaaagta gtacttctct tcacagtatc tggcggatca 120 acactggagg gtgaggtgtc agcttccaga aagatcatca tgaagttata tgtgtttctg 180 gttaacaccg gaaccacgct gacatttgac actgagctaa ctgtgcaaac tgtggctgat 240 nttaagcatg ccattcaaag caaatacaag attgctattc agcaccaggt tctggtggtc 300 aatggaggag aatgcatggc tgcagatcga agagtgtgta cttacagcgc tgggacggac 360 acaaatccaa tttttctttt taataacaga aatgatctta ttgaaag 407 554 179 DNA Mus musculus misc_feature (1)...(179) n = A,T,C or G 554 gactgagata aaatcaaaga caaaattaaa gagaaagaca aagagagaag aagaaaaaga 60 agcatggnng tnatgannng agatcaagaa agaaaatgga gatgtaaaga ttttactgaa 120 aagtgggaag gagaaaccaa aaacaaatat agaagactta caaattaaaa aagtaaaaa 179 555 219 DNA Mus musculus misc_feature (1)...(219) n = A,T,C or G 555 cgttgaaaca tgcccgtcct tcaccanact gagcttccac agcgcggtgg ttggtacagg 60 actctccgtg agactgatgc tctatacaca ngagaaacng ctgtcttcan ancaaacaca 120 aacaaangan agttttcttt ccttcctatt ggcgcaatcc atacttattn caggaaattc 180 cttaagacgt ntagatgtaa aatacaaaac tgtgcacaa 219 556 750 DNA Mus musculus misc_feature (1)...(750) n = A,T,C or G 556 gcttacaggt ggtgcagaaa gaagtctggt cacaactggc tacagtgaac gagctgggta 60 ccccaaggac atcttaccag ttccagccaa agatctgatc tacgtacacc tgcgtcatgc 120 tgagaccctc aagcctcact aaaagggtcc ctgcctagtt ctgtttacta atctgcctta 180 ttctgttgtt gttcccatgt taaagataga gtaaatgcag tattctccac atagagatat 240 agacttctga aattctaaga ttagaattac ttacaagaag aagtggggaa tgaagaatga 300 aaaattactg gcctcttgtg agaacatgaa ctttcacctc ggagcccacc ccctcccatc 360 tggaaaacat acttgagaaa aaacattttc tggaacaacc acagaatgtt tcaacaggcc 420 agatgtattg ccaaacacag gatatgactc tttggttgag taaatttgtg gttgttaaac 480 ttnccctatt cccttcccat tcccccttcc agtttgnggg ntttttcctt taaaaagctt 540 ggggaaaaat ttttaagtcc gtcgtcgaga ctcctctacc ctgtgcttaa aggggtattg 600 aagtttcgac ccccanagct nttggnctgn ggnggctttc atggttggct ggntttattt 660 tcaaaccccc aanaactttt gggccnnggg gggcttttaa tgnttgccta nctttaatta 720 aatcttaccc tttttacaat ttttaaaaaa 750 557 218 DNA Mus musculus 557 agtcatgcag gaaaacctca gcatttgctt catcaggaga tgacgttaaa atatgggatg 60 cttcgttcct gacattggtg gataaattca accctcacac gtcaccgcat ggaatcagtt 120 caatctgttg gagcagcaat agtatccttt aaaaaaaagt aatcactttt tgttagtttt 180 caatgatctg tgcaactgtt ggcccataaa aaaaaata 218 558 223 DNA Mus musculus misc_feature (1)...(223) n = A,T,C or G 558 gactgagggt cccttacant cccttaaaaa tccattctcc cttccttgct ccttgcagca 60 gtaacatgta tgagtaccat gcaccaactg atcgtgccat tggagctcct taaacagtaa 120 tcacaaccaa gctaggggaa catttgtatc cgataaaggg gtgggagtgc aggttttagg 180 cactcctttg ggagaacaaa gaaattaatg taaataaaaa aaa 223 559 222 DNA Mus musculus misc_feature (1)...(222) n = A,T,C or G 559 aattgtctct tgagttccac tgggaatgcc cagtctgggg ctgtgagaaa cactgtatca 60 aagagatccc ggctcagcac ctgagacaca ggcatgaggc ctgcaatggg acagagcaac 120 cggaactcct aaagactgtc ttccaaagtt gtgctgggcc ttttgngggg aggaacatga 180 ctgtgtcatg gggaaaatgc atacatctgt ttttacttaa ca 222 560 380 DNA Mus musculus misc_feature (1)...(380) n = A,T,C or G 560 actgaggtag cccagagctc gagagctggc ttcctgacca tcagacaagc ttcgccaaaa 60 gtcttcacct aagcaaacag gagaaagaag ggnttctntg tgnnnccccg nctgtnctgg 120 ntctgactct gtacgaccgn cacaccnagc tggccttgaa cttaanagan ctgcctgcct 180 ctgtnctgac tgctggnatg gaagggatgt gccactactg agagcttgtt ttagtgctta 240 cancttgctn tgctgctaag ccagatgccc tgagtgtgat nctctagaat gacaaggtgn 300 gagagaacca attccccann ttatcctcac acccacacat gagntgcgnc aagtgctccc 360 acctctgaca ataaaaaaaa 380 561 149 DNA Mus musculus misc_feature (1)...(149) n = A,T,C or G 561 aggactgagg taaaatcaaa gacaaaatta aagcagnana gcacaaanag tagaagaaga 60 aaaagatgca taangtaatg antngagatc aagaaagaaa atggagatgt aaagatttta 120 ctgaaaagtg ggaaggagaa accaaaaac 149 562 126 DNA Mus musculus misc_feature (1)...(126) n = A,T,C or G 562 gtctcgggct ggtgagtang gctcagtggg taagagcann cgactgctnt tccgaaggtn 60 cgaagttcan ntcccagcaa ncacatggct ggcgtcacaa ccntccgtnn cgagatctga 120 cgccct 126 563 134 DNA Mus musculus 563 atggattttc ctgtaaactg caagataacc gggacaccag tctcactcaa tcctttttgc 60 cgggaacccc ttcctcccta ttaatgcatg ataatgaata ataataataa gaatttcatc 120 tctaaaaaaa aaaa 134 564 424 DNA Mus musculus misc_feature (1)...(424) n = A,T,C or G 564 aactgagcct atcctctact cctatttccg aagctcctgt tcatggagag ttcgaattgc 60 tctggcgtta aaaggcattg actatgagat agtgcccatc ancctcataa aggatggcgg 120 gcaacagttc actgaggaat ttcagaccct gaaccccatg aagcaagtgc cagcgctgaa 180 aattgatgga atcaccattg tccagtcact gancatagnn ctngaccgng ganaaaactc 240 tgactnngng ncccgttnct nccttagnna cctaacntac gagcnatcnn gcgcatgann 300 gntnanctcn tnnctggtgg anngcagncc cttngaaacc tgtctgtcct gaagcaagtg 360 gcacaggaga accagatgca atgggcccaa anggtattac ttccggnttt aacgctctgg 420 aaaa 424 565 341 DNA Mus musculus misc_feature (1)...(341) n = A,T,C or G 565 tttcagctca gttacttatg gcttccccta aaattgcttc cctctcttgg ggacaaatga 60 aagtgcaagg ctctacntta acctataagg attgcaaagt atggccagga ggcagtcggg 120 cttgggactg gagggaaaca ggaaccgagc attctcctgg agagcagcca gcagatgnaa 180 aggaagttgc tgagaaaggg gtacagactc ttgtgattgg cagaggaatg agngaggcct 240 tgaaggtgcc tccgtcgatt gtggagtacc tgganaaaca aggcattgat gtgcgcngtc 300 ctccaaacag aagcaggccg ngaangagta taatgccttg g 341 566 439 DNA Mus musculus misc_feature (1)...(439) n = A,T,C or G 566 caccacagac ttccaggaga gctttgtcac gtcaggtgtg ttcagtgtca cggagctgat 60 ccaagtgtct cggacacctg tggtgaccgg aaccggaccc aacttctcac tggggagagc 120 tgcagggtca cctggcatat gacctgaacc cggccagcgc cggcatgaga aggactctac 180 ccagcacctc ctccagtggg agcaagcggc acaagtcggg ctcgatggaa gaggacgtgg 240 acacgagccc cggcggggac tactacacgt cggccaactc acccacgagt agcagccgca 300 actggacgga agacatagaa ggaggcatct catccccggg tgaanaagac agagatggac 360 aaantctcca ttnnacagcc cgtcccccca ggactccccc nggttntcca gcttnacaca 420 acaccacagg ccggtcatt 439 567 469 DNA Mus musculus misc_feature (1)...(469) n = A,T,C or G 567 actgagcctc ctggtgcaag ctatatttaa tggtgatcca gatgaagtcc gagcactaat 60 atttaagaaa gaagatgtta nctttcagga caatgagaag agaacccctt tgcatgctgc 120 tgcctatctt ggtgacgcag aaatcattga gctgcttatt ttatctagga gctagagtta 180 atgccaaaga cagcaaatgg gttgacacct ttacacagag cagtttncat cgtgtagtga 240 ggaagcagtt cagatacttt tgaagcattc tgcagatgtt aatgctcgag ataaaaattg 300 gcagacccct ttacacatag ctgctgctaa taaagctgta aagcgccgct gaatctttgg 360 tacctctttc tgagcaatgt ggaacgtgtc ccgaccgagc anggaagaac tgnattacat 420 catgnagctt ttcagtgggc atgggcgana tgggcaaact actcttgtc 469 568 385 DNA Mus musculus misc_feature (1)...(385) n = A,T,C or G 568 gtcttctagt aagaacaaag nctgangacn tgatctctca gctgcacnct aacctcctgg 60 gctccatgct gacctgtaaa gctgccatga agacantgat tcagcaggga gggtctattg 120 ttaatggggg aagtattatn ggtnagaaag gcacccgnng gccaactctg catacagtgc 180 caccaaagga ggactcgttg gnttntcacg ctcggttgct aaagaggttg cncggaagaa 240 aatgccngtg antgtgntgn caccaggatt tattcgcacg gatatgacnn tgacactgga 300 aggaaganca ctncnngana aacattcctc ttgggaggtt nngagaaact cntgagggan 360 cacatgccgt tgcgtttttt tttag 385 569 303 DNA Mus musculus misc_feature (1)...(303) n = A,T,C or G 569 gactgaggtg gggtctttcn cccaagagga ggaagaagag aacctacggc atgacaagcc 60 cccctacacc tacttggcca tgatcgcctt ggtaattcag gccgcaccct tccgcaggct 120 gaaactggct cagattatcc gtcaggtcca ggcagtgttc cccttcttca gggacgacta 180 tgagggctgg aaggactcca tccgccacaa cctttcctnt aatnggtgct tncataaggg 240 gcccaaggac cctgcaaagc cccaggccaa gggcaacttt ttggncgggg gatgggagcc 300 tga 303 570 532 DNA Mus musculus misc_feature (1)...(532) n = A,T,C or G 570 gactgagatg gtggctcgct gatttctccg atccctaatc cgggtcacag aatggttaaa 60 gcagctttaa gtanagagtg gattattttc ccctcagttt gtcttctgtt tgcggctctg 120 aaagaatgtt gtgggcgctc tttttcctgg tgactactat tcacgctgaa ctctgccatc 180 cagatgcaga aaatgccttt aaagtaagac ttagcatcag agcagctctt ggagataaag 240 catatgtctg ggacacggat caagaatacc tcttcagagc aatggnggca ttctccatga 300 gaaaagttcc caacagagaa gcaacagaaa tttcccatgt cctgctttgc aacataaccc 360 agagggtgtc gttctggttt gtggtcacgg acccttccaa caattatact cttcctgcag 420 ctgaagtaca gncggccata agaaagaata ggaaccggat caacagngca ttttttctgg 480 angaccntac tctggaattt ttaaaaannc cttntactct tgctcccccc ga 532 571 256 DNA Mus musculus misc_feature (1)...(256) n = A,T,C or G 571 tatttacttc ttgtggacct ctcacagatc angcngnnaa ggngnatagn gccttgnttg 60 cccaaggggt natggaagga ggtgtcntcc attccacctg ctganggcgc ctacagagga 120 gaataattca gaccncncag ncnngggtga ctaccagtcc ttggcctcag ttcctgcctc 180 cagatttctg ccttgagggg gctaccctga cttccctgga tgatgaacta caagntgtaa 240 gataaaataa accctt 256 572 240 DNA Mus musculus misc_feature (1)...(240) n = A,T,C or G 572 actgaggtct cctgctcacc agntgncttg acagtttttc ttgcaacatt ggccattggt 60 tttcactgcc ttcaaaagat canaattact ccagaaattg gagagttgga tttaaaagaa 120 aaaacttgaa caaatggaca atatgtctat aacaaataca ccancaagta acgatgcctg 180 tctgagcatt gtacatagtt tgatgtgcca tangacaagg tggggaaagt gaaacctttg 240 573 350 DNA Mus musculus misc_feature (1)...(350) n = A,T,C or G 573 aatgggatac gacacgggnc ttacacagcc tctcggaaac atatctatat tgatanaaat 60 acngaagatt atnttgcnca gggtttcaca aggcaaacag ggtacctttc acagccagna 120 nggcttttgg agtncggcac caaactcgtg gnaggaacca cttccngggg aaggggtggc 180 caagaagcac ctgggcttgc ccgntcttta ataccggtga agggaggccc aaaagangaa 240 aacagggagc naacgggttt ctggcattna tggcccctcc tccttttgct ggnngctgnc 300 attaantgaa ncannccgcn ncggaanatt cccttagggt tggggggcat 350 574 523 DNA Mus musculus misc_feature (1)...(523) n = A,T,C or G 574 catgaacgtg ctggagccag tgtggttcaa ctcacctgga atctgagcac tcaggagtct 60 gaggcaagat tgccaagagt tcaaggccac cctcagctac atgggtctca aatactcaag 120 agttcactct gcggctgagg atgacctcaa gcctctgatc ttcctgctgg gatcactgag 180 agctgggatt acagcattgg acgcgttctc acgaccggcc aggaaagacg caacaaacca 240 gaatcttctg cggcaaagct ttattgctta catcttcagg agccagagtg caagaagcaa 300 gagagagaga aaacgaaacc ccgtcccttt tttaggagag ttatatttcg cctaggacgt 360 gtcactccct gattggctgc agcccatcgg cccgagttga cgtcaccggg gaaggcagag 420 cacatggagt gganaaccac cctcggcata tgcgcagatt atttgtttac cacttanaac 480 acaagctgnc agcgccattc ttgtaacggc gaatgtgggg cgc 523 575 274 DNA Mus musculus misc_feature (1)...(274) n = A,T,C or G 575 gaactgaggc tttatggaag gcagtggtcg gancagggca gaatcctacc ctgacagcag 60 cacactggtc attgccgtgg cangngagga gacgactctg gtgtgtacaa cataaatctt 120 gaaaaatgga ggctggagaa gcacattcca ggcatcanag attaaggttg tggattatcc 180 ctggtccctc cagnggcanc caaangtgac anaangtgga agantgactg ggngcatcnt 240 gaanctggga agccgtgcgg ggcctatgat ggga 274 576 420 DNA Mus musculus misc_feature (1)...(420) n = A,T,C or G 576 tatttgtata actttgcnag tgctgcaaca nagaagataa ctgaatctgt tacagaaaca 60 gctcagacaa tcaagaaatc cgtggaagaa ggaaaaatag atgatatcct tgacaagact 120 attttaggag attttcaaaa agaacagaaa aaatttgttg aggaacagaa tacaaaaaag 180 tcagaagcag ctgtgcctcc gtgggttgag agtcatgatg aagagacaat tcancagcag 240 attttggctt tatcagctna aaaatnngtg agtcgggctg gcgaganggc tcagnaggta 300 ngagctntga ctgctcttcc anaggtcctg ngtncananc ccannntcca catggtggct 360 cacanccacc catantagga tctgactccc tcttctagag agtctgaaga cagctacttg 420 577 492 DNA Mus musculus misc_feature (1)...(492) n = A,T,C or G 577 cactatccga tgaagatatg accatggtgc tgaagaagac agcgacnngg angatcagga 60 cctggataaa atgtttgngg cctggcttgg agaactggac aggcttactc agagttgnga 120 tnctgacaag cccaaggaac acantaataa ngatctnctc ttnnccngga annaantatn 180 ngcaactttt nttnccgctt ntccatatac aacttgnatg aanctntgaa tnatngngag 240 actgtgnacc tggatnccct gatggctgac ctctgntcta tagagcagga gctcagcagc 300 attgnctcag gaaatagtaa gcntnacgtc acagaaccnt aaagttcctc agaagctacc 360 tgctgnccga catacgtcac aacatggcac cctgagagga ccgtcatctt cctctaatag 420 aacaactaaa ccttcccatg ctaactactc cctggatgac atcactgctc agttagaaca 480 ggcttcctcc tg 492 578 165 DNA Mus musculus misc_feature (1)...(165) n = A,T,C or G 578 agaagtctgt ggaatgttga gcatctgagg ggnaacatat ggnggcacca tcccaggcat 60 tccaaatgga tttggtcggg ctgttntatc aatacnngaa ganaataata tggacaactg 120 gtnaagagaa tgcaatannc ncagtncagc cccagtagcc caggg 165 579 357 DNA Mus musculus misc_feature (1)...(357) n = A,T,C or G 579 aggctccctg ctgccccatc ctggccacaa ctttgtgcgg caccatctta gaaaccgtcc 60 cgacctatat ggccccttct ggatctgtgc taccctggcc tttgtcctgg cagttactgg 120 caatctcact ttggtgcttg cacagagacg ggacccctcc attcactaca gcccccagtt 180 ccacaaggtg accatagcag gcatcaccat ctactgctat gcgtggctag tgccgctggc 240 gctgtggggc ttcctgcggt ggcgtcaggg cacgagggag cgcatggggc tgncaccttc 300 ctgganacag tctggngtct acgggctact cactctttgg nttcatccct actgggg 357 580 437 DNA Mus musculus misc_feature (1)...(437) n = A,T,C or G 580 gactgagatg agcagtttgc agatcaaggt aagacaaagt caaagcagac accaatggtg 60 ttatcaaaac cagcaccact tgcagnaaaa gacaggagga agaggagana gagggacaga 120 gcttgctcan tctttacttc aacnnagctg atcanaagca atcttggnng nataacaccc 180 anccaagtcg ggaaggtcct tgcaaaggga ncccaagcct tccccngctc tacttcangt 240 ngaagnncct ttngaangag cnttcgcctt gaaaacctnn agcttctccn anggangtnt 300 acngccnagg ggcttcaatc ggaccgtccc aggatcnang gaagaangct nttgcccata 360 gangnttgct ggacccccnc agnaaactng attnggcaag tcncagnttt ggtncttggg 420 aagaacagct ggccttt 437 581 345 DNA Mus musculus misc_feature (1)...(345) n = A,T,C or G 581 agactgaggt caagtggact ccagctaant actgtcaatc aacagcctgt ttcccttcca 60 cctgcctatt cctgagggtg aggtcttttc cctggtccca ggacttcccc acccctcctc 120 caaataccaa gactatgggc ttaaaagttt caaatgggtg ctggagagat ggctcagcag 180 ttaagagcac cgactgctct ttcgaaggtc ctgagttcaa atcccagcaa ccatatggtg 240 gctcacaacc atctgtaatg gaatctgatg ccctcttctg gggtgtctga agacagctac 300 agtgtactca catatattaa ataaataatt ctttaaaaaa aaaaa 345 582 397 DNA Mus musculus misc_feature (1)...(397) n = A,T,C or G 582 ccactgagct gttgaataag tgctncagct ncgncttggg agtttgnctt gccagacngc 60 tctgctnttg cacctgaaca gcccangggc canngtggac cctgnnacan tcatngagag 120 gggcaggttt atgctaancc tatgtntaca acagtntttt ggggggtgta gntccaccac 180 ntgccacatt cacttgnnat ganggcnctg tagncaagct agcacccaga gccccttnca 240 aggctacaca attacaggtt cctcggccac tctggaactg aaggggcaag cctgctccna 300 ngnnacccta nccnggngtg ctggccgaca gnctaggccc acatctctgn tttgctggct 360 tccnttgtac tctcaacccc tgccttgttc tgggatc 397 583 122 DNA Mus musculus misc_feature (1)...(122) n = A,T,C or G 583 catgatccca cctcccccca gtctcccggg ccctcctcgg nctggcatga tgcctgcccc 60 ccacatggga ggccctccca tgatgccaat gatgggcccc cctccgcccg gaatgatgcc 120 cg 122 584 254 DNA Mus musculus misc_feature (1)...(254) n = A,T,C or G 584 actgagggtt ccaagnctgc cctttggtat tcaaacggga gccgctttgg actgactggc 60 tgccttcctc ctcctccccc tcctccccct tctgcttcag atttatttat tatatgtaag 120 tacactgtag cagttgtagg acacactaga cgagggcacc agatctcatt gtgggtggtt 180 gngaaccacc caccatgtgg ttgctgggan tngancnnag gatcttcaaa aaagcagncg 240 gggggtctaa cccg 254 585 274 DNA Mus musculus misc_feature (1)...(274) n = A,T,C or G 585 gactgaggta ctacataaat agccaagnnt attccatttt tagtaccagg agttctatta 60 aattagagta tgaaggaaac tcatttgtat catggaaaat accagaaagc tgtaaagttg 120 aaaacactac atcacccann acaacactac nctgcntnag ggctggantt cacacantna 180 anccaatngc tggannccaa naagtggaac ggcctctgac tgtggntaat tcttatatnt 240 gctacttgcg ggatttcaca gacgggtaag tgga 274 586 467 DNA Mus musculus misc_feature (1)...(467) n = A,T,C or G 586 gacctgaggc caggccatct gccttcaccc gctctatgtc atgcttccct gcaccctggc 60 tgcctcccta gctttcatgc tacccgtggc cactccaccc aacgccattg tcttctcttt 120 tggaggcctc aaagtgtctg atatggcccg tgcaggattc ctgctcaata tcatcggagt 180 gctgactatc acattatcca taaacagctg gagtatccct atcttcaagc tggacacatt 240 tcccacctgg gcctactcca acacaagcca gtgccttctc aatccgccta attccactgt 300 accaggccac tagactatgg tacaacctag ctctgctagg ggaaaagccg ctggtgccac 360 tcctcggagc caggagaggg cgctccaaac tccaagtccc gggacagagg tgcagaatcg 420 gntgggcgca tgcgaaatca tgtattcgng tgtttgccta catcctg 467 587 477 DNA Mus musculus misc_feature (1)...(477) n = A,T,C or G 587 ggggaaacgc cgacctgant acnntcccta agcccaacag acactcacac tggttcgtca 60 tgaagtcgga gaaattccat gatgagctct ccgaccacgt attctttacg tntctgatcc 120 agaactgaat ggtaattctc cagaacagcc ttntggtact cctcactgaa catgcgaggc 180 ggggtcctgg gattcaacgc aaaaggagta tcagagccgg gcctgacgtg agatccactc 240 gaccaccact aaaagatctg tcctgatgcg gggctgtact aactgcagga ctcaactgat 300 gctggctcag agaccctgct gtntgatgtc agctagcatt agagagactt taaaggacac 360 gcctggcagg gggggctggc gtatgccntt agtcacagcc ctggannagg cnggaggagc 420 tcttgagttt gaggccagcc tggnctacag aacgagttnt gggacagcct gggctgg 477 588 477 DNA Mus musculus misc_feature (1)...(477) n = A,T,C or G 588 gactgaggtg tgcatgcctg cgtttccatg aatgacgcat accaggagga cagaagactg 60 atacaccagg ctggagttac agacagttgt nctcnngttg actnaggagg nngcannctn 120 cttngnctgc tgngccatca ttgctggatg cctttannta ctgaganang nttctactgt 180 gnntccnngg ngtttnntan ntcnacctca antaacatgn ggttggnngc taacnnttta 240 tgtntttnag aagtgacttt nancttctgg ncctcctatc tnctcctctt cctcctcttc 300 ctcttcttca tcctcatcct ccccttcctc tncctnctcc tntncctcct cctnctgaga 360 gctgggacca caggtatgta ccacacgccc agcttataca gcacactctg cagactgagc 420 tcaagtgcgg tttcatgggt gtggatggca aaaggtgttt aagctaaaag gaattca 477 589 305 DNA Mus musculus misc_feature (1)...(305) n = A,T,C or G 589 actgagaaca cccatcatgg tagttggaag aaggatcgtc ggctcacccc tcctcncctt 60 cgttcaggca cacctgccag aggcaagacc tcngtggntn ggatgaagtc ntcttctnct 120 atgtgcttgg gggtcctgga aggacctggc ccccttcaag ggaccatnag agaagaannn 180 ttgttntggg aggcctttac tagaaatgaa gggangctta tgngcctggc ttttnncnac 240 atcccnagag gtatgnggng ggaaantntg ntgcnanaat cttnttgggg gcagttgaac 300 cgatg 305 590 358 DNA Mus musculus misc_feature (1)...(358) n = A,T,C or G 590 ctgccatcat gctgtnacat tcaccataga tagaanactt ncntntntag gggaganacn 60 gacaagacat cntatcgaca gcaactataa aagtgcatat ccncannnnn gatgancctc 120 ctttnatcga ccagctgggc tttggngngg ccccaggctt ccagacgttt gtgtcttgcc 180 aggagcagag gctcatctac ctgccctccc cctggggcac ctgcaatgct gttaccatgg 240 actcggattt cttcgactcc tacagcatca cggcctgccg gattgattgn gaaacgcgtt 300 acctggtgga aaactgnaac tgccgtntgg tgcacatgcc aggggatgcc ccatactg 358 591 517 DNA Mus musculus misc_feature (1)...(517) n = A,T,C or G 591 tgttaccttt agtgaacaag agcatgttcc caaactcaat tttgggtcgt ccacccttca 60 ctncaaccca ccaacagcat aataacttct ttgctctctc accaactctt tattcacacc 120 agcaacttat agatgcacaa ttcaactttc aaaatgtaga cttgtctaga gctgtgtcct 180 tacagcctct gacatatgga actgtcagtc caatacagac cnggancatc tccatttatt 240 tcgaggaagg aagagaataa gcgatgaaaa aagcttttcc tcttgatggn aaacggcagc 300 gtttccattt caccccacca agagccaact ataatncaac caggctagng cctttatcaa 360 gggtgacaga aggatatttc catgcccacc ggntgtttca cacgcactat ataccagaat 420 atagtncaga tggtggtccc accctnntng nagaaattnc cacctgnana gaaaccctcc 480 gagaaaatna caactngccc tggagggcca aagataa 517 592 307 DNA Mus musculus misc_feature (1)...(307) n = A,T,C or G 592 cacatttttg gtcacngaca gcgatatctn aataggagga actgggcagg agcagggcat 60 tctctccagc aggngagtgg tcacgactac tacaactcca acccgaaggc catcactacg 120 ggcttaaatg gccgattcgg ctaccgccgg aacactccag ccctccgcca gcncacatcg 180 gtgtttggag aagncacacc atttcccatt ttctgaagac attgcgtcac aaggcttgac 240 ctgcgtcttc aagacagatg tttagatgaa ctgtcaacga tattctatat ttttaaagat 300 tgattcg 307 593 275 DNA Mus musculus misc_feature (1)...(275) n = A,T,C or G 593 gctgttgaag ctgcggntca gggtgnggcc atcaccggga ccagactttc acaactggaa 60 ctggcccaat gcaatgattt ttgntgncac agtcatcacc accatcggtt atggcaatgt 120 ggctcccaag accccagctg ggcgcctctt ctgtgtcttc tacggcctct tcnggggtgc 180 cgctngngcc tgacatggat cagtgccctg ggcaagttnc ttcgggggga cggngcaaag 240 aggttagggc cantttctta accaaggaag aggag 275 594 334 DNA Mus musculus misc_feature (1)...(334) n = A,T,C or G 594 aaatggcttc caaaagagct ctggtcatcc tggccaaagg agcanaggag aatggagaca 60 gttgattcct gtggatgtca tgcggctagc cggtattana gtcactgang cangcttcgg 120 nttgnnaagn gaccccgggg cacnngtaaa cccgtgatgt aantggatta gtaccaaaat 180 acccagccct ngaaaagatg caaaaaacgc nttggaccat tnccaaangn aggggggtnc 240 cttccngggn aggaaatcnt ggntgccnaa aaatttnatc tcattcgcct tannggggaa 300 tgnaaaaccc tcaagnggcc cgggaaaaga agga 334 595 493 DNA Mus musculus misc_feature (1)...(493) n = A,T,C or G 595 gaactgagga tccttttgtg gcattccaca tcaacaaggg tcttgtgaga aagtatatga 60 actctcttct gattggagag ctggctccgg agcaacccag ctttgaaccc accaagaata 120 aagcgctaac tgatgaattc cgggagctgc gggccacagt agagcgaatg ggcctcatga 180 aggccaacca cctcttcttc ctggtctacc tgcttcacat cctgctgctg gatgtggctg 240 cctggctcac cctttggatc tttggaactt ccttggtgcc cttcatcctc tgtgcagtac 300 tgctcagtac agttcaggct caggcaggtt ggctacagca tgactttggg cacctgtcag 360 tctttggcac ctcgacatgg natcacctgc tacntcattt tgngattggn cacctgangg 420 gggcccccnc cagctggngg accacatgca tttcagcacn atgccnagcn tagctgcttc 480 cgcaaggacc ccg 493 596 115 DNA Mus musculus misc_feature (1)...(115) n = A,T,C or G 596 ggattgaaaa tgaattngat tcctaaatga gaagctcgag ggtgaggcac cgtttcgaac 60 tctgcngtgt gcaangaaga cgaggaagtt ccagcatggc ctcgggggga tgttg 115 597 205 DNA Mus musculus misc_feature (1)...(205) n = A,T,C or G 597 ctgaggtgta cagagccaat gggccagatg gagctgtggg ccgaggccag agaatccacc 60 tgcagttatg ggacacggcg ggggcaggag aaggtttcgt agcttaaccc actgcattct 120 tcagggacgc ttttgggttt cctgctttct tgttcgacct ggacaaatga ancaaagttt 180 cctcaattgt ccgaaactgg ataag 205 598 166 DNA Mus musculus misc_feature (1)...(166) n = A,T,C or G 598 tgaggatgag ttccacccgt tntnngaggc gctgctgccg catgtgcgcg ccttcgccta 60 cacctggttn aacntgcagg cagcgcaagc gcaagtactt caagaancnc gagaagcgca 120 tgtccaagga cgaggngccg ctntttttta tgatcaatat gagaga 166 599 325 DNA Mus musculus 599 atagaaggtg gtgatggact acagctcaga aaggaacata ctctcaaaat atttgcttat 60 atcaattcct ggactcagag gcaatgtcta tgctgcttca aggaatataa gcatttggag 120 atttttaacc aagtagtatg tgcacttatt aatttagtca ttgcccaagt tcaagtgctc 180 cgggaccagc tttgtaaaca ttgtactacc attaacatag attccacgtt ggcaagatga 240 gagtaatcaa gcggaagaac cactgagtat agatagagaa tgtaatgaag gaaatacaga 300 aagacaaaaa tcaatagaaa aaaaa 325 600 500 DNA Mus musculus 600 gactgaggta tttacataag gaatttgcag agtcctggtc agttccaagg ttggcagaag 60 gctttgatgt cagcactgat gttatccgaa gggttttaaa aagtaagttt gtacccactt 120 tagagcagaa actgaggcag gaccaaaagg tcttgaaaaa agctgggttt acccgagaga 180 ttggtcagct ccccgtttct gaagatacct tgaaggcgct cagtgcaggc cgctctgtgt 240 ctggcctgct gatggcaggg gatgaagtct cctctaaaag tcagaatcac agcacagctt 300 tgaaagtggc gaagtcgcac cctcacagca cagacgcaca gaagaaacgg gaagggaggg 360 ataaaagaat ccaagtcttg gaagagagcc tagtgcctgc caccacagcc ttgggtcatc 420 agcgagagct tcagaaatcc cgccaccagt gacttccgag gccaccggaa gagctggcag 480 tgatacgtta ccaagtgctg 500 601 149 DNA Mus musculus 601 gactgagagg aagacgaaca gctctcccca ctggagccat aactttaccc atgagccttc 60 actctcagcc agggcagaca agagcccagc gcgtctgaga ctgttcctgc tctgacccag 120 atatccaacc tgctagtgtg tgaggtcat 149 602 339 DNA Mus musculus misc_feature (1)...(339) n = A,T,C or G 602 gtcccatact acaaggaacc cactgatctg gtngaanaag atggccaaga ttactacntt 60 ngcgaccagg ngagatgatg cagcagtgat atngtagcan ggnacttcat tgagcangct 120 ganttntcng ggnacctgtn cgggacatgn anggaagntg tcttggctga gcangccatn 180 aacctcatct gcgtgctann ngtatgacct acnngggggg cgcngcatcn anaagactgn 240 tcttgtgtnc gattctacat ctttgggcag cctncctcgc tggacgtgct ggagcaacga 300 ctgcnacngc gcaacactga gactgatgag agtctggca 339 603 452 DNA Mus musculus misc_feature (1)...(452) n = A,T,C or G 603 gaccccattg tgatagctca tcgcttgtct accgtncgta ntgctgacgt cattgctggg 60 gntgatgntg nngtnattnn gnagcaagga antcatgatn agctcatgag ananaagggc 120 anttacttca aacttgnnat gncncanaca gcagtgaaat ganattgant tatgganatt 180 gaancttgta aatctaagga tganattgat aatttagaca tgtcttcaaa agattcagga 240 tccagtctaa taagaagaag atcaactcgc aaaagcatct gtggaccaca tgaccaagac 300 aggaagctta gtaccaaaga ggccctggat gaagatgtac ctccagcttc cttttggcgg 360 atcctgaagt tgaattcaac tgaatggcct tattttgtgg ttggnatatt ctgtgccata 420 ataaatggag gcttacagcc agaaaaaaaa aa 452 604 471 DNA Mus musculus misc_feature (1)...(471) n = A,T,C or G 604 actgagaatg gtccagaact acccatgagt cagtttggct ggagctcgtg agcattcaat 60 aatgagtggt gcggctttag gacttganat tgtttttgnc ttttttctgg cattgntcct 120 cctgcatcgc tatggagact ttaagaaaca gcacagactg gtaatcatcg gcacactgct 180 tgcttggtgt ctctgctttc tcattgtctt catactgccg ctggatgtca gtacgacaat 240 atataaccga tgcaggcatg ctgctgcaaa ttccagccct cctgaaaata ccaacgttac 300 gggactggat gcatctgtca ctccagctcc aagacagcat ccatgtttca agccgnggag 360 ttacattcca gatggaatca tgccaatttt ctggagggta gtttattgga catcacagtt 420 tttgacgtgg atcctgtnac cttttatgca gncatatgca agatctggag g 471 605 408 DNA Mus musculus 605 cactgaggat ggcctcaggc aaagtacgct gcacccgaaa gctgcggagc tggatcgtgg 60 agcaggtgga gagtggccat ttcccagggg tgtgctggga cgatgcagcc aagaccatgt 120 tccggattcc ctggaagcat gcaggcaagc aagacttccg agaggaccag gatgctgcca 180 tattcaaggt gagagttcct gaaggcaccc caaagcactt ttgtctgttt ggggtttgga 240 taaaggaaat actagaaagt agaacctggg ctggtgagat ggctcagcgg ttaaaagcaa 300 ctggctgctt actcttccag aggtcccgag ttcaattccc aacaaccaca tggtggctca 360 caaccatctg taatgggatc tgatgccctc ttctggtgtg tctgaaaa 408 606 279 DNA Mus musculus 606 ctattggaag aggcaaccat ttcagtttgc aagtctttgg ttgaaaacaa ccctcgaaca 60 ggaaatcttg ctgcgctaac taaggtcttc ctatctagaa ccagggagct caggctctca 120 gccgagtgtc agaaccacat cttcatctgg cagacacaca atgctctgtt tattatttgc 180 tgcttgctga aagtgttcat ccgtgagctg tctgaggaag agctgcagct tcattttaca 240 tatgaagaaa agtcccccgg cagctacagt tctgactct 279 607 535 DNA Mus musculus 607 gactgagtat aggtactgct tgctttctgc actaccaccc tcaagaaact cagctataca 60 agttggggga atgaatgaga aacgtcattt cactcattat gtacagacta cacgggactg 120 cagcagtcag agcccaaagg acccactgat gaagaggaaa atatcgctaa gagcaaagga 180 caggcaactc gaggtggaac agtgtaaaga cctagggtgt tccatttggc cacacctaag 240 gaaacacctc cttcttgtct gaagaatggt tgagtgctga tctaaggatc agcatcgagg 300 cacttacttg aattaaaaaa cctactataa aatgcattcc gaatagtaac caggccgggt 360 agaggctggc gacggctaaa cccttctccg tggtgtctgt ttttgtacac aacgctacga 420 agggggaaag ccaggcttgt gggtattctt acactcacgg ctaagaccca gaagccgggg 480 cagcatcagg accagatccc aatttcccaa atgactggca ctgaagaggg ggaag 535 608 458 DNA Mus musculus misc_feature (1)...(458) n = A,T,C or G 608 gactgagaca gctctggccc tcctgctgct cccatagccc gaattanaac caccaggaag 60 aaagaatctt atactgattc tgtggaggac ctgagatccc ggggatgtgg ccactggaca 120 gtgcttcggt ctcttcacct gaggggagcc tccccctaaa gaagaaactg agtagagccg 180 tgacagggag acgccattca cagacgaatc tgaagtcact gcaccttgaa gggtagatgg 240 gtgcacaagg aatgggcggc atgctgtccc gtttctccca gcactggaca gaaccaagct 300 gtgctggtgc aaccctttaa tcccagcacc tgggaggcgg agacaggtgc atctctgagt 360 ttgaggccag gctggtctct agttccagga gagccaagaa tccttaaatt taaaatatat 420 gatatatagg tcaatcacan agtgcttgcc tagcatcg 458 609 531 DNA Mus musculus misc_feature (1)...(531) n = A,T,C or G 609 actgagctgc caatggtgtc cttaccatac tggaacttac caagaccggc taacaaagct 60 gcaggaccac cttcggcaac tttctattct cttcaggaag ctgcgactgg tctatgacaa 120 atgtaatgag aactgtggtg ggatggaccc cattcctgtt gagcaactga ttccatatgt 180 ggatgaagat ggctcaaaga acgacgaccg ggctggtcca cctcgttttg ctagcgaaga 240 gagacgagaa attgtagaag taaataagaa actcaaacag aagaatcaac agctgaagca 300 gattatggat caattacgga atctcatctg ggacataaat gccatgctgg caatgaggaa 360 ctaaagcgat atttaaatct cctgctctac tcatgtgatg aagttgggtt ttttcccccc 420 tcttgagtat tcctcccttt gaaaaacgtt atttatgtct ttattttaac agctagcact 480 aaagnttctg ttttcacttt aaaagtattt actagctttt ttttaatact g 531 610 441 DNA Mus musculus 610 tgagggggca gctggcatcc tctgctacgt gggagcctat gtcttcatca cctatgacga 60 ctatgaccac ttcttcgagg atgtgtacac agctcttccc tgccgtggtg atcatagctg 120 taggagcctt gcttttcatc attggcctga tcggctgctg tgctacaatc cgggagagcc 180 gctgtggact tgccacgttt gtcttcatcc tgctcttggt tttcgtcaca gaagtggttg 240 ttgtggtttt gggatacgtg tacagagcaa aggtggagaa cgaggttgat cgcagcattc 300 agaaagtgta taagacctac aacgggacca actccgacgc tgccagccgt gctattgact 360 atgtgcagag acagttgcac tgttgtggaa ttcataacta ttcagactgg gaaaatacag 420 attggttcaa agaaacaaaa a 441 611 400 DNA Mus musculus misc_feature (1)...(400) n = A,T,C or G 611 gaactgagta acaggatctc ggtgactggc tcattgtgga aagtacagtc tctggagtag 60 aagaggagga ctgagaacta caggctcaga tctctattna gacatccaac agaattaata 120 ctatcattgg ctataacatg aagctattgn gttaaaggan agaagtcgag tgntaaaaga 180 cttcctactc caggatatcc tactgaagaa gtccagaana agcatggtgg ccctgactga 240 cagcagacat gctgnctgat gctaggctgc nggggctgcg tgtgctntcc caccctttgt 300 gnctngaagn ngacngtgct caaanngatg ngganaggan cggagtccgg anatcactgg 360 gactcggaca tcgnctacac ngagggttga acccacaggt 400 612 393 DNA Mus musculus misc_feature (1)...(393) n = A,T,C or G 612 catgcgctgt ggatatggag acagcccttc aaaaggagca gttccatatg tgcaagcatt 60 tgactcgctg cttgccaatc ccgtggcaga gtacttgaag atgagtaagg agatcggggg 120 agatgtgcag aaacacgtaa ggacacggng gccctttctt tctcctccta tttaaggact 180 ggangctttt cttcacatct cttcaccctc atcatagggg cgtccggnag ccccctgact 240 ccttttcttc ttcctttatt ggtccaggaa cagaaatggg gttcattttt ctaggtctcc 300 tgttttatta catattctgt gtgtttcttt tatgacaaag cttgnntggt cataaaatac 360 aactgngntc atctttgtgg gggaaaaaaa aaa 393 613 465 DNA Mus musculus misc_feature (1)...(465) n = A,T,C or G 613 actgagacca gatcactcct ggntgaagtg acagctgtgg tgaagattga aaaagatgtt 60 ggtggcaata atgggggtag cggcaatggt ggcggtgccg ccttttctca gactcgaagc 120 agcagcacag gcagtagcag cagcagtggt ggcggaggag ggcagcagaa ccagacatca 180 ggaggctcgc tgcaaggaag tcagcagaaa gagggagagc aaagtcagca gacacagcaa 240 caacaaattc ttattcagcc tcagctagtt caaggaggac aagctcttca ggcccttcaa 300 gcagcaccat tgtccggaca gaccttcaca actcaagcta tttcccagga aacccttcag 360 aacctccagc ttcaggctgt tcaaaactct ggtcccatca tcatttcgga caccaaccgt 420 ggggcccaat ggacaggtca gttggcagac ccttcagctg caaat 465 614 234 DNA Mus musculus 614 gactgagcct acacagtcca gacatccgag ggtgtacgcc caacagccgc ttctgaggcc 60 cgtttgaaag ccttggctgt ttgccacggg cctctggacc actacgactt tctgatcaaa 120 tctcaggagc tgagggagga tgaacatcaa agaagagtcg ttcagtgttt gcagaagtta 180 caggaggacc ttaaaggata cagcatagag gaaggagggc tcttttcaaa gctt 234 615 194 DNA Mus musculus misc_feature (1)...(194) n = A,T,C or G 615 gaggccataa taacttcntg tggnactctc agaggccngn acacngaagc atggcttggt 60 nccataacac angaacnngc atcgaaggcg ngngcngang ggcccacagg ccnacagnag 120 gagagggccc caaagctacc aagggagnct ctggccacan atgngactcg ttgntcctcc 180 tgggactgcg atgg 194 616 128 DNA Mus musculus misc_feature (1)...(128) n = A,T,C or G 616 gactgagcct gtgcctactg cactagccca agtggacaga gagaagatct atcagtggat 60 caatgaactg tccagtcctg agnnagntnt ccatgatgtc tcaaagnata agctttaaga 120 aaagaaca 128 617 484 DNA Mus musculus misc_feature (1)...(484) n = A,T,C or G 617 tctggggagc tcctgcatta agtcagactg aggctacgag ggccccggtt ctgtactggt 60 gtctccggtg ccgcaccaga tgctgcccta catgaacgtg ggcacgctgt cgcgcactga 120 gctgcagctg ctcaacccag ctgacttgtc ggcggaagcg gcggcaccgc accatcttca 180 ccgatgagca gctcgaagcc ctgggagaac ctcttccagg agacgaagta cccagacgtg 240 ggcactcggg gagcagcttg gcccaggaag ggtgcacctt cggaaggaga agggnggagg 300 tctggtttta agaaccgccg agccaagtgg gagacgacag aaagcgatcc tcntcggagg 360 agntcagaaa aacgcccgaa gaagtggaac aaagaacgtc ctnaaaaagc cttcgccgga 420 gaagagggga agaaggaagg taaaagcgat ttggactnng gacagcttga cgggccgcgg 480 cccg 484 618 464 DNA Mus musculus misc_feature (1)...(464) n = A,T,C or G 618 tgttcaatcc aatgactcca ccacaagtca atagctatag tgagccatgc tgtctccgac 60 ccctccacag ccaaggagtc cccagcatgg gaacagaagg actttctggt ctgccctttt 120 gccaccaagc caactttatg tcagggtccc agggttatgg agcagccaga gagaccagca 180 gctgcactga aggatctctc tttcctcctc ctcntcctcc tnggagtana gtcanattaa 240 caaagaggcg gactctntcc atntcgcccc tttnngatgc cagcctggac ctgcaaaccg 300 naatccggaa nctnacccaa ctnacntggg aggntntnat naactntcgc tgtacatann 360 ngggcggttn ctacggncat ctntccattg nnaccatgag cccttcttaa ggattcccac 420 ctnagatgag ncatcaaaaa ggaacttcac ctcccttatg gagg 464 619 495 DNA Mus musculus misc_feature (1)...(495) n = A,T,C or G 619 gagccgttca gtccaatgca ttgatagtta atttgacaga ttcaaagggt acttgccttt 60 atgcagaatg ggagatgaat ttcacaataa catatgaaac taccaaacca aaccaataaa 120 actataacca ttgcagtacc ctgacaaggc gacacaccga tggaagcagt ttgtggggat 180 gaccggaata gtgccaaaat aatgatacaa tttggattcg ctgtcctctt gggcctgnga 240 attttaccaa ggaagcatct catttattca attcatgaca tcgggctttc ctacaacact 300 tagngatagc acaagtattt tcctgggngc tgnagctaaa gggagttcat actggttaaa 360 aancctggag aattttcaaa gntncctttg naaggccatc ctttaagggg caatagnggt 420 tttaaactta acaaaccctg acttccctgg ccgttcaaaa aatattgggg ggnatttcnc 480 cctgcaggct ttttg 495 620 274 DNA Mus musculus misc_feature (1)...(274) n = A,T,C or G 620 tctggggaac ctcctgcatt aagtcagact gagggcngna cccacagtcc agtaagctag 60 atggcagngt tactatngat ctacnggcnn gatggctatc ccagcangtt gntcctggnc 120 tacaaagtct tgnatgacnn gangaaggcc atccctggnt ttcctcttgn gncgcacaan 180 acccgnctgc acattgcana ggacccctct cttggactat gagtacttgc ccntgntgnn 240 cctgaaatca ttcatccngt cttctttgga actc 274 621 501 DNA Mus musculus misc_feature (1)...(501) n = A,T,C or G 621 tgcttactga gcgtcananc ttncacatgg aacangttga aatatgctga actacgtgcc 60 cggcagcaaa tggagcagca gcagcagcat ggccagacac ctcagcaggc gcaccagcac 120 acgggagggc cggggatggc cccacttgga gccacaggcc accctggcat gatgccgcat 180 cagcagcccc ctccctaccc actgatgcac catcagatgc cgccacccca tcctccccaa 240 ccaggtcaaa taccaggccc tggctccatg atgcctggcc agcccatgcc aggtcgcatg 300 atccccgctg tggcagccaa cattcaccct actgggagtg gccctacccc tcctggtatg 360 cctccaatgc ccggaaacat cttaggaccc cgggtacccc tcacagcacc aaacggcatg 420 tgtaagtagc acagtgggac gacattaccc agcatcctgc tttggaagct acagataagg 480 aagaaatgct ttcttcgtga a 501 622 323 DNA Mus musculus misc_feature (1)...(323) n = A,T,C or G 622 gactgagaat cctacnattc ctcatcatga cnccttctca ggncactttt gaaataagag 60 gaactctttt accangagag gnctttgcaa tatgnggaag ctgcgatgcc ctgnnaaact 120 gnaatcctca aaatgctgcg gctcttatta ntgaanacga cacaggagac agcgngttgt 180 ggaaagcagc gattgctctc aatanaggag ngncagngaa gnaccgcnac ttcagaggcn 240 gctttttaga accannggaa ggatgtcttt atatattntt ttattactgn aggacttngc 300 atagtancaa ctttaagttt gaa 323 623 138 DNA Mus musculus 623 gactgagaaa gagtagttga gcagctgcgc agaacctgat agtcaaacaa gagcagccgg 60 acaagttcca gatacagcca ttgtcacagt ctgaaaacaa actacaaaca gcacagcagc 120 agccactaca gccactgc 138 624 383 DNA Mus musculus misc_feature (1)...(383) n = A,T,C or G 624 gactgaggtt tgatctgtgg atgaaatgaa tcatgatttt caagctcttg cattanaatc 60 tcggggaatg ggagagcttt tgcctaccaa aaagttttgg gaacctgatg attcaacaaa 120 ananggacaa ngaggcgtat ntcttggcna ngatgaangg anagagactg catggggaac 180 ttctcatcat tcaatgtccc agcctattat ggtgcagaga agatctggac agagttttca 240 tggaaacagt gaagtaaatg caattctttc tccacgctca gaaagtggga ggccttggtg 300 tgagcatngg tagaatatgt attaagttcc tctcctgctg ataaatggga ttctcgattt 360 aggaagggaa cttttggaac tat 383 625 363 DNA Mus musculus misc_feature (1)...(363) n = A,T,C or G 625 gactgagagt ctatgatgga agtcaaaggg aagaaaaagt ttacaggaaa gagtccacag 60 acatcacaag gaaagaataa atttcataag aacagtgagt ctagttcttc aaagacattc 120 ccaaggaaag ctgttaagga aggcggacct aaagtcacat ctaagaactt tgagaaaggt 180 gccacaaaac ctggcaagaa aggtgtgaag cagttcaaga acaagccaca agggggcaaa 240 ggaccgaagg acaaatttca gaaggcaaat anattcagca agaagcggaa attccagcca 300 gatggtgaaa gtgatgaatc aggagccaag aaacccaagt gggatgactt tcaaaaaaaa 360 aaa 363 626 540 DNA Mus musculus 626 tctcccgact ctcgagagac tacattcgtc gtcctcctct tgctgcttct tgccgtgcct 60 ggagttactg tccgtctctt aagaagtctg ccaggccggt tacatttctc tttccacgag 120 ctccttaccc ataagtatct tccctgagct gtcagtcgct gacccggttg actttcgacg 180 ccccctcccc aactcctcgc aagcctgatc tctgaccttt gaaccctaga caccctcatc 240 aacactcttc cctcagtgta tccccacatc caacagtcgg gatgccgggt gctcccacat 300 cctctctgtt ccaaataagg cccaccccag gtaggttgtg gctgaggagt acgagcctga 360 ggacagcaag agtttgtagt atatagtcca ctgagatccc tgacgcctcg ctccacatca 420 ggaaggtccc accctgaaat tccggctcca catacaggat cttgagtctc cgaacacctg 480 gatccttcga gatgtgaggt cctgtgtcca ggtgagcagt gtgctcttca aaaaaaaaaa 540 627 639 DNA Mus musculus misc_feature (1)...(639) n = A,T,C or G 627 ggcggtttga agcctctgtg atcgaggagc ggcgcaaggg cgcggaggac ctgctgcgct 60 tcacggtgcc catccctgca ctcaacaaca gcccccaact caaggagttt ttccggggcg 120 gggaggtgac acggccctct gaggtgtcca gggacctgcg aatcctgcca ccccctctca 180 tccccacacc acctccggat gaggcccggc tacttcagcc gctgcctgcg gaaaggaggg 240 gccaggagga gttggaggtg ccagtggatc ccctcccgtc cagccctgcc caggaggcct 300 tggaccttct cttcagctgt gacagtacgg aggaagcttc cagctccctg gctcgaggtc 360 ccctctctga ggctgaactt gcccttttcg acccttactc caaagaggaa agtacaggcc 420 ccagccctac ccacacaggt gagctggcag ccattgaggt agagtccaaa aggctggacc 480 aggaaccctg ggagccagga ggacaggagg aggaaaaagc tgaggatgga gagcctgccc 540 cagcttacct tggccaggcc acagagctca tcactcaagc cctgcggaat gaaaaggctg 600 gcgcctacgc tgctgntntn caaggctacc aagaagggg 639 628 770 DNA Mus musculus misc_feature (1)...(770) n = A,T,C or G 628 gtggggtctt tcagtgctgg accctgactg ccaagaagaa ctacagggca gatggcatcg 60 ggagcagccc actctctaat caggatgctt tccgtctatg gtgcctcttc aacttcctgt 120 ctgaggacaa gtacccgctg atcatggttc ccgatgaggt agagtatctg ctgaagaagc 180 tccttggcag cctgagtttg gagatgggcc tgggcgagct ggaggagctg ctggcccagg 240 acgcccagtc agcccagacc gccgtggggc tcagcgtctg gcagtttctg gaactcttca 300 actcaggccg ctgccttcgg ggtgtggggc gcgactccct cagcatggcc atccaagaag 360 tctaccagga gctcatccaa gacgtcctga agcagggcta tctgtggaag cgagggcacc 420 tgcggaggaa ctgggccgag cgctggttcc agctgcaacc cagcagcctc tgctactttg 480 ggagtgagga atgcaaggag aaacgaggca ccatttcccc tggatgctca ctgctgtgtg 540 gaggtgcttc cggaccgcga aaggaaagcg ctgcatgttt tgtgtgaaga ctgccagccg 600 cacctatgag atgagcgcct cagacacccg ccagcgccag gaagtggacg ggccggtcac 660 nngcncgccn tnngtttanc tgggcctgtt caccgaaant gaccttttgg ggcccctttt 720 ncggtaggng actaanaaca aggcttgact cccgtccggc tctgccctta 770 629 521 DNA Mus musculus misc_feature (1)...(521) n = A,T,C or G 629 gacgtctggg gagctcctgc attaagtcag actgaggtcc cttcactgat gttgtcacca 60 ccaacctaaa gcttggcaac ccaacagacc gaaatgtgtg ttttaaagtg aagaccacag 120 cacctctgca ngtactgcgt gcggcccaac agtggggtca ttgatgccgg ggcctctctc 180 aatgtgtctg tgatgttaca gcctttcgat tatgatncca atganaaaag taaacacaag 240 tttatgngtt cagnctatgt ttgctccacc tgactcttnt nanatggagg cagtatnnca 300 ggnggcaanc ccggaagacc ttatggattc aaaacttaga tgtgnttncn antcngccac 360 catnaaangc tagtccacat gntgnagaaa tanataaaat catacctacg gagtgcntnc 420 aanacanaag caccggcagc cgcaaagtcc ctgacatcgc ccctcgatga cacagaagta 480 aagaaggnga tggaagagtg caggcggctg caggggggag g 521 630 800 DNA Mus musculus misc_feature (1)...(800) n = A,T,C or G 630 gacgtctggg gagctcctgc attaagtcag actgaggtgg ggtctttcac gctggcttcg 60 cgagcagtcc ggacccacga tcgcttttgg caaccagaac cggcgcttca gcccccgggg 120 tgacgtgcag cccgccgccc agacacatgg ccccgagccc aagaccccag catgtcctgc 180 actggaggga cgcccacaac ttatatatan tgtacgaant gatgntnttg ctcagtcggg 240 cctggagccg cctgaggggc ccagaagtcc cagaggcatg gctggcaaaa acagtaacag 300 gagcagatca gatagaagct gcggctctgc tgacacctac ccctgtctct ggtaacctcc 360 tccctcatgg ggagactgaa gaaagtggat ctcctgaaca gagtcaagca gcccagaggc 420 tctgccttgt ggaagctgaa agttcccctc ctgaaacttg gggactttca aatgttgatg 480 agtacaatgc aaagccagga caagatgacc ttagagagaa ggaaatggaa cgcacagctg 540 gcaaggccac actacagccc gctggcctgc aaggggctga taagaggctt ggggaggngg 600 tggctagaga agagggagtg gctgagcccg cttatcccac atcacagntg gagggtggnc 660 cagcttgaga atgaagagga tggagaaaca gtgaagactt accaagcttc tgctgctttc 720 atagctncgg gatacaaacc cagcacccct gtgccttttt tggggaggca naacatcaag 780 ccacggaaga aaaaggaaca 800 631 658 DNA Mus musculus misc_feature (1)...(658) n = A,T,C or G 631 gacgtctggg gagctcctgc attaagtcag actgaggtac ccacccggcn gcatggcaac 60 cctacagctg ntcatagctc ccttgctgtg nntcctgctt ngggtctttt gngctccagg 120 tgccagancc catgaccatg nggctgatgn ccatnatggn agcntggncc tggataagan 180 cacagtgcac gaccaagagc acatcntgga acatntngaa ggtgncatcg accaaccaga 240 ggcggagatg tccccacagg aactgcagnt ccattactta aaantgcatg attacgacgg 300 caacagtttg cttgacggcc tanagctctc catagccatc actcacgtgc acaaggagga 360 ggggagtgag caggcgccag tcatgagcga ggatgagctc gtcagcatca tagatggtgt 420 cctgagggac gatgacaaga ncaattgacg gctacatcga ctacgctgag tttgcaaaag 480 tcactgcagt agaccgttgg ctcttttcct tttgtgcaca tgtgaccctt gctaatgnga 540 tggacgtgtc tggtaatgcg aaacaactta tttccgtcta ctgctcaaca cttttggtaa 600 aaaccctgtg gcannctgnt anaatggggt ggaggaaana aaccacatga ctggggaa 658 632 247 DNA Mus musculus misc_feature (1)...(247) n = A,T,C or G 632 gggtgagcca tagactatcc taggaaacca aaccagggcc cngcnttgtt cagagagggg 60 acagataatg nactccctga nccgnngnat cnaggatagc accccacagt gcatncctgn 120 ctattnagag gcacanactc tcagcacgtg ggagaccttg ctacctacgg acaatncttg 180 atntacagnt gtattgccac ttncttgctc aacaaacctg ttactttntt ggaaataata 240 tttaatt 247 633 378 DNA Mus musculus misc_feature (1)...(378) n = A,T,C or G 633 ccatggtaac atgcttatnc tgtntacact tctatatgga caagaagtct aaactaggaa 60 cctacctact ctggacaacc attcccatct ccacccanag gacaccaatc atcgtgacac 120 cacgtccatc ttttactaag ttcccccaac ctcttcctcc tctcactagt agacttaata 180 cagaagcaag gatctaggcc gggtgttgct actctgaaac ttattgcacg agatattgtc 240 aatttatccc ctaactgacc tcccagagaa gaaagaagtg ggaagaaacg gcgaatagaa 300 ggcaagagac actgatcagt tagaggggaa actctacatc ttctctggtt gagagtctgg 360 naactgaaga aggcaaaa 378 634 248 DNA Mus musculus misc_feature (1)...(248) n = A,T,C or G 634 ttatcatggg gcgcaagttg gatcctacga agaaggagaa gcgtggaccc ggccgaaagg 60 cccgaaaaca gaagggtgcg gagaccgaat tggtcagatt tttgcctgca gctgncgatg 120 agaattccat gaggctgtcn agtcttnccc gaatncgggc anccaagagg agggcagggt 180 ctgttgacgt ccctaagcca aataagtctc ctgggatcaa aacattgcct ggagagttat 240 ccaaagga 248 635 683 DNA Mus musculus misc_feature (1)...(683) n = A,T,C or G 635 ggactttgaa tatgtcgggg atcgccctca gccgccttgc gcaggaaagg aaagcctgga 60 ggaaggacca cccttttggc tttgtagctg tcccaacaaa gaaccctgat ggcacaatga 120 acctgatgaa ctgggagtgc gctatccctg gaaagaaggg gactccatgg gaaggaggct 180 tgttcaagct acggatgctt ttcaaagatg actatccgtc ctcaccacca aaatgtaaat 240 ttgagccccc actgtttcat ccaaacgtgt atccttctgg cacagtgtgc ctgtccatcc 300 tggaggaaga caaggactgg aggccagcta tcaccatcaa acagatctta ttaggaatac 360 aagaacttct aaatgaacca aatattcaag acccagctca agcagaggcc tacacaattt 420 actgccaaaa cagagtggaa tatgagaaaa gggtccgagc acaagcgaag aagtttgccc 480 cctcataagc agcggccctg ggctccatga cgaggaaggg attggcttgg caagaacttg 540 tttacaacct tttgcanatn taagtcgctc cgtacagnta ctantcncct ggganggntg 600 agcgggcncc attttccttt tccgccattg gatattcagn cttttgattt ttgantatta 660 annaaaactt gcttttattt taa 683 636 665 DNA Mus musculus misc_feature (1)...(665) n = A,T,C or G 636 tctggggagc tcctgcatta agtcagactg aggtcctcag tatggcagcc tggagcgggc 60 gtggggcgcc atgatgacag aagcagataa ggtcagcgag ctgcaccagg aggtgaagaa 120 cagcctgctg aatgaggacc tggagaaagt caagaactgg cagaaggatg cctatcacaa 180 gcagatcatg ggtggcttca aggagacgaa agaggccgag gatggcttcc gaaaggccca 240 gaagccctgg gctaaaaaga tgaaggagct agaggcggcc aagaaggcct atcacttggc 300 ttgtaaggag gaaaggctgg ccatgacccg ggagatgaac agtaagacag agcagtcggt 360 cacccctgaa cagcagaaga aacttgtgga caaagtggac aaatgcagac aggatgtgca 420 aaagactcag gagaagtatg agaaggtgct ggaagatgtg ggcaagacca caccacagta 480 catggagggc atggagcagg tgtttgagca gtgccagcag tttgaggaga agcggctggt 540 cttcctgaag gaagtcctgc tggatatcaa acggcatctc accctancgg aaacagcagc 600 tacttgcatg tctaccgaga actggagcag gccttccggg gggcccgatg ccccaggagg 660 acctt 665 637 233 DNA Mus musculus misc_feature (1)...(233) n = A,T,C or G 637 acttgcaaaa ttatgaagga ntctanaagc agagganaac ataaaagncc ancnccttng 60 nnccncttat ccncaccctc cctgagtctt ggcatggaca cacctatnaa ngaccttcct 120 ggngcagata catnctcgna tgtgaaggga gaaaagctta ctcgctgnaa acttgccagn 180 ctctacaggc tngcagactt gnttgggngg gcgcacctgg caaatacgta cat 233 638 343 DNA Mus musculus 638 tctggggagc tcctgcatta agtcagactg aggattacaa cattccagag tcccactggg 60 gaagaacaag atacttcaat aaatgaagga gaacaaagaa aactcaagcc cttcagtcac 120 gtcagcaaac ctggaccaca caaaaccatg ttggtactgg gataagaagg acctagcgca 180 cacaccctca caacttgaag gactcgatcc agccactgag gcccggtacc gccgagaggg 240 ggctcgcttc atctttgatg tgggcacacg tttggggttg tatcctgaat ctctgggatt 300 tgttgtgaat aaactccatc accaagaatt agattaaaaa aaa 343 639 596 DNA Mus musculus misc_feature (1)...(596) n = A,T,C or G 639 tctggggagc tcctgcatta agtcagactg agnattaaat ctgagagaat ctgacatcag 60 agtgtgtgat gaatcatctt gtaaatatgg aggtgtctgc aaagaagatg gagatggttt 120 gaaatgcgca tgccagtttc agtgccatac aaattacatc cctgtctgtg ggtcaaacgg 180 ggacacctac cagaatgagt gctttctcag gagggctgct tgcaagcacc agaaagacat 240 aaccgtggtg gcgcgtggac cttgctactc tgataacggn tctggatctg gagaaggagc 300 agaggaggaa ggctcaggag caggngctna caggaancat tccaagtgtg gaccgtgcaa 360 gtacaaggcc gagtgtgacg aggatgcgga gaacgttggg tgagtntgta atatagnctn 420 cngtggcttc acnannnnac nctncccgcg ntganganng ancntcctan aatgnccgnt 480 gtgtcntccg aaaggcgact tgcataaagc actgaacnga tcgacanant agcnngtcng 540 ccnctggnca tacacagatg angtggagat tattgnnaaa gaaggacgac gggctg 596 640 578 DNA Mus musculus misc_feature (1)...(578) n = A,T,C or G 640 cccagttgtg acatgatgga actaaggcgc cgttatcaga acttatatat tcctagtgac 60 ttttttgatg ctcagtttac atgggtggat gctttccctt tgtcaagacc atttcaactg 120 ggaaattact gcaattttta tgtgatgcac cgagaagtag agtccttaga aaaaaatatg 180 ggctgttctt gatccacctg atgctgacca cctgtacagt gcaaaggtaa tgctgatggc 240 tagccctagt atggaagact tgtatcataa gtcatgtgct cttgctgaag acccacaaga 300 ccttcgtgat ggttttcagc atcctgctag acttgttaag tttctagtgg gaatgaaagg 360 caaggatgaa gccatggcca ttggaggcca ctggtctcct tcgctggatg gaccaaaccc 420 agaaaaagat ccctctgtgt tgattaaaac tgccattcgt tgttgnaagg ctctgacagg 480 cattgatcta agngtatgca cacagnggta ccggtttgca nagattcgnt accatcgccc 540 tgnggagacc cacaaggggc gnacagttcc agctcatg 578 641 716 DNA Mus musculus misc_feature (1)...(716) n = A,T,C or G 641 tctggggagc tcctgcatta agtcagactg aggcctgaaa ctcagcaccg aggctctgca 60 ccccactccg agagcgacat cccagagcag gaggaggaga ttctagggtc tgacgatgac 120 gagcaggaag accccaatga ctactgtaaa ggaggttatc atcttgtgaa aattggagat 180 ctatttaacg ggagatacca tgtgattcga aaattgggct ggggacactt ttccacagtg 240 tggttatcat gggatattca gggaaagaag tttgtagcaa tgaaagtagt taaaagtgct 300 gagcattaca cagaaacagc actagatgaa atccggctgc tgaaatcggt tcgcaactca 360 gacccgaatg atccaaatgg agaaatggtt gttcaactac tagatgactt taaaatatca 420 ggcgttaatg gaacacatat ctgcatggtg tttgaggttt tggggcatca tctactcaag 480 tggatcatca agtccaacta tcaggggctt ccgctgcctt gtgtcaaaaa aattattcag 540 caagtgctac agggcctgga ttacttacac acccaagtgc cggatcatcc acaccggaca 600 tcaaaccaga gaacatcttg ttgtctgtga atgagcagta cattcgaagg ctggctgcag 660 angccacana gtggcagcgc tcangagctc ccccaccatc ggggtcttgc aggctg 716 642 276 DNA Mus musculus misc_feature (1)...(276) n = A,T,C or G 642 gtctggggag ctcctgcatt aagtcagact gagtgctcca ctccagctac gggaactggt 60 gaactgtcgt tgggcggaag aagtgacaca gcagcttgac actctccagc tgtgtagtct 120 caccaaacat gaagaaaatg agaaagacaa atgngaaaat caccatgaaa aacttagtag 180 tgttttgctg gacttgtnag aagtgtatct gccatnagtg ngcnctttgg ggaggaatgg 240 ngngcnganc aaatgttntn tttggtttac atacta 276 643 102 DNA Mus musculus 643 gaacggtcat caaagctccg ctgtgcttgg ttactggtgt tcctggcagg ttcctccgtc 60 ctcttatatt acacctttca ttctcagtca cttcattaca gg 102 644 781 DNA Mus musculus misc_feature (1)...(781) n = A,T,C or G 644 gtttatcaat gccagcaaga agaatagtgc agcccatgat tgaccagtca aatcgagcag 60 ngagccaagg agcagcntat agtccanagg gtcagcccat ggggagcttt gtgttggatg 120 gtcagcanca catgnggatn cggcctgcag gacccatgan tggaangggc atnantatgg 180 gcatggatgg ccagnggcac tatatgnann cttngccatg tnangcaatc tctnggcaag 240 gggaagtttg canagcatgc cnggggacta cnttnctcag ggtggtccnn tgggaatngn 300 tatggcccan ccaagttaca ctcctnccca gatgacccca caccctactc agttaagaca 360 tggaccncca atgcattcat atttgccaag ccatccccac cacccagcca tggtnatgca 420 cggaggaccc cctacccacc ctggaatgac tatgncanna catagcccca caatgttaaa 480 tnctgtacat nccaatgttg gcggacaggt tatggacatt catgcccant attttaangg 540 aactcnngga anaaggaaac acacncaaaa actattttaa gactctctga actttgacca 600 natgtgacac ttaatatgaa actccagaca nctgtgatta ttttttactt tnntggnatt 660 tntcatcnag caacagagga ccantgngac angaacacan atgtgaaagc gacgggctca 720 tcgtgacaat tttgnccatg caaagatcct ttggagaaan actncgagag ttataactac 780 t 781 645 158 DNA Mus musculus misc_feature (1)...(158) n = A,T,C or G 645 gcctgagccg ggctgggctc ccatttgggt tgatgcgccg ggagctagca tgngagggct 60 accccatcga gctgcggtgc ccggggagtg atgtcatcat aggtggtggc aaacgggcag 120 gatgagtatt taataaaagt tcgcaagttt ccaaaaaa 158 646 117 DNA Mus musculus misc_feature (1)...(117) n = A,T,C or G 646 acttttcctc ccccccttga tctcgctgcc tgtgaaagcc ngggnntagn tcaactaaga 60 cgcctcctgc gagaaagcca gagaagagct anggggctgg gggaaggagt ctaaaat 117 647 105 DNA Mus musculus misc_feature (1)...(105) n = A,T,C or G 647 cattagtcag actgaggcgn caagcccatc tgngtgngct cgcatccaac tgtgatgagc 60 ccatgtntgt caagctggtg gaggcacttt gtgctgaaca ccaaa 105 648 212 DNA Mus musculus 648 gaaagcgatt tcgctcacgt tttattagca caaggaagac agccggctcc ccgaggcaga 60 agatcgcagg caccattcgc tcgccaccca gactctgcgc gcagccccgg agccagagag 120 gaggatcgtg aaccgaagcc agcttcgcag ttctagtttt gaaagcgccg ctggaaaggg 180 gcttaaatcc gctttttttt tttttaaagg gg 212 649 299 DNA Mus musculus misc_feature (1)...(299) n = A,T,C or G 649 ctttggggag ctcctgcatt aagtcagact gaggaagcca gagctatgca gttctccagc 60 tcatccagga catcagatga gaatgtggac tatttgttca aggtcatcct aagagcttgt 120 ccggatggtg ctgaatggct gangacattc tgtatcccga gtctgttcct tgcccagtgt 180 gatttctgtg tggctccaga ggctcccctg tcacagcacc ttgcccattn ggtttctttg 240 aggatgatgn ctgccttcac caaataaaat ttgctntctt tgccctcaaa caaaaaaaa 299 650 238 DNA Mus musculus misc_feature (1)...(238) n = A,T,C or G 650 caggaaagaa aggaaaggaa aagaaaaata gagagggcaa ggacaaggaa aatggctctg 60 tatctaccag tgagacacca ccacctccac caccaaatga aattagtcct ccacatgctg 120 cggaagaaga ggaagatgnt gactggtngg gaggatacta attgtggaat cntcnaaggc 180 nctngnatgg ttgngatcnn tgaccatnct nanaggtctg acacttaaat gttgattt 238 651 359 DNA Mus musculus 651 atgttcccct tctctggctg ctggaggact gaactgttat tgttgctact cctggctgtg 60 gctgtgagag aatcctggca gatagaagaa aaatcgtgtg acctggtagg agagaaggat 120 aaggagtcaa agaacgaggt ggctctcctg ggagaggtta cggccactgt ttaacaaaag 180 ttttgagagt actgtgggcc agggctcaga cacatacagc tacatattca gagtatgccg 240 ggaagctagc aaccactcct ctggagcagg cctggtccag atcaacaaaa gcaatgacaa 300 ggagacagtg gttgggagaa tcaacgagac tcacatcttc aatggaagta atagaatca 359 652 771 DNA Mus musculus misc_feature (1)...(771) n = A,T,C or G 652 gacgtctggg gagctcctgc attaagtcag actgagtgcc accatggcaa ctgcaccgta 60 caactactct tacatcttta agtatattat tattggggat atgggagtag gaaaatcttg 120 cttgcttcat caatttacag aaaaaaaatt tatggctgat tgtcctcaca caattggtgt 180 tgaatttggt acaagaataa ttgaagttag tggtcaaaaa atcaaactgc agatttggga 240 tacagcaggg caggagcggt tcagagcggt tacacggagc tactatagag gagctgcagg 300 tgcgctcatg gtgtatgaca tcaccagaag aagtacatat aaccacttaa gcagctggtt 360 gacagacgca aggaatctca ccaatccaaa cactgtaata attctcatag gaaataaagc 420 agacttggaa gcacagagag atgttaccta tgaagaagcc aaacagtttg ctgaggaaaa 480 cggcttattg ttccttgaag caagcgcaaa aacgggagag aatggagaag atgcttttct 540 tgaggctgcc aagaaaatct atcagaacat tcaggatgga agcctggatc tgaatgctgc 600 cgagtctggt gtacaacaca aaccctcagc cccgcaggga ggacggctaa ccagtgaacc 660 ccaccccaaa gagaaagctg nggctgctag tgacctcttt gctctggccc ctcatttgac 720 ctttcacctn tgnctggtgg aagcagactt tttactggct ccttggcttt g 771 653 396 DNA Mus musculus misc_feature (1)...(396) n = A,T,C or G 653 actgagggga caaacaagtg actcctgtca cccctctggg tgccccttan aggccatcca 60 gcccaacctg accaatgtcc acagccaggg aacagccaat cttcagcacc cgggcgcacn 120 gtattccaga tngaccccac tacaaagcgg aactggatcc ccgccggcaa gcacgcactt 180 accgtgtcct atttctatga tgcaacccga aatggtgtac cgcatcatca gcatnngggg 240 gngccaaggc catcatcaac agcactggtc actcccaaca ttgaccttca ccaaaacctc 300 tnagaagttc gggcaatggg gcagacagtc nagccaacac ttgtctacgg cctaggcttt 360 gcctctgaac agcagctgac ccagatatat ttgtat 396 654 384 DNA Mus musculus 654 gacgtctggg gagctcctgc attaagtcag actgagaaga tggacgacat gtcgcccagg 60 ctgagagcct ttctctctga acccattggg gaaaaggatg tggcctgggt ggatggcatc 120 agccgtgaac ttgccatcaa tttggtcacc aaaggtttca acaaggccta tgtcctgctt 180 gggacagttt cttctgatgc acaagaatga agcagagttc cagaggtgga tcatctgctg 240 ctgtggagct accggagtgt gaggcccgcc agagctccac ctgcctgaag gagtggtgct 300 cctgtttcct atagatatct ctggcctggc agctctacct cagataaagg ctacccatgc 360 tacctacaga caaccaaaaa aaaa 384 655 443 DNA Mus musculus misc_feature (1)...(443) n = A,T,C or G 655 gaactgaggt tgcttctata actggatcac gagtttgctg cacaaagtac catgtctcga 60 tcccggcagc ccccacttgc gtgagctgtg ncntccatag nanggatgtc taggaatcag 120 atcccanaga gncccgggaa ggacccnanc acnctgacca cnatncanac ctgctgtngc 180 tgntcntnga ccttnatcaa atcctatgtn aagagggcgt nttgtaagga cggaaggaan 240 attaccctgg ganaagcnaa tgnaanttgg gctttantat tgtcacaact aaggttgggn 300 tgtaaaggaa nctcaactgt ctcttttaag ctactcaagc ctgaaaaaat aggcatttta 360 gatcagtctg cagtgtgggt ggatgaaatg aattattatg atatgcggac tgacaggaac 420 aaagggattc ctcccttgtc tct 443 656 398 DNA Mus musculus misc_feature (1)...(398) n = A,T,C or G 656 gactgagatc ctgatggcng ttgtacagcg tggagcctgt ccaanatgaa gagacccctg 60 cctgtgccga tgagtttgac gactttgtca cntatgangc caangangng acngacagng 120 catatntggg gtntgagagc ncctacagng agcagtgaga ccttcacana ngaggacacc 180 agcaccctgg ngcacccctg agctgcngcc tgaaggggac gtggacagtg ctggtggctc 240 aggggtgccc tctgagtgcc tggacaccat ggaggagcct gaccatggtg cattgctgct 300 gctcccaggc agntcngtgc ttnacgctcc nagngtaggt gtttgtgnag tgcgcagtgn 360 anccttntag ttcnccantc ttgggctagg tgagccat 398 657 107 DNA Mus musculus misc_feature (1)...(107) n = A,T,C or G 657 actgaggctc agacaagaga aaagctctag aagagaccaa agcatataca actcaatctc 60 tagctagtgt tgcttatcaa atnnatgcat tggccaacaa aaaaaaa 107 658 462 DNA Mus musculus misc_feature (1)...(462) n = A,T,C or G 658 ctgagggttc cggcgctncc cgtgaaaaac tngaatggca ctggccctgt ncacccagcc 60 ttgctcaggg ntgaccgnga tnctgctgtg tgcagcgtag ctgccgangt gcctgacacg 120 agcacccaaa cccatcctgc acccaccacc agtangcaaa agcnactgtn gaagcctgtg 180 cctgnagtgc ccggngtgtg ccgaaagacc aanaaaaaac acctcaagaa aaagcaagaa 240 tcctgaggat gtggttcgga ggtacatgca gaaggtgaaa aaccccgcct gatgaggact 300 gtaccatttt gcatgggagc ggctgntcac agnatctggg ctatgagggc gtgctccgaa 360 aacaagagtg tgcggnccga gcttgtgggc cgnctgggcc gtnggggnca natgtatcac 420 ntggntctgn ctggnggcca tgtactccaa tggcaaaaag ga 462 659 416 DNA Mus musculus misc_feature (1)...(416) n = A,T,C or G 659 ctgggagatg tgacgccaca caatattaaa cagttgaaga gactgaacca ggtcatcttt 60 ccagtcagct ataatgatga attctacaag gatgngctag aggttggcag agctagcaaa 120 acttgcatat ttcaggngat atagctgtan gtgcagtgtg ctgcangggn tggatcattc 180 acagnaatca aaagagacct ttncntcatg acactaggga tgccttgcac cttaccgaag 240 actaggaata ggaactaaaa tgttaaatca tgtcctaggc atctgtgaga aggatgcncn 300 cctttttgac aanatctatc tgcatgtgca ggatcagnna gttgagncca gcngattgac 360 nttttacccg ggaaagtttg gctttttgag attatccgna gacaggagaa caactt 416 660 125 DNA Mus musculus misc_feature (1)...(125) n = A,T,C or G 660 gaagagtggc agacagaaag aanaggctct ggtccaaaga gagaggatgt gtctctggaa 60 catggatgcc attancaagg atgtttttaa taagagtttt attaatcaag ataaaagaaa 120 aacaa 125 661 349 DNA Mus musculus misc_feature (1)...(349) n = A,T,C or G 661 ctcgaccctg cctgaccggn ctctanngaa ctgncagtac agttcagnca ccttcancnc 60 angtgagcgc aagcgaaggc ctcatggaga ccggaagtct tgtgagatgg ggctgcagct 120 acgacagacc ttcnaggcag gcatnctcac acagctgcac ccccgctctc agatcgacat 180 ctacgtgcag gtgctgcaag cagatggtgg gacctacgca gcatgtgtga atgcagccac 240 gctagcagtg atggatgctg ggatacctat gcgggacttt gtatgcncat gttcagctgg 300 ctttgtggat ggcncancac tancggacct canccacgtg gaggaagca 349 662 156 DNA Mus musculus 662 gactgaggtg tggaaatgta aactttgcta ggagaccagc tgtaacagat gtggtcgagt 60 tgcagtaatg tgaattgggc tagaagatca gagtgtaaca tgtgtaatac tccaaagtat 120 gctaagttag aagaaagaac aggtaagaaa aaaaaa 156 663 513 DNA Mus musculus misc_feature (1)...(513) n = A,T,C or G 663 gactgaggtt gaagctggaa tttgcccctt acgagcaaga agatgatgag tgacgctagt 60 gacatgctgg ccgcggcgct ggagcagatg gacggaatca tagcaggttc taaagccttg 120 gagtattcca atgggatttt tgattgccaa tctcccacct ccccatttat gggaagcttg 180 cgcgctctgc accttgtgga agacctgcgt ggattgttgg agatgatgga aacggatgag 240 aaggaaggat tgagatgcca gatcccagat tcaacagcag aagtgcttat tgagtggctt 300 caaaatcaaa tgacaaatgg ncatctacct gggancggan atgtgtatca agaaaggttg 360 gcacgtntag aaaacgacaa ggantccctn gttcttnang caagtggtac ttgagnccat 420 tcctttntna ngacangtgg nccttncaac tttgaatctc atgtatgtgc aacacctgta 480 ttaanncacc tgaatattac atgccatcta agc 513 664 252 DNA Mus musculus misc_feature (1)...(252) n = A,T,C or G 664 acgtgttcga ggatgatagg gaagggacga tcgggagaga tttccatcga tgacattcgg 60 ataagcactg atgncccncn ggagaactgc atggaaccca tatcagcttt tgcaggggnc 120 nccctcncag nnaggnaccg agcccncagg gnacncangn gcccgttcta ttncatncca 180 gnctactngt attacgttat ggcggccggg gnccnccgtg ctggtgcttg gcgggggggg 240 gcctgccctt gg 252 665 322 DNA Mus musculus misc_feature (1)...(322) n = A,T,C or G 665 gcccttgctg tcagtgcnna gtgaaangaa tgcggagttg anangtgagg anntggctnc 60 tacttnagac ngacgagctg aatgatgccc ctgnttgcgc ccncgnaatc anatgacagc 120 gaggacactc ccagcangct cttcggggcc agaggaaaca canncttacc agatccagga 180 actnctgagc agnaccaggt ctgtcagncc catcccanct ttccagttgn gccacagcct 240 cttctgacgg cacaacagtt agccctttgc tgtgncccgg ggcgatgccg nnaggccccc 300 catccctcaa tcaggcaatc ct 322 666 348 DNA Mus musculus misc_feature (1)...(348) n = A,T,C or G 666 aatcaggaat gattctccat cccagagaga tgaagtaatt caatggttgg ccgaactcaa 60 ntaccagttc aacctctatn cagaancatt tgctctggca ngcagncttt tggataggtt 120 tttagctaca gtaaaagccc atccaaaata tttgaattgt attgcaatca gctgtttttt 180 tctggctgct aagactgttg aggaagatga gaaaattcca gtgttaaagg tattggcaag 240 agacagtttc tggggatgtt cctcatctga gattttgaga atgggagaga attattctgg 300 ataaatngna ttgggatctt nacacggnta caccattgga tttttctt 348 667 162 DNA Mus musculus misc_feature (1)...(162) n = A,T,C or G 667 ggctctggcg gccactggga aggaggaggg cctgagcgcc cggctgctgg ccctggtggg 60 ntctgntctt tatcgntggn ggcattatag ggaagantgc cttgnanggg ccgatgcgaa 120 ggatggcagg ntggattgan ggatctacca caccatggga tt 162 668 295 DNA Mus musculus misc_feature (1)...(295) n = A,T,C or G 668 ctttggaaga agaaccagga tgactttgag tgtgtgacca ctcttgaggg ccatgaaaat 60 gaggtcaagt cagtggcttg ggccccatct ggcaacctct tggctacctg cagcagagat 120 aagagcgtgt gggtctggga agttgatgaa gaggatgagt atgagtgtgt cagtgtcctc 180 agctctcata cgcaggatgt taagcacgtg gtttggcacc cgagccagga gcttttagct 240 tntgctagct atgatgacac agngaagcta taccaggaag aaggggatga ctggg 295 669 219 DNA Mus musculus misc_feature (1)...(219) n = A,T,C or G 669 gactgaggtt gtggagcatg gcctgtttgt cangcactgc acngtggaag tgtatttgct 60 gganctgaag ctctgtgaga tcagtgaccc caccantgtg ctaagntgcc attttagcaa 120 agcagacacc attgcaacta ttgagaagga gatgaggaag ctcttcaaca tccctgcaga 180 acgtgaaaca cggctttgga acaaatactt gagcatcac 219 670 519 DNA Mus musculus misc_feature (1)...(519) n = A,T,C or G 670 gtctggggag ctcctgcatt aagtcagact gagtcctaac aggggcttta cagaaatgca 60 ctgtatgagc ggccactcta attttgtgnc ttgtgtgtgt atcataccct caagtgacat 120 atatcctcat ggactgattg ccactggagg aaatgaccac aatatttgca ttttctcgct 180 ggacagtcca atgccacttt atattttaaa gggtcacaaa gatactgttt gtagtctttc 240 ttctggaaaa tttgggacat tacttagtgg ctcatgggac accactgcta aagtctggct 300 gaatgacaaa tgcatgatga cattacaggg tcatacagcc cgcagtatgg gcagtaaaga 360 ttttacctga acagggctta atgctaactg gatcagcaga caagaccatt aaactatgga 420 aggctggaag atgtgagagg acttttttag ggcatgaaga ctgtgtaaga ggcttggcaa 480 tcttgagtga gacagaattt ctttcctgtg caaacgatg 519 671 431 DNA Mus musculus misc_feature (1)...(431) n = A,T,C or G 671 tgaggtgatg ctgggagcag aactccaaaa gnccagaagc ttcgtgaagc tatggctgcc 60 ttaagaaaat cagctcaaga tgtccagaag ttcatggatg ctgtcaacaa gaaaagcagt 120 tctcaagatc tacataaagg aaccttgggt caggtgtctg gagaactgag caaagatggg 180 gacctgatag tcagcatgcg gattctgggc aagaagagga ctaagacatg gcacaaaggc 240 acccttattg ccatccagac tgttggncta ggantanaat acagagtgaa ngactgacna 300 ccaaggaccn agtntgctat ccagggaacc atagtgncta tnatnaccac ccttccgctn 360 actatgctgn ttgaggacan ccgantggtg nccaagtaca aagatggaaa tcangcctgg 420 ctttatgctg g 431 672 386 DNA Mus musculus misc_feature (1)...(386) n = A,T,C or G 672 tggcactctc ttttctgctc ttaccctgcn ncaacattcc tttccaggga cagccngntg 60 ananctnttc acggagtgnt gnaccntgan gcgangantt taaaagttgn ggcttgaaag 120 acaggaagat acggatggct tcctcgtctg gcaacagacg atgatntcac tatccccaga 180 gctgntntna atatgatgat caaagagact cttnctaatg tccgggtggc cancgatgcc 240 cgagagctgg tagtgaactg ctgcacggaa ttcattcacc ttatatcttc tgaagccaac 300 gagatttgta acaagtcaga anagaagact atttcaccag agcatgttat acangcactg 360 gaaagtttgg gctttggctc ttacat 386 673 253 DNA Mus musculus misc_feature (1)...(253) n = A,T,C or G 673 ttcctaacat gcttgagttn cgaaccagtn ttncttggag atgaacnctn tttngcaaga 60 gcgaggnncn naaancnttn nctttcagga catggaatct gaattggaga anacagaagc 120 tnagctcaat gcagnagtca gagagaaanc atctctctct gcgagtaatg cttcactngg 180 aaaaacggnt tactgaatta accagagcca acgagctact aaaggctaag ttttctgaag 240 atggtcacca aaa 253 674 127 DNA Mus musculus misc_feature (1)...(127) n = A,T,C or G 674 gactgagatg ggagatcttt ggtcagcncn ncctatgaag gtgaatgctt cccaggctcg 60 tcagtttaaa ccttgtatta agcaaataaa tttccctaca aacctcatac gactggaaaa 120 aaaaaaa 127 675 408 DNA Mus musculus misc_feature (1)...(408) n = A,T,C or G 675 gacatggtgt tactgtggag tttatgataa tgccttaaac aatgacaact acaaccttgc 60 tagaggcttc aattaccacc aaggacctga gtggctgtgg ccaattgggt attttcttcg 120 tgcaaagttg tatttttcca aaatgatggg cccagagact gctgcagaag actgtatngt 180 ttggttaaaa atgttctttc tagacattat gttcatcttg agagatcccc atggaaaggc 240 cttccggagc tcaccaatga gaacggccag tactgccctt tcagctgtga gacacaggcg 300 tggtcaatgg ctgntgttct ggaaaccctc tatgatttat agttggctca taaatagtaa 360 ttgtgtgaac acttgacatt attgaatgca aggtcataaa gaaatgta 408 676 433 DNA Mus musculus misc_feature (1)...(433) n = A,T,C or G 676 actgagtctc catgaagtgc caggagcacc cgtgcgtgtc ccctgtctct aatcatgtgt 60 atgagcggcg actcattgag aagtacattg cagagaatgg cacagatcct atcaacaacc 120 agcctctctc agaggagcag ctcatcgaca tcaaagttgc tnacccannn cgacccaanc 180 ctcnctccgc caccancntc ccagccatnc tgaangcctt gcacanatga gtgnnatgca 240 ggnnatgctg cacaggtnca ctctncgcca gnaactgctg acaacccggc aggagctgnn 300 ccatgctctg taccaacacg atgcttgcct gccgagtcat tgcccggctn acnaaagagg 360 ncactgcngc tngagangct ntggctactc tnaanccaca ngctggnctt atttgtacct 420 caggctgtgc caa 433 677 111 DNA Mus musculus 677 aactgagatc cggacatggt ggcagtgttg gaagtgatct ccagtctgga gagatacccc 60 atcaccaaag aggcactgga ggagacacgg actagggaag ctcatcaatg a 111 678 495 DNA Mus musculus misc_feature (1)...(495) n = A,T,C or G 678 gactgagaga ctgtgaatcc tgcaggatga ctgaatgaac ccttgattca cggacatgcc 60 ggaggagttc aacatgggca cacacgactg tcacagacgg cagattcngn tnctacttgn 120 gggngnngaa ganntagcct ntctacangt tncannnnga tnnaagggag nacntngntg 180 ntggcggaac acctgacttc caggcaacta gggtgaggat cttataccca tacccactgt 240 gacacaacca ttccaaccag gtcacaccta ttccaacaag gccacacctc cagatggtgc 300 cactccctgg tccaaggata tacaaaccat cacattccac tccctggtcc ccatagactt 360 gttcaaaaac atgagtctat gggggccata cttaaacaaa gcataatgca aaatgcattt 420 agtccaactt tcaaagtcct catagtctat agcagtccgc aacaacatta aaagtccaaa 480 gttcaaaaaa aaaaa 495 679 423 DNA Mus musculus misc_feature (1)...(423) n = A,T,C or G 679 gactgaggaa gccagagcta tgcagttctc cagctcatcc aggacatcag atgagaatgt 60 ggactatttg ttcaaggtca tccttattgg ggactccaac gtggggaaga catgtgtggt 120 tcagcatttc aaatctggag tctacagtga gtcccagcag aacaccattg gggtggactt 180 caccgtgcgc tccctcgaga tagacggcaa gaaagtgaag ntgcnagggt ncacacacgg 240 naggncanga gcnctnccgn accatnaccc aaagctacta ccggagtgcc cacgcagcta 300 tcatcggtta tgatctcaca cggcggncca cattnaaatc tgtccctcac tggatccacg 360 agatagaaaa atatgggagc tgccaactng ntcatcatgc tgatcgggaa caaatcagac 420 ctg 423 680 166 DNA Mus musculus misc_feature (1)...(166) n = A,T,C or G 680 taagagtgag ctggtacaga aagccaaact ggctgagcag gctgancgct atgatgacat 60 ggctgagcta tgaaggccnn aacagancag ggacacgaac ttttccaatg aagaagagga 120 attctactct nttgttgcct acaanaacgg tggtaagggg gccccg 166 681 206 DNA Mus musculus misc_feature (1)...(206) n = A,T,C or G 681 tcgtacgctc tcaaccagag actatagcat gtgctngnat ctaccttgcn ngtagagcac 60 ttcaaattcc cttgccnact cggncccant ggnttcttct gtttggnacc acagaagagg 120 agattnagga aataatgcat agagacgctt agactntata ccatggaaaa agcctaacta 180 tgaatgagct ggaaaaggaa gtagaa 206 682 277 DNA Mus musculus misc_feature (1)...(277) n = A,T,C or G 682 aggccgaagg actgaatntt ccataataca tncttaaaac cttcaagaat ggttctagca 60 gatcttggaa gaaaataaca tcagcattac ngctcattga gcantgccac cattatcaat 120 gaagaggtat ttaaatngct attgctgaaa gaaagtatgt ccagcattta ttggaagcag 180 atgttattat taacntaggg aagcacctca gaaaaatgtt aaagcctggc atttggttct 240 tgaaaanatg gccttcnggg ggggggccaa aaaaaaa 277 683 151 DNA Mus musculus misc_feature (1)...(151) n = A,T,C or G 683 cgcagttact cttttcatgt ataaagcagg gatgctgnat ctacctcaca cgggtactaa 60 aagcaaaaca cgggaatcca aagccctggg gcacatgccc gacatctgaa aagctggngg 120 tttctcccac ctcccttccg agtgcatgct g 151 684 471 DNA Mus musculus misc_feature (1)...(471) n = A,T,C or G 684 gatggaagcg tccagactcc ggcagaaggc agaggagctg gtcaaggaca gcgagctgtc 60 accaccgaca tctgccccct ccttggtctc ctttgatgac ctggctgagc tcacaggaca 120 ggatacaaag gtccaggtac atcctgctac cagcactgcc gccaccacca ccgccaccgc 180 caccacggga aactccatgg agaagcccga gccagcctcc aaatctccgt ccaatggcgc 240 ctcctcggac tttgaagtgg tccctactga ggagcagaat tcacccgaaa ctggcagcca 300 ccctacgaac atgatggacc tggggccccc acccccagag gacaagcaac ctgaagctcc 360 acctgcagcg cctggagacc acccttagcg tgtgtgcaga ggagccagac cacaagccag 420 ctnttnaccc acctgggccg catggcctnt agtttaaaaa aggtgggccc c 471 685 217 DNA Mus musculus 685 gactgaggaa aggcctggaa gaagaggcca ccaaacaacc caaccctctc tccagtccct 60 tgatctactc gtcgcctgca tctggagacc caatggccca agcctactgg cagtgctacc 120 cctggcttat tctcctctgt gcatgtgcct ggagctaccc agagcccaag taccttggaa 180 gggaagatgt gagaaactgt tcaaccagcc ctgaggc 217 686 168 DNA Mus musculus 686 gactgaggct ccagccttcc cccagccctg gttgaaatcc tcagtggtta ttcatgaaga 60 cgcacccacc atgttttatg ggactcattg cattactagt gtaagataaa cctagttgta 120 ttcatttctt gtggctgatg taataaattt aaaacaacaa caaaaaaa 168 687 408 DNA Mus musculus misc_feature (1)...(408) n = A,T,C or G 687 ccagcaccta aagaaggtcc tatgccagtt ntggcactta tgtagtgttt agaggcaggc 60 agcagggggc ctatngtcca tgtggacaca cacttcatcc aggctgncct actctcccgc 120 ccttgggctt ccttggcctn tgatganttn ggctgatggc caacacctca cagccatgag 180 accgagcaaa aagagactgg ggantttctc agctggcttt cgcccttcct canaggagtn 240 ggcccttggg accttgccct gaaagctggt gatcgctgnn aaccccacca tncctcccca 300 anggccttna tgggcacggg cccatgatct tnacctggtt tnagccctga gcgccntgag 360 tgcccgggcg ncnggancta cctggttttt agggaggatt cttggatg 408 688 452 DNA Mus musculus misc_feature (1)...(452) n = A,T,C or G 688 acacagcacc tgcctttgag ggccgcncgg agatctgata atgccctcaa ggctggntgn 60 ctatgctgnt gaaagctaat gaccatgagc tggctcaggc catnctgann gnagccagca 120 tcaccctgcc tcatggaacn ctttnnnaat gctatagacg agcnggccaa ccgcttataa 180 acctgcacca tctattgncc tgtccccacc tnntngaact tgctgctgca ncacacagga 240 ggagganagc ctgtatcctc cccnagccca cccctagtgn gcgccgngaa ttcccactga 300 aagtgcgcct cttccacagg caaggacgng aggntnaatg ccagcctgcc tgacaccggg 360 gggggcaact naagaggcag ctggcccagc cnggagggca tttgagccnt tcctggcana 420 natggttntt ttttgggaaa gctgcttaca ac 452 689 428 DNA Mus musculus misc_feature (1)...(428) n = A,T,C or G 689 ataggagcag aatgttcagc agaggcctac atacnnaana ctctcgaggg aacaggcttg 60 ccatttcaca gttgatgaga gttctgtggc tgggaagaga gtcgacagta acgaaacagt 120 ctcgccatct tcactgcctt catctgtgag aactgctggg ctaaagcccg aaactggacc 180 cctcatgttt tggtcacagc aaaatatcac agaacagggt tactctgaca actctctgtc 240 cagagaactt acacttctgt ctgcctgcaa tgctgatagt tgtcagatgc caaaactcca 300 ctgccaccgt tcaccacccc ctttgccacc aaagaaatac tctacagcca gngcaccaag 360 gttagagaga gttggactta gccctgatgt cggggttacc gaggcgttta acactaatcc 420 ctccagcc 428 690 306 DNA Mus musculus misc_feature (1)...(306) n = A,T,C or G 690 gaaagcttga ggccttcccc anctggcaaa aatgaagaaa cagatccacc ccgttcctcc 60 tcaggggngg gnnactttnt ctttancacc atttcccaca atgccaagcc acacgggncc 120 ccttgccntn atcccnacct tatgattctt tatccttggc ttgggaanaa cagccttcct 180 tttaagcctc ccccaaagtc ccctctttgg aacccaaggt ttnaagggng gggggggntc 240 ctaaaangtn tntccnaagc ctcataaact cttaatggaa actcaggaac ccttggattg 300 gacccc 306 691 474 DNA Mus musculus 691 gtgtatgtgt cttacaacta tggaaaatca ttcagtaaga tttcagagaa gctgaacttt 60 ggcgtgggca acaacagcga agctgtgatc tcccagttct accacagccc tgccgacaac 120 aagaggtaca tctttgtgga tgcttacgcc caatacctct ggatcacgtt tgacttctgc 180 agcactatcc atggcttctc catcccattc cgggcggctg atctcctcct ccatagcaag 240 gcctccaacc tcctcttggg ctttgacagg tctcacccca acaagcagct atggaagtca 300 gatgattttg gccagacctg gatcatgatt caggaacacg taaagtcctt ctcttgggga 360 atcgacccct atgatcagcc aaacgctatc tacattgagc gacatgaacc ctttgggttc 420 tccacagtgc tccgcagtac agacttcttc cagtcccggg aaaacccagc cggg 474 692 126 DNA Mus musculus 692 ggaagaaagc tcgcacattt gacttggagg ccatgttcga gcaaactcga aggacagcgg 60 tggaaagaag ccggaaaaca ctggaagcaa gagaaaaaga ggaagaaatg aacagaaaca 120 aaaaaa 126 693 283 DNA Mus musculus misc_feature (1)...(283) n = A,T,C or G 693 agagaagcca gccaaagaat gtctcgtggt attccagccg attcttccca cttccgatgg 60 gttaagccac cgttactgat tcgcatttgg tgtttgctat tggactgaac ctgctgatat 120 cctgacatga agcttagagt cgatctaaag aactacttct aaacaggtcc acaatgccct 180 tgtcctagta accgtatctc tcccctacct ctggtcggtg ctctagaagg gagattgatg 240 cattgnagaa ccccaaataa aataggcttt ggaaaaaaaa aaa 283 694 434 DNA Mus musculus misc_feature (1)...(434) n = A,T,C or G 694 ccaggtccca gtgataagaa atcagaacta ctgccagcta agtggaacag caataaagaa 60 ctgtatgccc tccggtatga gtctaaggat ggagccagaa aactccttct gaaagctgtc 120 tctgtggaga acggcatgat catcaacgtg ctggaacttg gcacacagca ggtggcagac 180 ttgaccctga acttagatga ttatattgat gcagaagacc tgagtgactt ccacaggacc 240 tataagaaca gtgaggagct tcggtctcag atcagatctg gaattatcac acctatccat 300 gagcagtggg agaaggctcg tgcaaacagt cctccgaggg agttcccacc tgccactgcc 360 agagaggngg acccactcca gatttcctca caccgncctc atactancag gcagcctgct 420 tggcgtgatc ccct 434 695 405 DNA Mus musculus misc_feature (1)...(405) n = A,T,C or G 695 ggaagaaagc tcgcacattt gacttggagg ccatgttcga gcaaactcga aggacagcgg 60 tggaaagaag ccggaaaaca ctggcggaac cagtatttgg aaggctgggc cagaggtggc 120 tgtcaccatt gcttgttgac ccagacagta tagaacattg tgacacacac tgatgtggct 180 gctgctgttg aatccctgct ttaatgagct gtaggagata cttaatgaag ccttacttcc 240 agatggcttt tccagatggt tggcagttct aggaaccacc ttagggtctc cagagaacac 300 tggcagtgng ctttttttgg ctctaactca gatctctctt gtactagagg acggtctgga 360 gtctgggaac agctggattt aaatcaagtg ctgtgatagt acttg 405 696 101 DNA Mus musculus 696 ggaagaaagc tcgcacattt gacttggagg ccatgttcga gcaaactcga aggacagcgg 60 tggaaagaag ccggaaaaca ctggaagcaa gagaaaaaaa a 101 697 433 DNA Mus musculus misc_feature (1)...(433) n = A,T,C or G 697 gtcggatcat aaggcagcct tctgtcagtc tgctctgccc cttccctcga ggagcgccct 60 gccttgctga ctttctctgc ctctggcttc ctgtgatagg tggtgtcatt cccctccaac 120 ctgagtgctg gcaggtacac tgctggccac cagcagatgc ccatgaagat gctgacaatg 180 aagatgctgg ccctgtgctt ggttcttgct aaatcagcct ggtcggagga acaggagaag 240 gtggttcatg gaggcccgtg tttgaaggac tcccaccctt tccaggctgc ctctacacct 300 caggtcactt gctgggnggg ggggcctcat tgacccacag ngggtgctga cagctgccac 360 tgcaaaaaac cgaatctgca ggngatcttg gggaaacaca aactacggca aacagagact 420 tttcaaaggc aaa 433 698 436 DNA Mus musculus 698 gtggggtctt tcacccgtag ccgactcttc accttcccgt aaccgcgtct cttaccggtg 60 atggcggtga actgctggat taaccccttc agcgccgacg acgccgcgga gcccccgtgg 120 gcagccatct taccgccgcc gccgccgccg cggaacaaca acacagacac acacggggct 180 ccctccccca ctccgcggcg tgctgtgcgc aggcgcactg gcaggcccga agctccgccc 240 tctccctgtc tgtgcgcgtt ttgcgcaggc gtactctccg cgagccgccg ctttggtttg 300 aagcctgtgc tgctggctgg tagctattct ttgaaacatt tggtgccttc tctgaattcc 360 ggagatatcc tcctaagtac cgcattgaat cccaacatcc caaagaatct tcggacctga 420 aataccaaac tcttgg 436 699 177 DNA Mus musculus 699 aatgggagct gactgacatg gtggtgtggg ttactggagc gtcaagtggc attggcgagg 60 agctagcttt ccagttatct aaactcgggg tctctctggt gctgtcagcc cgaagggcgc 120 aggagctgga gcgggtgaag agaagatgcc tggaaaatgg caatttaaaa aaaaaaa 177 700 352 DNA Mus musculus misc_feature (1)...(352) n = A,T,C or G 700 gttaatcctg ccatacgaaa gatttattaa gggagaagaa gataagcctc tgccgccaat 60 caaggcctcn gcaaactnga atgccctgcg aggccnaaat gagantnaan caaaagtctc 120 gggaaacana cgtancngng nggactacgc ccccttttga gnaagaaaaa actggctaag 180 tccaagctga attggcctcg ctggccattt aaatggcgcg ccctcgagga attnggatcc 240 ggcgcgccat ttaaatggcc gctatggcca attcttttgg tttttaccct ggaagaaata 300 ctcataagcc acctctgtta tttaccccca atcttcacaa gaaaaactgt aa 352 701 434 DNA Mus musculus 701 gtttattgaa aatatggcat aacagattaa acagctccac gtggtgtttt gaaattcatg 60 ccaactgtag gctgagtgac ctgaaggtta gagagactgc caaagtccag gagcttcagc 120 atctccttgg tgtcgggatc cacctcaatg atctcctgat ctagggctga gacctcagga 180 acgtagttat ctctcctctc tctctcttct tcctgcaact tgatagagat gcctctcaca 240 ggccctctct gaatccgctt catcagatgc gtgatatagc cggctatctt gttccgaagc 300 ttcttgctgg ggatgatggc gatctcctcg cacacgcgct tgttggtggt gaaagcatta 360 cccagacgcg tgtagtactt ctagatgatg acccgggcag ccttcttcac ggtcttggtg 420 cgaaccagcc tttt 434 702 363 DNA Mus musculus misc_feature (1)...(363) n = A,T,C or G 702 gcccgtggga ttgacgtgca acaagtgtcc ttggttataa actacgatct acctaccaat 60 cgtgaaaact atattcacag gagtcgatag cggcagttga tgacgagatg gcactcagaa 120 acggcgttga cgtaatttag gacgtggaan cataagcgaa acagcacact gtttgaacaa 180 agagcgagtc gaattggcag agggggtcga tttgggagga aaggtgtggc tataaacttt 240 gttactgaag aagacaagag gattcttcgt gacattgaga ctttctacaa tactacagtg 300 gaggaaatgc ccatgaatgt ggctgaccta atttaatccc tgggatgaga tagttttgaa 360 tgc 363 703 333 DNA Mus musculus 703 atgatttcct gctaaatggg agcctgggac tgggagggct cctcctcctg cttgtcatca 60 tcctgttcat ctgcttgtgc cggttcagcc agagagtgaa gagactggaa aggaatgccc 120 aggtctcagg gcaggagccc cactatgcat ctctccagca gctgccagtg tccagtagtg 180 atatcacaga catgaaagaa gacctcagca ctgactatgc ctgcatcgcc aggagcacac 240 ccacttgagt gcccccaaaa gctctcctcg ccctgggtgc gtgctcagtc acactatggt 300 catctagtaa agtctggttc cccacttctg aaa 333 704 528 DNA Mus musculus 704 agtttgtgag aagcttctat aatggtctgc ttggctctcg tcagagctgc ctatgagcac 60 atctacctgg tgaggaaggt cagtcatgcc tgcagatgcc atcaacatcg ggcttggagc 120 tcaaagccag ctgcatcaca gtctgctgtc cagggtgctc caggcagtgt gctggagata 180 cttggtaaat cctaccctca ggatgaccac actaacctca cccagaaggt cctttccaag 240 gtgggcagga acctgcacaa ccagaagttc caccctctgt ggctgattaa ggagcgggtg 300 aaggagcact tctaccagca gtatatggtg cgatccagga cacctctatt ctccgtctat 360 gaccagcttc ctccagtggt caccacctgg cagaactttg atagcctgct aatcccagct 420 gaccacccca gcaggaaaaa gggggacaac tattacttga atcgggcaca catgctgaga 480 gcacacacat cagcgcatca agtgggactt gctgcatgcg ggacttaa 528 705 513 DNA Mus musculus misc_feature (1)...(513) n = A,T,C or G 705 ggccaagctc agacattacg gagcccagag ccagaggcga tggagctgag ccaccgacaa 60 ggtacaacca cgttgacaag gacacacccg aacgacaagg agggccagca ggacatgaac 120 tccttcagag ctaaccatag ctccttggac aactccaaat ttaagtacca tgcaaggctc 180 tcccagagcc ccttaggcag ctccctgggc cagggctacc tggagactcc acctctacca 240 ccaactccta cctgcaggac ttctctgnct atgaactccc atcctgagga cctgaagaag 300 gggcatccag atccagctcg agagatgcca gggagacctt ccgagaggga tgtgtcgggg 360 gaggaaggnc aagacttcag gtcccaaaac aaangacagg ggcctttgac caagaaggac 420 agggtcnttc ttgaaacatc cgccccaaan ttgggagcaa gatgggggac caactgatct 480 ttgaggatna gctcgacagg ccattggtga aaa 513 706 518 DNA Mus musculus misc_feature (1)...(518) n = A,T,C or G 706 aaaactagaa aagagaagac aaaatcaaag accgaagaag caacagaagg aatggaagag 60 gccgtttcct ccaaagcaaa gaaaacaaac aagaaagggc cttctgagga tgatgtggat 120 ccccctaaat ccaggaaggc caagaagcag gaggaggagc ctcaagacga cactgcttct 180 acaagcaaaa cctccaagaa gaaaaaggag ccccttgaga agcaagcaga ctctgaaacc 240 aaagagataa taacagagga gccttccgaa gaagaggcag acatgcctaa gcccaagaag 300 atgaagaaag ggaaagaagc aaacggagat gccggagaga aaagccccaa gctgaagaat 360 ggactctccc aaccttccga agaagaggca gacattccta agcccaagaa gatgaagaan 420 gggaaagaag caaacggaga tgcttggaga gaaaagcccc aagctggaag aatggactnt 480 cccaaccttc cgaagaaaaa ggtagacatt cctaagcc 518 707 278 DNA Mus musculus 707 tgccccccca ggagacaaag agcctcatga aggcttccta cacgcccgag gtgatagaga 60 agtcggtgag ggatgtggaa cactggcacg ggaggaagac ggatgaccta ggccggtggc 120 accggaagaa tgctatgaac atgaacttgc agaaagcgct ggaagagaaa tacggagaga 180 agagcagatc caaggccaag tagttgaaag gacattggga ggaagcttga gaatgttgcc 240 aataaagaaa taaaggctgt ggtctgcaaa aaaaaaaa 278 708 423 DNA Mus musculus 708 tgctgaagac agcgcagaat caccccatgg taagcactct gggccacctc ccttcatgtg 60 cccacagctc agtcttttgc agttcatgat tgaaggcctg gcaagatggc tcagtgggta 120 aaggtgcttg ctgccaagcc gaaggacctg agttcaatcc ccaggaccca tgtgatgatg 180 gaggggttca tgacttccct gaagttgttc tctgccctgt ctgcacacag acagaatggc 240 aaatgcaata caaaggaaaa cgttcacaaa gaaatctata gccggcatgg tggtgcacgc 300 ctttaatccc cgcacttggg aggcagaggc agcgaatttc tgagttcgag gccagcctgg 360 tctacaaagt gagtgccagg acagccaggg ctacacagag aaaccctgtc tcaaaaaaaa 420 aaa 423 709 198 DNA Mus musculus misc_feature (1)...(198) n = A,T,C or G 709 cttgttacct aaaaccccgg gcagaggagg agaggagant agcagcggag gaaaagaaga 60 gacangggng ggggggncaa tttngtttgg atttgacggg gcgcncannn tgacanaann 120 gncaagtgag gcgtcagcga gcttgctttt ctctagtcgt tgagaacgaa taaagcttca 180 ttgtgcgaaa aaaaaaaa 198 710 277 DNA Mus musculus 710 gtgtataggt gtgaaccaag tgcacgtcta gttcccttgg aggccagaaa gaaggcggtg 60 tcagatcccc aggaaccata gttacagatg gttgtgtagt ctcccctccc ccagcctgaa 120 tcctgcttgc tcaggggtgg agcttcccgc tcaatcgttc agccatgccc actgctggaa 180 gctgccgctt tgctgttcgg agccggagcc gtacacgtgg tcaccctgct attggacccc 240 aagactaatt ggcgggaatc ggccccttcc cctgctt 277 711 410 DNA Mus musculus misc_feature (1)...(410) n = A,T,C or G 711 gtgtataagg tgtgaaccaa gtgcacgtct agttcccttg gaggccagaa agaaggcggt 60 gtcagatccc caggaaccat agttacagat ggttgtctcc tgtagctcaa cctggcctgg 120 aattctctat gtagctgcaa gtgaccctga ccttctgagt cttctctacc ttccagtgta 180 gtctcccctc ccccagcctg aatcctgctt gctcaggggt ggagcttccc gctcaatcgt 240 tcagccatgc ccactgcngg aagctgccgc tttgctgttc ggagccggag ccgtacacgt 300 ggtcaccctg ctattggacc ccaagactaa ttggcgggaa tcgggcccct tcccctgctt 360 tataattgcg tgtggaacag taaaattgag ctttgatcag aaaaaaaaaa 410 712 521 DNA Mus musculus misc_feature (1)...(521) n = A,T,C or G 712 gggtggtaag ggtggtggaa acccangtgc cncgtcttaa gtttcccttt gggaaggccc 60 agaaaagaaa ggcgggnggt caagaatccc ccaggaaacc cataagttta ccagnatggg 120 ttggatgttt taaaccctca agacagggat gggggcttgg gggcttgggc caacaacttg 180 ctcaacattc ttctgagtct gacgggctgg tggagtgtga gcgtggctcc taaatttctt 240 gggtaggact gaagaagcac ttttaagatg tggaaactca gagaggatgc cactgttttg 300 aactattttg aaggcacagc caccagagct ttaggtcaga agaggtcctt ggaactggaa 360 ttacaggtgg ctgtgagcct ccagggacag ggtattttat cacagcaaca gaaatgaaac 420 caaaacaact ccacaataaa attcttgggt ttcttggggc caagaagatg acacgataag 480 gataaagaca ctggccaagc atgaccttca gagtttggcc c 521 713 508 DNA Mus musculus 713 attgactcgt ggtgcaaaga caacagctat gtgatcgctg gctattacca agctaatgag 60 cgtgtgaagg atgccagccc aaaccaggtg gcagaaaagg tggcctccag gatcgcagag 120 ggcttcggtg atgccgcact catcatggtg gacaatgcca agttcacgat ggactgcgca 180 gcgcccacga tccacgtgta cgagcagcac gagaacaggt ggcggtgcag agacccacac 240 cacgactact gtgaagattg gccggaggca cagaggatct cagcttcact cctggacagc 300 cgctcctacg aaacactcgt ggattttgat aatcatctgg acgacattcg gagcgactgg 360 acaaacccgg agatcaacaa agcagttctg cacctgtgct agacaaggac cacactacag 420 cgaagacgga agcatatttt tacatttata gaggaatagt aggttagccg gaagggaagc 480 tgcaagtgtg ccttggaggg ggtgccgg 508 714 532 DNA Mus musculus misc_feature (1)...(532) n = A,T,C or G 714 gactgaggaa tagaagacat cttaagtagg ggctcaagag ctggatagcg tcatcaagca 60 agggtacctg gagaagaaaa gcanagatca tagcttcttt gggtcggagt ggcagaagcg 120 ctggtgtgtt atcagcagag ggctcttcct ctactatgct aatgagaaaa gcangcagcc 180 caaagggacc ttcctcatta agggctacag tgtccggatg gcccctcacc tgcgaaaaga 240 ttccaagaaa gaatcctgct ttgaactgat ctcccaggat aggcgcagct atgagtttac 300 agcntctagt ncagctgaag ccagagactg ggtggatcaa ataagtttct tgttaaaaga 360 tcttagctcc ttaaccattc ccttcgaaga ggaggaggag gaagaggagg aagaagagaa 420 agaagaggaa naaatgnaca atgacgtcga tggctttgac tccccaaggt ctggctccca 480 gtgcagagcc atggccttgc ctgagcctac tgagaaagag gaggacattt at 532 715 326 DNA Mus musculus misc_feature (1)...(326) n = A,T,C or G 715 gcttctgcaa agagagtccc agccttgcca cgaggcggaa gtgactgagc tgccacatcc 60 ttcanngtgg agacatccag aagacagaca acttggccag agggaaatga aggtgaagag 120 aagccgagga gattggaatc tagtgccgaa tttgcatccg atgccgagcc taggangtca 180 nagaagacct agggtacaaa agaggaagna gcaaagggga agntcttcct tctgatcccc 240 tctattaggt ggaggacctc ggnggngaga cctccgcctt ctgctctgta tcgctgcact 300 tgantaccat aagggggagc cctacc 326 716 210 DNA Mus musculus 716 gccgcccgtg cgtggattgc cacgcatttg aattcatgca gcgcgccctt caggacctac 60 ggaaaaccgc ctacagcctg gacgcacgga cggagaccct cctgctgcag gctgagcgcc 120 gggctctgtg tgcctgctgg ccagctggac gctgaagatc tttggccagt gatattcctt 180 gtcaataaat gcctgctagc aaaaaaaaaa 210 717 495 DNA Mus musculus 717 aaaagcttca ctggcctgaa catgaacttg ctaagaagtt tgttctaaat gcagaagagg 60 cattgatcac tgacagcaaa agaagctttt cgagtttgtc ctctgggatt ctcaaggaca 120 ctttcacaac tggaaccagt agttacaatg ttctactaca gagcaaggag gagaaaaagc 180 accgttcaca aaagcggttt tcctctgcca gctccaaaca acataggaag cccagcaaat 240 ctcctagctc ctctcatagc aaagatccta gcaggatgac agccctggtg cctgggacag 300 gcgctggcac ttggtactgc ctagacgggc agtctgctgt ttttgttact agctcagtac 360 caagtcctgt aaaggtcacc cgtgatatct ctattacagg aagcggccta gcactgccac 420 ctaaaccaaa tagcaagggc aaacgacgca acctgacccg gcttccaaag ccaaagcaac 480 agcctcagct gtgta 495 718 147 DNA Mus musculus misc_feature (1)...(147) n = A,T,C or G 718 atgagaagac gagaacaaag aaagttgata atgaactcaa ccctgtctgg aatgagattt 60 tggaatttga cttgaggggg ataccactgg actctttcat ctttccatgg tggattgttg 120 tcaanagatt ttgagacaat tggacca 147 719 303 DNA Mus musculus misc_feature (1)...(303) n = A,T,C or G 719 gctctgggtg ctctaggatg agcgctacac atctgtggct tttgggtata aagactgtgc 60 ggcttattac caagccgcaa gcccaagaac caaggtagat gccatccaca cccctgttct 120 ctgcctcaat gcagcagatg accccttctc cccagtccat gccttccctc tgcaggctgc 180 ccagaagtct ccctatgtgg ccctgctcat cacaagctcg gggtggccac attggcttcc 240 tggaaagggc tgatgccctg gcaacactgn tacatgaacc ggggactaaa ttaatatgcc 300 caa 303 720 391 DNA Mus musculus 720 gtgttttgtc tgcatgtatg tcagtgctcc acaggcatgc ttggtgccta cggaggccag 60 aagaggacat caggtcccct gtgagttaca gatagctgcg agctgccacg tgggtactta 120 gaattgaact caggttccct ggaagaacag ccaatgctgt tgacttggtc ttgcctcacc 180 acctgtcttt cctcagtcca tgagtgttgc cttagcaaaa ctccacgtgc gtctttatct 240 gacatcgttc tatcggtcag agtctttgga agaggcaaga agccgcagga atctctccat 300 ttatttctct ctatgagtct tgaccattgg agctcaacaa cgcatgtaaa gtgaaccaat 360 acatgtgtgt cattatcgaa gaagaaaaaa a 391 721 525 DNA Mus musculus misc_feature (1)...(525) n = A,T,C or G 721 gtaaaatatg aagttacaga ggatgtatat acttccagga aaaaacaaca ccagaccatg 60 atgcattatt tttgtgcact aaatactctt cagtacaaga agaaaatagc tttgttagaa 120 cctctactgg gatacatgca ggctcagata agtttcttta agatgggttc tgaaaatctc 180 aatggacaac tggnagaatt cttagctaac attggaacaa gtgtacagaa tgttcgaaga 240 gaaatggatg gtgatgtaga gaccatgcag cagacaatag aagacttgga ggtagccagt 300 gaccctttat atctgcctga cccggatccc accaagtttc ccatcaatcg aaatttaacc 360 cgaaaggctg gatacctaaa tgctaggaaa tcttcaatat tgcaagcaga gagtaaaaag 420 gaccatgaag agtggatctg tacaataaac aacatatcta aacaaatata tttgagtgaa 480 aatccagagg aaactgctgc acgagtgaat caagtctgct ctaga 525 722 324 DNA Mus musculus misc_feature (1)...(324) n = A,T,C or G 722 attttatcat gtgggcatcc tgctgcaact ggttctgctt ggatggacag cctgnggagg 60 caccaccacc acagggagcc aggacacaag cctattccaa ccctgggtac agctccttcc 120 cttcccccgc aggctcggaa cctagctgca aggcctgcgg ggtccatttc gcaagcacaa 180 cccggaagca gacctgcttg gactgnaaga aaaacttctg catgacttgn tcgagccaag 240 aggggaatgg gccacgcctc tgccttctct gcctacggtt ccgagccacg gccttccagc 300 gggaggagct catgaagatg aagg 324 723 352 DNA Mus musculus misc_feature (1)...(352) n = A,T,C or G 723 cctacaagga gaagatgaag gagttatctg ngctgncgct catttgctcc tgcttntact 60 ntcancctca cccgacacca tntacnagca tggcaanntg ganntaacca ngctgaacnt 120 gntcaaaagg tgggnactac ccaccttttg agcaagttca gcctggttaa gtccaagctg 180 aattggcctc gctggccatt taaatggcgc gccctcgagg aattcggatn cggcgcgcca 240 tttaaatggc cgctattggc caattttttt gctttttacc ctggaangaa atacttcnat 300 aagcncctnt gntatttanc cccaatcttc acaagaaaaa ctgtaatctg tc 352 724 288 DNA Mus musculus 724 aatccagcaa ctatcacgag aatactcctt agccacttca attgggataa agagaagcta 60 atggaaaggt actttgatgg aaacctggag aagctctttg ctgagtgtca tgtaattaat 120 ccaagtaaaa agtctcgaac tcgccagatg aatacaaggt catcggcaca ggatatgccg 180 tgtcagatct gctacttgaa ctaccctaac tcgtatttta ctggccttga atgtggacat 240 aagttttgta tgcagtgctg gagtgaatat ttaactacaa aaaaaaaa 288 725 108 DNA Mus musculus misc_feature (1)...(108) n = A,T,C or G 725 ccggctggac ccccattatc cngggggggg gggatcgaaa cttgggcaan ggaggctcca 60 ccccctccca ntgatcttct gctccncatn ccggaactct acccgctc 108 726 457 DNA Mus musculus misc_feature (1)...(457) n = A,T,C or G 726 gtgacggtgt tcgagtgacc atgncatagc gccttgactg cccgacaccn ngtaggggtg 60 caggactttg tcctgctgga gaatttncca gnagaggctg ccttcattga gaacctccgc 120 cggcggttnn gggagaacct catttatacc tacatcggtc ctgncctact ntnngnncaa 180 tccctaccga gacctacaga tctacngccc ggcatcttat ttnaacgggn nncgtgntag 240 nnagtannnt angacngtnc cancctcatt tngttngcac nggcttgaca ctgtataccg 300 ggcacttcgt actgagcagt cgagnacccg gcagtgatga ttntctgggn ngagagcggg 360 ggcaaggcaa gacagaggca cacaagaagg gagggnaaga ctttgcctna gtanganaga 420 cttgaagcaa atcctaaagt gaagccccgc ccctcag 457 727 478 DNA Mus musculus misc_feature (1)...(478) n = A,T,C or G 727 gaactgagga ggctgtgcat aggtgttctg cagaccatga actgatcact agtccccaga 60 cattcatgag cacagtgtga ggctcctgac ccacntccaa gntctctnng nnctctntga 120 ctaagcnacc tccngngnnt acnnctanan gccacgatnc naatcctgcc ntntngttac 180 tgnnnttgcn aatagagacc tttcacatgt nagaggtgta accngacaan aaacggctnc 240 gancggagtg ggnngatcga tatggaantg agatnctatt tttntcaaan actatngcaa 300 nantgntcga ctnagncggc cccggactgg gacaangtgc ntgctcaagt acacccgagt 360 acaacgagcc acaacgagag ccgcaccaaa tgctgacatc atcgagaccc tgagggaaga 420 agggttttca acgggctgtg acagcccaga gccggatggg gaggactcac tggaatta 478 728 389 DNA Mus musculus misc_feature (1)...(389) n = A,T,C or G 728 ggagatgtct gcttgnccat gactggctgn cttcgnggac tgaggntcat acgtgccngn 60 aaacaatcct aangctgccg tncctannaa tcacatccca ngctagactn gaccntcana 120 cctgtnaacc canacgggcc anaaacaagc ttaccagtna gtttggtctc aggancaggn 180 gtgtgagccc ttggngctgg ggctattgga ttggcctacc tacatcctca acagtctcca 240 ctctgcctga atgatcctga gggtatcaga aagccctaca ctgttggtac ctgggcccca 300 acatactgtg aacggaaatg ggccttcttt cttttcctat aggttatttg ctggcagttc 360 tattaaactt gtttctaaga gaaaaaaaa 389 729 337 DNA Mus musculus misc_feature (1)...(337) n = A,T,C or G 729 gaactgaggt cgtctgtatn acaacataaa cttccagcga aaatcagttg tgggatttgt 60 ggagctgact atatttccca cagttgccaa cttgaataga attaagttga acagtaaaca 120 gtgtagaata taccgagtcc ggatcaatga cttggaggcc cgcttttatt tataatgatc 180 caaccttaga agtttgtcac agtgaatcga aacagtaagt tgggcacgtt aagaagctgc 240 tgtttgtacg tcatcctgtc actgttttca gagattgttt ttcaacaaac tttcccattc 300 ttattgtaat aaagctatgt gttgtataaa aaaaaaa 337 730 362 DNA Mus musculus misc_feature (1)...(362) n = A,T,C or G 730 gaactgagga ccttggcacc atggttacct tgaaccgata tgcaacgtga cctcaaggat 60 ccagctactg gctgcatcaa gcanactgct nnntcctgct ncaagatgga atgaancnac 120 tnttctgntt atgaanagaa ncctgnntga ggcnaacgaa ccnttgannc actgcaccgc 180 ctnncagncg ctccanacca ctcatntcan naagctcagc ttttttntac tccaggntta 240 angcagcatt ancacttcat tnntattctg cttttggaaa agcagtgatn agatgaacat 300 ttgatcttcn ctgtttatca tcanttnttt actttggagg ananagcttg gaagataagc 360 ca 362 731 434 DNA Mus musculus 731 gaattgaggc tgcttctggg acaacggcca cctgtaccgg gaggaccagc cctcgcccgc 60 gccgggtctc cgctgcctca actggttggc cgcgcaaggc agccgcgagt cgctcaccga 120 gcccagcccg ggcaaccaca actactgccg gaacccggac caggacccgc gcgggccctg 180 gtgctacatc agcagcgaga ccggcgtccc tgaaaagcgg ccctgcgagg acgtgagttg 240 cccagagacc acttcccaag caccaccgcc atcctctgcc atggagctgg aagagaagtc 300 tggtgcacca ggtgacaaac aggcacaggt gttccctcct gctaacgccc taccagccag 360 gagtgaggca gccgaggtgc agccagtgat cgggatcagt cagcttgtga ggatgaactc 420 caaggaaaaa aaaa 434 732 515 DNA Mus musculus misc_feature (1)...(515) n = A,T,C or G 732 gaactgaggt gcgatgcctc tgcctctggc gttgtgaggc cacttgcgag tatttgaaat 60 gctggttaat tccggactga gtggactcac ctgtgacctg gaaaggggcc tgaatgagcc 120 gntgctgaac gcccctgagc agctcttnca tctccttctg gatgttgcag acgacctcct 180 ccatcaaccc tacatcagct atccccttcc agaacatcaa agtgtcctct ggcacaaacc 240 ggatgagaca gaaggggagc agacacatta cccagaaacc tcagcacatg gctacaacgt 300 tcatttccat tccaaaggat tctgtgttaa aacatgaaag actggctgct tccacaagtt 360 ggacggttgc tgggggtgag aggagatgat cccagttaca tcagtgctca tgtttatgag 420 gaaaaccagc agaggtaaca aaggggtcta taaccctgag ctgtacggga aagtacctga 480 aatctcttca gactctttct ttataccctc ctctg 515 733 142 DNA Mus musculus misc_feature (1)...(142) n = A,T,C or G 733 gaactgagag ttctgatggt cagtccacag naagacggcc ttgcgtctgt gggtgttgga 60 gactccattc taaagatata aaaagtgaaa gaggngaagg ccacctntct acctcaatac 120 gantcattat ttgttctaat ga 142 734 475 DNA Mus musculus misc_feature (1)...(475) n = A,T,C or G 734 gactgagacc tcctcaaaga aggcatgctg accaaacaga acaactcgtt ccagcgatcc 60 aagaggaggt actttaagct tcgagggcga acactttact atgctaaaac tgcaaagtcg 120 attatatttg atgaggtaga cctgactgat gccagcgtag cagaatccag caccaaaaat 180 gtcaacaaca gttttacngg tcatcactcc atgtaggaag ctcatcttgn gtgccgacaa 240 caggaaagaa atggaagatt ggattgcagc actcaagact gtccagaaca aagagcattt 300 tgaggttaaa aganangcat atntgtctat gggagcctgc tgangnctct cctgccttca 360 ttctgatcca cccccaccaa ctccaccctt cacccccaga gtattcttcc ccaggggacc 420 ccagnatntg tcctngtaaa atngagnncc catggcttct ttcttttgat aggac 475 735 130 DNA Mus musculus 735 gaactgaggt tcgtcttggc accagaacaa ggcactgcaa catcaggcct ttgccctaaa 60 cagctcacga tgccaggaac tggccaatta ctactttggc ttcagtggat ggtcgaaaag 120 gatcatcaag 130 736 365 DNA Mus musculus misc_feature (1)...(365) n = A,T,C or G 736 gaactgaggt gcaggngtcc ggggcaggcc cgggacaagt cctacttact gccaccacag 60 nccaccaagc agttcctcat ctcccctccc gcctcacccc ccgtggggtg gaagcagagt 120 gaagatgcaa tgccagtgat caactatgac ctgctctgcg ctgtctccaa gctgggccca 180 gnatngngga gatgaaggca cacaatttat natttgatnc naatgtcang tgtactgngg 240 nntgaganca tngcttnnan tgaaagagga gcgacagann gcaagaatgt gacccgnagg 300 acactngnga ttacctntaa caaacgttga tgtttgaaac taataaagaa ttggtgcttt 360 ttaag 365 737 415 DNA Mus musculus 737 gaactgaggt aaatttgcta tgctagatta cactccttca aatgtcccgc tggtgaatac 60 tggtctaaag acgtctgttg caagaactgt tctgcaggta catttgtcaa ggcgccctgc 120 gaaatccccc atactcaagg acaatgtgag aagtgtcacc caggaacatt cacagagaaa 180 gataattacc tggatgcttg tatactttgc tccacctgtg ataaagatca ggaaatggtg 240 gccgactgct cagccaccag tgaccggaaa tgccagtgcc gaacaggtct ttactactat 300 gacccaaaat ttccagaatc gtgccgccca tgtaccaagt gtccccaagg aatccctgtc 360 ctccaggaat gcaactccac agctaacact gtgtgcagtt catctgtttc aaaaa 415 738 524 DNA Mus musculus 738 gaactgagga tctcatctgg cggtcgggta ctggaagaag cgagggggag agcgcaccgt 60 tgcagagaga cggcaagaga aaagggagac tgagagtcgc gccacgccgg cgccccaaga 120 cccaggagga gcccgcagca gttaggttgt gctgggaatt ctcccctccc ttttgctcca 180 caatgccttg gtgagcggtc acggcgaccg agctactggt ggaagaattg gggctgagat 240 gtcgcggcgg gtggccgcag atggggatgc tggagaagga aggagttcac ctcaagttcg 300 caatctgtgt cggaaagctg gtccggcctg ggagggcgtt tcgagcaccg gccgcttccg 360 gatctggtgg actgatcggc tttaaacact tcccctagat acccctcccc attccctgtt 420 gcgttccctc tgtcctgcgc caacccgctt gctaaaacag ctgagtggcc aagctgacaa 480 taaaatctca tgcctttgcg gtgaggggca ggggtcatga ctca 524 739 439 DNA Mus musculus misc_feature (1)...(439) n = A,T,C or G 739 ggctcagtgg ataaaggcac ttgctgccaa gtttattgat ganaangang angnngnnac 60 cnacgtanan acagcnncca gactcacttn tgcnnnctta ntgacctgta cgtgcatgct 120 gggacncact gtacacnctc acacnaatgg acnngaccca agatgncaca cncanggngg 180 ggganannaa tacacngatt cacngagnca taataggtgt cttgcgtact nnntgnncac 240 ancatggnag gaangacagc catgctcctg gcactgcaga ggccagatgt tgtggaacga 300 ttggttgttg tanacataag cccggtagga accacacctg gatcacacat tggagccttc 360 atagcagcca tgaaggctgt tgagatccca gagaaggtgc cgcactccca agcccgaaaa 420 ctggcggata agcagctta 439 740 253 DNA Mus musculus misc_feature (1)...(253) n = A,T,C or G 740 aggcacaagg gatggaccac caccngctca gccgaccacg ggagagagtg ctgctctcct 60 atctctcccc atagagaaaa caacaggtnt nttcaagcca gtgncaccga gctccactga 120 ntgtacaggc agcagctaca gccaaaagca ggccactcac gggaagtccc ttacagaacc 180 tgntcaggtc acccaggcta agatactaaa tatctttcaa attacacata ttcttgaggt 240 aaaaaataaa caa 253 741 136 DNA Mus musculus 741 agaggagagc cagcacgcac catggcaccg gccggacaca tcctcacctt gctgctctgg 60 ggtcacctgc tggaactctg gaccccaggt cactccgcga acccctccta ccccaggcta 120 cgcctgtcac ataaag 136 742 512 DNA Mus musculus misc_feature (1)...(512) n = A,T,C or G 742 cggacagaac tggactttca cgtttgactt ctcttttttg agccaagaag aggatctggn 60 atgggcngga gctncggntg cagctgccgg gccccatgga catacccact gagggcccac 120 tcaccattga cattttccac caggccaagg gggatccaga gcagggaccc cgctgactgc 180 ctggagcgca tttggatgga gacgttcacc gtcattnctt ctcaggtcac gtttgcctca 240 ggcagcacag tcctggaggt gaccaagcca ctctccaagt ggctaaagga ccccagggca 300 ctggaaaagc aggtgtccag tcgagcagaa aagttgttgg catcagccct acaccccacc 360 tgtacctgtc gccagcacca atgtgctcat gctctactcc aaccggcctc aggagcagag 420 gcagctaggg ggcgccactt tgctttggga agctgagagc tcctggcggc cccaggaggg 480 acagctgtct gtagagaggg gcggatgggg ca 512 743 487 DNA Mus musculus 743 gaactgagtt cctgaagaat tcatgtacaa ccctttaacc agagtttatg gagaacctca 60 caaaagacct gaagtccaga atgctactat tgagtttatg gctccttcag aatacatgtt 120 acgaccacca caacctccag tgtacctctt tgtatttgat gtatctcaca acgcaataga 180 aactggatac ttgaattcag tttgccagag tttgttagac aatctggatc tgcttcctgg 240 caacactagg acaaaaatcg gtttcataac atttgatagc actatccatt tctacagtct 300 tcaggaaggt ctctcccagc ctcagatgct aatagtttca gatattgacg gtatgtgtta 360 tactcaaact cactcaactt cctggagaat tgtccctttc agaaatgttt cctgaggtct 420 ttgatgtgtc aggaatgtgt gacatgactc tagtataata aagagaaatc atttggaaaa 480 aaaaaaa 487 744 359 DNA Mus musculus misc_feature (1)...(359) n = A,T,C or G 744 gtgagccacc actctnagnt cctgccgccc tcattgngac cttgggtcct cagcncatgc 60 tcgcacttgt gactacagac ttcccagctc tagaactacn tgctaagnct gagngcccgc 120 agacagatct naagagggca tcagatcact tggaactggt agttnaagac agctgtgagt 180 cnccatggag atgcngggaa tggnaactag gccttctgtg agagcngcag nntggcatag 240 ccgcctctcc accncagagt tttaaacata nataccctac cgattcncaa ctgcncctgt 300 cgtgcaagtg tgcagtccct tagntcgctg tttctacttc ccttttaaag aaaaaataa 359 745 130 DNA Mus musculus 745 tctcaaagtc ataatcctca cactccaact tgtattaacc caggctccca tttgctgaag 60 taaaagtact gagttttcca cttaccagta cttttgagta ctgtagcaag tggctgggtc 120 ccattaaaaa 130 746 349 DNA Mus musculus 746 gaactgagaa aaatattttg acaaaagaag agactactta aaattcaagg aaaaatttga 60 agcaggagga ttccagtctt cacagtcgac ctgaaaattc ctaggctctt tctggacttt 120 cacacaagtg gaatttactc ctctggactt gcagaaatga ttccaggaca aaagcagctt 180 gagtcacagt gtgtatcagc acttgttctc tgtaaacaag agttactaaa ttgttggaat 240 agcaaaagat ctcatcatcc aaactatgaa ggactgcctt aattaaagtg agggatctat 300 tctaagaaaa agcataaaat cattatataa aaagtttatt ataaaaata 349 747 215 DNA Mus musculus 747 gactgagaga agctgatggt ccagggcatc taaccaaagt ggtagaagaa tcaaagcttt 60 caaaagaaaa tcaggcaaaa gcaaaggaat ccgacttatc agacactctg agtccaagca 120 aggaaaaaag cagcgacgac actacagacg cccagatgga tgagcaagac ctaaatgaac 180 cccttgctaa ggtgtctcta ttaaaaggta tttta 215 748 454 DNA Mus musculus misc_feature (1)...(454) n = A,T,C or G 748 actgagtttt gtggctaagc ccagactgct tgagtgaaac agccttcagg gacgttccat 60 tctttcgttt atcccagtgc ttacaaccca aaaacaaaat tggattgcca caagtcggcc 120 actggctgag gaagtgcact cggnccctga cacaaatgca tcagtcagga gaaagagcca 180 gcttctcagg tgtcttcaga gaaggccaga ctgacagctg cggtcaccca ttgcagtgct 240 agcagcnatt tcatggactg gaagtgcttg ttggtacttg atccagaaaa ctgtttctca 300 atctcttaag aggtganggc nggatcntga nctntaanaa ccataaaggc ttccgtgcat 360 atangtgacc cacaagagct ggataaactg cacctgagca gaagtgcagg actcccttgg 420 nggctctgnt ttanataaga aagtgtattt tttg 454 749 241 DNA Mus musculus misc_feature (1)...(241) n = A,T,C or G 749 aacattgcca tcgtgaagcc aggcaaaaag ggacagccag ccgttatcat ggcagtggat 60 cctcgatacc ggggcagagt gagcatctct gagtccagct actccctgca tattagcaat 120 ctgacctggg aagactcagg gctttacaac gcccaagtca acttgaagac atctgagtcc 180 cacatcacga agtcttacca tctccgtgtc taccggaggc tgtnaaagcc ccacatcact 240 g 241 750 466 DNA Mus musculus misc_feature (1)...(466) n = A,T,C or G 750 gaactgaggt tttgtgtgga cagtaatgac cgcacgtttc cgattgcctg ctggcagaac 60 ctacaatgtc cgagcatcag agttggcccg agacagacag catacagagg tcgtttgcaa 120 cattcttctt ctggataaca ctgtacaggc tttcagagtt aacaaacatg atcaggggca 180 agttctgttg gatatagtct tcaagcatct tgatttgact gagcgagact attttggttt 240 acagttggct gacgattcca cagataaccc aaggtggctg gatccaaaca aaccaataag 300 gaagcagcta aagagaggat caccttacaa tttgaacttt agagtcaaat tctttgtaag 360 tgaccccaac aagttacaag aagagtatac aaggttggtt tatggaacta tttctttnga 420 aaacattatc ggagatctaa tatgaaaaat aaaattaact aggcca 466 751 504 DNA Mus musculus misc_feature (1)...(504) n = A,T,C or G 751 gactgaggca ttgccttttg gcactcgggg agnaagatgc agcaggttcc gtctcagaag 60 taatggctgg atccctgaaa gccaacgggc tcggtgtggt ccacccgtca gaaggcatag 120 gtagatggtg ggcatctgcc tcagacatag ttctcaagtt cagccagaag aatgcagcgt 180 tgagccctct gcagcccgtg tcgacggagg tgttgtctcc aggaagcatc atggaaaggc 240 gtggtggtgc acaagggcct tcaggatgcc tgcgcctggt gacggntgcg cctcaggttc 300 tgggcctgac tcggaagggt gcctgtgagc agaagagctg gcacgcgcag ctcagtggac 360 catcagtgcc aacccgtcct gtaccctggc tgaggggtgt gctaannggc anattcctgg 420 ttggctcctn gtaaggcgng gcacaaaatc accatcgaaa gaaagggcct tcggnatgcc 480 ttctgtctgg atattgccct gtag 504 752 532 DNA Mus musculus 752 gaactgagaa agtgagtgag aaggtgggag gagcggaagg caccaagctc gatgatgact 60 tcaaagagat ggagaggaaa gtggatgtca ccagcagggc tgtgatggag ataatgacaa 120 aaacgattga atacctccaa cccaatccag cttccagggc taagctcagt atgatcaaca 180 ccatgtcgaa aatccgcggc caagagaagg ggccaggcta ccctcaggcg gaagcactgc 240 tggcagaggc catgctcaag ttcaacctct tggagatgga tatagaacag gtgagccagc 300 tctccgcact tgttcaggct cagctggagt accacaagca ggcagtgcag atcctgcagc 360 aggtcactgt cagactggaa gaaagaataa gacaagcttc atctcagcca agaagggaat 420 atcagcccaa accacggatg agcctagagt ttgccactgg agacagtact cagcccaacg 480 ggggtctctc ccacacaggc acacccaaac cttccaggtg tccaaatgga tc 532 753 367 DNA Mus musculus misc_feature (1)...(367) n = A,T,C or G 753 gaactgagta gcgctgggga cctgtgaccg cngcatccag ctaaccatgg gacagnttgg 60 ctctgntcac cagcccctta ggagaggact ccatcaaggn cccactgcnn attccncatc 120 atgnaggccg anaggatcct tccagccagg ggagctgncc tttgaaaacc naggncgngt 180 actgctggtn ntccntgcca nccaccttca ngagaggctc ctgttnctgc tggcccacgg 240 atggggaggn gggccctgga cgnagncttt gtgtggaagg nagctctgac cctgggnctg 300 accttctata ctactgcttc tncataggca ncacgttcta cnacaaatgg ntgacaaaga 360 gcttcta 367 754 389 DNA Mus musculus misc_feature (1)...(389) n = A,T,C or G 754 taagcagtac gctaatggac atagacagca caatttccag tggacgctca accccggcca 60 tgatgaatgg acaggggagc acgactgctt caagcaaaca cattgcctat aactgttgct 120 gggaccagtg ccaggcatgc ttcaactcca gcccagacct ggcagaccac attcgctcca 180 tacatgtcga tggtcagcgt ggaggggtgt tcgtttgctt gtggaaaggt tgcaaggtgt 240 ataacacccc gtcaaccagt cagagttgnc tacagcggca catgctgaca cacagtggag 300 acaagccttt caagtgtgna gttgntggnt gcaatgccag ctttgcttct cagggagggc 360 tagntcncca tgtacccaca cacttcagt 389 755 797 DNA Mus musculus misc_feature (1)...(797) n = A,T,C or G 755 aagtaaaact gagggncaag tcctccatac caaggaccag gctaaaacca gattacactg 60 cccctccctg ggccctattg acttaaagca gccactgtaa tcatgggcaa tatctttggg 120 aaccttctga agagcctaat cggcaagaag gagatgcgca tcctgatggt gggcctggat 180 gctgccggga agaccaccat cctctacaag ctgaaactcg gggagattgt caccaccatc 240 ccgaccattg ggtttaatgt ggagacagtg gaatataaga atatcagctt cacagtctgg 300 gacgtaggtg gccaggacaa gattcggccc ctctggagac actacttcca gaacacccaa 360 ggcttgatat ttgtggttga cagcaatgat cgggagcgag tgaacgaggc ccgggaagag 420 ctgatgagga tgctggcgga ggatgagctc cgggatgctg tgctccttgt gtttgcaaac 480 aaacaggatt tgccgaatgc tatgaatgct gctgagatca cagacaagct ggggctgcac 540 tccctgcgtc accgcaattg gtacattcag gccacctgtg ctaccagcgg ggacgggctg 600 tatgaaggct tggactggct ggccaatcag ctcaaaaaca agaagtgaga gccaggcagc 660 cctctctgac taccccaccc actcctgaca cacacctgct gnctccttac cccaattttc 720 ccttcttcct ntttgaaagt ggccaaggtc ctgggtatca tgtccacatg cccagcaagc 780 gccttgcctt tctcctc 797 756 452 DNA Mus musculus misc_feature (1)...(452) n = A,T,C or G 756 attgttatct aaagaagcta tccctaacag attttactac caacacagca gtcgaattca 60 gcccattatt ttggttgctg aggaaggctg gacaatcacc ctgaacaagt catcatttaa 120 attaggtgac catggctatg ataattccct gcctagtatg cacccgtttc ttgctgccca 180 cggacctgcc tttagaaaag gttacaggca gagcaccatc aacactgtgg atatttatcc 240 aatgatgtgc cacatcctgg gactaaaacc acatcctaat aatggaaccc tcagtcatac 300 caagtgcttg ttggtggacc agtggtgcat taatctccca naagccattg gaattgttgt 360 tanngcacta ttgntattaa ccatgctaac aggcctgatg atattnattg nggagcagan 420 catnccacat cccgnccatt ctcccgtctt ca 452 757 247 DNA Mus musculus 757 agtgggcata tgaacagtgt gcaactggga gaaacttgtc tccccggcca ttaggactag 60 tccttgaagg ggttccttca aacttgagcc atttacaggt accacgcgga gcctgagaaa 120 agaaaaacca taaagaccgc cacactcaag atggcgttgg actcggcaag cgtggcagtg 180 acgtggcgac tcggctcacg ccgaacaact tcaaaatact atattactcc atttttaaaa 240 aaaaaaa 247 758 108 DNA Mus musculus 758 gactgaggct cagacaagag aaaagctcta gaagagacca aagcatatac aactcaatct 60 ctagctagtg ttgcttatca aataaatgca ttggccaaca aaaaaaaa 108 759 468 DNA Mus musculus 759 tgagcaccat gaaggtgaag gagacaaact caaagccaaa gttggcaagc cgtggcacgt 60 tccagaggaa gggcatcaag attgtgggga aatggaagca agtgacgatc gacccgaatc 120 tgtttgcaga tggacagatg gatgacctgg tgtgctttga agagctgaca gattaccgtt 180 tagtcaagaa tccctcccgt ttgttctcaa gtgaggagac aaagaagaga aaggcccagg 240 ctgtttcaga agaggaagaa gaggaggaag gacagtccag ctccccaaag aaaaagatca 300 agttgaagaa gcagagagat gcggcacgag ctgccgaagg cgctgctgcc cagaatgagt 360 atgaagtcaa agcgtccgag ccagaggctc agggagaagt cactgcttgt tctgatcaaa 420 aggtcggagg agccaaatca gaaagcctgg cccaggctgc tccaagaa 468 760 153 DNA Mus musculus misc_feature (1)...(153) n = A,T,C or G 760 ctcttatgaa ctcctagaag gcagngacat ctactttcca gagattgtga agcctccccg 60 gaatccagag ctagttgccc ggctagagaa gattaagata cagctagcca atgaggagta 120 taagcaggat cactcgcaat gtcacttgtc agg 153 761 495 DNA Mus musculus misc_feature (1)...(495) n = A,T,C or G 761 tgaggacttg ctgaaaatga atattgatat gaacaagcat cttgtgactg gttctgttca 60 agccaaggta ctgaaatggg gtgaagacnt agaagacttg atgtcaccag actacatatt 120 gatggcagac tgtatatact atgaggagtc cttggaacca ctgctgaaaa cattaaaaga 180 tctcagtgga tctgaaactt gtattatatg ttgttacgaa caacgtacaa tggggaaaaa 240 tccagaaatt gagaagaagt attttgagct cctgcagcta gactttgact ttgaagaaat 300 ccctttggac aaacatgatg aagaataccg aagtgaagac attcatattg tgtacatcag 360 aaagaaaaag ccaaaaccgc catcatgaag cgcttctcca tcttagccac gccccgcaac 420 atccctgggt aaggtcaaga tgtgaacgga gcatgtgcat acccgcatgg aaaactgcct 480 cacagatttc tccag 495 762 420 DNA Mus musculus misc_feature (1)...(420) n = A,T,C or G 762 agactgagac agctagcagc ggtgcctgag ttccagggca ctagggcctc tcttcaagtc 60 ctctcctgag ccagtggccc tcacagagtc cgagaccgag tatgtcatcc gttgcaccaa 120 acacaccttn tctgatcact tggtgttcca gnttgactgc acaaacaccc tcaatgacca 180 gactntggag aatgtcacag tgcaaangga gcccactgag gcatacgaag tgctctcgta 240 ngggcctgcg cggagcttgc cctacaacca gnctgggacc tgctacacac tantggctct 300 gcccactgaa gaccccacag ntgtggcatg cacgttcagc tgtgtgatga aagttcactg 360 ttaagggact ggngatccca acaanaggag aantcganga aagaaggcta tgaggatgag 420 763 286 DNA Mus musculus 763 gaactgagac ccattgtgcc gaaaatcttc tcaaggcgga cacttaccgg aagtggcggg 60 cagccaaggc aggagagaag accatctctg tggtcctaca gggctggaga gatggctcag 120 cggttaagag cactggctgc tcttccagag gtcctgagtt caattcccag caaccacatg 180 gtggctcaca accatctgta atggaatccg atgtcctctt ctcgtgtgtc tgaagacagc 240 tacagtgtac taatatacat aaaataaatg aataaattaa aaaaaa 286 764 131 DNA Mus musculus misc_feature (1)...(131) n = A,T,C or G 764 gagatctgac ccttgcanac cggcctggng gagggaaatg natacnnntg anaanggnan 60 tcacttcttt tctgctggcc ctctaagaca tttntgcttc atatttataa acnaaataaa 120 cttaaagccg g 131 765 408 DNA Mus musculus misc_feature (1)...(408) n = A,T,C or G 765 atatacccta gcagacatcc tgatgttcga gagtcactag gtcccctgtt ggcccctacc 60 cctctccgtc catggcccca gatgacactt cagggcttct ctgtgtatcg atggntgtcc 120 tanaacttgc tctgtagacc aggctggccc caaaatcaga gctttgacct gcctctggct 180 cccaagngca gggattaaag gcgtggggca cctctgtcag gctgatacac tgtatctcat 240 ggatatgtct cttaactttt taatagtccc tcagtttctt cattccactt taattactaa 300 tccctgtttg tcaagtacag tttgacagag tctgagtttg cttgattaga ttcaggttaa 360 aatccgnttc ttactctatt aaacaaagnt taaattacaa aaaaaaaa 408 766 191 DNA Mus musculus 766 gaactgaggg ttccaagact gccctttggt attcaaacgg gagccgcttt ggactgactg 60 gctgccttcc tcctcctccc cctcctcccc cttctgcttc agatttattt attatatgta 120 agtacactgt agcagttgta ggacacacta gacgagggca ccagatctca ttgtgggtgg 180 ttgaaagaca c 191 767 471 DNA Mus musculus misc_feature (1)...(471) n = A,T,C or G 767 aatacacaaa ctcgagctac ttctaaacta cctgttaaat ccaaagaagc ggatttgctt 60 agacatcttc atccaggagg gccagagcct gatgttacaa aagtcaccaa atcgagacga 120 gagaatgggc aggtgaaagc ggcagagact gccagcagga ggaacctcag aaacagctac 180 aaaccgttta ataagcaaaa accggaggag gaactaaagg ataaaaatga gctgctggag 240 gctgtcaaca agcagttaca ccagaagctg acagagactc agggagagct gaaggacctg 300 acacagaaag tggagctact gggagaagtt tcaggataac tgcttagcac ttttggagag 360 caaaggtctc aacccaggcc aagagaccct ggcatcaaag caggaaccca ccacagatca 420 cacggactcc atgctgntgc tcgaaacttt gaaagacgaa ctgaaggttt t 471 768 219 DNA Mus musculus misc_feature (1)...(219) n = A,T,C or G 768 tgacatgtga gcttggggtt atactgtgcc ataattaaca ttgccttgac nactntggac 60 accgagactg gcctcataag tagaaggctt tntttttttt tttttaanac agactcncca 120 tnttnntgna tatgcgaaag nantttggtc cnncaccccc tctntgggac anaaactntn 180 tgtgtancct tgggtgnana ccaccgtagg ccttgaact 219 769 423 DNA Mus musculus 769 gaactgaggt gactcctgct caggtcatgc cgttatctgc tgatccagcc ggccctgcca 60 ggtgaccatg tctgtcctcg gcccagttct tctccaggtg ttctgggccg ggtgtgtcgt 120 caccctgcgg tcccctctgc cagctgcttt cactgccaat ggcacacatc tacaacactt 180 ggcaagggac cccaccacag gtaccctcta tgtaggggcc accaacttcc tgttccagtt 240 gagccctggg ctgcagctgg aagccgtggt gtccacgggc cctgtgaatg acagccggga 300 ttgcctgcca cctgtgatac ctgatgaatg tccccaagcc cagcctacta acaaccctaa 360 ccagctgctc ctggtgagcc cagaggctct ggtggtgtgt gggagcatac accagggcat 420 ctg 423 770 554 DNA Mus musculus 770 gaactgagat gatgactttg accagtttga caagcctggt gcagaacggt cctggagaag 60 aagagctgct gacgaggact gggacagtga actggaagat gacttgcttg gagaagattt 120 actgtctggc aaaaagaacc agtcggattt gtcagatgaa gagctgaatg atgatctgtt 180 acagagtgat aacgaagagg aagaaaattt cagttctcag ggtgtcacca tcagtctgaa 240 taccacctct ggcatagtta catcatttga gctgtctgac aacaccaatg accaatccgg 300 agaacaggaa tctgagtatg aacaaggaga tgatgagcta gcctaccaca aacctgagga 360 acaagaactg tatactcaag agtacccaga ggaaggacag tatgaaggcc atgatgcaga 420 gttgacagaa gaccaaatag aatatgggga tgagccagag gaggagcagc tgtacagtga 480 tgaagtgctg gacatcgaaa tcaatgaacc tttagatgaa tttacaggag gaatggaaag 540 aggaatggga aacc 554 771 104 DNA Mus musculus misc_feature (1)...(104) n = A,T,C or G 771 gactgaggca tactccagca cccagntggt acagttctga aacagctaca gccaccgcca 60 nggngcccaa gagagctgga attttatacc atggtttact gctg 104 772 456 DNA Mus musculus misc_feature (1)...(456) n = A,T,C or G 772 gaactgaggc attttgtgaa agaaggaaga tcctgtctgc tgcatggata atggactgga 60 acacagaaag accatgcagg gttcggctgt agaaggccgg tatctccata ggccaganna 120 caccatcang atctcctggg actggagtta tanaggttgt gagctgccat gttgaaccaa 180 nctggttact gagggacaca ggcatgtgga tggaaaccct gctgggagaa aaacantanc 240 tggtntgtcn ctttatagcc cncttnatga tgcaaganan aatcggctnc ncacaactng 300 nctctgacct ntncatgctt gctgtacctt gtgctcaccc tacccacaca ccntcgnnat 360 catnatcaac ataacgtttt taaatatann aagtntattc aaatatatgt gtataaatac 420 atntatanat aaatatgtga atacattaaa aaaaaa 456 773 163 DNA Mus musculus misc_feature (1)...(163) n = A,T,C or G 773 cacactttcg cgctcagcgt cgacggaggc tctgtggctc tctacgtaaa actgntgaaa 60 gaattccaga gggtgccatt tgctcgggcc tagcagggac tggagctaga gcgtggcgct 120 ggnctctttg nggggtcagg ctggaacagg gagaccctga ctg 163 774 400 DNA Mus musculus misc_feature (1)...(400) n = A,T,C or G 774 gactgaggac ttaagatgcc ttctttgntc atacaccgtt taggacatgg aagattttca 60 ggtccggtga agacantgcn acccnagtga gcattncana tcatgtntaa agagaggtaa 120 gagatatgct gcanagtcca aagaacaaga tgggtgtggc tcagatggct ttacatattt 180 caaganccaa gaccccctgt ctgctacaac tctgctgtgc angccctgag cacanctgca 240 gctttctctg acacaccatc ccacagggac tttctcacct atacagtgtt ctcatgtcaa 300 ataagatcgt tgtacaaggt ctttgttaca ttgaaccctg aatttattca gttatgttaa 360 gngcaataaa atacctgggt tttgtacttg cagaaaaaaa 400 775 181 DNA Mus musculus misc_feature (1)...(181) n = A,T,C or G 775 gactgagggt ttctctgngt agccctggct gtcctggact cactctgtnc accaggaccc 60 nnacccaaga gatctgcttg cttttgcacc tcangactaa atctaangaa agatggatac 120 ctacaatggt gaatttgngg actctgtttg agcagcttgt gcagccggat ggagattatc 180 a 181 776 172 DNA Mus musculus misc_feature (1)...(172) n = A,T,C or G 776 gatatccctg agatggacac agtccacctg ngtggcctaa ggatgcaggg cagaggaact 60 gcccatgggc agtggttcat cggccaagct gagagtgtgt attttggatt tccggtttgc 120 ggagatgctc tcttccgggt gttctgccca aaataaagga cctggacaag aa 172 777 318 DNA Mus musculus 777 gaactgaggt acaccaaatt gaagaccgcc ccaacatcta catcttcaat ctggctttgg 60 ctgatgcgct ggccaccagc acgctgccct tccagagcgc caagtacttg atggaaacgt 120 ggccgtttgg cgagctgctg tgcaaggctg tgctctccat tgactactac aacatgttca 180 ctagcatctt caccctcacc atgatgagcg tggaccgcta cattgctgtc tgccatcctg 240 tcaaagccct ggacttccgg acaccagcca aggccaagct gatcaatata tgcatctggg 300 tcttggcaaa aaaaaaaa 318 778 453 DNA Mus musculus misc_feature (1)...(453) n = A,T,C or G 778 gaaagcagtt atgatgccgn caaagccctg cancgcctgg tgaagaagcc tgtgcccaag 60 ctgatcgaga agtgctggac agaggatgaa gtgaaacgct tcgttaaggg gctccgacaa 120 tactggcaag aacttcttca gaatcagaaa ggagctgctt cccagtaagg aaaccgggga 180 actgattacc ttctattact actggaagaa aacaccagag gnnttcagct nccgtgccca 240 ccgncgccac cgcaggcagg cagtgttcac gaagaattaa gactcgcaca gcgtccaccc 300 ctgtnaacac gccctncaga ccaccttcca gtgaattctt ggacctgagt tcaaatccca 360 gcaaccacat ggtggctnac aaccatcctg taanagagat ctgactccct cttnctggag 420 tgtctgaaga cagctacaag cgtacttaca tat 453 779 571 DNA Mus musculus 779 ggtttcacta tgtagaccct ggtcggcctg gaactctata gaccagactg gcctcgagct 60 cagatccgtc cccctctgct gtcccagcac ggggattaag aacgcgccac cactacagct 120 gaccggagct tcactttggt tagacacaaa cacaacacag cttgtcgtca aacaccgtga 180 catgaatgag aaggaattag aagcccagga ggcacgaaag gcccagttgg aaaaccacga 240 accagaggaa gaggaggagg aagagatgga ggctgaagag aaagaagctg ggggctcaga 300 tgaggaacag gagaagggta gcagcagcga gaaagaaggc agcgaggatg aacactctgg 360 aagtgagagt gaccgagaag agggtgacag agatgaggca agtgacaaga gtggcagcgg 420 tgaggatgaa agcagcgagg atgaagcacg tgctgcccgg gacaaagagg agatttttgg 480 tagtgatgct gattcaaaag atgatgctga ctcttgatga tgaggacaga gggcaggccc 540 acaggggcag tgacaatgac tcggacagcg g 571 780 145 DNA Mus musculus misc_feature (1)...(145) n = A,T,C or G 780 cagcgccggt ggctggcgac ttcacggctg nngacgtcat gacgagcgag gngattgang 60 atgacanana gttttattng anggccatga cctactgtaa gcagatccca cccacggtgg 120 acggcatgct cggggggaat gtcca 145 781 302 DNA Mus musculus misc_feature (1)...(302) n = A,T,C or G 781 cagcacgtct taaaacattt actgctaacc agattgatga antaaaagac ccttcaggac 60 tcttttatat ccttcctttt caaaagggat acttggngaa tngggatgnc cagcgacang 120 nttgggatta tctttttgga aaagaaatgt atcaggnnga gtctttanat actaatatta 180 ntatnacaga accatatttt aactncactn cnatccaaga ntcantgaan gaantcctat 240 tcgaagaana ncaggtccaa gcaggattaa gagtaaatgc cggggctctc agcgcacaca 300 gg 302 782 182 DNA Mus musculus misc_feature (1)...(182) n = A,T,C or G 782 tcattgaaca catccaggtg aacaaggcac ctaagatgcn ccgacgaacc tacngagctc 60 atggncggat taacccatac atgagctccc cctgccacat tngagatgat cctcantgag 120 aaggaacaga ttcgttccaa anccacnaat aggaggttng cacagaacaa aaagatatcc 180 ca 182 783 453 DNA Mus musculus 783 gaactgaggc ctctaatttt aagaagacaa ccatggcatc cagtgcccag agaaaaagga 60 tgagtcctaa gcctgaactt actgaagacc agaaacagga aatccgggaa gcttttgatc 120 tctttgatgc tgatggaact ggaactatag acatcaaaga actgaaggtg gcaatgaggg 180 ccctgggctt tgagcccaag aaagaagaaa ttaagaaaat gataagtgaa attgataaag 240 aaggaacagg aaaaatgaac ttcagtgact ttttgacagt gatgactcag aaaatgtctg 300 agaaagacac taaagaagaa atcctgaaag ctttcaagtt gttcgatgat gatgagactg 360 ggaaaatatc attcaagaat cttaagcgcg tggccaagga gctgggtgag aacctgacag 420 atgaggaact gcaggaaatg attgatgaag ctg 453 784 260 DNA Mus musculus 784 gaactgagga ttcccgagga ccggtgcagc agcctttgga ggatcggctc ttcccaccta 60 cggtctctgc agtctatagc acggtccctg tagtcctggc tatcctggag cttgctgtat 120 aaaccactgt ggccacaagc tcccagagat gttcctgcct ctccctccca tactggaact 180 aaagctgttc atcatcacat tcctttcaat aagcgtttct ttaataatat aacttggaag 240 ccatatgaaa taataaaaaa 260 785 115 DNA Mus musculus 785 gaagaagatg gactcacatg agcacaagtt cagaaatgaa tagtttgaaa gtaggttctt 60 ggaaaataaa taaataaata aataaataaa gacaatggaa tggaaagaaa aaaaa 115 786 400 DNA Mus musculus misc_feature (1)...(400) n = A,T,C or G 786 actaactgat gatgatgttg aacagagccc aggcaatgcc ttatgtggat cggcagaacc 60 gaatctgtgg gnttctggat attgaagaca atgagaacag tggcaaattc ctccggagat 120 actttatcct ggatacccan nncaactgcc tcctctggta catggacaat ccccagaacc 180 tggccgttgg ggcaggagct gtnggatctc tgcagctgac ctacntcncn aaggttntna 240 tagntncccc aaagcagaaa cctaaaacac cattntgctt cnntatcaat gccctgtctn 300 agagatnttt tnttcaagcc antgaccana aagatctgan ggactgggnn cnaagacntt 360 gnaccaagcc canccaagat tacctgtacc caaagctgcg 400 787 542 DNA Mus musculus 787 gaactgaggc acgggcagtg gttctgtatc ccacgcaatc atccgcagcg ttgcccccac 60 tggccaccta cacacagtag agttccacca gcaacgggca ggacaaggcc cgggaggaat 120 tccaggagca tcggctgagc cagtgggtga ctgtgcacac ccaggatgtg tgctgcagtg 180 gcttcggtgt ggtccacgtg gctgacgctg tcttcttgga tatcccatca ccctgggaag 240 ctgtgggcca tgcctgggat gccctcaagg ttgaaggtgg gcgtttctgc tccttctctc 300 cgtgcattga gcaggtgcag cggacatgcc aggcgctggc agcccatggc ttcacagagc 360 ttagcaccct ggaggtactg ccacaggtct acaatgtgcg cactgtcagt ctgcccttgc 420 ccgacctggg ggccaacaac ttagagacca acatgggctc tgatgccagc cccttccgta 480 gtggcacacc catgaaggag actgtgggcc acactggcta cctgactttt gccactaaaa 540 cc 542 788 300 DNA Mus musculus misc_feature (1)...(300) n = A,T,C or G 788 aagaatcatg gtgagcacaa ngaagaaata antgaagcgg ngccaggggg tggttcctca 60 tgagatgnaa ggccaccana ggaaagcacc cannaaatga tggaggagga ggaagaaata 120 ccgnnaccta nttcagcggt ggcaccacca ggtgctccna agaaggaaca tgtnaatgtn 180 gtgttcatcg tacatgttga tgcnggcaag tcaaccattg taggacaaat aatgtatttn 240 actggnntgg tngacaaaag gacacttgnn aagtatgatc ganaagctaa taaaaaaaaa 300 789 359 DNA Mus musculus 789 gaactgagat ccctgctgtc tgaatggagg accacagtag gccacgggag gaggagaatc 60 aagatgctgc agttgacagt caggtgaccc tctgaagctc atctgcctct tcaaccatca 120 ggtctaggtg gctgtgctgt agactctgtt accctgtgac gtgctggtgc ggggagttcc 180 atagggagga cgctccatgt cctggaagcc agaaatgggg ctggtgtcat ttgaggatat 240 agctgtggaa ttcacctggc aggaatggca ggacctgaat gaaggtcaga gaactctcta 300 cagggatgtg atgctggaga actacagcaa cttgctgttc ttggggcaca aaaaaaaaa 359 790 245 DNA Mus musculus misc_feature (1)...(245) n = A,T,C or G 790 aatctcagga tgcacataag ntgctttgnn ngacaccntg gaggaagana acgagaagga 60 tctggtagag actagctaaa cgcnttaana gagaaaaaga gantggtggc atcattaatt 120 ntgnggaana ggangcgaac anaangaagc aganagnntt ngggagcaca ctgaatggca 180 aggatggaac tgggtcccat ctagngacag ngcctnctgg acctagcttg gctgatgctc 240 tcatc 245 791 533 DNA Mus musculus misc_feature (1)...(533) n = A,T,C or G 791 atggagctaa tgcacccatc cgaagaacaa agaagagccc aaagcccggc ccttgagagt 60 gggtgacaca gaaaagccag agcctgaacg gtcccctccc aaccgcaagc gtcctgctaa 120 tgaaaaggcc acagatgact accactatga gaagttcaag aagatgaaca ggcgctactn 180 gaggcagcgg taggggctgg ataacgatgt gatgcacagg ggtgcgtttg tgtgcatgtg 240 caagcgtggg ggcacacaca catgtcctct tgcataaaac ctgcttatta gctcttgagt 300 tccccatcag atagtgcttc tgctcagtgg ctggatttct gttctggttt tggttggaga 360 ctgtagctct ctgtgtatcc taggccatga actccctcct cctccctact actgggattt 420 tagacccccc accccctgca ttttcaagca ctaactttgt aactattngg aagaaaacaa 480 tggtgtctat gtctatctat attgtttccc taccctaggg catgacactg ata 533 792 498 DNA Mus musculus misc_feature (1)...(498) n = A,T,C or G 792 gactgagaca gctcagtgta naanagagan gacggagaag ganatggaga nggagaanga 60 naaggagnng angaaganna agaagacgat cancatgttt gatggcagac gtcttcttnc 120 nncganctcc ctgtccttag gaaaagaggg aaacngatgg aacanggnta taggcctaag 180 acnggntttc tgtgtgtacc cctgnctgtc ttggaactca ctctgtagac gaggctgncc 240 ttgnattcag aaatcnncct gcctctgctt cctgantgct gngattanag gcgtgcacca 300 ccatgcccng ctggaattca acacttntat cttttgcttg gtgacttatt atagtttgct 360 gagaaaaaaa gttcaatttc ttttgtttaa aaattgtgaa tgcacatttg catatttgag 420 acagcatctt gctatgtatc ccagtctacc cttgctgttt tgttaaaata caagtaacaa 480 acttgtcaaa aaaaaaaa 498 793 427 DNA Mus musculus misc_feature (1)...(427) n = A,T,C or G 793 aactgagaga cggaagcagc tacttgaggc gagccacagc tcagatcatg gaaatcagta 60 tgcaagccca ggagaactgc aggagttggc atcatattca tgtannatca gtgntaactc 120 tgggctacng agacgaatgt tggactacta tgtgtctcac tgacaagaca ctgnnggtca 180 ncgatgggag acagaactca ccatttaaaa agatnaagaa ngaacaccac ccnactaaga 240 tatgaaaaag gaagcacgan ggnaangctg agagaaacag atgctaccca cagggcagcg 300 gagccatttg gttgttttgg tctttgtacc ancaactccc actcctgtga acggngtcca 360 gttccagctg nactacacgg tttttccttg cagtcaaaac gcgaacaatg gaccccactc 420 ctccagc 427 794 446 DNA Mus musculus misc_feature (1)...(446) n = A,T,C or G 794 gaactgagac tgaaggnctt ttaccagagt ctctgctgtt ctcctcggat tcttcctcct 60 cctcatcgtc atcggagtac ttcttctttg gggnctttct ccgcaaacgc ctgctttgcc 120 tcattggccg agaaggatgc cgcctcagtc ttcggctgca gaagtcagtg tcgctgncct 180 cattggatgg tggctcttct tcactttcat ctggattttc atcagacaca acaaactcat 240 cctgagatct gtccaggaaa agccagatac atcacgatgg tacacttaga gtttggtntg 300 ntttggnaca ttnagaagng ataaccagtt tttcaaagnt ccaaacacat tgtaaagaac 360 ccaggaaaac attaagtaaa tntaaagata tatttggaaa attatgtcaa ctttgccaat 420 aaaatgtatg ttctaccatc taaaaa 446 795 219 DNA Mus musculus misc_feature (1)...(219) n = A,T,C or G 795 cttcacatca tttggnctgn accatangcn tgnnngnntg gtnntctnca gngcctggac 60 ccattgacca gccccctgag ggggaggatg agcacatgga gtctctggac ttagaggctg 120 acaggatccg gcaggagctg atactcactc atttcagtta gaatgagggt agagggagga 180 ggaaggcttt ccagaataaa ccgacaattt cccccctta 219 796 462 DNA Mus musculus misc_feature (1)...(462) n = A,T,C or G 796 gaactgaggt ctactgcgcg ccgcgcgagc atacgccgcc gtccagaaac cagtccaacc 60 caagcaggac gatgaaccac cctcctctgc gttcatcaaa gaatacaagg acatcatccc 120 caacatagag aaggttgntg atnntgtgnn tggaangttg nctttggana tggccgnccn 180 gactganntn nnanaggtcc cgnagngaac aatncgatga acnanatggt ggntnaccct 240 gangngtncn gagcntngnn ggcttattcn ngagccttga atgacaggnt ccgcgttntt 300 gtatacctca tgcagataca tnnaaaggac aaagcccaca aacgccatct gntgatgagc 360 atcgaccgga ggaaaaagtt gntcaaaatc ctccgtcaga ccaactatga tgtcttcgaa 420 aagacatgca nggagctagg ggtggnatat accttacccc ct 462 797 500 DNA Mus musculus misc_feature (1)...(500) n = A,T,C or G 797 actgagacct ataggatnag nnataatggg agcattttta gacaagccna agcatgnaga 60 ancntaatgc ccangggcag gngantgggt taccatacng cctacgcngc atgcaaggtt 120 gncgagttga aatggaggac agcacacacg gctgttgatc tngtttgcca agtggacttg 180 agacatggnc attctttgct gtatatgatg ggcatgctgg ttctcaggtt gccaaatact 240 gctgtgagca cttgttagat cacatcacca ataaccagga tttcagagga tctgcaggag 300 caccttctgt ggagaacgta aagaatggaa tcagaacagg gtttctggag attgatgaac 360 acatgagagt tatgtcagag aagaaacatg gtgcagatag aagcgggtca acagctgtgg 420 gcgtcttaat ctctncccaa catacttatt tnattaactg tggagactcg agaggtttac 480 ttttgtagga ataagaaaag 500 798 524 DNA Mus musculus misc_feature (1)...(524) n = A,T,C or G 798 tgagttgctc taggtcgtaa ccagcctttg aaaaaggaga aaccaaaatg gaaaagtgac 60 tatcccatga cagatggaca actgcgcagc aagagggatg aattctggga cactgcacca 120 gcttttgaag gccggaaaga gatctgggat gccttgaagg ccgctgcaca tgcttttgaa 180 agcaatgatc atgaactggc acaggcaatc attgacggtg caaacataac actaccacac 240 ggtgcactga cagagtgcta cgatgagctg gggaaccggt accagctgcc agtctattgc 300 ctggcaccac caatcaacat gatagaggaa aagagtgaca taaagactct tgatattcct 360 gagccacctc ccaattctgg acacnaatct cagctccgcc tgcggctctc cacaggcaaa 420 gacctcaggc tcgtggtccg cagcacagac acagtgtttc acatgaagag gcgcttacac 480 gccacaaagg gcgtggagcc aggcagccag cgcttggttc ttct 524 799 407 DNA Mus musculus misc_feature (1)...(407) n = A,T,C or G 799 aactgaggac ttttcccgca ggctgcgagg ggacccacag ttcgtggcca cttgcctcct 60 ggggagggcg actctcctcc catccactca agatgctcag gggtccggga cccgggcggc 120 tgctagctgc tggcagtcct gtgcctgggg acctcggtgc gctgcaccga agccgggaag 180 agcaagaggc aggctcagca aatcgtgcag cctcaatccc cggtggctgt cagtcanagc 240 aagcctggct gttttgacaa tgggaagcac tatcagataa atcagcagtg ggaacggacc 300 tacctaggca acgccctggt ttgtacctgc tatggaggaa gccggggttt taactgcgan 360 agcaagccct gngcngtaag tggaaggcan ntctggggcc ctgggca 407 800 513 DNA Mus musculus misc_feature (1)...(513) n = A,T,C or G 800 gattggcata agatatttct tcaagattgg acagctgctg gcctgctact tctgttagct 60 gcaagagata acaccatcat ggatctgcag acacagctga aggaagtatt aagagaaaac 120 gatcttttga ggaaagatgt ggaagtaaag gagagcaaat taagttcatc aatgaatagt 180 atcaagacct tctggagccc agagttaaag aaagagcggg ccttganaaa agatgaagct 240 tccaaaatca ccatttggaa ggagcagtac cgagttgtac aggaggaaaa ccaggttagt 300 ttcatttata catttatctt tatgggctga gtccatgtat ataaacaaaa agaggcattc 360 cttttccatc ccgtcttaga tttcccccat ctttggtctt ttattttttt tatttatcct 420 ttttacttta gaactctgtt tctantatct tagccttttt aagacttgtt cctgtacatg 480 gtgcaaaaca ctcacacata taaaattaaa aaa 513 801 490 DNA Mus musculus misc_feature (1)...(490) n = A,T,C or G 801 gaactgaggg tctgcactga acctgagctc accagttcag ctagactgcc tggccagtga 60 actccaaaga ctgacctgtc tctcccttcc cgttgctgga attacagaaa gtatttgctg 120 gcctcctgtc ctggaaaaat agctggactt tccaggatac agtgagtgag tacaagcaag 180 ttgctgtaga gtgacaagaa cctcacaagc taaaagaaga gaaagcattt tggacattgc 240 gtaacagaag agaatatcta ctaaggtgct tgtcagctgt gaaaatgtct gacaagaacc 300 aaatcattgc cagggcttcc ttgattgagc aactggtgtc taaaaggttt tttgaagaaa 360 tcancttgna gctgtcaagt ctganttata ttttggtata ttntntccat atggcattcc 420 agggtggntc accatggngc aatgtgntag tcctttacng agngacttac agagtcatca 480 acaactcaag 490 802 414 DNA Mus musculus misc_feature (1)...(414) n = A,T,C or G 802 caatgcttac ctgctnttgn ccgaagatct gaanagcgtg nggtatggga gggaccaggc 60 agcaattacc tgacaaccca gagcgattng tcagtcctgc aanctgtgtt gggagcccan 120 attttcacct gcggnagaca ctactgggaa gtgcaagnng ngaaagaaga cggagtggca 180 agtggngatc tgcanggact ttgngaacag aaaggggant ttcncccaaa nctgnccggg 240 gacctcttcn cactcatagg cttaaaaatc gncgaccnat tacaagtctc ttggnttnca 300 tctcccctga aagggcaaca tgtcncggag nancccgtgn cntacaggct ggngnagttn 360 tttggactat gactctgnan cccataancc ttatacaatt gcgaacagga tgga 414 803 318 DNA Mus musculus misc_feature (1)...(318) n = A,T,C or G 803 cacaaacgtg tatcttggta tgcaggggnn taccagtagg acaacttata gaattggctc 60 tctccttnnn tgngggtccc anagacagna ctccggccat cagacttgga agccagcacc 120 tctaccagct gaatcatctt tgcctgcctt aaagtgaatt tccttaagag ggagaatgtt 180 ctaggngtgg cttcacagag acagtggtta ccggccngtt ttntnagcgn agcttgaagt 240 gggaggctgg gtggcacaca tgggagacca aagagatgtg acttntttcc ctagcctctt 300 ttggtgtgtg tgtgtgtg 318 804 167 DNA Mus musculus misc_feature (1)...(167) n = A,T,C or G 804 aactgaggga actggaagct gcaagcatcc tcagctgaca actgcacctc cgcgaatggc 60 tgggtctctg tagtaaaact gcggtggnag gccattgtga ttgtnataga cccngagaaa 120 cctgnactga cgccctttta aactgcagtc aggaggaggc tgactaa 167 805 494 DNA Mus musculus 805 aactgagatt gccttgggtc cccggtattc acgcccatca aggcagacat aagcggtaac 60 atcaccaaaa tcaaagccgt atatgacacc gacccagcca agttcaagac cctgcagaac 120 atcctggagg tggagaaggg gatgtatggg gcggagtggc ctaaagtggg ggccactctg 180 gcactgctgt ggctgaaaag gggcctgcgc ttcatccagg tgttcctgca gagcatctgc 240 gatggggaac gcgacgagaa ccaccccaac ctcatccgag tcaacgccaa caaggcctat 300 gagatggccc tgaagaagta ccatggctgg ctggtgcaga agatcttcaa ggccgccctg 360 tacgcagcac cttacaagtc cgacttcctc aaggcactct ccaaggggca gaacgtgaca 420 gaggaggagt gcctggagaa gatccgcctc ttcctggtca actacacggc caccattgac 480 gccatctacg acat 494 806 265 DNA Mus musculus misc_feature (1)...(265) n = A,T,C or G 806 aactgaggaa ggggaagaag aaggagatga ggaaaacgat ccagactatg acccaaagaa 60 ggatcagaac ccagccgagt gcaagcagca gtgagcagtg actggccttg aggacggccg 120 ccctggccta ccttctgctt tcctggaaaa gatgaatata catcatatga acctattttg 180 agtttttctg ttgtttgttt gcctaatttt gtttttatag cctaaaataa aaatatgaca 240 cagntttagc tctcaaaaaa aaaaa 265 807 115 DNA Mus musculus misc_feature (1)...(115) n = A,T,C or G 807 gtagtcccgc ttccaccaaa actctgtgtt tcctttctct caaaataaaa ctcaacaagc 60 cataaagctt ncgacgccgg tggaganggc gcccncgnat ttatggcccc tgaat 115 808 544 DNA Mus musculus misc_feature (1)...(544) n = A,T,C or G 808 gactgagagc tgctctcaga nctgctgctg ctgctgctgc tggcacganc tntngtccga 60 gtccnntgag gaggaggacg aagagganga ataggaccan gnacaggccg aggaagagga 120 ggaggaggag ganctagaga ggctttcatc tgagtcactg tcttctgaag aggatgaggc 180 ggatgtctca ctctctgatg aagactcact ggccgaactg tcactgctag agatcnnctc 240 tnngtagana nngttcttct ttgtcttctt tgcgacaagg tctcacgtan cctaggctan 300 gcctgaagat gctgctgaac gcttgacccc tccgcttccc ttacacagcg tcacggatgg 360 atctcagaac cttgtgcatg ctaggcaagc nctctgcaaa ctgagctaca tctcancccg 420 acttctaccc tgtgcttgga cctcaaaggt ttcccaaatg antctctgct ccctgatgag 480 gagagtagct cgatcctgcc ncanacganc cagcncgggc ttcactctaa ccatctccaa 540 aaaa 544 809 338 DNA Mus musculus misc_feature (1)...(338) n = A,T,C or G 809 tcccacctgt acctgtgtct gtgtccagcc aggaagacnn gttgcctnan ctacctcccc 60 tgcctaantt accanacacc ggntgagaac tacgtgactc ccattgnaga ctccccagca 120 gccgaatacg tgaatcagga tgngcctctc tccaatcagg cggtccntnt gaagnccaag 180 aagccngccn ggntccnagc anaacnccna tagncatnag ttgtgcctan gccagatctc 240 ttagccatnn ccngngttga ggaccaggan gctaggtgga agntcntncc aggcttgctn 300 ccttgggaca agacttgngg ntatcaccgc tgagctgg 338 810 240 DNA Mus musculus misc_feature (1)...(240) n = A,T,C or G 810 gactgagaat agtatacaag cttcaggagg gactccggaa gccaagggca ttgagaaacg 60 caagctttct cagaaacgaa ggacactgta gctgccagca gcagtccatg agcatctcca 120 agcccaagta cctggagcaa ctagaaaact acctgcgcaa ggaactcctc ctgctggacc 180 tgagcacgga ttctgcacag gaactgaggc tgcaggtnaa agcccacaga cccaacatgt 240 811 133 DNA Mus musculus misc_feature (1)...(133) n = A,T,C or G 811 gagatcttcg aagaactgtt gctgtaactc ttggtatatt tggaacttat ggcntacaca 60 atccacangc atacagatac tgtgaagcag atttttgctt tagaataaaa aagctgtgat 120 acaagaaaaa aaa 133 812 512 DNA Mus musculus 812 actgagtgta tcctgagggt accggcgggt gtttgaggag tacatgcggg ttatcagcca 60 gcggtatcca gacatccgca ttgaaggcga gaattatctc cctcaaccaa tttatagaca 120 catagcatct ttcctgtcag tcttcaaact agtattaata ggcttaataa ttgttggcaa 180 agatcctttt gcttttttcg gcatgcaagc tcctagcatc tggcagtggg gccaagaaaa 240 taaggtttat gcatgtatga tggttttctt cctgagcaac atgattgaga accagtgtat 300 gtcaacaggt gcatttgaga taactttaaa tgatgtgcca gtgtggtcta agctggaatc 360 tggacatctt ccatccatgc aacaacttgt tcaaattctt gacaatgaaa tgaaactcaa 420 tgtgcatatg gattcaatcc cacatcatcg atcatagccc tacctatcag caccgaaaac 480 tcttttacac taagggattt tgcaagagca gg 512 813 410 DNA Mus musculus 813 gaactgagag tcagtcgctt tgaatccaag atccatgact tgcgggaaca aatgatgaac 60 agcagcatga gttctgggtc tgggtctctc cgaaccagtg agaagaggtc cttgtatgtc 120 agggccctgt ttgattatga tcggactcgt gacagctgtc taccaagcca gggactcagt 180 tgaaggcaaa gagggataaa gtgacagatg attgtgactc tcgcgagggg gggtgagccg 240 ggaagtgttg attctctgat ggtaactgac agcagtggac agtgctcaat cctccctccc 300 agggaagaaa agcaaagatt cgaagtaagc atgataatag ttggtttacc agtgttcctt 360 ccaaggagac atatattttt taataaatga tagttgcaat gaaaaaaaaa 410 814 100 DNA Mus musculus 814 gaactgagct ctaagaacag gtggaattag ctatggataa ttcatacaat ttaaatgaac 60 aaagctcatg gaatggaatc tcatctgaga agaaaaaaaa 100 815 152 DNA Mus musculus misc_feature (1)...(152) n = A,T,C or G 815 ttgattcaag atgtcacaga cagtncttcc cnnntgggga gtctgacatt tgaagaggaa 60 gaactgactc gagctgatcc tgagcaatgc catgtgcccc tgtgagtaga acgaatgatg 120 atgcagtcat tcctgaaaaa tgtgggacaa ga 152 816 365 DNA Mus musculus 816 gaactgaggt ttagagtcag gtcctcccgg ccaatgctac tggggaaata gcccaggcgg 60 gctgccaggt ctccatagta acctccctga acctggagaa gaagttaaaa gtccatctgg 120 ggaaacggca cttatgcttg ctgaacgcct gtgtacaatc ttccctctta cttgaatctc 180 agcttaaatg ccatttgctc atggatagaa tgttgccact acaactaatc ctcacaatgt 240 catgtttgct gccacttttg atggcttgct ggttgcctgc ctctacccct ttgttcactg 300 ttgtatcccg ggtatgaaaa agagctttgg cgctaagctt ctctgtaatt tctaaagaaa 360 aaaaa 365 817 546 DNA Mus musculus misc_feature (1)...(546) n = A,T,C or G 817 gaactgagat tggcttgggc aaaagaatcc agagacccta ggatttcaga aggccagcag 60 tctccactgg agaagaagat cctgagtttt ggtggtgtgc atacaacagc agcaagacac 120 ttgataactc agaaatgcca tgaggagagc aaagcactct gcaaggagca agctaattct 180 ctggactact ggcttgcaaa agcagagtcg tattataata agagaatggt ggagagaatg 240 aaaaaagaca caggtgatga aacaaagaca aaagtgcaag aggaaccacc atcaccatca 300 ccaccaccac caccaccacc acgcagagag agacagaaac agcattactg ggtgcctgag 360 agagagaaga agcaaataga aaggcacatt catagaacaa gccatgccag agaatttaca 420 gaccaaccct ggagacagcc acgactcttc agtgaaacaa cactacccaa aattgtgcta 480 gaggaggaaa gcatcccaca agcacagaaa agaaggcagg cncacgagag agaactgctc 540 caaatt 546 818 239 DNA Mus musculus 818 aactgagatg gatgtccatg gcagaataag agaaattctt gcagagacta tacgagaaga 60 attagcaccg gatcaacaac atttatcaac agaagatctg atcaaagctc taagacgtcg 120 aggaatcatt gatgatgtaa tgaaagaact taattttgtg actgatagtg ttgatcaaga 180 actcccttct tctccaaagc aaaccgttgg ttttgataag cagtcaacat taaaaaaaa 239 819 457 DNA Mus musculus 819 gaggctcgac ttcggatggt agacattgtg gagaaggaag atgtaaatga agccataagg 60 ttgatggaga tgtcgaagga ctcccttcta ggtgaaaagg gacagacagc taggacccag 120 aggccagcag atgtgatatt tgccaccatc cgtgaattgg tgtcacaggg ggcggagtgt 180 ccacttttct gaggctgaac agcgctgcat atctcgtggc ttcacaccag cccagttcca 240 ggcagctctg gatgaatatg aggagctaaa tgtctggcag gttaatactt ctcggacacg 300 gatcaccttt gtctgatagc cagtttttac accctcctgc ctacaccaga gggcatgctg 360 aatgccccct caagaaaaaa tctcattctc ccatgctgca cttttttatt ctgccaataa 420 agtgttttga ttgcctcttg cttgttaaaa aaaaaaa 457 820 125 DNA Mus musculus misc_feature (1)...(125) n = A,T,C or G 820 tgggattaca gatgtttgct gagggaaaat ggccagaaaa tcctcattcc tacgtttgtt 60 ccttanaaag gctgttgggg caggtaatcc agctcctgca cagttctgct gagagccaca 120 taaaa 125 821 253 DNA Mus musculus misc_feature (1)...(253) n = A,T,C or G 821 gactgaggct atatcggcgt ggttaaccga agccagaaag acatcgaggg caaaaaggac 60 atccgggctg ctctggcagc cgagaggaaa ttcttcctct cccacccagc ctaccggcac 120 atggctgacc gcatgggcac cccacacttg cagaaaaccc tgaaccagna antgaccaac 180 cacatccgga gagtcactgt cgacccttcg cannaagntg nagagccaac tgctgtccct 240 ggagaaggaa gtg 253 822 495 DNA Mus musculus misc_feature (1)...(495) n = A,T,C or G 822 gaactgagga gtgccagtgc acaaccaagg naagtccatc agctttatta acccatcaaa 60 atcaagtgca gggaaaggat atgctgcctc aaacccaaac aaattggccg tatcaagaac 120 tatgggtttt ttaactgaca tgaagccggc agaaaaacta aactgttcct agcgctaaaa 180 cagtacaggt gcttgattca aaaggagttg atgtcacacc ccgacctctc taccatccag 240 atccacatgc tgcgtcagca aagccaaaca aactcttgac atcacaagaa ggatcgcttg 300 gatcagatta tatttcttcc tatagcctct atcanaatac actaaaccct agcatgttag 360 ggcagtacac aaggtcagtc ctggggagca gntcagtgtc gaagtcaagc atctcaacaa 420 ctgagtcgat gtcagaggac cttgaagatt cctcttacaa gaggggatag attggccagt 480 tttacagatg tacga 495 823 182 DNA Mus musculus misc_feature (1)...(182) n = A,T,C or G 823 tacagcaagt ccaaaggant gccnactctc canaggattt aactggnagn ggnatgagac 60 ttctgatttc acagctcgnt ggctacctga aagngaaaac aaaaattcan nncatntttt 120 atctatggca tgncngcaaa ncatcaaaan aaagcgattc ttaaacccgt gaaaaaaaaa 180 aa 182 824 313 DNA Mus musculus misc_feature (1)...(313) n = A,T,C or G 824 ccacaggtgt cggccagcag tatcctgacc cagcaacggc atggtgnnat gtggggctat 60 atgccaagag ganagccgtc tatnnggana actctctcta tcagcctctt tcttgcctcg 120 gganatncgn gctcttctca ataagcctaa ggctttactg ntaagaatcc caggaggttt 180 ctgggataag acaccattgc ttaaactcgg ggnatgcagg aaaggaaagg gcagacactg 240 ngaagggctc atagaaaanc actttcaaca attttgggaa taccaaggag aagaatttcc 300 tagagaaaaa gaa 313 825 336 DNA Mus musculus misc_feature (1)...(336) n = A,T,C or G 825 ctgagactga gtaagagaga gagagaagag agaagnagaa ggagaagatg aagaagaaga 60 agaagaagaa gaagaagaag aactgctttc cctcgtntcc ttgctggtct gtcctccccn 120 angaccctga cttgnaacac cnaanccntn cacaaccagc ancccancca ngcancaaat 180 gacacacacc aaggctcatc tggctcctga ggttcaaagt gagttttnnt tgtgttttat 240 tctaacatgt tttttcagag ttttctgctt tgaaaatgaa gttctttttt agctggngaa 300 gaataaataa tatttccaag agccgccctc ccagga 336 826 520 DNA Mus musculus misc_feature (1)...(520) n = A,T,C or G 826 tcatcagaaa agctaagttt gctatacagt aaggatcagg agatctgacc ctggttgcag 60 aaccattcct ggttgcagaa tacagggttg tattcccact tcatctttcc agaccatcct 120 aggaaatact aggaatcctt ggaagggaaa gaaggaacat tgttggttgg aataaaaaca 180 gggttgaatg agttccagaa agcaggcttc tcaaactcgt ggacaacaat ctgctgaaga 240 agacaacttt aagaaaccaa ctcgaagcaa tatgcagaga agtaagatga gaggagctgc 300 ctcgggaaag aagtcagctg gttcgcagcc aaagaatctc gatccagccc tgcccggaag 360 atggggaggn ccgctctgct gagaaccccc cttccggttc tgtgcggaag accaggaaga 420 accaagcaga aggctcctgg cnaacggaga cggaggcagt acccagggga agtcccccag 480 cccccctcgg aagaaaaagg gcacggggct gacccccact 520 827 360 DNA Mus musculus misc_feature (1)...(360) n = A,T,C or G 827 actgagactg aggtatcagt ccctcacctg accctgttcc tgaacacagt gcacccatct 60 atgagttccg gtgacagagg ttcagaacag tggccaaata aaactgaact tggcaacaaa 120 nanctttgan aggaaattat gtacctgcca tgaaccagga gaggtgtgtt cctgtttgtt 180 cacgagcaga cttcatcaga aagcatgaat gttaacctac aggatccaag gagcatggcc 240 aacctgcagg caggcagagg gagctgttca cctcccaccc tccttcctct cagtggcatt 300 gtggtcacca tctgtttctg aacaacctta aatgcacttt ccttcctgca cagctaactt 360 828 421 DNA Mus musculus misc_feature (1)...(421) n = A,T,C or G 828 acactcacgt ccttgtgcag ccttcgccac catcctcctt cagaactcat tcatctctca 60 cagttgaacc tttgcncaca tgaaacagtn agtctctctt tttaaagata anttnctatt 120 ttgattatac atgtggatgc agatgccctt ggagaccaga catgtnggag ttgnggtgaa 180 gatggttata aaccactnga ngtggngttg tnctggctgc cctataactc actntggggn 240 ccaggctagc ctgaactgcg atgtctttta cctaggtttt ttcctcccag ttcactgatc 300 ctgtnntgca tgncnnannn nacctccctt aaanacatat annccaccan nntntgcanc 360 aatttcagaa ggctcaaggn gggggacgcc ctggccctat nttgaccagg tgaaactgca 420 g 421 829 536 DNA Mus musculus misc_feature (1)...(536) n = A,T,C or G 829 gaactgagag tcctttggac agaactaccc agtaggtaag ctgatgggac tctggactgc 60 atcagcatgg ccctgacctg cacctttaac agaagaccct naataaannn ctgntggccn 120 tccaccgnat gcagtcncaa nctncttgat ggaggaaggg gctngtgtca gagaanaana 180 ggcacncttc annacanggn ncccatncac caaagangaa acntanaccc accantatan 240 ggntncaagg agagccgaat gatgaantcc atccactact gngngtaaag ggggatggca 300 aatcgaaana agantcaagc angccggcct aaaggatnaa aagcaggagg agccatctca 360 gaactgctgn gaanaccgtg gaacccttgg ttcttctcac tctgtcatca ggtanccttt 420 ggacagngtg gccaatcatc tgagattggc tttagttgaa aacaaaggcc tntgcctccc 480 acccaggagg tgaangagng gattttnngt ttgaatgacg aaggcgaatt atgccg 536 830 333 DNA Mus musculus misc_feature (1)...(333) n = A,T,C or G 830 gaactgagga agaaatggaa gccagaatna agcaggtact ccgctccctg cgtctggagc 60 tgggtgccga ggtactggtg gaaggactgg ttcttcagta cctttaccag gaaggaattn 120 tgacagaaaa ccacattcaa gaaatcaaag ctcaaaccac aggcctccgg aagacaatgc 180 tgttgctgga catcctgcct tccaggggcc ccaaagcttt tgacaccttc ctcgattccc 240 tccaggaatt tccctgggta agagagaagc tggagaaggc gagagaggaa gtcacagccg 300 agctgcctac aggagaaaaa atccctggaa gca 333 831 226 DNA Mus musculus misc_feature (1)...(226) n = A,T,C or G 831 gatgcgtttg gcagagggag cagtggagat tctangtcng ggcttaaggc ctggggcttc 60 caatgatnct ctggtnatgg ntggangcct agatgcctca ccgcanggng caggacgngn 120 gggtcctcnc ttaantgcac acnggcagca anangcacag gcggagggag gaaatatagn 180 ccnggctgtc actcaccntn tcggntgtgt ctcccctggt tgacca 226 832 111 DNA Mus musculus 832 ctagactgag tccaggctga tactgatttg ggcgccttgg ctgcagaaat agaaggagct 60 ggtgctgcca aggagcagga gcctcagaag tcaaagggaa agaagaaaaa a 111 833 385 DNA Mus musculus misc_feature (1)...(385) n = A,T,C or G 833 agcacacagc tggggcttcc ctaggcgagg agagatggat ctgatccgta tgggtttgaa 60 aggcccgaag actttgacta tgcggcttat gaagaattnt tttccacgta cctggtgata 120 ctcaccaaga gggcgatcaa atggtccaaa cttctaaaag gaaacggtgg tgtcccggaa 180 aagcgtgaca gngaaacgct atgtccngaa gggaatcccc gntggaacat cgtgnccnnn 240 cgtgtggatg gctcgngagt gganctcagg ccccggatgg accanagccn tgnatactta 300 ccatcgactg ctnccanggc nagatcagct ccaggtctgg acnaggtcnc attaggacan 360 nacttgtacc ggacattccc tgact 385 834 303 DNA Mus musculus misc_feature (1)...(303) n = A,T,C or G 834 gaactgagtg tcttctaatt gttgccatca tgacggagtt tgtatgcctt gataccttta 60 tgctgtttaa gaatcatgtc tttgggggac tggagaaatg actcaacagt taaaaaagca 120 ctgctgctct tccagaggac ccaagtctga ttcccagcac ccacatgatg ttcacaacta 180 tccttaactc cagttccagg ggatntaatg ctctcttctg atcttntgga gtaccaagca 240 cacacatgat gtacagacat atatacaggc aaagtacaca tacaataaaa tgaataaatc 300 taa 303 835 316 DNA Mus musculus misc_feature (1)...(316) n = A,T,C or G 835 gaactgagag catacctgcc ctgctggagt tcatacccat tcctgagcaa cactggtttt 60 tgccatggaa tccgtanatc cagcttgtct gtgcagtagg ccactgttca aaatgaagan 120 aaggaaaaaa gagagtggca acacggaagc cagccacaca cctgggattg cnggctctat 180 tcgtggatct taatgagtaa caaggaaaag caaaatgcta tttatctttt tggcaaaaat 240 taattgntag tatttcatga ttctagagat gtatttctcc aactanaata aaatttttgg 300 atcgtaaaaa aaaaaa 316 836 286 DNA Mus musculus 836 gaactgaggg cacagagacc gtgaagtctg caacacggct gctcatcagc ttccagcatt 60 cccagccatc gaagtccaca gtggagtggc tgctccctgg gcacctgtga agattcagga 120 ggaacccacg gtcacgcttt atgcctttca agtcattcca tctggaaaga tgaacagaat 180 gagaaatgtg tgtgtgtgtg ccatagaagt tgttagttca tacgttcaaa tgccttggca 240 tttattagtt ttgagtaaaa acaacgttac ctttcaaaaa aaaaaa 286 837 432 DNA Mus musculus misc_feature (1)...(432) n = A,T,C or G 837 gactgagacc ctgtcccatc atttgaggtg gcgcggactc tagacgacag actgcagcgt 60 cccagctttg accccagtgg gcagcgccta caagacgtgc acatcgcgtg gaagaggtgc 120 ccanagccac ccantgccag agagcanaan gaggggacag tgtcccacgg ggcacacgcc 180 atncaanggt aaccacntgc canagtcccg aggacaccct cgtgacagac accttgctgc 240 agaagaatga ggccgagaga cagangggtc tccaagaagt ccacatcacc ttggcagcca 300 ggctggggga ggcagaggag aaaatcaagg tgttacattc agcgctaaag gccacacaga 360 cagagctgct ggagctgagg aggaaatacg atgaggaggc tgcttccaag gccgatgagg 420 taaaaaaaaa aa 432 838 188 DNA Mus musculus misc_feature (1)...(188) n = A,T,C or G 838 agactgagta caagacagca aaatacaact gccaattata cagctgcgga aagtatgggc 60 tgaagcagtg cactacgtat ctgggctaaa ggaagactac agcaggctct tccagggaca 120 aagagcagca atgttnnnag attgtgttag aagcgtagna gccatgtgta tcatgtactc 180 aatgaatt 188 839 457 DNA Mus musculus misc_feature (1)...(457) n = A,T,C or G 839 atatatctat ctggcctttn caaattggnc cctgcnnant ggcttncacn aagaagggtt 60 ntngtangaa ganggnccat catcgaggtg gtgatccang antacaccat cntcattnac 120 nagcncattc ntagngtgga nttcattang ccgtgctcct tggacactcn naganatcca 180 nangttngct atgaaggann tgnacgattc cngatgtnca tatngacacc nggctcatta 240 aagncatgtg ggtcaaggga ataaggaatg ctccattgca tctgagtatg ttcgtccaga 300 anacatagta cggaggagga gtcaccagac aagctttaca cattgataac ttactgnctg 360 tnaccacatt caaactctac agaangtcaa tgtggatgag anctaacctg ctgantgtca 420 aataangttg cagaactgcc aaacaggtaa aaaaaaa 457 840 325 DNA Mus musculus misc_feature (1)...(325) n = A,T,C or G 840 gaactgaggt acctttcaga tgaaggcgtt gaagcctgca caagctctcc tgggaaaggc 60 agcataaatg acatcatcct gattgctctc aatgnagann aaggcaccta tgatcacacc 120 attgnntncc gcaaaggagg tgatggacag ncacaaaggn ntactnggcc ancgcagnaa 180 ntntaccaan ctnctcgagc tnggaactaa ngngaanggg cttttgagaa ggaagatcca 240 ctgactganc catnctggaa gcccactgat ngattttcca cttnttcaga gagagactca 300 atatgctgga tatgattttt ggaga 325 841 470 DNA Mus musculus misc_feature (1)...(470) n = A,T,C or G 841 tctgacctgg cgtttgatga nanagattgg aagctccaag tcagatcntg aaganctttn 60 angctcctcc acaaatctcn ncgaccacnn cccttcatcc tggcgagacc acgatgacgc 120 aacctcaacg cactccgcag gcaccccagg accctccagt gggggccatg cttcccagag 180 tggagacaac agcagtgagc aaggcgatgg gttagacaac agcgtagctt cacctggcac 240 aggtgatgac gacgatccag acaaggacaa aaaacgccag aagaaaagag gcatattccc 300 caaagtcgcg acaaatatca tgagagcgtg gctcttccag catctcacac acccgtaccc 360 ttcagaagaa cagaagaaac agttagcgca agacacggga ctgacaattc tgcaagtgaa 420 caactggttt atcaatgcca gaagaagaat agtgcagccc atgattgacc 470 842 260 DNA Mus musculus misc_feature (1)...(260) n = A,T,C or G 842 ctgagactga gcatgcatgc tttatacant ccataacaca tacgatgaca ttgaaancac 60 tnncggttgc agatctagga tgnggctgtg gngtacttat nanntngaac aggcaatgct 120 aggagcaggg ttgngtgttg gatttgacat anatgaanat gcactagnna atatttaata 180 tngaatngcg gaanagtgng agctaacant ggttgntatg atncntagtg atgtgtactc 240 attatctaac agaatgtcca 260 843 358 DNA Mus musculus 843 gaactgagat ggccgccaag agcgagttat gtttgacaaa attacatcac gaatccagaa 60 actctgttat ggactcaaca tggactttgt tgatcctgct cagatcacca tgaaagtaat 120 ccaaggccta tatagtgggg tcaccacagt ggaactggac accctggctg ctgagacagc 180 cgcgaccttg accacgaagc accctgacta tgccatcctg gcagcaagga tagccgtctc 240 taacttgcac aaagaaacaa agaaagtgtt cagtggtacg tctggtataa aaacatgaga 300 aagcgtttaa tagtgtcata aaattatagg aataataagt gaattttaaa aaaaaaaa 358 844 543 DNA Mus musculus misc_feature (1)...(543) n = A,T,C or G 844 tgaggtgccc tatgagacac tgaacaaacg cttccgagct gctcagaaaa acatcgatcg 60 agagactagc cacgtcacca tggtggtagc tgagcttgag aagaccttga gtagttgccc 120 agctgtggac tctgtggtca gcctattgga tggtgtggtg gagaagctga gtgtcctcaa 180 gaggaaggca gtagagtcca tccaggccga ggatgagagc gccaagctct gcaaacgtag 240 gatcgagcac ctcaaggagc acagcagtga ccagccagca gcagccagca tgtggaagcg 300 gaagcgcatg gaccggatga tggtggagca tctgctacgc tgtggctact acaacacagc 360 tgtgaagctg gctcgccaga gtggcatcga ggaccttgtg aatatcgaga tgttccctga 420 cagccaaaga agtnggagga gtccttggag aggcgtgaga cagccacctg ccttgcctgg 480 tgccatgata acaagtcccg actccggaag atgaagagct gcctagagtt tcagcctcag 540 gtc 543 845 275 DNA Mus musculus 845 gaactgaggg ccggcacatg ggtgaggggg taccccctgg ggcgtgagct gccccgcaca 60 ggatgccccg tgccccccac tccatgcccc tgctgctcct gctgctgttg ctgtcatcgc 120 tcccccaagc ccaggctgcc tttccccagg accccacccc tctgttgacc tctgaccttc 180 aaggtgcctc tccatcatcc tggttccggg gcctggagga cgatgctgtg gctgcggaac 240 ttgggctgga aaaaaaaaat ttttaaaaaa aaaaa 275 846 537 DNA Mus musculus misc_feature (1)...(537) n = A,T,C or G 846 tgggaaaccg gcaccagtcg actctacagt gctctcgcca agaccgtcaa cagcagtgca 60 gctgctcagc acccggagta cttggtgtca gctgaccccg aacatctgga gcccatcgat 120 cctaaggaac ttctggagga atgcagggct gttctgcaca ctcggccacc ccgctaccag 180 cggggatttt gtggacctga ggacagattg ctccagcagc cactctccca ttcgcgtcat 240 gcagtggaac atcctcgccc aagctctcgg agaaggcaaa gacaactttg tgcagtgccc 300 cgtggaagcg ctcaaatggg aagagaggaa gtgcctgatc ctggaggaga tcctggctta 360 ccagccagac atactgtgcc tccaggaaag tggaccncta cttttgacac ctttccagcc 420 acctcctcag tagactgggg ctaccaangc accgtttttt ccccaagccc tggtcaccat 480 ngnctagant gtggaancac aacaacggtc caagatggct ggtgccttat ttttttc 537 847 158 DNA Mus musculus misc_feature (1)...(158) n = A,T,C or G 847 gaactgaggt tgctgttctg gctgaggcca tctatggccc tggnagtgtt ttcattcaag 60 acaaagtcca ttccatcttt atttattagc tgagcaaatt cagctaataa ttttcaagac 120 ccagattcaa gcaataaaac atttctctgc aataccaa 158 848 123 DNA Mus musculus misc_feature (1)...(123) n = A,T,C or G 848 gactgaggtg ctgctgactt ctgataaagc tgcggccaat ttctcagatc gttctttgct 60 gaagaacttg ggacattggt taggaatgat cacattagct aanaataaac ccatcttaca 120 cac 123 849 543 DNA Mus musculus misc_feature (1)...(543) n = A,T,C or G 849 aactgaggtg aagagactgt tttctgaggc tgcgttggag gctgtgaccg agcagagagc 60 ccatgtgaac tgatggggag gctttctgaa taacatggcc ttttgccatt agccttgcca 120 tgaccacatt tttcaccagc agtccctccc tggattcaag atgcaaagca ggaggaggaa 180 gtgggctagg aaactagttc ccaggcctcg gggccgggag gcagagagtc aagtgaagtg 240 ccaatgtgaa atctcgggga caccattttc aaatggggag aagctaaggc ctcacagcct 300 tccccatccg gagcagagac catatagctg tcctcagctg cactgcggca aggcttttgc 360 ctccaagtac aagctgtata ggtaggtgac actcccattc ctctttcagt ttccaggttc 420 ctggagctca caaccagaga ctccattgag agtgaacggt aaagntgtcc tgtgagtata 480 ctatgaactc taaccatttg aagtcactca ctaaatagta ataatggttt agctggatat 540 gga 543 850 307 DNA Mus musculus misc_feature (1)...(307) n = A,T,C or G 850 gtgttccaat ttgcaaggca agaaggagtt catggttttt atgacttagc agtggaagcc 60 aaactatcac tttcaccaaa ttcaacgtat taacagcaag tcaccaacca ttcagggctg 120 gagaggtggt tnagnagnta gggctgctct tccagaggat cccagttcaa atcccagcat 180 ccacatggna gctcacagca ntgtgtaact ncagttctgg ggattccagc ncccccatac 240 agactgtaca cgcngccaaa acaactaaga cataaaatan tgataaatac attctttaaa 300 aaaaaaa 307 851 546 DNA Mus musculus misc_feature (1)...(546) n = A,T,C or G 851 gaactgagga gtaatggagt ccaagcatca aggcgtgaaa aatctcaaca tggagaatga 60 ccatcagaaa aaggaggaga aggaagaaaa gccacaagat accatcagaa gggagccagc 120 tgtggccctg atctccgagg ctggcaaaaa ctgtgcgcct agaggaggtc gcaggcggtt 180 ccgggttcgg cagcccatcg ctcactatag atgggacctg atgcagaggg ttggggagcc 240 ccagggaagg atgagagagg agaacgtaca gaggtttggg ggtgatgtga gacagctcat 300 ggagaagctg agggaaaggc agctgagcca cagcctgcgg gcggttagca ctgacccgcc 360 tcatcatgac caccatgatg agttttgcct catgccctga gtcctgagct tttctctgaa 420 gatgacatgg ggacccctgc cttgtgatgt acaaattttg aggttactcc tttttatgta 480 gatctctccc tgttaccagc ttctaattga aacttgngnt ttttactcgg cctataatta 540 agcaaa 546 852 352 DNA Mus musculus misc_feature (1)...(352) n = A,T,C or G 852 gaactgaggt gacaggacac cctcaagggc tttgatgaga aggcgtacct gtcagccaag 60 cagctgaagc ctggagagga cccatacaga caacatgcct tcaaccaact ggagagtgac 120 aaactgagct cagaccgacc catcagggac acccgccatt acaggtatgg catctgctga 180 gtggacagga agggaaaact aagaaaagac cagtgttggn cagcttggtt tntttcactc 240 atatgtgttt attgatttat tacatttatt taccttattc atgtgtctgt gtgtgtgtga 300 tcgtgcacac atgcaaactg tatatatttt acaaataaat atgatgtcct ca 352 853 286 DNA Mus musculus misc_feature (1)...(286) n = A,T,C or G 853 cgttcctgga agaggaggag gaggaggagg aggagagacc aggattcgaa ctcaggccca 60 gcttcgatac gctatggaat cactgncagg gccagcttcc cctgtggctg agttcctgtc 120 tttgatagat ttctgtgaaa tcctcacagc cttctcaatt agcagctggc atctttattg 180 attgatcaaa aaccaattgg ggacaaggac cttcagcatt tggacaagca gattcccgat 240 taaatcaaag cattagaacc aattctcaac agtgtaaaaa aaaaaa 286 854 479 DNA Mus musculus misc_feature (1)...(479) n = A,T,C or G 854 cgttctgacg ccagcactga gattctctta cctgcctttg tagttattca catcaaagat 60 cttctttgca cggtantaca cgagcttcca gggccnganc agatgccctt ccctgcagag 120 aggtggaana cagtcagaga ggcggcntgn ggccatcgtg agatggtcac aaacaccaaa 180 ggaacctact ggagccctgc gtgacatggt taagttcatg tgcagcagtg tgcagaggca 240 tgctggacat anaggcatgc tggggctnca tgcncctgcn ctgtcagaac aggtacagtt 300 aacactgcct tgaggagcaa gngcacgctg ggtttgcaga tccactcacc ggattgccac 360 ttnaacatca tctgagaggc accaagctca ttatcnccca gncaangcct ccctacctnc 420 cctctctnna naagagcctt ctcctgcccn ctgccctncc tgtgtaaact gaaaacact 479 855 194 DNA Mus musculus misc_feature (1)...(194) n = A,T,C or G 855 atcagtcaag aagaattana agaataaggt tgggatccac tgntnccaca natgaagacn 60 tgacncccag cccagaccnn ganccagacc ctaccgagan ntntgncgga aataatggag 120 acctgtcacc ctgcaaggtg gaagaaaacn cngcccagaa gaatacagaa acagcctctg 180 gcatcgggga tgaa 194 856 439 DNA Mus musculus misc_feature (1)...(439) n = A,T,C or G 856 aactgagatg gccgccccat tggggtggag ggcatccagg tgctgggcac aggaaacctt 60 atcatctcag atgtgactgt ccagcattca ggtgtctatg tctgtgcagc caacaggcct 120 ggcacccggg tgagaaggac ggcccagggt cggctggtgg tacaagctcc agcagagttt 180 gttcancatc cccagtccat ctccaggcct gctgggacca cagccatgtt cacctgccaa 240 gngcaggggg agccaccgcc taatgtcaca tgnttgaaga atggacaagn gctgggggca 300 ggaggccatg tnaggctcaa gaacaataac agcacacttg agcatttctg gagtcggacc 360 tgannatgag gccatctacc aatgtgtggc tganaacatt gctggctcgn cncaagccag 420 cgccaggctg accgtgctg 439 857 104 DNA Mus musculus misc_feature (1)...(104) n = A,T,C or G 857 aactgaggtg tttggccttg gttccgtggc tcacatggtt ttaggagaaa actctggcag 60 ctatctcggc gtcnacttgg gttttggatt cggagtgacc atgg 104 858 301 DNA Mus musculus misc_feature (1)...(301) n = A,T,C or G 858 gactgagggt aaacttgatg attaccagga acgaatgaat aaaggggaaa ggctcaatca 60 agaccagctg gatgcngtat ctaagtacca ggaagtcaca aataatttgg agtttgcaaa 120 ggaattacag aggagtttca tggcattaag tcaagatgta agtaaaaaat actgtgtaaa 180 atataaaaat taagttagtg gaaactattt ggagttagtc tgtacattac tgttgatgag 240 ttctctgcca ggtgtggaaa ttggattaaa tcatttctta ttaatttgcc aaaaaaaaaa 300 a 301 859 321 DNA Mus musculus misc_feature (1)...(321) n = A,T,C or G 859 actgagggct ggagggacat ctgaagaggt ctcatcatgg cggacagcnc tctggggaca 60 gctttngnga tgcctanacn gagggntggn tactgnacca tgaacacant ggaggatncc 120 tcctttgctt ctttncgctt ttctcctgnt ttaaaacccc atagtaaagt actttctttn 180 tctccttctt tcttttatta acattcagaa atacacctgt nntgngctga gttattntgg 240 aggataaatn atagtttttg ctttngtgaa gnnggcattn ncacctttgc cctaanaaaa 300 tngagtgtag aaataaaaaa a 321 860 497 DNA Mus musculus misc_feature (1)...(497) n = A,T,C or G 860 aactgagcat tggaaaaagg tcagcaagga tgtctcagtg ggtaaaggca agcctgatgt 60 tctatcaggt acctgcctgt aaggaaagaa tggacttctg aaaaatgaaa caggagagtc 120 agagcctctg agcaagacct gggaggtgct ctggagtgct ctgatgaaac cttacagaaa 180 aaagtgaagt cggactcacc tagttcccaa agagtgggaa gacctcaatg acctcttact 240 gcccagggaa aaaggattgg aactcattaa ctctttgtga accagagaga aaagaaagga 300 agaaaattgg aggctggaga gatggctcag ctgttaagaa cactgactgc tcttccaaag 360 gtctangagt tcaattccca gcaaccacac agtggttcac tatcatcttt aatgggatcc 420 gatgcccttt tctggtgtgt ctgaagacag tgtactcata tgcataaaat aaataaatat 480 ttctacaaac aaaaaaa 497 861 411 DNA Mus musculus misc_feature (1)...(411) n = A,T,C or G 861 aggaggaaag cctggaangc tcccaccaag cggcggcggt ncacggntnt gatggaggga 60 aagnacatgn tccacatgcc caaggggacc acngccccgc atccgtgang atnctggagc 120 accancangc agcctaaggt ctccatanaa catcncgtag tttnatcgnc ttggngnttg 180 attncanagc agacaccnag cacagggact angccttttt gagttttcag ccgcttaggg 240 nctaccccan agatggatga gtgatctgnc cttgggacag tnacaatgac ggnnngcant 300 agcttctgtn ctagcantat nctagnnntc ctganngaaa ctaggaccan gccccaacca 360 aggccangtg cccaaccagn nctgactgcc aaagccaaaa gccaccaagc t 411 862 436 DNA Mus musculus misc_feature (1)...(436) n = A,T,C or G 862 gacgtgaacc tggaactnac caactctgct agactgngna gcnntgncaa tngctctagc 60 acagatnaac tnngagggcn tnanncccac tgaaataagc cagngacaaa aagaccgnat 120 gttgtgatca cacttaaata aggnangtan actgtctggt caagcangta ggggcanacg 180 agcagaacgg ctagcccgct angggatgtg gggagggcag aatgggcatt tgttgnttaa 240 tggatgtaaa ggttcagttn tgcaaaagga aaaggtgagg cttgatgaca ttgctctcta 300 gcagaacgct canctagcat ttctgagacc tganntcatg tncaacagct catgcacaca 360 cacatgcaca ggagaaagaa tggaangaan ctaccccttt tacttaaaaa aattgnattn 420 attttttatt ttatgg 436 863 524 DNA Mus musculus misc_feature (1)...(524) n = A,T,C or G 863 gaactgaggt gtgatccgct cactgcatga gcatgggccg attggagcat accttctgca 60 cagagacccg gccctacaac cagggagccc ggctgacggc cttcgagctg gtgtacgagc 120 agatccctgc aactctcatc actgacagca tggcggcggc tgccatggca caccggggtg 180 tgtcagccgt ggtggtggga gctgaccgtg ttgttgccaa tggagacaca gccaacaaaa 240 taggcaccta tcagctggcc attgtcgcca aacaccacgg tgtccccttc tatgtggctg 300 cccccagttc atcctgtgac ctccatctgg agactggaaa ggagattgtc atagaggaac 360 gccccagcca ggagctaact gacctgaatg gagtcaggat tgctgcacag gaaatccggn 420 tttgggaatc ctgcctttga tgtcaccccc cacgaactca tnacaggngg natnatcact 480 gaactgggtg nntttgcccc tgangagctc cgaggagccc taag 524 864 107 DNA Mus musculus 864 tgagactgag gggaggcaca cggtccaagt ccttttactt tctgaggatg ggcagatcct 60 ggcagaagca gatggactga gcacaaacca ctgggtaaaa aaaaaaa 107 865 454 DNA Mus musculus misc_feature (1)...(454) n = A,T,C or G 865 ggtgtcaaca tctccagggg gcccgaancg ccatctcccg cgccgccagt gtcttcgttt 60 tgtatgccac atcctgtgcc aataacttcg cantgaaagg aaagcgcaag actctcaatg 120 ccagtgacgt gctgtcagcc atggaagaga tggaattcca gcgattcata acaccattga 180 aagaagctct agaagcgtac aggcgggagc agaaaggcaa gaaggaggct tcggagcaaa 240 agaagaagga caaagacaaa aaggattccg aagagcaaga caaaagcaga gaggaggagg 300 aggaggatga agagagactg gacgaggacg accagaacga agaggaggaa atagacaact 360 gaatggagag agtaggcana ctgtggcgtg gtggagggga ccctgagatc ctgagacatg 420 tctgtgtgaa ggctttccct gcaaggcaga gcca 454 866 295 DNA Mus musculus misc_feature (1)...(295) n = A,T,C or G 866 ccctgttccc caggcagagt acanaactna gcnttgctgg tgaaggtccn actggaggac 60 acccaagttc ancatgatct tgacagacct gtgactgacc tgaccctccc tncagtcctg 120 tgccactgac acatatgctt gatgccttct gctttgtcct agtacccaag acggtgagtg 180 aagcaggggt caaaagttca gttctcagct gcatagtgag tttgaggcca gcctgggtta 240 aatgatacac tgctttaaca caatgaaata aaggacagga gagattggtt tggaa 295 867 361 DNA Mus musculus misc_feature (1)...(361) n = A,T,C or G 867 gactgaggtt tatcatggct tccagcccac cgtgttgatg cggctggtag cttcagcata 60 ttctatcgct caaatggtac tatnnttaag ngaagaantg aaagagggtt agttccaant 120 gactgtccag gtcattctgt gcacgtcanc attnctgccg ataaaccaga nttcttcagg 180 gcacagagnc ttaagttact ccagantttc agtngtnatg ntttttcaca gtanttttta 240 aaatntntga tnccaaataa gaangcatat agntgatatt attnatgtcn gatttatggg 300 ggaaagttnc tctaaaanca tagtcctatc tttncatatt atatatcaga tttttttcaa 360 a 361 868 504 DNA Mus musculus 868 gccgaggacc agcagccaag cactaggact ggacatccca gcaatgacca gctctcctgt 60 ctccagagtt gtctacaacg gcaagaggaa tagcagtccc cgctctccca ccaacagcag 120 tgagattttc acaccggcac acgaagagaa tgtgcgcttc atttatgaag cctggcaggg 180 tgttgagcga gacctgcgca gccagctgtc cagtggtgag cggtgcctag tggaggagta 240 tgtggagaaa gtccccaacc ccagcctgaa gaccttcaag cccatcgacc tgagtgacct 300 gaagccgccg gaacacgcag gatgccaaga agtcctagag ctcctggcgc cctcccctgg 360 cctccagaag ctcaggtgca cttgatggtg gtttcctgtg ttcctgtggc gctgctcctg 420 gggggaagag tgtgctctag caggccggga tcccagagcc agcaggattg atgaccaggg 480 cccttccttt cctctccagg gtct 504 869 405 DNA Mus musculus misc_feature (1)...(405) n = A,T,C or G 869 actgaggtgg ggtctttcac gatgacccga gagtgacgac gacgacgagg aggaggacat 60 ggtctcggag gaggacgagg aggaggagga ggatggctga cgccgaggag acccaggatt 120 ccgaggacga ggaggaagat gacatggaag aagacgacga tgactccgat tatccggagg 180 agatggaaga cgacgacgac gacgctagtt actgcacgga aagcagcttc aggagccata 240 gtacatacag cagcactcca ggtaaccacc caggccgccg ggagactcct tccccacctc 300 ctccctcccc ctggcttgct ccctctccag tgcagtgcat cctgcttcct anctcccccc 360 ccccttcccg gcctgtcccc cacgcggagg ccacggcgcg tttag 405 870 556 DNA Mus musculus misc_feature (1)...(556) n = A,T,C or G 870 gactgaggtg accataggac ngnggcttac cggcacntac cacctgatat canaggtntg 60 ccctctgatg atttcccnaa gccacctgag gnntgngaan cataaatcct antgncacng 120 aaggaccatt atggaccata ggaccctgaa taggtgtttg nctatncaga gaacnctann 180 ctcctattaa cnggtatatt ntnttcganc ngnagaccnt ntncntgtcg gggtgccccg 240 tnganagcag agtaaacggn tggataatag agtacgatcg acanctgaag aagacntgag 300 nagagtttag ggtccctgag cttgccccga atanngancn aagagnggga ggacataagn 360 gctcgagaac taagaggant ttcagttcgc cttggnttag agaatcttcc agccgagggc 420 tcctcagatc tcagatgccc actggctaat gtcgccagta aacccattga gccagagaag 480 ttgcatggca aaggtgacgc atcgagtcag tccttgggat gcttgggncc tgggctgact 540 tctctgaagg cgaacg 556 871 461 DNA Mus musculus misc_feature (1)...(461) n = A,T,C or G 871 ggttgcagac aatgatggtg agttcctgtt aatagaagcg gccgactttc tccctaagtg 60 gttggaccct gataacagng ccaacagggt gttttttcat catggggagc tgtgcattat 120 tcctgtgccg aggaaatctg aaaggatacc atggttaccc atgacaccac caacaatcca 180 gcaagctttg agtataatct cggcacaccc agaagctgtt ttggcttnnn aatctataca 240 agctgctgtg gacaggcgcg tcagtgggta cccagaaagg gtcgaagcat ccctccatcg 300 agcacactgc ttccttccag ccggcattgt ggcggtgctc aagcancagc ccaggctgct 360 gtcggcagcc gtccanggcc ttctacctac gggaccccat ttgacctaag agcctgtcgt 420 gtnttcaaga catttttgcc tgaaacacga aataatggcc t 461 872 289 DNA Mus musculus misc_feature (1)...(289) n = A,T,C or G 872 tgaggtctgt ttctgcaggc atctncgtgg ctccatgant cttccctttg atgacagaga 60 cctggnctgt gagtgggaga gngaagacct gcccctgacc attcagcttc cattccgnct 120 tatcctgcnt gtngggnacc tgccctttga tgaatactgg atccccctgt gcangaactc 180 ttggctaatg acatgcatgg attgatttac cttacatagc gctattgagc tcaaattgtg 240 ataatgctgc cattgagaga aactcaccca cgaactgctt ataaaaaaa 289 873 465 DNA Mus musculus 873 gactgaggaa tttaactaag atgatggcaa cttgtactcc aagaaagagg aagcgatata 60 cactgaatgc tgataatgat gatagcctat taacagatat ttcatcaagc aaattaagat 120 gtgctgaaaa tctatttcca tcacctaata agaaacataa ttatcaaagc agtgttcaaa 180 aggaagacaa gtcttgctcc caccaactcc atttcccttc aagtccactc aaaacaactg 240 aaaatagtag gttttcattt gcaaaccaca gctcattatt taaaccagct atgtctactg 300 tatctttcta cagtaaagag aaatactacc tcaatccact cgagaggaag ttgataagag 360 agtgtagatc tatttgtcta gcaactgaaa gtggagataa acctattccc agtgtgacag 420 aaaatattca gagaaaacca gtctgtacca agaagaataa aaaaa 465 874 386 DNA Mus musculus misc_feature (1)...(386) n = A,T,C or G 874 gactgagttt ttagttgcat ttttaaagaa ggaaggctca tggtgcaaat tgttatttcc 60 agtacggggg ctgaaggcct ggcagaatgg gtgctgatgg anctacaggg ngagatcgag 120 gctcgctaca gcaccgnatt agctggaaac ctcctgggag acctacatta caccactgag 180 ggangagatg tnatcnacnn tacccnagcc tnaatcctgc ttnctcnnat ngnagnnttn 240 ngctcattcg ntntnccacg cccactgntg gaacntgagg agccacacac ngncaccttt 300 ctactggacc agagattatt nggcngggaa ntnggctccc ctccnncttg cttcatnact 360 ggtgtcgcaa caataaaatt agaacc 386 875 533 DNA Mus musculus misc_feature (1)...(533) n = A,T,C or G 875 tctcctggtc tgtgttctga ttcttctttg gaggagagtt taaggatcac agttggcaat 60 gaccacttct gtgttagcac accagagcgg cggcggntca gtgaccggct gggatctcca 120 gtggatggtc tgcaggacat ggacagggat gacctgactg atgattctgt cttcactcga 180 agctcccagt gttctcgggg gtcttgaacg atacatttct cgggaggagg gaccacttag 240 tccctttctt gggacaactt ggatgaggac taccgaacaa ggagaaactt ttctgcatcg 300 acctggagtt tagtccccag agcagttgtc atgatgaatt ngttgaggga aacagagcgg 360 tatnagaaac aaacttaaaa gctcctccta ttccatacga tctgaggaaa gaggccggga 420 ggccaaaaag gcccccgttt ttgatgacnc agagaagggt acnccagctc aaggaggggg 480 gatcacttca angttttnac atcnngggac tcgaaaacct atcggggagg cgg 533 876 306 DNA Mus musculus misc_feature (1)...(306) n = A,T,C or G 876 gaactgagat ggcctcacgg tacatgatcc agctcacttc tgtgttcaag gatgtctgtc 60 taacgccaga agagatgaat ctcgtggtgg ccaaagtgtt gacgatgttc tcaaagttga 120 atcttcaaga aattccacct ttggtctatc agcttctggt tctctcttcc aagggacgca 180 naaggagtgt tcttggacgn atncatagcc ttcttcaggg agctggataa gcagcacaga 240 tacatttttt ccacataaga atgcactttg gcttatacaa taaaacttta aacattaaaa 300 aaaaaa 306 877 541 DNA Mus musculus misc_feature (1)...(541) n = A,T,C or G 877 cggagcacca taacatggng tgggaagtga agacaaatca nnatgcctaa tgcagtncag 60 aaactcctgc tggtgatgga caagagagca ccagggatga gngactcgct ggagttgctg 120 cagtgtaatg agaatttgcc atcctctcca ggatacaact cctgtgatga gcacatggag 180 cttgatgacc ttcctgaact tcaggctgtt caaagngacc ctacccaatc tgncatatac 240 cagctaagtt cagatgtatc tcatcaagaa tatccaagat catcttggag ccagaatacc 300 tnagatatac cggaaaatac tcaccgtgaa natgaggngg actggctaac agagttangc 360 aaatattgcc actagtncac aaagtcccct gatgcantgc tcattttata acaggtagga 420 gcatggatta tgttttgcnt tntcanactt gcatttatta ggggccagca atnatactan 480 tgtaagctnc anntgggtta angaancctt gcccaccaag cnctgaaggg cgcaaacctt 540 g 541 878 340 DNA Mus musculus 878 cacaacacag tcggattctt ctcaacagcc tttattgcag gatcgccttg atgcttctac 60 ggggacccca ggcgcccagg gagccctgct tatatgtacc ccagcacagg agaaggctcc 120 gtggccccct ggggttggtc agtctgccag cacccaattt gcatgcaccc gcttgggagg 180 ggttggcccc aaattcgaat tgacgcctgc gcagtggtgt tgtttatgac aacggcaacc 240 ggaaaccggc gccatcttgg agttggcttc ccacagagag gagagggaga ggagagggag 300 aggagaggaa gaggaagagg aagaggaaga ggaagaggat 340 879 537 DNA Mus musculus misc_feature (1)...(537) n = A,T,C or G 879 gaactgagag atgaagcaga tgaatcttgt cactgggaaa cagngcctaa taaagagggc 60 tcctttctcc atcagtgcct tcagttacat ctgtgagaat gaggccatcc ccatgccaac 120 ccactgggan aacgtgaacc ctgacgttcc ctaccanctg gtttccctgc agaaccagac 180 gcacgagtat aatgaagtgg ccagtctttt tgggaaaaca atggatcgga accganttaa 240 aaggattcaa aggatccaaa acttanactt atgggagttc ttttgcagga aaaaggctca 300 gctcaagaaa aagagaggtg tcccccagat caatgagcag atgctatttc atggcaccag 360 cagtgaattt gtggaagcaa tttgcattca caactttgac tggagaatca atggtgtgca 420 cggngctgtc tttggaaaag gaacctattt cgctagagat gctgcgtact ccagtcgttt 480 ctgcaaagat gacatcaagc acgggaacac attccagatt catggggtca gcttgaa 537 880 481 DNA Mus musculus misc_feature (1)...(481) n = A,T,C or G 880 ctgaggactg gattcagcat caaaatacct cccccacatt gagagctgtc ggcagttaag 60 gcaacaatac cctgattgga atcctgagat cctcccatcc agaagaaatg agagcaatag 120 gaaagaaaat gaaactccaa gaagacgttc tcattccccc agccccagac attctaggag 180 atcaagctca ggtcacagaa tccgtcgctc tcgaagtcca gtccgttata tctatagacc 240 aaggagtcga agtccaagaa tttgccaccg tttcatttct aaatatagat ccagatccag 300 gtccagatcc aggtcccgtt ctccatatcg tagtcggaat ctccttagaa gaagtccgaa 360 gtcctatcgg tcagctagcc cagagaggac atcaagaaaa tcagtgagat caggtacacc 420 gatnntccta atgccatcat tttttttgag ttttggaaat gagatattgg attttaatta 480 a 481 881 429 DNA Mus musculus misc_feature (1)...(429) n = A,T,C or G 881 gaactgagga agcatcatga cgaagaggca ttggaaacgc tgacagtatc ccccatctgg 60 gttccgcacc catggggcag acacatgctc atcaccagca agatcagctt cttcattttg 120 acaacattgc actagctgct ccggaaccca cactggctct gcgattctgt ggaaacatgc 180 aaacagaccc tctcgcccag accaacacgg gatctggacc attccatgat cctgtaagca 240 catccttcca tttagcatac cccagattac tggggctgtt attagcatgt cgttcagcag 300 cagagcgncc ttccttttcc aattgcaaaa aatttaaggt aaaaagagct aaggagagtc 360 ttatctttgg ggtatggcca tagcctattc cccctttttg ttttattaat aattctttta 420 aggttctaa 429 882 537 DNA Mus musculus misc_feature (1)...(537) n = A,T,C or G 882 gaactgagca ggctcctctn cncatgctcc tccaaggaat ggtaaggtgg cccttgaccc 60 acacacatat ctatcaagaa ctcaagagca cagacntgaa gtaccnggaa ccgtgtgcgc 120 agccgcatca gcnacctgan ggaccccang ancccatgcc tgaggcggan tgtgctcagt 180 ggggccattt ccccatagct cattgccang atgacagcgg angaaatggn cagtgatgag 240 ctgngggagc tgaggaacgc catgactcag gaggccatcc gtnagcacca ntatggcgaa 300 gacaggcggc accaccactg acctcttgcg gtgtatcaag tgcaagaaga agaattgtac 360 ctataaccag gtgcanacac gcagtgccga tgagcccatg accacttttg tcttatgcaa 420 tgaatgnggg aatcgctgga agttctgctg acggaaccac ccaccaggat ggcagaggat 480 aaggtgaaga agacccagca ggaagcacag accacgtgac ccagagcaaa aaaaaaa 537 883 220 DNA Mus musculus misc_feature (1)...(220) n = A,T,C or G 883 ggacccacca ggtttcagct gctcccacca gctctgcagg ggatggattc aaggcaaacc 60 tcgtctttaa ggagattgag aagaagcttg aagaggaagg ngaacagnnc gtgaagaaaa 120 tcacggcggc atttttgcct tgaaagtgaa agatggccct ggaggcaaag aagctacctg 180 gntggtngat gtaaacaatg gcaaaggatc tgtgcttccc 220 884 264 DNA Mus musculus misc_feature (1)...(264) n = A,T,C or G 884 gaactgaggg cttcttggta atgcccaggc taaggcacta ggaccagcct cagagcagtc 60 agagaatgag aagaagccca agagngnagn gaagaagaaa aggtggaatc ntcccaaaat 120 gtctcttgcc canaacnttt natcgggttg cctcaanaga aggcaagctt cctcagnagc 180 tcacgganag gtcctgctng aaacctnncc gcngntttct atgnannaat ttntttcata 240 cntttttttt gggggggggg gccc 264 885 123 DNA Mus musculus misc_feature (1)...(123) n = A,T,C or G 885 cagaaagaaa gcttttagta aaacancctt tttaatagcc tggccacgca agaaggtgaa 60 tgtttnggct cttaagagga anaagttcaa aaaataaatt gtcttgtaat gtaaaaaaaa 120 aaa 123 886 440 DNA Mus musculus misc_feature (1)...(440) n = A,T,C or G 886 gaactgagga acttaagaag tatggagtta ccacantagt acgagtatgt gaagcaactt 60 acgacactac tcttgtggag aaagaaggca ttcatgttct tgactggcct tttgatgatg 120 gtgcaccacc atccaaccag attgtcgatg actggctaag tcttgtgaag attaagtttc 180 gtgaagaacc tggttgctgt attgctgtcc attgtgtcgc aggccttggc agagctccgg 240 tgcttgttgc cctagcatta attgaaggtg gaatgaaata tgaagatgca gtacaattca 300 taagacaaaa gcggcgtgga gcttttaaca gcaagcaact tttgtatctg gagaagtacc 360 gtccgaaaat gcggctccgc ttcaaggatt ccaatggtca tagaaacaac tgttgtattc 420 aataaaactg gggtgcctga 440 887 389 DNA Mus musculus misc_feature (1)...(389) n = A,T,C or G 887 catggaaaag tgccggcttc cagccctttg cggcttttgc agtggatgac cgtgtggaga 60 tgctaagcgg tggacagcgg cagaacacta ggaaacagaa ggcttgggac aaagttaata 120 gcgcctgttc acaaagttca caaaggaccc gttttcactg tgtcctacaa ttgggtcatg 180 tagggctggc caggtggctc agcgtttaag aacacagttg ctcttccaga aggcctgctt 240 ctattcttcc tagcacccac atgggtgctc acaaccacta gggtcactct gcttccaagg 300 gtttgatgtt ctcttntggg gctntgagga ctgagcaaag aggnggtgcc tggttataca 360 tacaggcaaa acattcataa aataatcag 389 888 361 DNA Mus musculus misc_feature (1)...(361) n = A,T,C or G 888 aagaaaactt caaactccac agtcggagga gagtgacttg cattatgcgg acattcatgt 60 gctcaggcaa attcggccac actctctcca cacagtgaaa tgcctgcatt cagaatctgc 120 tacagagtac ncnncncttc nnttccccca ggccacacct cantatgaca gcaacaacgg 180 aaccctggtg tgagccctcg ggaagacgtt ccgatttcta cgattttacc atcctgtggg 240 aataacctac tgttctcgag aacaaggaca atggccatgt tttaatctta aaggacacca 300 gagcatctgg aattatgggt ctccctactc tttccactat gaatcttttg gtttgccact 360 g 361 889 137 DNA Mus musculus misc_feature (1)...(137) n = A,T,C or G 889 aatacatttc aactgtatga aattggttta ttgttcatca naaatgttat ttgccttcac 60 aaagtctggt ttcaatgaac cagctatgta atgggatatt aaataaacat ggaattttac 120 atgttcaaaa aaaaaaa 137 890 174 DNA Mus musculus 890 gaactgaggt atagctccat gaataactta aacgaccccc caaattggaa tatcaggccc 60 aatgccaggg ctgatggggg tgatggaagc aagtggaatt atgccctatt ggtgccaatg 120 ctcggattgg cagcatttcg ttggatttgg tctagggaat cccaaaaaaa aaaa 174 891 188 DNA Mus musculus 891 tccttctgtg tgctgcagtc ttgtggcgtt ctgcaggccc cctgccagtg accccaggct 60 ttttatggct gtgagactca ttaaaagctc aggggtgaga cgtgaccttt ggaggtgact 120 ataactgaag attgaattac agaagccaaa aaattaaata aataaaaggt aaaattataa 180 aaaaaaaa 188 

What is claimed is:
 1. An isolated polynucleotide comprising a contiguous stretch of at least about 60 nucleotides first disclosed in at least one of SEQ ID NOS:1-891.
 2. An isolated polynucleotide according to claim 1, wherein said polynucleotide sequence comprises at least one of SEQ ID NOS:1-891.
 3. An in vitro process for producing an isolated polynucleotide incorporating a sequence capable of hybridizing to a sequence first disclosed in one of SEQ ID NOS:1-891, comprising the steps of: a) obtaining a polynucleotide template encoding a sequence capable of hybridizing to an GTS of SEQ ID NOS:1-891; b) contacting said template with a polynucleotide probe comprising at least about 25 contiguous bases first disclosed in SEQ ID NOS:1-891; c) processing the combined probe and template to allow the specific detection of the combined probe and template; and d) isolating a clone encoding said template.
 4. The process of claim 3 wherein said template is mammalian cDNA.
 5. The process of claim 3 wherein said template is mammalian genomic DNA.
 6. A process according to claim 4 wherein said template is of human origin.
 7. A process for identifying novel polynucleotide sequences comprising the steps of: a) retrieving a computer readable representation of a polynucleotide sequence first disclosed in at least one of SEQ ID NOS:1-891, or an amino acid sequence encoded thereby, from a computer addressable form of electronic data storage medium; b) retrieving a computer readable representation of a test polynucleotide or polypeptide sequence from a computer addressable form of electronic data storage medium; and c) comparing the sequence of said test polynucleotide or polypeptide sequence to a sequence first disclosed in at least one of SEQ ID NOS:1-891, or an amino acid sequence encoded thereby.
 8. An isolated murine embryonic stem cell line comprising an engineered retroviral gene trap vector in at least one gene comprising a polynucleotide sequence first disclosed in one of SEQ ID NOS:1-891. 